Clinicopathologic features of multiple phyllodes tumors of the breast.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1126-1126
Author(s):  
Fumi Yoshidaya ◽  
Naoki Hayashi ◽  
Atsushi Yoshida ◽  
Hiroshi Yagata ◽  
Hiroko Tsunoda ◽  
...  
Keyword(s):  
Surgical Procedure ◽  
Malignant Tumors ◽  
Phyllodes Tumor ◽  
Clinicopathological Characteristics ◽  
Good Prognosis ◽  
Histological Type ◽  
Benign Tumors ◽  
Borderline Tumor ◽  
Phyllodes Tumors ◽  
New Findings

1126 Background: Phyllodes tumor of the breast is one of the rare neoplasm accounting for 0.3-0.5% of all breast tumors. It is difficult to diagnose the histological type of phyllodes tumors preoperatively by radiological and even pathological findings. The aim of this study is to clarify the clinicopathological features of phyllodes tumors. Methods: We retrospectively reviewed records from 116 patients with phyllodes tumors who underwent surgery between 2003 and 2011. We determined the clinicopathological characteristics, including the presense of multiple lesions and the type of surgical procedure, of each histological type of phyllodes tumors which were classified as benign, borderline, and malignant. Results: The median follow-up time was 23.3 months. Benign phyllodes tumors were presented in 91 patients (78.4 %), borderline were in 17 patients (14.6 %), and malignant were in 8 patients (6.9 %). Ten patients (8.6 %) had multiple phyllodes tumors; 9 for ipsilateral and one for bilateral breasts. One hundred two patients underwent lumpetcomy and 14 patients underwent mastectomy. No patients received chemotherapy or radiation therapy. Noteworthy, all multiple tumors were diagnosed histologically benign. The median age at operation were 41 years (range, 12-72 years) for benign tumors, 44 years (26-67 years) for borderline, and 47 years (39-60 years) for malignant. The size of malignant tumors was significantly large (a median, 11.3 cm; range, 6-27 cm) compared to benign (a median, 4.4 cm; range 1-21 cm) and borderline (a median, 4.7cm; range 1-16 cm) (p = 0.001, and 0.03, respectively). Local recurrence developed in 14 of the 91 patients (15.4 %) with benign, 2 of the 17 patients (11.8 %) with borderline, and 2 of the 8 patients (25 %) with malignant tumors. Four patients (50 %) with malignant tumors but none with benign and borderline developed distant metastasis. Of the 4 patients, 3 had undergone mastectomy and one had lumpetcomy for initial treatment. No benign and borderline tumor had malignant change when tumors recurred. Conclusions: Our new findings indicated that multiple phyllodes tumors may be histologically benign. Furthermore, patients with benign or borderline phyllodes tumors had good prognosis regardless of surgical procedure.

scholarly journals Large Malignant Phyllodes Tumor of the Breast: Case Report of a Young Female and Review of Literature

2020 ◽  
pp. 137-146
Author(s):  
Melissa Kyriakos Saad ◽  
Imad El Hajj ◽  
Elias Saikaly
Keyword(s):  
Malignant Tumors ◽  
Pectoralis Major Muscle ◽  
Phyllodes Tumor ◽  
World Health ◽  
Low Grade ◽  
Accurate Identification ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Post Surgery ◽  
The Right

Background: Phyllodes tumors are rare fibroepithelial neoplasm of the breast, representing 0.3 to 0.5% of all female breast neoplasms. The term ‘‘phyllodes tumor” by the World Health Organization (WHO) categorizes it into benign, borderline, and malignant tumors based on histopathological characteristics. Malignant phyllodes tumor is an uncommon but aggressive breast malignancy and accounts for approximately 25% of all phyllodes tumors.Case Presentation: A 23-year-old female patient Gravida 0 Para 0, previously healthy, with no family history of breast or ovarian cancer was referred to our institution for managing a right breast mass increasing in size over a period of 1 month associated with reddish-brown discoloration of the skin. Breast ultrasound showed an isodense oval mass measuring approximately 16x14x12cm in the right lower outer quadrant of her breast. Core biopsy and FNA done revealed a low grade phyllodes tumor. MRI of breasts showed a huge mass of the right breast occupying all quadrants, measuring 15x14.5 cm in its greatest axis with involvement of the pectoralis major muscle, with no evidence of suspicious axillary lymphadenopathy. Distant metastatic work-up with CT scan of chest abdomen and pelvis and a PET scan did not show distant metastasis. Hence, the patient underwent right total mastectomy with a final pathology compatible with malignant phyllodes tumor. She is on regular follow up and 18 months post-surgery is still disease free.Conclusion: Management of malignant phyllodes tumor remains debatable, especially when it comes to the effect of adjuvant radiotherapy and chemotherapy. From a surgical perspective, whether phyllodes tumors should be considered as epithelial breast cancers or as soft tissue sarcoma is another debate. On the other hand, although challenging, accurate identification of phyllodes tumor initially may aid in decreased recurrence.

scholarly journals Clinico-pathological study of ovarian tumors in Goa medical college: a tertiary care centre in Goa, India

2019 ◽  
Vol 8 (10) ◽  
pp. 4071
Author(s):  
Manjusha Jindal ◽  
Dweep Jindal ◽  
Mrinalini Sahasrabhojane ◽  
Viraj Naik
Keyword(s):  
Ovarian Neoplasms ◽  
Malignant Tumors ◽  
Tertiary Care ◽  
Germ Cell Tumors ◽  
Ovarian Neoplasm ◽  
Histological Type ◽  
Benign Tumors ◽  
Management Options ◽  
Medical College ◽  
Epithelial Tumors

Background: Ovarian neoplasms are a distinct entity in women health care and are increasingly contributing to morbidity and mortality among women. The burden is not only related to the increasing incidence but also to the varied pathological features depending on the tissue of origin and pathogenesis. The study was carried out to find the prevalence and determine the clinical presentation and histo-pathological distribution of ovarian neoplasms. Management options were also noted.Methods: It is a retrospective study carried out at Goa Medical College between January 2013 to December 2015. All patients diagnosed and treated for ovarian neoplasm were included in the study. Data was tabulated using Microsoft Excel and descriptive statistical analysis was carried out using SPSS version 23.Results: A total of 3111 patients were admitted in gynecology at Goa Medical College during the specified time period. Of these 358 cases were diagnosed with ovarian neoplasm. On histopathology 196 were benign tumors and 162 were reported to be malignant. Commonest presenting symptom was abdominal distention seen in 51.1% of the patients, pain in 44.4%, followed by dyspepsia in 26.85%. Epithelial tumors were most common (Benign - 39.3%, Malignant - 41%) followed by sex cord stromal tumors and germ cell tumors in 7.26% of cases.Conclusions: Surface epithelial tumors were most common neoplasm. An alarming high no. of malignant tumors (45.25%) was found in present study. 44.4% tumors presented in 41-50 years age group. Presenting complaints were vague and nonspecific leading to delay in diagnosis. Histological type correlates with prognosis; therefore, preponderance of histological type will guide treatment options and patient education with respect to epidemiology.

scholarly journals Rare Case of Recurrent Phyllodes Tumor of Bilateral Breasts with Metastasis to the Retroperitoneum and Duodenum

2020 ◽  
Vol 2 (5) ◽  
pp. 01-05
Author(s):  
Poya Pourghaderi
Keyword(s):  
Rare Case ◽  
Malignant Tumors ◽  
Left Kidney ◽  
Phyllodes Tumor ◽  
World Health ◽  
Phyllodes Tumors ◽  
Common Presentation ◽  
History Of ◽  
Locally Recurrent ◽  
Health Organization

Phyllodes tumors are uncommon fibroepithelial tumors of the breast. These tumors are graded based on the World Health Organization criteria into benign, borderline, and malignant subtypes. While benign phyllodes tumors are by far the most common presentation, borderline and malignant tumors have important clinical implications, as they are more likely to locally recur and metastasize. The most common sites of distant metastasis include the lung, bone, heart, and liver. Rare spread to the small intestines, kidney and pelvis have also been reported. We report a case of a 71 year-old woman with a history of locally recurrent phyllodes tumor of the breasts found to have retroperitoneal and intraperitoneal metastases. The retroperitoneal mass was just below the left kidney, extending into the pelvis, and overlying the psoas and iliacus. The second mass involved the second portion of the duodenum, the proximal transverse colon, and the overlying mesentery. This case of delayed metastatic spread of phyllodes tumor to two sites, seventeen years after first presentation, represent a rare case.

scholarly journals Caso Clínico: Tumor Phyllodes

2018 ◽  
Vol 10 (2) ◽  
pp. 150-154
Author(s):  
Yolanda Elisabeth Vintimilla Pogo ◽  
Maolly Lucette Schuldt Cruz ◽  
Pablo José Erráez Jaramillo ◽  
Marcia Cumandá Patiño Patiño ◽  
Jessica Alexandra Naula Calle
Keyword(s):  
Adjuvant Treatment ◽  
Phyllodes Tumor ◽  
Fine Needle Biopsy ◽  
Good Prognosis ◽  
National Registry ◽  
Tumor Evolution ◽  
Pathology Report ◽  
Borderline Tumor ◽  
Malignant Phyllodes Tumor ◽  
The Right

BACKGROUND: The phyllodes tumor represents less than 1 % of mammary tumors, with an incidence of 2.1 per million worldwide, the age of presentation is between 35 to 55 years. Latina women are at higher risk of phyllodes tumor than other ethnic groups. In Ecuador, the cities with the highest incidence are Quito, Guayaquil and Loja according to the National Registry of Tumors. In Cuenca, one case is presented per year. CASE REPORT: Female patient of 46-year-old woman with a history of resection of fibroadenoma in the right breast 2 years; who 6 months ago, presented a rapidly growing, mobile, defined multi-lobed tumor that occupies 80 % of the right breast, BIRADS II ultrasound; mammography BIRADS 0. Fine needle biopsy presents histopathological result of phyllodes borderline tumor. EVOLUTION: Mastectomy was performed with high-grade malignant phyllodes tumor pathology report with negative limits, the patient does not need adjuvant treatment, and it remains good prognosis. CONCLUSION: Malignant phyllodes tumor is rare, but it should be considered as a differential diagnosis in patients older than 35 years, it is standardized treatment surgical, without having demonstrated that an adjuvant treatment can reduce loco or regional recurrence.

A Rare Case of Recurrent Phyllodes Tumor of Bilateral Breasts with Metastasis to the Retroperitoneum and Duodenum

2020 ◽  
pp. 1-4
Author(s):  
Poya Pourghaderi ◽  
Andrew M. Nouri ◽  
Poya Pourghaderi ◽  
Sara E. Chapin ◽  
Zoltan Nemeth ◽  
...  
Keyword(s):  
Rare Case ◽  
Malignant Tumors ◽  
Left Kidney ◽  
Phyllodes Tumor ◽  
World Health ◽  
Phyllodes Tumors ◽  
History Of ◽  
Locally Recurrent ◽  
Health Organization ◽  
Iliacus Muscle

Phyllodes tumors are uncommon fibroepithelial tumors of the breast. These tumors are graded based on the World Health Organization criteria into benign, borderline, and malignant subtypes. While benign phyllodes tumors are by far the most common presentation, borderline and malignant tumors have important clinical implications, as they are more likely to locally recur and metastasize. The most common sites of distant metastasis include the lung, bone, heart, and liver. Rare spread to the small intestines, kidney and pelvis have also been reported. We report a case of a 71-year-old woman with a history of locally recurrent phyllodes tumor of the breasts found to have retroperitoneal and intraperitoneal metastases. The retroperitoneal mass was just below the left kidney, extending into the pelvis, and overlying the psoas and iliacus muscle. The second mass involved the second portion of the duodenum, the proximal transverse colon, and the overlying mesentery. This is a rare case of delayed metastatic spread of phyllodes tumor to two sites, seventeen years after first presentation.

scholarly journals An approach to malignant mammary phyllodes tumors detection

2009 ◽  
Vol 66 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Ivan Ilic ◽  
Pavle Randjelovic ◽  
Ratko Ilic ◽  
Vuka Katic ◽  
Maja Milentijevic ◽  
...  
Keyword(s):  
Mast Cells ◽  
Malignant Tumors ◽  
Periodic Acid ◽  
Soft Tissue Sarcomas ◽  
Biological Behavior ◽  
Benign Tumors ◽  
Ki 67 ◽  
Phyllodes Tumors ◽  
Stromal Component ◽  
Her 2

Background/Aim. Mammary phyllodes tumors (MPT) are uncommon fibroepithelial (biphasic) neoplasms whose clinical behavior is difficult to predict on the basis of histological criteria only. They are divided into benign, borderline malignant and malignant groups. Sometimes it appears difficult to distinguish these tumors from other types of soft tissue sarcomas. Because of the relatively scant data on the role of biological markers in MPT histogenesis, we have decided to undertake the following study, trying to shed more light on the issue by investigating the following elements that make up MPT: their histological patterns, biological behavior, enzymohistochemical, histochemical and immunohistochemical characteristics (ICH) together with the mast cell analysis. Methods. We examined the biopsy material of 35 MPT in our laboratory. Enzymohistochemistry was performed on frozen sections (method of Crowford, Nachlas and Seligman). The used methods were classical hematoxylin-eosin (H&E); histochemical Massontrichrome, Alcian-blue, Periodic acid Schiff and immunohistochemical LSAB2 method (DacoCytomation). Ki-67, ckit, vimentin, estrogen receptor (ER), progesterone receptor (PR) and Her-2 oncoprotein immunohistochemistry was performed on all tumors. Results. The patients were ranged per age from 30-62 years (mean 43.3 years, median 39 years). A total of 35 cases of MPT were included: 20 benign (57%), 6 borderline malignant (17%) and 9 malignant (26%). Twenty-two patients (62.8 %) underwent segmental mastectomy, while 13 (37.2%) had total mastectomies. Twenty-eight patients had negative surgical margins at original resection. The mean size of malignant MPT (7.8 cm) was larger than that of benign MPT (4.5 cm). Significant features of the malignant MPT were: stromal cellularity, stromal cellular atypism, high mitotic activity, atypic mitoses, stromal overgrowth, infiltrative tumor contour and heterologous stromal elements. Benign MPT showed strong enzymohistochemical Leucine Amino Peptidase (LAP) activity in both epithelial and stromal components while it was weak or absent in the epithelial parts of the malignant tumors. Acid mucopolysacharides were present in the stromal component of all types of these tumors. Benign MPT had a lower Ki-67 than did borderline malignant MPT (4 versus 28). Malignant MPT had a greater than 8-fold higher Ki-67 activity than did benign tumors (35 versus 4). Intracytoplasmatic c-kit expression was associated with a pathological diagnosis of malignant MPT, correlating with increasing grade (p < 0.05). In hypercellular stroma of borderline malignant and especially malignant forms of MPT, high activity of ER in mast cells was confirmed. Oncoprotein Her-2 activity, mostly in epithelial components, correlated with the degree of malignant progression of MPT (p < 0.05). Conclusion. Besides the well-known malignant features additional parameters have been found to be high Ki-67 and ckit stromal expressions, and weak LAP activity in the epithelial part of malignant MPT, as well as mast cells with a high expression of ER.

scholarly journals CONTENT OF STEM TUMOR CD133+ CELLS IN BRAIN NEOPLASMS OF DIFFERENT HISTOLOGICAL TYPE

2017 ◽  
Vol 39 (3) ◽  
pp. 219-223
Author(s):  
N I Lisyaniy ◽  
D N Stanetskaya ◽  
A N Lisyaniy ◽  
L N Belskaya
Keyword(s):  
Brain Tumors ◽  
Malignant Tumors ◽  
Diagnostic Value ◽  
Immunofluorescence Assay ◽  
Histological Type ◽  
Immunohistochemical Method ◽  
Benign Tumors ◽  
Cell Content ◽  
The Brain ◽  
Resistance To Chemotherapy

Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. The aim of the study was to analyze the content of CD133+ cells in different brain tumors by immunofluorescence assay and immunohistochemical method. Materials and Methods: The samples of different brain tumors removed during neurosurgical operations were studied for CD133 expression. Results: Immunofluorescence assay of tumor imprints revealed CD133+ cells in 40–85% of tumors regardless of histological type. In malignant tumors, the count of CD133+ cells was higher than in benign tumors. Immunohistochemical method used for detection of CD133+ cells was less sensitive than immunofluorescence technique. The number of CD133+ cells may vary even in tumors of the same histological type. In 20–30% of malignant tumors (glioblastomas, medulloblastomas), the content of CD133+ cells was very low or not detected at all. Conclusions: In tumors of the brain of different genesis and degree of anaplasia CD133+ cells are found out. In malignant tumors (glioblastomas and medulloblastomas), CD133+ cells are much more frequently detected than in benign brain tumors. The content of CD133+ cells in brain tumors is highly variable being small and some malignant tumors, indicating low predictive and diagnostic value of cancer stem cell content in clinical practice.

Statistical analysis on the behavior and recurrence of breast phyllodes tumors.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. e294-e294
Author(s):  
John Shangming Ye
Keyword(s):  
Statistical Analysis ◽  
Early Stage ◽  
Survival Rates ◽  
Phyllodes Tumor ◽  
Vital Role ◽  
Accurate Diagnosis ◽  
Benign Tumors ◽  
Tumor Patients ◽  
Phyllodes Tumors ◽  
Diagnosis Accuracy

e294 Background: Statistical analysis on the behavior, diagnosis accuracy, treatment, and recurrence of breast phyllodes tumors. Methods: Thousands of phyllodes tumor cases have been analyzed by mathematical statistics in order to assess the behavior, diagnosis, classification, treatment, recurrence, and five-year survival rates. Results: The age of breast phyllodes tumor patients generally ranges from ten years old to over eighty years old, and the disease most frequently occurs between ages of forty and fifty among various ethnicities. For clinic-pathological features, over 70% of the patients' tumors may be classified as benign, about 20% borderline, and less than 10% malignant. Patients who had ages over 40, larger tumor sizes, permeative borders, atypia, high stromal hypercellularity, and especially high mitotic activity were observed to develop borderline and malignant phyllodes tumor more frequently. Recurrences were noted in about 13% for all patients, but the ratio of recurrence rate of benign : borderline : malignant tumor is approximately 1: 1.5 : 3. A five-year survival rate was observed in almost 100% of patients with benign tumors, 98% with borderline, and about 88% with malignant. Accurate diagnosis at an early stage plays a vital role for effective treatment. Conclusions: Early stage accurate diagnosis, post-excision pathology analysis on the fibroepithelial tumor tissue for confirming the clinicopathological features, and wide excision (with negative margins) may reduce the risk of tumor recurrence and improve the respective survival rates of the breast phyllodes tumor patients.

scholarly journals Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Hung Shen ◽  
Heng-Cheng Hsu ◽  
Yi-Jou Tai ◽  
Kuan-Ting Kuo ◽  
Chia-Ying Wu ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Early Stage ◽  
Frozen Section ◽  
Medical Center ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Borderline Tumor ◽  
Chi Square ◽  
Early Stage Disease ◽  
Chi Square Test

AimTo retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors.Patients and methodsWomen with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital’s centralized database.ResultsA total of 903 ovarian tumors were enrolled, including 237 (26.2%) benign, 150 (16.6%) borderline tumor, and 516 (57.2%) malignant. The overall accuracy of IFS among all specimens was 89.9%. The sensitivities of IFS in diagnosing borderline tumors (82.0%) and malignant tumors (88.2%) were lower than in diagnosing benign tumors (98.7%, p &lt;0.001, Z-test). The specificity of diagnosing malignant tumors (99.7%) was significantly higher than that of diagnosing benign tumors (94.7%, p &lt;0.001, Z-test). The group with discordant IFS and final paraffin pathology (FPP) had younger age (47.2 ± 14.0 vs. 51.5 ± 11.8 years, p = 0.013, Mann–Whitney U test), and higher percentage of early-stage disease (85.2% vs. 65.1%, p = 0.001, chi-square test) and mucinous (39.3% vs. 3.3%) and endometrioid histologic types (34.4% vs. 20.2%) than the concordant group (all by chi-square test). Menopause (OR 0.34, 95% CI 0.15–0.76, p = 0.009), multicystic tumor in ultrasound (OR 2.14, 95% CI 1.14–4.01, p = 0.018), and ascites existence (OR 0.33, 95% CI 0.14–0.82, p = 0.016) were factors related to the discordant IFS by multivariate analysis.ConclusionsIFS has good accuracy in the diagnosis of ovarian tumors. We recommend more frozen tissue sampling for sonographic multicystic tumors in premenopausal women to improve the accuracy of IFS.

Retrospective study on parotid gland tumors

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 22-23
Author(s):  
Ibric Cioranu ◽  
Vlad Petrescu Seceleanu ◽  
Viorel Ibric Cioranu ◽  
Andreea Smarandache ◽  
Sorin Vasilescu ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Maxillofacial Surgery ◽  
Squamous Carcinoma ◽  
Benign Tumors ◽  
Warthin Tumor ◽  
Parotid Tumors ◽  
Non Hodgkin Lymphoma ◽  
Adenoid Cystic ◽  
Modal Treatment ◽  
Surgery Department

During 2011-2012, 56 patients diagnosed with parotid tumors were admitted to the Maxillofacial Surgery Department of “Lucian Blaga” University and in Euroclinic Hospital. 72% were benign tumors and 28% malignant. All patients received surgical treatment (total or partial parotidectomy). For the malignant tumors, radiotherapy was added to the modal treatment (94% of the cases). Pleomorphic adenoma was encountered in 70% of the benign cases, followed by Warthin tumor in 15%. Adenoid cystic carcinoma was noticed in 31% of the malignant cases, mucoepidermoid carcinoma in 25% of the cases, and squamous carcinoma and non-Hodgkin lymphoma on 12.5% of the malignant cases.  

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