Tumor Grade Is Associated With Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study

Purpose Patients with cancer are at risk of venous thromboembolism (VTE). Tumor-related factors could help estimate patients' individual risk for VTE. Currently, only scarce information on the association between tumor grade and VTE is available. We thus evaluated the role of tumor grade and its association with VTE. Patients and Methods The Vienna Cancer and Thrombosis Study is a prospective, observational cohort study including patients with newly diagnosed cancer or progression of disease after remission. Study end point is the occurrence of symptomatic VTE. Results Seven hundred forty-seven patients with solid tumors received follow-up for a median of 526 days. VTE occurred in 52 patients (7.0%). At study inclusion, 468 patients had low-grade tumors (G1 and G2) and 279 had high-grade tumors (G3 and G4). In multivariable Cox regression analysis including tumor grade, tumor histology, tumor sites, stage, sex, and age, patients with high-grade tumors had a significantly higher risk of VTE compared with those with low-grade tumors (hazard ratio, 2.0; 95% CI, 1.1 to 3.5; P = .015). The cumulative probability of developing VTE after 6 months was higher in patients with high-grade tumors than in those with low-grade tumors (8.2% v 4.0%; log-rank test P = .037). Patients with high-grade tumors had higher D-dimer levels (P = .008) and leukocyte counts (P < .001), and lower hemoglobin levels (P = .008). Conclusion The tumor grade may help identify patients with cancer who are at high risk of VTE. The association of tumor grade with recently identified biomarkers indicates a link between tumor differentiation and pathogenesis of cancer-associated VTE.

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Antibiotic Allergy and Blood Eosinophils Percent Could Be Prognostic Indicators of Glioma

10.21203/rs.3.rs-148347/v1 ◽

2021 ◽

Author(s):

Liming Cao ◽

Zhanghua Lv ◽

Weiliang Wang ◽

Xue Li ◽

Jing Shi ◽

...

Keyword(s):

Regression Analysis ◽

Cox Regression ◽

Tumor Grade ◽

Blood Eosinophil ◽

Low Grade ◽

High Grade ◽

Cox Regression Analysis ◽

Low Grade Gliomas ◽

Antibiotic Allergy ◽

High Grade Gliomas

Abstract Background: Antibiotic allergy and blood eosinophil percentage (EOS%) may play an important role in the prognosis of gliomas, but few studies reported the relationship between antibiotic allergy and glioma as well as EOS% and glioma. The aim of our study was to estimate the relationships between antibiotic allergy, blood eosinophil percentage (EOS%) and glioma prognosis and to conduct a nomogram model for glioma patients. Estimating the effect of antibiotic allergy and EOS% on glioma prognosis may conduce to finding low-cost and safe prognostic indicators of glioma.Methods: We conducted a retrospective cohort study with 656 glioma patients to estimate the associations between antibiotic allergy, EOS% and glioma prognosis by Kaplan-Meier and Cox regression analysis. Stratified analyses were performed according to tumor grade. We constructed a nomogram with age at diagnosis, gender, tumor grade, antibiotic allergy, EOS% to predict the survival probabilities of glioma. Results: During 12 months follow-up, a total of 227 patients were alive and 318 patients died. Antibiotic allergy and EOS% >1.65 conferred a survival advantage on glioma patients. In the stratified analysis by tumor grade, antibiotic allergy was significantly associated with the prognosis of the prognosis of low-grade gliomas (HR = 0.36, 95%CI: 0.13-0.97) and high-grade gliomas (HR = 0.58, 95%CI: 0.36-0.93) in the univariate Cox regression analysis. However, after adjusting for confounding factors in the multivariate Cox regression analysis, antibiotic allergy was only significantly associated with high-grade gliomas (HRadj = 0.50, 95%CI: 0.30-0.82); the relationship between EOS% and glioma prognosis was restricted to low-grade gliomas (HRadj = 0.50, 95%CI: 0.30-0.82). The C-index of nomogram was 0.74.Conclusions: Antibiotic allergy was a protective prognosis factor of high-grade gliomas, EOS% >1.65 was a protective prognosis factor of low-grade gliomas. The nomogram with antibiotic allergy and EOS% could effectively predict the survival probability of glioma.

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Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases

Journal of Neurosciences in Rural Practice ◽

10.4103/jnrp.jnrp_576_17 ◽

2018 ◽

Vol 09 (03) ◽

pp. 312-316 ◽

Cited By ~ 1

Author(s):

Meenu Gupta ◽

Saurabh Bansal ◽

Deep Shankar Pruthi ◽

Manju Saini ◽

Nadia Shirazi ◽

...

Keyword(s):

Prognostic Factors ◽

Elderly Patients ◽

Retrospective Analysis ◽

Cox Regression ◽

Rank Test ◽

Karnofsky Performance Scale ◽

High Grade ◽

Concomitant Chemotherapy ◽

Cox Regression Analysis ◽

High Grade Gliomas

ABSTRACT Background and Objectives: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. Design and Setting: Retrospective analysis of 24 elderly patients of ≥60 years with newly diagnosed HGGs, who were treated at our department between January 2009 and December 2012, was done. Patients and Methods: Age, gender, Karnofsky performance scale (KPS) score, extent of surgery, and use of temozolomide were evaluated using univariate and multivariate analyses. Survival was determined using the Kaplan–Meier method, and differences were compared using the log-rank test. Cox regression analysis was conducted to identify the independent prognostic factors. Results: The median overall survival of the patient cohort was 10 months. The 1- and 2-year survival rates were 45.8% and 16.6%, respectively. The analysis revealed that KPS score and use of concomitant chemotherapy were significant prognostic factors. Conclusion: The results of our analyses demonstrate that KPS score and use of concomitant chemotherapy yield encouraging outcomes in elderly patients with HGGs, validating the results published in research papers.

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Prediction of Venous Thromboembolism in Patients With Cancer by Measuring Thrombin Generation: Results From the Vienna Cancer and Thrombosis Study

Journal of Clinical Oncology ◽

10.1200/jco.2010.32.8294 ◽

2011 ◽

Vol 29 (15) ◽

pp. 2099-2103 ◽

Cited By ~ 136

Author(s):

Cihan Ay ◽

Daniela Dunkler ◽

Ralph Simanek ◽

Johannes Thaler ◽

Silvia Koder ◽

...

Keyword(s):

Venous Thromboembolism ◽

Thrombin Generation ◽

Multivariable Analysis ◽

Rank Test ◽

Cumulative Probability ◽

Total Study Population ◽

Patients With Cancer ◽

Increased Risk ◽

Progression Of Disease ◽

Tumor Types

Purpose Patients with cancer are at increased risk of venous thromboembolism (VTE). Laboratory tests measuring the overall thrombophilic tendency might be useful to assess VTE risk. The aim of this study was to investigate thrombin generation, a key process in hemostasis, as predictor of cancer-associated VTE. Patients and Methods The Vienna Cancer and Thrombosis Study (CATS) is a prospective observational cohort study of patients with newly diagnosed cancer or progression of disease after remission. The study end point is occurrence of objectively confirmed symptomatic or fatal VTE within a follow-up period of 2 years. Thrombin generation was measured with a commercially available assay. Results One thousand thirty-three patients with malignancies of the breast (n = 151), lung (n = 148), upper (n = 44) and lower gastrointestinal tract (n = 125), pancreas (n = 67), kidney (n = 34), prostate (n = 122), and brain (n = 134) or lymphoma (n = 126), multiple myeloma (n = 26), and other tumor types (n = 56) were observed for a median observation period of 517 days. VTE occurred in 77 patients (7.5%). Patients with elevated peak thrombin (defined as values ≥ 611 nM thrombin, representing the 75th percentile of the total study population) had an increased risk of VTE with a hazard ratio of 2.1 (95% CI, 1.3 to 3.3, P = .002) in multivariable analysis including age, sex, surgery, chemotherapy, and radiotherapy. The cumulative probability of developing VTE after 6 months was significantly higher in patients with elevated peak thrombin than in those with lower peak thrombin (11% v 4%; log-rank test: P = .002). Conclusion Measurement of thrombin generation may help identify patients with cancer at high risk of VTE.

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The role of radiotherapy and chemotherapy in adult optic nerve gliomas: a SEER-based analysis

10.21203/rs.3.rs-214021/v2 ◽

2021 ◽

Author(s):

Xiaoning Lin ◽

Rong Huang ◽

Jinyun Su ◽

Heng Li ◽

Zhong Liu ◽

...

Keyword(s):

Optic Nerve ◽

Cox Regression ◽

Tumor Grade ◽

Adult Patients ◽

Age At Diagnosis ◽

Low Grade ◽

High Grade ◽

Grade Group ◽

Kaplan Meier ◽

The Central Nervous System

Abstract Background: Optic nerve gliomas (ONGs) are uncommon tumors of the central nervous system in adults. The aim of this study was to define their characteristics, prognostic factors, and the impacts of adjuvant radiotherapy (RT) and chemotherapy on outcomes.Methods: Adult patients (age ≥18 years) with ONGs from the Surveillance, Epidemiology, and End Results (SEER) database were included. Univariate and multivariate Cox regression models were utilized to analyze the factors associated with survival. Kaplan-Meier method was used to evaluate the impacts of adjuvant therapies on overall survival (OS).Results: A total of 179 adult patients diagnosed with ONGs were identified between 1991 and 2016, with a median follow-up period of 64.0 months. The median age at diagnosis was 41.0 years. After excluding 18 patients with unknown information, the remaining patients included 142 (88.2%) low-grade tumors and 19 (11.8%) high-grade tumors. Multivariate analysis showed age at diagnosis, tumor grade, adjuvant chemotherapy were significant factors for OS. The 5-year OS rates for patients with low- and high-grade ONGs were 85.5% and 10.5%, respectively. The employment of adjuvant RT or chemotherapy would significantly shorten OS time in the low-grade group and could not prolong OS time in the high-grade group.Conclusions: This is the largest retrospective study of adult ONGs up to date. The overall prognosis of high-grade ONGs in adult patients is still poor despite multi-modality treatments. Adjuvant RT or chemotherapy might not be considered in adult patients with low-grade ONGs unless the malignant transformation or aggressive progression has been confirmed.

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The role of radiotherapy and chemotherapy in adult optic nerve gliomas: a SEER-based analysis

10.21203/rs.3.rs-214021/v1 ◽

2021 ◽

Author(s):

Rong Huang ◽

Yanlin Huang ◽

Jinyun Su ◽

Heng Li ◽

Zhong Liu ◽

...

Keyword(s):

Cox Regression ◽

Tumor Grade ◽

Adult Patients ◽

Age At Diagnosis ◽

Low Grade ◽

High Grade ◽

Grade Group ◽

Kaplan Meier ◽

The Central Nervous System

Abstract PurposeOptic nerve gliomas (ONGs) are uncommon tumors of the central nervous system in adults. The aim of this study was to define their characteristics, prognostic factors, and the impacts of adjuvant radiotherapy (RT) and chemotherapy on outcomes.MethodsAdult patients (age ≥ 18 years) with ONGs from the Surveillance, Epidemiology, and End Results (SEER) database were included. Univariate and multivariate Cox regression models were utilized to analyze the factors associated with survival. Kaplan-Meier method was used to evaluate the impacts of adjuvant therapies on overall survival (OS).ResultsA total of 179 adult patients diagnosed with ONGs were identified between 1991 and 2016, with a median follow-up period of 64.0 months. The median age at diagnosis was 41.0 years. After excluding 18 patients with unknown information, the remaining patients included 142 (88.2%) low-grade tumors and 19 (11.8%) high-grade tumors. Multivariate analysis showed age at diagnosis, tumor grade, adjuvant chemotherapy were significant factors for OS. The 5-year OS rates for patients with low- and high-grade ONGs were 85.5% and 10.5%, respectively. The employment of adjuvant RT or chemotherapy would significantly shorten OS time in the low-grade group and could not prolong OS time in the high-grade group.ConclusionsThis is the largest retrospective study of adult ONGs up to date. The overall prognosis of high-grade ONGs in adult patients is still poor despite multi-modality treatments. Adjuvant RT or chemotherapy might not be considered in adult patients with low-grade ONGs unless the malignant transformation or aggressive progression has been confirmed.

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Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas

Journal of Clinical Oncology ◽

10.1200/jco.2005.03.0999 ◽

2006 ◽

Vol 24 (2) ◽

pp. 315-320 ◽

Cited By ~ 5

Author(s):

Fredrik Mertens ◽

Ulf Strömberg ◽

Anders Rydholm ◽

Pelle Gustafson ◽

Henrik C.F. Bauer ◽

...

Keyword(s):

Soft Tissue ◽

Chromosome Aberrations ◽

Cox Regression ◽

Prognostic Significance ◽

Soft Tissue Sarcomas ◽

Tumor Grade ◽

High Grade ◽

Prognostic Information ◽

Cox Regression Analysis ◽

Increased Risk

Purpose To investigate whether previously observed correlations between tumor karyotype and risk of metastases could be reproduced in an independent set of high-grade soft tissue sarcomas (STSs). Patients and Methods In a previous study on high-grade STSs with clonal chromosome aberrations, we identified a number of cytogenetic variables, besides tumor grade and size, that were associated with significantly increased risk of metastases. In the present study, we have tested the predictive value of these cytogenetic variables in a new set of 156 high-grade STSs, all located in the extremities or trunk wall. Results Of the 10 cytogenetic variables that turned out to provide prognostic information in the previous series, encompassing 122 trunk wall or extremity STSs, three were significantly associated with metastases also in the new series. In a final Cox regression analysis including these three cytogenetic variables, as well as tumor grade and size, on the combined series of 278 high-grade STSs, four parameters were found to be significantly associated with metastasis risk: tumor grade 3, tumor size ≥ 5 cm, breakpoint in region 1p1, and gain of region 6p1. Conclusion Our findings suggest that independent prognostic information may be gained from cytogenetic analysis of high-grade STS.

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BIOM-63. DIAGNOSIS AND PROGNOSTIC SIGNIFICANCE OF CIRCULATING miR-2276-5p IN PLASMA OF GLIOMA PATIENTS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.060 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii15-ii15

Author(s):

Shiguang Zhao

Keyword(s):

Regression Analysis ◽

Roc Curve ◽

Cox Regression ◽

Low Grade ◽

High Grade ◽

Circulating Mirnas ◽

Cox Regression Analysis ◽

Relative Expression ◽

Low Grade Gliomas ◽

Lower Expression

Abstract Circulating microRNAs (miRNAs) in plasma have the potential to become diagnostic and prognostic biomarkers for various cancers. This study hopes to use plasma circulating miRNAs as biomarkers for diagnosis and prognosis of glioma patients. METHOD: In this study, the plasma circulating miRNAs of 124 patients with glioma and 36 controls was collected to detect the relative expression of miR-2276-5p, and the specificity and sensitivity of the diagnosis were verified by ROC curve. The follow-up survival status was analyzed by cox regression analysis. RESULT: In the GSE 139031 database, it was found that the expression of circulating miR-2276-5p in plasma of glioma patients was significantly lower than that of patients with non-gliomas. Using our plasma samples, and it is indicated that the expression of circulating miR-2276-5p in plasma is lower than that of healthy patients, and compared with low-grade gliomas, patients with high-grade gliomas have a lower expression of circulating miR-2276-5p. ROC curve analysis found that the AUC value was 0.851. The low expression of circulating miR-2276-5p in plasma of glioma patients indicates a poor prognosis of glioma patients, After univariate and multifactorial cox regression analysis, which can be used as an independent prognostic risk factor for glioma patients (P< 0.05). CONCLUSION: The expression of circulating miR-2276-5p in plasma of glioma patients was significantly lower than that of the control group, compared with low-grade gliomas, patients with high-grade gliomas have a lower expression of circulating miR-2276-5p. The lower the relative expression of circulating miR-2276-5p indicated that glioma patients had a worse prognosis.

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Optic nerve gliomas in adults: a SEER-based study

10.21203/rs.3.rs-214021/v3 ◽

2021 ◽

Author(s):

Xiaoning Lin ◽

Rong Huang ◽

Jinyun Su ◽

Heng Li ◽

Zhong Liu ◽

...

Keyword(s):

Optic Nerve ◽

Cox Regression ◽

Tumor Grade ◽

Adult Patients ◽

Age At Diagnosis ◽

Low Grade ◽

High Grade ◽

Grade Group ◽

Kaplan Meier ◽

The Central Nervous System

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Effects of the ANXA6 polymorphisms on glioma risk and patients prognosis

10.21203/rs.2.16678/v1 ◽

2019 ◽

Author(s):

Tuo Wang ◽

Yao Sun ◽

Zichao Xiong ◽

Jiamin Wu ◽

Xiaoying Ding ◽

...

Keyword(s):

Regression Analysis ◽

Cox Regression ◽

Rank Test ◽

Low Grade ◽

Nucleotide Polymorphisms ◽

Glioma Patient ◽

Chinese Han ◽

Cox Regression Analysis ◽

Increased Risk ◽

Glioma Risk

Abstract BACKGROUND Glioma is the most frequent malignant primary brain tumor, and the outcomes for patients with glioma remain poor. The purpose of this study is to explore the association between ANXA6 polymorphisms and glioma risk as well as the prognosis of glioma patients in the Chinese Han population.METHODS We selected nine single-nucleotide polymorphisms (SNPs) in ANXA6 which were genotyped by Agena MassARRAY from 593 glioma patients and 589 healthy controls. The odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression analysis to evaluate the association SNPs with glioma risk. The association between polymorphisms and survival of glioma patient were evaluated using the log-rank test, Kaplan-Meier and Cox regression analysis. RESULTS: Overall analysis found that rs3762993 was significantly associated with an increased glioma risk. Stratification analysis found that rs11960458 was strongly associated with an increased risk of glioma in age >41; rs3762993 was also found to be associated an increased with glioma risk in age >41, ≤41, male and low-grade glioma; but rs4958892 was associated with a decreased risk of glioma in age>41 and male. Interestingly, rs11960458 and rs888988 were correlated with poor prognosis of glioma patient. Furthermore, age, extent of resection and chemotherapy were found to be key prognostic factors in survival of glioma patients.CONCLUSIONS In conclusion, our results indicated that ANXA6 polymorphisms were associated with glioma susceptibility and prognosis. Further studies are required to confirm the results and elucidate the mechanisms of the ANXA6 polymorphisms affect the glioma risk and prognosis.

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Circulating Lipopolysaccharides and Impaired Antioxidant Status in Patients With Atrial Fibrillation. Data From the ATHERO-AF Study

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.779503 ◽

2021 ◽

Vol 8 ◽

Author(s):

Danilo Menichelli ◽

Roberto Carnevale ◽

Cristina Nocella ◽

Vittoria Cammisotto ◽

Valentina Castellani ◽

...

Keyword(s):

Atrial Fibrillation ◽

Antioxidant Status ◽

Cox Regression ◽

Rank Test ◽

Low Grade ◽

Cox Regression Analysis ◽

Analysis Group ◽

Increased Risk ◽

Group 2 ◽

Post Hoc

Objectives: Atrial fibrillation (AF) is characterized by an oxidative imbalance, which is associated with an increased risk of cardiovascular events (CVEs). It is unclear whether low grade endotoxemia may contribute to the impaired antioxidant status in AF patients. We investigated the relationship between circulating lipopolysaccharides (LPS) and antioxidant status in AF patients.Patients and Methods:Post-hoc analysis from the ongoing prospective observational cohort ATHERO-AF study including 907 patients. Antioxidant status was evaluated by the activity of glutathione peroxidase 3 (GPx3) and superoxide dismutase (SOD). Patients were divided into two groups to evaluate the risk of CVEs: (1) LPS below median and GPx3 above median (n = 254); (2) LPS above median and GPx3 below median (n = 263).Results: The mean age was 73.5 ± 8.3 years, and 43.1% were women. Median LPS and GPx3 were 50.0 pg/ml [interquartile range (IQR) 15–108] and 20.0 U/ml (IQR 10.0–34.0), respectively. Patients of Groups 2 were older, with a higher prevalence of heart failure. LPS above the median was associated with reduced GPx3 [Odds Ratio for LPS 1.752, 95% Confidence Interval (CI) 1.344–2.285, p < 0.001] and SOD (OR 0.525, 95%CI 0.403–0.683) activity after adjustment for CHA2DS2VASc score. In a mean follow-up of 54.0 ± 36.8 months, 118 CVEs occurred, 42 in Group 1 and 76 in Group 2 (Log-Rank test p = 0.001). At multivariable Cox regression analysis, Group 2 was associated with a higher risk of CVEs [Hazard Ratio (HR) 1.644, 95%CI 1.117–2,421, p = 0.012], along with age ≥ 75 years (HR 2.035, 95%CI 1.394–2.972, p < 0.001), diabetes (HR 1.927, 95%CI 1.280–2.900, p = 0.002), and previous cerebrovascular disease (HR 1.895, 95%CI 1.251–2.870, p = 0.003) and previous cardiovascular disease (HR 1.708, 95%CI 1.149–2.538, p = 0.008).Conclusions: Our study indicates that circulating LPS may contribute to impaired antioxidant status in patients with AF. Patients with coincidentally high LPS and reduced GPx3 activity showed the highest risk of CVEs.

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