Relationship between serum vitamin D levels, adipocytes, and bone density in pre-adolescents and teenagers with newly diagnosed acute lymphoblastic leukemia.

Abstract Background Vitamin D is a critical factor in bone remodelling, calcium absorption and may promote anti-inflammatory cytokines in the gut. Inflammatory bowel disease (IBD) is associated with a reduction in serum Vitamin D levels and a chronic inflammatory state, both of which are strong risk factors for bone density loss affecting IBD patients. Despite European and North American IBD maintenance guidelines for Vitamin D monitoring and bone density scans, there are limited North American investigations into factors influencing serum Vitamin D levels in the IBD patient population specifically. Aims We investigated whether patient demographics, disease severity indexes and/or inflammatory markers were linked to low serum Vitamin D levels in our IBD patients. We also established the extent of Vitamin D serum deficiencies and supplementation rates in our IBD patients. Methods A retrospective chart review of a single clinician’s practice at London Health Science Centre, Victoria Hospital, over the past 20 months, was performed to: 1) assess the frequency of low serum 25-OH Vitamin D (25-OH D) in the IBD patient population and 2) determine whether patient disease severity was linked to lower 25-OH D levels. A multivariate regression analysis was performed assessing Crohn’s Disease (CD) or Ulcerative Colitis (UC) patient factors: age, sex, disease duration, seasonality, current pharmacologic treatments, past surgeries, CD Activity Index, UC Mayo score, C-reactive protein, and fecal calprotectin (Fcal) level. Results 175 IBD patients had at least one 25-OH D measurement with 71 patients actively on Vitamin D therapy. Of UC and CD patients who were not on Vitamin D therapy, 63% (17/27) and 79% (61/77) were 25-OH D deficient, respectively. 25-OH D levels in the CD population was associated with Vitamin D supplementation (regression coefficient [RC] 23.99, 95% confidence interval [CI] 14.54 to 33.45), summer season ([RC] 9.90, [CI] 0.56 to 19.24), and past bowel resection ([RC] -10.61, [CI] -20.48 to -0.76). 25-OH D levels in the UC population was associated with Vitamin D supplementation (regression coefficient [RC] 47.23, 95% confidence interval [CI] 27.62 to 66.83), and Mayo severity scores ([RC] -23.01, [CI] -41.82 to -4.20). Fcal (78 patients) was inversely associated with 25-OH D levels but the trend was not significant. Conclusions Overall, 25-OH D levels were lower in both the UC and CD patient populations relative to the already deficient Canadian population. However, IBD patients are responsive to Vitamin D supplementation. Tools with more objective evidence of disease severity such as UC Mayo score and fcal should be prioritized for identifying the IBD population requiring supplementation. Funding Agencies None

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Prognostic characteristics of 492 newly diagnosed breast cancer patients by serum vitamin D levels.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.e12619 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. e12619-e12619 ◽

Cited By ~ 1

Author(s):

Luke Joseph Peppone ◽

Mohamedtaki Abdulaziz Tejani ◽

Karen Michelle Mustian ◽

Michelle Christine Janelsins ◽

Charles Stewart Kamen ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Cancer Patients ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Serum Vitamin D ◽

Vitamin D Levels

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Serum Levels of Vitamin D in Patients with Multiple Myeloma

Folia Medica ◽

10.3897/folmed.62.e50321 ◽

2020 ◽

Vol 62 (4) ◽

pp. 730-735

Author(s):

Vasko Graklanov ◽

Veselin Popov ◽

Ralitsa Raycheva

Keyword(s):

Multiple Myeloma ◽

Vitamin D ◽

Serum Vitamin ◽

Reference Value ◽

Serum Levels ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Maximum Value ◽

Vitamin D Levels ◽

International Myeloma Working Group

Aim: То investigate the serum levels of vitamin D in newly diagnosed patients with multiple myeloma. Patients and methods: In this study we measured the serum levels of vitamin D in 37 patients (19 women, 18 men) at a median age of 68 years and a diagnosis of MM according to the International Myeloma Working Group (IMWG) criteria. The immunoassay tests used for the quantification of 25 (OH) – Vitamin D were original ELISA kits Immundiagnostic and the measurement was done before starting the treatment. Results: Serum levels below the optimum (<30 ng/ml) were recorded in all 37 patients. The median value of vitamin D was 4.3±6.5 mg/ml, the maximum value measured was 24.7 mg/ml, which is below the lower limit of the reference value for deficiency. Conclusions: In this study, we found extremely low serum vitamin D levels in most of the newly diagnosed MM patients.

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STUDY THE SERUM VITAMIN D LEVELS IN PATIENTS OF CHRONIC KIDNEY DISEASE

10.36106/ijsr/0703036 ◽

2021 ◽

pp. 1-3

Author(s):

Brahmarshi Das ◽

Narendranath Hait ◽

Jayanta Kumar Rout ◽

Debarshi Jana

Keyword(s):

Chronic Kidney Disease ◽

Vitamin D ◽

Kidney Disease ◽

Kidney Diseases ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean

INTRODUCTION: Chronic Kidney Disease (CKD) is dened as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney 1 function over a period of months or years. Early on there are typically no symptoms. Later, leg swelling, feeling tired, vomiting, loss of appetite, or 1 confusion may develop. Complications may include heart disease, high blood pressure, bone disease, or anemia. AIM AND OBJECTIVES: Study of Prevalence of hypovitaminosis D in patients of chronic kidney diseases. Search for commonest etiology of hypovitaminosis D in CKD. MATERIALAND METHOD: A Cross-sectional study on 100 cases of newly diagnosed Chronic Kidney Disease patients and matched control subjects is undertaken to study the prevalence of Vitamin D deciency in CKD population and correlation between their serum 25-OH-vitamin D level. 100 Patients who are newly diagnosed as CKD are selected after proper initial screening at Midnapore Medical College, Paschim Medinipur. RESULT AND ANALYSIS: Our study showed that in non-dialysis Syndrome the mean VitD (mean± s.d.) of patients was 25.6620 ± 8.5476. In dialysis the mean VitD (mean± s.d.) of patients was 10.9476 ± 2.6508. Difference of mean VitD in Dialysis vs Non-Dialysis was statistically signicant (p<0.0001). In eGFR 1 (<15) the mean VitD (mean± s.d.) of patients was 11.1130 ± 2.9562. In eGFR2 (15-30) the mean VitD (mean± s.d.) of patients was 24.0750 ± 8.2995. In eGFR3 (31-45) the mean VitD (mean± s.d.) of patients was 26.8296 ± 7.3646. In eGFR4 (>45) the mean VitD (mean± s.d.) of patients was 36.3167 ± 4.9898. Difference of mean VitDin eGFR was statistically signicant (p<0.0001). SUMMARYAND CONCLUSION: Vitamin-D deciency more pronounced in advanced stages of CKD. Vitamin-D deciency was most prevalent in female gender, younger age group and connective tissue disorder. Vitamin-D deciency was more marked in hemodialysis patients compared to non-dialysis CKD patients.

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Vitamin D levels in patients with non-Hodgkin lymphoma/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma

Journal of International Medical Research ◽

10.1177/0300060520943421 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094342

Author(s):

Vasko Graklanov ◽

Veselin Popov

Keyword(s):

Vitamin D ◽

Cell Lymphoma ◽

Serum Vitamin ◽

B Cell Lymphoma ◽

Lymphocytic Leukemia ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Non Hodgkin Lymphoma ◽

Large B Cell Lymphoma ◽

Vitamin D Levels

Purpose To investigate serum vitamin D levels in patients newly diagnosed with non-Hodgkin lymphoma/diffuse large B-cell lymphoma (NHL-DLBCL), multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). Patients and methods We measured serum levels of vitamin D by ELISA in 103 patients prior to initiation of treatment, of whom 37 were diagnosed with MM, 32 with CLL and 34 with NHL-DLBCL. Results Suboptimal serum vitamin D levels (<30 ng/mL) were observed in all 103 patients. In 14 patients, serum vitamin D levels were between 20 and 30 ng/mL, while all other patients had vitamin D deficiency (<20 ng/mL). Severe vitamin D deficiency (<10 ng/mL) was observed in 32.3% of NHL-DLBCL patients, 28.1% of CLL patients and 81% of MM patients. Conclusion We observed low serum vitamin D levels in the majority of patients newly diagnosed with NHL-DLBCL, CLL and MM.

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Data for the measurement of serum vitamin D metabolites in childhood acute lymphoblastic leukemia survivors

Data in Brief ◽

10.1016/j.dib.2018.04.030 ◽

2018 ◽

Vol 18 ◽

pp. 1427-1432 ◽

Cited By ~ 3

Author(s):

E. Delvin ◽

M. Boisvert ◽

M.-A. Lecours ◽

Y. Théorêt ◽

M. Kaufmann ◽

...

Keyword(s):

Vitamin D ◽

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Serum Vitamin ◽

Childhood Acute Lymphoblastic Leukemia ◽

Vitamin D Metabolites ◽

Serum Vitamin D

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Comparison of the effect of vitamin D on osteoporosis and osteoporotic patients with healthy individuals referred to the Bone Density Measurement Center

BioMolecular Concepts ◽

10.1515/bmc-2019-0005 ◽

2019 ◽

Vol 10 (1) ◽

pp. 44-50 ◽

Cited By ~ 3

Author(s):

Banafsheh Shahnazari ◽

Jamileh Moghimi ◽

Majid Foroutan ◽

Majid Mirmohammadkhani ◽

Amir Ghorbani

Keyword(s):

Vitamin D ◽

Bone Density ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Control Group ◽

Bone Density Measurement ◽

Mineral Density ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Impact

AbstractObjectiveOsteoporosis is the most common metabolic disease of the bones. Osteoporosis reduces bone density, predisposes a person to fractures, and imposes high costs on societies. Osteoporosis develops from a variety of causes, one of the most significant is vitamin D deficiency. This study investigates the impact of vitamin D on osteoporosis.Materials and MethodsIn this clinical trial, 400 patients referred to the Bone Density Clinic of Kowsar Hospital in Semnan were selected by convenience sampling method. Bone densitometry tests were carried out using DEXA (x-ray absorptiometry) and serum vitamin D levels were measured by the ELISA method. Subjects with vitamin D deficiency were treated for 8 weeks with (50,000 Vitamin D units per week. At the end of the treatment period, all subjects were evaluated for bone density and the results of both groups were compared.Results13% of subjects had osteoporosis and 14.2% had osteopenia. 19% of subjects had vitamin D deficiency, 38.8% had insufficient levels of vitamin D, and 42.3% had sufficient vitamin D levels. The level of vitamin D in patients with osteoporosis (5.50 ± 5.5 ng/ml) was less than those with osteopenia (7.83 ± 4.8 ng/ml) and those with normal bone mineral density (23.88 ± 18.42 ng/ml) (P <0.001). The prevalence of osteoporosis in the intervention group after intervention with vitamin D was significantly lower than the control group (32.3 versus 67.7 and P <0.001).ConclusionThe prevalence of serum vitamin D deficiency in osteopenic and osteoporotic individuals was higher than in normal subjects, with a significant relationship between age and sex. Thus, treatment with vitamin D improves bone density indices.

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Serum Vitamin D Levels in Children with Immune Thrombocytopenia

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190614152709 ◽

2020 ◽

Vol 20 (2) ◽

pp. 221-226 ◽

Cited By ~ 1

Author(s):

Giuseppe Lassandro ◽

Francesco Carriero ◽

Viviana Palmieri ◽

Valentina Palladino ◽

Anna Amoruso ◽

...

Keyword(s):

Vitamin D ◽

Immune Thrombocytopenia ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Chronic Itp ◽

Increased Risk ◽

Vitamin D Levels ◽

Newly Diagnosis

Objective: Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by thrombocytopenia with an increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as an immune modulator. We decided to evaluate serum Vitamin D levels in a cohort of children with immune thrombocytopenia in order to discover if Vitamin D concentrations may predict ITP duration. Methods: Thirty children were enrolled in this study (sixteen with chronic ITP and fourteen with newly diagnosed ITP) to assess serum Vitamin D levels. Results:: The results showed that 80% of the enrolled children presented a D hypovitaminosis status. Children with newly diagnosis ITP showed no statistically significantly higher median values of Vitamin D compared to chronic ITP. Conclusions:: This study may suggest that Vitamin D deficiency does not represent a chronicity factor for ITP. However, further studies are needed to understand the role of Vitamin D in ITP pathogenesis.

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