Serum Levels of Vitamin D in Patients with Multiple Myeloma

Aim: То investigate the serum levels of vitamin D in newly diagnosed patients with multiple myeloma. Patients and methods: In this study we measured the serum levels of vitamin D in 37 patients (19 women, 18 men) at a median age of 68 years and a diagnosis of MM according to the International Myeloma Working Group (IMWG) criteria. The immunoassay tests used for the quantification of 25 (OH) – Vitamin D were original ELISA kits Immundiagnostic and the measurement was done before starting the treatment. Results: Serum levels below the optimum (<30 ng/ml) were recorded in all 37 patients. The median value of vitamin D was 4.3±6.5 mg/ml, the maximum value measured was 24.7 mg/ml, which is below the lower limit of the reference value for deficiency. Conclusions: In this study, we found extremely low serum vitamin D levels in most of the newly diagnosed MM patients.

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No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160173 ◽

2017 ◽

Vol 75 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Soniza Vieira Alves-Leon ◽

Samira L. Apostolos-Pereira ◽

Walter Oleschko Arruda ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Large Population ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Control Subjects ◽

Vitamin D Levels ◽

The Mean ◽

25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

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A Study of Serum Vitamin D Levels in Newly Diagnosed Pulmonary Tuberculosis

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i1.93 ◽

2018 ◽

Vol 6 (1) ◽

Author(s):

Dr V Ram kumar ◽

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Vitamin D Levels

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Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1209 ◽

2014 ◽

Vol 7 (3) ◽

pp. 112-116

Author(s):

Anil Jain ◽

Pankaj Shah ◽

Datt Modh ◽

Bhaskar Thakkar ◽

Ashish Katarkar ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Normal Population ◽

Serum Vitamin ◽

Serum Levels ◽

Multifactorial Disease ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunological Effects ◽

K Deficiency

ABSTRACT Allergic rhinitis is a common condition affecting 5 to 40% of general population and its prevalence is increasing. It is a chronic condition characterized by inflammation of nasal mucosa. As per recent studies, there is an association between serum vitamin D levels and allergic rhinitis status. Vitamin D has major role in the regulation of calcium metabolism. In addition to this, it also has a number of immunological effects and takes part in immunomodulation, which can significantly affect the outcome of allergic responses like in allergic rhinitis. Aims and objectives To establish the correlation between vitamin D3 serum levels and allergic rhinitis. Materials and methods Vitamin D levels were assessed in 23 patients with allergic rhinitis diagnosed clinically by allergic rhinitis and its impact on asthma 2008 criteria and results were compared with vitamin D status in the normal population of same region. Results The levels of serum vitamin D levels were significantly low in the patients of allergic rhinitis. Conclusion Measuring of serum levels of vitamin D could be considered in the routine assessment of patients with allergic rhinitis. How to cite this article Thakkar B, Katarkar A, Modh D, Jain A, Shah P, Joshi K. Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease. Clin Rhinol An Int J 2014;7(3):112-116.

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Relationship between serum vitamin D levels, adipocytes, and bone density in pre-adolescents and teenagers with newly diagnosed acute lymphoblastic leukemia.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.e20009 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. e20009-e20009

Author(s):

A. Butturini ◽

S. Mittelman ◽

D. R. Freyer ◽

V. Gilsanz ◽

N. Hart ◽

...

Keyword(s):

Vitamin D ◽

Acute Lymphoblastic Leukemia ◽

Bone Density ◽

Lymphoblastic Leukemia ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Vitamin D Levels

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The relationship between serum vitamin D level and COVID-19; a review study

Journal of Preventive Epidemiology ◽

10.34172/jpe.2020.34 ◽

2020 ◽

Vol 5 (2) ◽

pp. e34-e34

Author(s):

Yasaman Koohshoori ◽

Ehsan Ramanian ◽

Nasrin Moradi ◽

Shahrzad Shadabi ◽

Minoo Motahhar ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Length Of Hospital Stay ◽

Hypovitaminosis D ◽

Serum Levels ◽

Potential Effect ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

Introduction: Coronavirus disease 2019 (COVID-19) from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important epidemiological events in the past 100 years has become, the consequences for public health and economic systems around the world. Vitamin D is an important micronutrient that has been reported to improve immunity and protect against respiratory diseases. In this study, we intend to review articles that examine the relationship between COVID-19 and vitamin D. Methods: This is a review that uses articles from studies published in 2020 on the relationship between COVID-19 and vitamin D in databases such as; Web of Science, Science Direct, SID, Magiran, Google Scholar and PubMed. Keywords used included; serum levels of 25-hydroxyvitamin D, vitamin D, COVID-19, SARS-COV-2 and coronavirus 2. With this search, 32 articles were finally selected for this purpose and their results were reviewed Results: Of the 32 studies reviewed, only three showed no association between vitamin D levels in the blood and COVID-19 disease. Other studies had a relationship between the severity of the disease, mortality rate and length of hospital stay, in different age, gender and location groups. Conclusion: It seems that the level of vitamin D in the blood has a potential effect on COVID-19 disease. Checking the serum vitamin D levels and supplementation in people with hypovitaminosis D can be a good solution to reduce the complications and problems caused by COVID-19.

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Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.66.3.268 ◽

2020 ◽

Vol 66 (3) ◽

pp. 268-274 ◽

Cited By ~ 1

Author(s):

Simone Bonatto ◽

Vera Maria Vieira Paniz ◽

Clandio de Freitas Dutra ◽

Ruth Liane Henn

Keyword(s):

Vitamin D ◽

Serum Level ◽

Peripheral Arterial Disease ◽

Ankle Brachial Index ◽

Serum Vitamin ◽

Serum Levels ◽

Arterial Disease ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Peripheral Arterial

SUMMARY OBJECTIVE To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD). METHODS A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0.90 or with arterial revascularization. Vitamin D serum level was categorized as sufficient (≥30 ng/mL), insufficient (>20 to 29 ng/mL), and deficient (<20 ng/mL). Prevalence ratios (RP) were calculated through Poisson regression. RESULTS The prevalence of PAD was 50.7% (95% CI 42-59). After adjustment for potential PAD risk factors, RP were 1.08 (95% CI 0.66-1.76) for insufficient serum level and 1.57 (95% CI 0.96-2.57) for deficient vitamin D serum level; (p for trend = 0.020). CONCLUSION Vitamin D serum levels showed an inverse and significant dose-response relationship with PAD.

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Vitamin D in athletes: focus on physical performance and musculoskeletal injuries

Physical Activity and Nutrition ◽

10.20463/pan.2021.0011 ◽

2021 ◽

Vol 25 (2) ◽

pp. 20-25

Author(s):

Sewoon Yoon ◽

Ohkyu Kwon ◽

Jooyoung Kim

Keyword(s):

Vitamin D ◽

Physical Performance ◽

Serum Vitamin ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Musculoskeletal Injuries ◽

Muscle Injuries ◽

Negative Effects ◽

Serum Vitamin D ◽

Vitamin D Levels

[Purpose] The aim of this review was to discuss the effects of vitamin D on physical performance and musculoskeletal injuries in athletes and provide information on the field applications of vitamin D. [Methods] A systematic review was conducted to identify studies on vitamin D in athletes that assessed serum vitamin D levels, vitamin D and physical performance, vitamin D and musculoskeletal injuries, and practical guidelines for supplementation of vitamin D. [Results] Several studies reported that a high proportion of athletes had vitamin D insufficiency or deficiency. Low serum levels of vitamin D in athletes were more pronounced in winter than in other seasons, and indoor athletes had lower serum vitamin D levels than outdoor athletes. Low vitamin D levels have been demonstrated to have negative effects on muscle strength, power, and endurance; increase stress fractures and other musculoskeletal injuries; and affect acute muscle injuries and inflammation following high-intensity exercises. Therefore, periodic assessment and monitoring of vitamin D levels are necessary in athletes; the recommended serum level of 25(OH)D is > 32 ng/mL and the preferred level is > 40 ng/mL (-1). In those with low levels of vitamin D, exposure to sunlight and an improved diet or supplements may be helpful. Particularly, 2000–6000 IU of supplemental vitamin D3 can be consumed daily. [Conclusion] Vitamin D is a potential nutritional factor that can significantly affect physical performance and musculoskeletal injuries in athletes. The importance and role of vitamin D in athletes should be emphasized, and the current levels of vitamin D should be assessed. Therefore, it is essential to periodically evaluate and monitor serum vitamin D levels in athletes.

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Prevalence of vitamin D insufficiency in Qatar: a systematic review

Journal of Public Health Research ◽

10.4081/jphr.2012.e36 ◽

2012 ◽

Vol 1 (3) ◽

pp. 36 ◽

Cited By ~ 16

Author(s):

Alaa Badawi ◽

Paul Arora ◽

Eman Sadoun ◽

Al-Anoud Al-Thani ◽

Mohamed H. Al Thani

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Sample Size ◽

Serum Vitamin ◽

Weighted Average ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels

Qatar has a high burden of chronic diseases including obesity, cardiovascular disease and type 2 diabetes mellitus. Low serum vitamin D levels have been implicated in the development and progression of a range of these chronic conditions. The prevalence of vitamin D insufficiency or deficiency in the general population of Qatar has still not been investigated. The aim of this study was to carry out a systematic review of published studies documenting the prevalence of vitamin D insufficiency or deficiency in the Qatari population. A search strategy was developed for online databases (PubMed, Ovid MEDLINE, Embase and Embase Classic) between 1980 to the last week of August 2012, and bibliographies of the included studies were further searched for additional reports. Search terms used were QATAR and VITAMIN D. Studies reporting the serum levels of vitamin D in several Qatari sub-populations were identified. Weighted-average vitamin D serum levels and prevalence of low vitamin D status (<75 nmol/L) were calculated. Subgroup analysis was carried out by age. The quality of each study was evaluated according to four criteria: national representativeness, representation of males and females, the sample size, and the sampling protocol. A total of 16 relevant publications were identified, and 8 of these (reporting from 7 unique studies) met our inclusion and exclusion criteria with a total number of 1,699 Qatari subjects. The pooled sample size weighted-average vitamin D concentration (±SD) was 45.3±14.3 nmol/L (95% CI: 44.6-46.0; range 29.2-66.9 nmol/L). The weighted-average prevalence of low vitamin D status was 90.4% (95% CI: 90.1-91.0; range 83%-91%). Age was inversely correlated with vitamin D levels and directly with its insufficiency/deficiency prevalence. There have only been a few studies on the prevalence of low vitamin D in Qatar a very high prevalence of vitamin D insufficiency/deficiency in Qatar that increases with age has been suggested. The present report underlines the need to develop a nationally representative study to further evaluate vitamin D status in Qatar. Given the growing evidence of the role of vitamin D in chronic disease, this study could help develop public health strategies for disease prevention in Qatar.

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Investigating the Relationship the Severity of Coronary Artery Disease with Serum Levels of Vitamin D in Men after Eliminating the Effect of Diet

Current Nutrition & Food Science ◽

10.2174/1573401314666181105143051 ◽

2020 ◽

Vol 16 (4) ◽

pp. 508-513

Author(s):

Farshad K. Birgani ◽

Majid M. Shahi ◽

Bahman Cheraghian ◽

Habib Haybar

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Artery Disease ◽

The Relationship

Background: Coronary artery disease (CAD) is one of the most common cardiovascular diseases that can lead to mortality, inability, and lower productivity levels. Objective: The aim of this study was to determine the relationship between serum vitamin D level and cardiovascular risk factors and the severity of CAD after determining and eliminating the confounding effects of dietary patterns in male patients undergoing angiography. Methods: This descriptive-analytic study was carried out on 132 men undergoing angiography during 2017 and 2018. To this end, food frequency questionnaire (FFQ) and physical activity questionnaire (PAQ) were completed for the patients. Fasting blood sugar (FBS), triglyceride, total cholesterol, HDL-C, LDL-C and vitamin D levels were also investigated. Results: Serum vitamin D levels significantly decreased with an increase in CAD severity (p=0.001). Also, low serum levels led to the highest severity of CAD (p=0.005). However, there was no significant difference between patients with vitamin D deficiency with different degrees of CAD (p=0.084). Also, the highest percentage of individuals with normal serum levels of vitamin D was observed in the group without any blocked blood arteries (normal) (p=0.023). Conclusion: This study shows an inverse relationship between serum 25(OH) D level and the severity of CAD. Our data show that vitamin D plays an important role in preventing CAD. These findings could help design prospective studies and clinical trials on a wider scale to investigate the effects of vitamin D interventions in preventing the development of CAD.

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