Premorbid body mass and mortality in patients with hepatocellular cancer: A systematic review and meta-analysis.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 477-477 ◽  
Author(s):  
Arjun Gupta ◽  
Avash Das ◽  
Nivedita Arora ◽  
Kaustav Majumder ◽  
Preet Paul Singh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Morbid Obesity ◽  
Body Mass ◽  
Meta Analysis ◽  
Hepatocellular Cancer ◽  
Dependent Manner ◽  
Increased Risk ◽  
Reported Data ◽  
Dose Dependent ◽  
Related Mortality

477 Background: Excess body weight is associated with increased risk of developing hepatocellular cancer (HCC), but its effect on HCC mortality remains unclear. We performed a systematic review and meta-analysis to assess the association between premorbid body mass index (BMI) and HCC mortality. Methods: Through a systematic search of major databases and conference proceedings, up to March 2016, we identified observational studies reporting the association between premorbid BMI, and HCC-related mortality. We estimated summary adjusted hazard ratio (aHR) with 95% confidence intervals (CI), comparing obese (BMI > 30 kg/m2) and overweight (BMI 25-29.9 kg/m2) categories with reference category using random effects model; heterogeneity was measured using the inconsistency index (I2). Results: 9 studies were included in which 6,052 HCC deaths occurred in 1,599,453 cancer-free individuals at cohort inception. 5 studies reported data as obese vs. overweight vs. normal BMI, and 4 reported data as obese + overweight combined (BMI > 25 kg/m2). On meta-analysis, pre-morbid obesity was associated with higher HCC-related mortality, as compared to individuals with normal BMI (obese: aHR, 1.96; 95% CI, 1.46-2.46, I2= 37%; overweight: aHR, 1.08; 95% CI, 0.97-1.21, I2= 0%), in dose-dependent manner. This effect was stronger in males [3 studies, aHR, 2.50; 95% CI, 2.02-3.09] vs. females [2 studies, aHR, 1.45; 95% CI, 1.08-1.97]. This effect was seen primarily in Western populations [4 studies, aHR, 2.10; 95% CI, 1.77-2.48], but not in Asian population [1 study, aHR, 1.10; 95% CI, 0.63-1.92]. Conclusions: In this meta-analysis, there was a dose-dependent increase in HCC-related mortality with pre-morbid obesity, particularly in men, and in Western populations. Strategies targeting obesity-induced metabolic abnormalities may provide novel pathways for HCC therapy.

scholarly journals Paternal smoking is associated with an increased risk of pregnancy loss in a dose-dependent manner: a systematic review and meta-analysis

F&S Reviews ◽  
2021 ◽  
Author(s):  
Nadia A. du Fossé ◽  
Marie-Louise P. van der Hoorn ◽  
Nina H. Buisman ◽  
Jan M.M. van Lith ◽  
S askia le Cessie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Loss ◽  
Meta Analysis ◽  
Dependent Manner ◽  
Increased Risk ◽  
Dose Dependent ◽  
Paternal Smoking

scholarly journals Gender-Related Differences in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis

Pulse ◽  
2021 ◽  
Vol 9 (1-2) ◽  
pp. 38-46
Author(s):  
Angkawipa Trongtorsak ◽  
Natchaya Polpichai ◽  
Sittinun Thangjui ◽  
Jakrin Kewcharoen ◽  
Ratdanai Yodsuwan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hypertrophic Cardiomyopathy ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Phenotypic Expression ◽  
Female Gender ◽  
Increased Risk ◽  
All Cause Mortality ◽  
The Impact ◽  
Related Mortality

<b><i>Background:</i></b> Gender-related differences in phenotypic expression and outcomes have been established in many cardiac conditions; however, the impact of gender in hypertrophic cardiomyopathy (HCM) remains unclear. We conducted a systematic review and meta-analysis to assess the differences in clinical outcomes between female and male HCM patients. <b><i>Methods:</i></b> We searched MEDLINE and EMBASE from inception to October 2020. Included were cohort studies that compared outcomes of interest including all-cause mortality, HCM-related mortality, and worsening heart failure (HF) or HF hospitalization between male and female. Data from each study were combined using the random effects model to calculate pooled odds ratio (OR) with 95% confidence interval (CI). <b><i>Results:</i></b> Eleven retrospective cohort studies with a total of 9,427 patients (3,719 females) were included. Female gender was significantly associated with an increased risk of all-cause mortality (pooled OR = 1.63, 95% CI: 1.26–2.10, <i>p</i> ≤ 0.001), HCM-related mortality (pooled OR = 1.47, 95% CI: 1.08–2.01, <i>p</i> = 0.015), and worsening HF or HF hospitalization (pooled OR = 2.05, 95% CI: 1.76–2.39, <i>p</i> ≤ 0.001). <b><i>Conclusions:</i></b> Female gender was associated with a worse prognosis in HCM. These findings suggest the need for improved care in women including early identification of disease and more possible aggressive management. Moreover, gender-based strategy may benefit in HCM patients.

scholarly journals Diabetes, Hypertension, Body Mass Index, Smoking and COVID-19-Related Mortality: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Author(s):  
Yahya Mahamat Saleh ◽  
Thibault Fiolet ◽  
Mathieu Edouard Rebeaud ◽  
Matthieu Mulot ◽  
Anthony Guihur ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Body Mass ◽  
Observational Studies ◽  
Meta Analysis ◽  
Related Mortality

Pre-Morbid Obesity is Associated with Increased Risk of Developing Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 152 (5) ◽  
pp. S976-S977 ◽  
Author(s):  
Siddharth Singh ◽  
Mathurin Fumery ◽  
Katherine Shaffer ◽  
Abha G. Singh ◽  
Larry Prokop ◽  
...  
Keyword(s):  
Systematic Review ◽  
Morbid Obesity ◽  
Inflammatory Diseases ◽  
Meta Analysis ◽  
Immune Mediated ◽  
Increased Risk

scholarly journals The prevalence, mortality, and associated risk factors for developing COVID-19 in hip fracture patients: a systematic review and meta-analysis

2020 ◽  
Vol 9 (12) ◽  
pp. 873-883
Author(s):  
Nicholas D. Clement ◽  
Nathan Ng ◽  
Cameron J. Simpson ◽  
Robyn F. L. Patton ◽  
Andrew James Hall ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hip Fracture ◽  
Mortality Rate ◽  
Meta Analysis ◽  
Crude Mortality Rate ◽  
Crude Mortality ◽  
Increased Risk ◽  
Associated Risk Factors ◽  
Reported Data

Aims The aims of this meta-analysis were to assess: 1) the prevalence of coronavirus disease 2019 (COVID-19) in hip fracture patients; 2) the associated mortality rate and risk associated with COVID-19; 3) the patient demographics associated with COVID-19; 4) time of diagnosis; and 5) length of follow-up after diagnosis of COVID-19. Methods Searches of PubMed, Medline, and Google Scholar were performed in October 2020 in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement. Search terms included “hip”, “fracture”, and “COVID-19”. The criteria for inclusion were published clinical articles reporting the mortality rate associated with COVID-19 in hip fracture patients. In total, 53 articles were identified and following full text screening 28 articles satisfied the inclusion criteria. Results A total of 28 studies reported the mortality of COVID-19-positive patients, of which 21 studies reported the prevalence of COVID-19-positive patients and compared the mortality rate to COVID-19-negative patients. The prevalence of COVID-19 was 13% (95% confidence interval (CI) 11% to 16%) and was associated with a crude mortality rate of 35% (95% CI 32% to 39%), which was a significantly increased risk compared to those patients without COVID-19 (odds ratio (OR) 7.11, 95% CI 5.04 to 10.04; p < 0.001). COVID-19-positive patients were more likely to be male (OR 1.51, 95% CI 1.16 to 1.96; p = 0.002). The duration of follow-up was reported in 20 (71.4%) studies. A total of 17 studies reported whether a patient presented with COVID-19 (n = 108 patients, 35.1%) or developed COVID-19 following admission (n = 200, 64.9%), of which six studies reported a mean time to diagnosis of post-admission COVID-19 at 15 days (2 to 25). Conclusion The prevalence of COVID-19 was 13%, of which approximately one-third of patients were diagnosed on admission, and was associated with male sex. COVID-19-positive patients had a crude mortality rate of 35%, being seven times greater than those without COVID-19. Due to the heterogenicity of the reported data minimum reporting standards of outcomes associated with COVID-19 are suggested. Cite this article: Bone Joint Res 2020;9(12):873–883.

Association of Body Mass Index and Dysmenorrhea: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 17 ◽  
Author(s):  
Hamideh Haj Nasiri ◽  
Nasim Bahrami ◽  
Kelly-Ann Allen ◽  
Zainab Alimoradi
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Body Mass ◽  
Meta Analysis ◽  
Pearson Correlation ◽  
Reproductive Age ◽  
Z Score ◽  
Newcastle Ottawa Scale ◽  
Reported Data

Background: Dysmenorrhea or menstrual pain is a commonly occurring disorder in reproductive age women with different proposed risk factors, including body mass index. Objective: This study aimed to investigate the association between body mass index and dysmenorrhea using a systematic review and meta-analysis approach. Methods: Academic databases Scopus, PubMed CENTRAL, Embase, ProQuest, Science Direct, and ISI Web of Science, and Google Scholar- were searched systematically from inception until the end of February 2020. Original researches published in English with observational designs were included to examine the association of body mass index and dysmenorrhea as the primary outcome. Newcastle Ottawa scale was used to evaluate the methodological quality of the studies. Due to the variation of reported data across studies, all data were converted to Pearson correlation coefficient and corrected by transforming to fisher’s Z score. Then meta-analysis was performed using a random-effects model with Der-Simonian and Laird method. Results: A total of 61 studies with 57,079 participants, of which 25,044 reported having dysmenorrhea, were included. While publication bias was probable, results were corrected using the fill amp; trim method. The updated results based on this method showed that pooled Fisher’s z-score for the association of body mass index and dysmenorrhea was 0.04 (95% CI: -0.009; 0.085). The pooled estimated effect size of correlation showed a trivial to slight correlation between body mass index and dysmenorrhea with corrected fisher’s z score of 0.12 (95% CI: 0.08; 0.17, I2=95%). Conclusion: No association was found between body mass index and dysmenorrhea. But this finding should be interpreted with caution considering the included studies' limitations.

Childhood maltreatment and eating disorder pathology: a systematic review and dose-response meta-analysis

2017 ◽  
Vol 47 (8) ◽  
pp. 1402-1416 ◽  
Author(s):  
M. L. Molendijk ◽  
H. W. Hoek ◽  
T. D. Brewerton ◽  
B. M. Elzinga
Keyword(s):  
Systematic Review ◽  
Childhood Maltreatment ◽  
Meta Analysis ◽  
Age At Onset ◽  
Severe Form ◽  
Dependent Manner ◽  
Prevalence Rates ◽  
High Prevalence ◽  
Meta Analyses ◽  
Dose Dependent

BackgroundMeta-analyses have established a high prevalence of childhood maltreatment (CM) in patients with eating disorders (EDs) relative to the general population. Whether the prevalence of CM in EDs is also high relative to that in other mental disorders has not yet been established through meta-analyses nor to what extent CM affects defining features of EDs, such as number of binge/purge episodes or age at onset. Our aim is to provide meta-analyses on the associations between exposure to CM (i.e. emotional, physical and sexual abuse) on the occurrence of all types of EDs and its defining features.MethodSystematic review and meta-analyses. Databases were searched until 4 June 2016.ResultsCM prevalence was high in each type of ED (totalN= 13 059, prevalence rates 21–59%) relative to healthy (N= 15 092, prevalence rates 1–35%) and psychiatric (N= 7736, prevalence rates 5–46%) control groups. ED patients reporting CM were more likely to be diagnosed with a co-morbid psychiatric disorder [odds ratios (ORs) range 1.41–2.46,p< 0.05] and to be suicidal (OR 2.07,p< 0.001) relative to ED subjects who were not exposed to CM. ED subjects exposed to CM also reported an earlier age at ED onset [effect size (Hedges’g) = −0.32,p< 0.05], to suffer a more severe form of the illness (g= 0.29,p< 0.05), and to binge-purge (g= 0.31,p< 0.001) more often compared to ED patients who did not report any CM.ConclusionCM, regardless of type, is associated with the presence of all types of ED and with severity parameters that characterize these illnesses in a dose dependent manner.

scholarly journals Des-Gamma-Carboxy Prothrombin in Hepatocellular Cancer Patients Waiting for Liver Transplant: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 32 (4) ◽  
pp. 370-374 ◽  
Author(s):  
Quirino Lai ◽  
Samuele lesari ◽  
Giovanni Battista Levi Sandri ◽  
Jan Lerut
Keyword(s):  
Systematic Review ◽  
Liver Transplant ◽  
Living Donor ◽  
Meta Analysis ◽  
Hepatocellular Cancer ◽  
High Rate ◽  
Western World ◽  
Eligibility Criteria ◽  
Increased Risk ◽  
Japanese Studies

Background The use of des-gamma-carboxy prothrombin (DCP) as a predictor of the risk of recurrence of hepatocellular cancer (HCC) after liver transplant (LT) has recently gained interest, especially in view of the recent extension of the eligibility criteria of these patients for LT. The aim of the present study is to look into this important matter based on a systematic review and meta-analysis. Methods A systematic literature review about the role of DCP in the specific setting of LT for HCC has been conducted. Results Three selected studies, which showed a high rate of homogeneity (I2 = 0.0%), confirmed that the tumor marker DCP is a useful predictive factor, indicating a 5-fold increased risk for HCC recurrence after LT (p<0.001). Conclusions The meta-analysis enabled us to underline the importance of DCP in the refinement of the eligibility criteria of HCC patients for LT. This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.

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