A Study of Serum Vitamin D Levels in Newly Diagnosed Pulmonary Tuberculosis

Aim: То investigate the serum levels of vitamin D in newly diagnosed patients with multiple myeloma. Patients and methods: In this study we measured the serum levels of vitamin D in 37 patients (19 women, 18 men) at a median age of 68 years and a diagnosis of MM according to the International Myeloma Working Group (IMWG) criteria. The immunoassay tests used for the quantification of 25 (OH) – Vitamin D were original ELISA kits Immundiagnostic and the measurement was done before starting the treatment. Results: Serum levels below the optimum (<30 ng/ml) were recorded in all 37 patients. The median value of vitamin D was 4.3±6.5 mg/ml, the maximum value measured was 24.7 mg/ml, which is below the lower limit of the reference value for deficiency. Conclusions: In this study, we found extremely low serum vitamin D levels in most of the newly diagnosed MM patients.

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STUDY THE SERUM VITAMIN D LEVELS IN PATIENTS OF CHRONIC KIDNEY DISEASE

10.36106/ijsr/0703036 ◽

2021 ◽

pp. 1-3

Author(s):

Brahmarshi Das ◽

Narendranath Hait ◽

Jayanta Kumar Rout ◽

Debarshi Jana

Keyword(s):

Chronic Kidney Disease ◽

Vitamin D ◽

Kidney Disease ◽

Kidney Diseases ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean

INTRODUCTION: Chronic Kidney Disease (CKD) is dened as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney 1 function over a period of months or years. Early on there are typically no symptoms. Later, leg swelling, feeling tired, vomiting, loss of appetite, or 1 confusion may develop. Complications may include heart disease, high blood pressure, bone disease, or anemia. AIM AND OBJECTIVES: Study of Prevalence of hypovitaminosis D in patients of chronic kidney diseases. Search for commonest etiology of hypovitaminosis D in CKD. MATERIALAND METHOD: A Cross-sectional study on 100 cases of newly diagnosed Chronic Kidney Disease patients and matched control subjects is undertaken to study the prevalence of Vitamin D deciency in CKD population and correlation between their serum 25-OH-vitamin D level. 100 Patients who are newly diagnosed as CKD are selected after proper initial screening at Midnapore Medical College, Paschim Medinipur. RESULT AND ANALYSIS: Our study showed that in non-dialysis Syndrome the mean VitD (mean± s.d.) of patients was 25.6620 ± 8.5476. In dialysis the mean VitD (mean± s.d.) of patients was 10.9476 ± 2.6508. Difference of mean VitD in Dialysis vs Non-Dialysis was statistically signicant (p<0.0001). In eGFR 1 (<15) the mean VitD (mean± s.d.) of patients was 11.1130 ± 2.9562. In eGFR2 (15-30) the mean VitD (mean± s.d.) of patients was 24.0750 ± 8.2995. In eGFR3 (31-45) the mean VitD (mean± s.d.) of patients was 26.8296 ± 7.3646. In eGFR4 (>45) the mean VitD (mean± s.d.) of patients was 36.3167 ± 4.9898. Difference of mean VitDin eGFR was statistically signicant (p<0.0001). SUMMARYAND CONCLUSION: Vitamin-D deciency more pronounced in advanced stages of CKD. Vitamin-D deciency was most prevalent in female gender, younger age group and connective tissue disorder. Vitamin-D deciency was more marked in hemodialysis patients compared to non-dialysis CKD patients.

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To Impact of Vit-D in Pulmonary Tuberculosis Patients Receiving DOTS

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i58a34123 ◽

2021 ◽

pp. 331-335

Author(s):

Gangaram Bhadarge ◽

Saurabh Hadke ◽

Neha Bhatt ◽

Meghali Kaple

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Serum Vitamin ◽

Good Health ◽

Newly Diagnosed ◽

Tuberculosis Patients ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Increased Risk ◽

25 Hydroxyvitamin D

Introduction: Vitamin D, also known as calciferol, is a fat-soluble vitamin that helps regulate bone metabolism and calcium homeostasis in humans. Vitamin D from the skin and right is passed on by the liver to 25-hydroxyvitamin D (25 (OH) D, which is used to assess a patient's vitamin D status. The enzyme 25-hydroxyvitamin D-1hydroxylase converts 25 (OH) D into 1, 25-dihydroxy vitamin D (1,25 (OH) 2 D) in the kidneys. Vitamin D is essential for good health. Turning the immune system to the host (MTB). Cathelicidin, an anti-bacterial peptide that prevents mycobacterium from replicating macrophages, shown to be stimulated by vitamin D. In cases of tuberculosis, high levels of serum vitamin D and hypocalcaemia. Enhanced macrophages may be blamed for high calcitriol levels in granulomas. Low levels of vitamin D, on the other hand, linked and tuberculosis (PTB) in several studies conducted worldwide. Aim: Study of Vit-D In Pulmonary Tuberculosis Patients Receiving treatment. Materials and Methods: This study included 40 newly diagnosed PTB patients of both sex with the age group of 18-60. The patients were comprised before and after the DOTS therapy. Time period of this study were from September 2020 to Арril 2021 а nоn-rаndоmised соntrоlled trial. Results: The weight of patients before DOTS was decreased as compare to the weight after DOTS. The level of vitamin D significantly raised in newly diagnosed PTB patients while the vitamin D level was decreased after DOTS therapy. Conclusion: Decreased level of vit-D in the blood can be linked to an increased risk of tuberculosis. As a result, serum Vit-D levels in TB patients can be necessary to control, as Vit-D deficiency may develop without symptoms and intensify once TB therapy starts.

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Vitamin D levels in patients with non-Hodgkin lymphoma/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma

Journal of International Medical Research ◽

10.1177/0300060520943421 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094342

Author(s):

Vasko Graklanov ◽

Veselin Popov

Keyword(s):

Vitamin D ◽

Cell Lymphoma ◽

Serum Vitamin ◽

B Cell Lymphoma ◽

Lymphocytic Leukemia ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Non Hodgkin Lymphoma ◽

Large B Cell Lymphoma ◽

Vitamin D Levels

Purpose To investigate serum vitamin D levels in patients newly diagnosed with non-Hodgkin lymphoma/diffuse large B-cell lymphoma (NHL-DLBCL), multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). Patients and methods We measured serum levels of vitamin D by ELISA in 103 patients prior to initiation of treatment, of whom 37 were diagnosed with MM, 32 with CLL and 34 with NHL-DLBCL. Results Suboptimal serum vitamin D levels (<30 ng/mL) were observed in all 103 patients. In 14 patients, serum vitamin D levels were between 20 and 30 ng/mL, while all other patients had vitamin D deficiency (<20 ng/mL). Severe vitamin D deficiency (<10 ng/mL) was observed in 32.3% of NHL-DLBCL patients, 28.1% of CLL patients and 81% of MM patients. Conclusion We observed low serum vitamin D levels in the majority of patients newly diagnosed with NHL-DLBCL, CLL and MM.

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Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.2016.79.3.153 ◽

2016 ◽

Vol 79 (3) ◽

pp. 153 ◽

Cited By ~ 3

Author(s):

B. Yuvaraj ◽

M. G. Sridhar ◽

S. Vinod Kumar ◽

T. Kadhiravan

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Bacterial Load ◽

Serum Vitamin ◽

Tuberculosis Patients ◽

Serum Vitamin D ◽

Vitamin D Levels

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Serum Vitamin D Levels in Children with Immune Thrombocytopenia

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190614152709 ◽

2020 ◽

Vol 20 (2) ◽

pp. 221-226 ◽

Cited By ~ 1

Author(s):

Giuseppe Lassandro ◽

Francesco Carriero ◽

Viviana Palmieri ◽

Valentina Palladino ◽

Anna Amoruso ◽

...

Keyword(s):

Vitamin D ◽

Immune Thrombocytopenia ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Chronic Itp ◽

Increased Risk ◽

Vitamin D Levels ◽

Newly Diagnosis

Objective: Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by thrombocytopenia with an increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as an immune modulator. We decided to evaluate serum Vitamin D levels in a cohort of children with immune thrombocytopenia in order to discover if Vitamin D concentrations may predict ITP duration. Methods: Thirty children were enrolled in this study (sixteen with chronic ITP and fourteen with newly diagnosed ITP) to assess serum Vitamin D levels. Results:: The results showed that 80% of the enrolled children presented a D hypovitaminosis status. Children with newly diagnosis ITP showed no statistically significantly higher median values of Vitamin D compared to chronic ITP. Conclusions:: This study may suggest that Vitamin D deficiency does not represent a chronicity factor for ITP. However, further studies are needed to understand the role of Vitamin D in ITP pathogenesis.

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Serum vitamin D levels in children with newly diagnosed and chronic immune thrombocytopenia

Seminars in Hematology ◽

10.1053/j.seminhematol.2016.04.020 ◽

2016 ◽

Vol 53 ◽

pp. S67-S69 ◽

Cited By ~ 4

Author(s):

Srđana Čulić ◽

Joško Markić ◽

Davor Petrović ◽

Paško Konjevoda ◽

Jasminka Pavelić

Keyword(s):

Vitamin D ◽

Immune Thrombocytopenia ◽

Serum Vitamin ◽

Newly Diagnosed ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Chronic Immune Thrombocytopenia

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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