Impact of a regular exercise program on amount of exercise and QOL metrics in patients on immune therapy.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. TPS11636-TPS11636
Author(s):  
Nicole Brenna Quenelle ◽  
Kathryn Blount Bollin

TPS11636 Background: Studies show physical activity has a positive impact on fatigue and quality of life both during cancer treatment with chemotherapy and radiation and post-treatment (1, 2). There may also be a survival benefit to increasing physical activity both during and after treatment (3). To date there is no published research on the role of exercise in ameliorating the fatigue patients can experience during treatment with immune therapy. Our study proposes to use the existing framework of the LIVESTRONG at the YMCA program to objectively measure improvement in activity level and objective quality of life measurements. Methods: Randomized controlled prospective study evaluating patient participation in LIVESTRONG at YMCA program during active cancer treatment to assess change in minutes per week of self-reported physical activity over 12 weeks. Assessments will be done based on attendance of 12 week program, activity log, functional assessments of physical activity pre- and post- program (6 min walk test, % change in weight, % change in max weight lifted and flexibility), and questionnaires evaluating fatigue (PROMIS 13a FACIT-F), pain (PROMIS pain intensity scale, ASCQ-Me short form), quality of life (FACT-G), Godin Leisure Time Activity Questionnaire, and inflammatory markers (ESR, CRP). Data will be analyzed on an intention-to-treat analysis. A sample size of 100 participants per group will achieve 80% power to detect a 60 minute difference with a standard deviation of 150 minutes 1 and with a significance level (alpha) of 0.050 using a two-sided two-sample t-test. Enrollment is targeted at 108 participants per arm to allow for 8% attrition, 216 total. Secondary endpoints will be assessed at a baseline functional assessment session for all participants and a follow up session after 12 weeks, including administration of questionnaires at both sessions. For physical activity measurements and survey completions, percent change in baseline and completion measurements will be calculated for each patient, then comparison using a chi-square test will be done to determine statistical significance.(Tomlinson et al. Effect of exercise on cancer-related fatigue: a meta-analysis. Am J Phys Med Rehabil. 2014;93:675-686; Irwin et al. Effect of the LIVESTRONG at the YMCA Exercise Program on Physical Activity, Fitness, Quality of Life, and Fatigue in Cancer Survivors. 2016 (published online October 28, 2016); Li T et al. The dose–response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies . Br J Sports Med. 2016;50:339-345).

2021 ◽  
Author(s):  
Mahnaz Azmodeh ◽  
Rastegar Hoseini ◽  
Ehsan Amiri

Abstract Background: New coronavirus (COVID-19) has a major impact on the individual's physical activity level (PAL); The COVID-19 quarantine outbreak caused a decrease in the PAL. Accordingly, it might also affect the general health and quality of life (QoL). This study aimed to evaluate the relationship between PAL with QoL and general health (GH) among COVID-19 recovered individuals (CRI).Methods: In this descriptive-analytical study, using the multi-stage (Cluster) sampling techniques, 890 CRI (male (n = 438) and female (n = 452)) were volunteered from different COVID-19 testing centers in Kermanshah province. After filling out the consent form, the PAL, GH, and QoL questionnaires were completed and anthropometric parameters were measured. The PAL was assessed using the international physical activity questionnaire (IPAQ-SF), GH was assessed using the GHQ questionnaire and the QoL was measured by the QoL questionnaire (short-form-SF-12). The independent t-test was used to compare the mean of variables between men and women and the Pearson correlation coefficient test was used to evaluate the relationship between variables using SPSS software version 24 at a significant level of (P≤0.05). Results: The findings of the present study showed that men and women with COVID-19 had inadequate PAL (876.11±40.23;739.08±27.02), insufficient GH (50.13±3.1; 54.15±4.28), and poor QoL (22.02±2.28; 19.23±1.87), respectively. The results also showed that men had significantly higher PAL (P=0.035), GH (P=0.047), and QoL (P=0.023) compared to women. Also, the results show that increasing the PAL improves GH and QoL. Conclusions: Considering the prevalence of COVID-19 and its negative impact on GH and QoL, maintaining adequate PAL can be considered as one of the effective strategies for improving physical and GH, and immune systems, by observing the hygiene protocol.


Pain Medicine ◽  
2020 ◽  
Vol 21 (12) ◽  
pp. 3458-3469
Author(s):  
Melek Aykut Selçuk ◽  
Ahmet Karakoyun

Abstract Objective To investigate the levels of kinesiophobia, physical activity, depression, disability, and quality of life in patients with knee osteoarthritis. Design A cross-sectional study. Setting A tertiary health care center. Subjects Ninety-six patients with knee osteoarthritis. Methods Pain intensity was evaluated by the Visual Analog Scale, kinesiophobia by the Tampa Scale of Kinesiophobia and Brief Fear of Movement Scale, depression by the Beck Depression Inventory, disability by the Western Ontario and McMaster Universities Arthritis Index, physical activity level by the International Physical Activity Questionnaire short form, and quality of life by the Short Form 12 Health Survey Questionnaire. Results Of the patients, 85.7% had high-level kinesiophobia, 70.6% had depression, and 64.4% had low, 27.8% moderate, and 7.8% high physical activity levels. Age, activity-related pain score of the Visual Analog Scale, Tampa Scale of Kinesiophobia and Brief Fear of Movement Scale scores, and Western Ontario and McMaster Universities Arthritis Index and Beck Depression Inventory scores were higher in the group with high-level kinesiophobia, whereas the mental, physical, and total scores obtained from the Short Form 12 Health Survey Questionnaire were higher in the group with low-level kinesiophobia (P < 0.05). Conclusions As the treatment of pain alone in patients with knee osteoarthritis is not sufficient to reduce fear of movement, we suggest that approaches to increase awareness of fear of movement and physical activity and cognitive behavioral therapy related to fear of movement should be included in the treatment program.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Rastegar Hoseini ◽  
Nariman Rahmani ◽  
Zahra Hoseini ◽  
Elahe Bahmani ◽  
Mahsa Ahmadi Darmian ◽  
...  

Background: High physical activity level (PAL) and anthropometric characteristics (AC) are positively associated with quality of life (QoL). Several studies have investigated rural-urban differences in PAL, AC, and QoL. However, cultural and geographical differences have not been studied yet. Objectives: This study aimed to examine PAL, AC, and QoL of middle-aged women living in rural and nomadic Areas of Kermanshah province (Sarpol-e-Zahab, Paveh, and Kangavar cities). Methods: In this descriptive-analytical study, using the multi-stage (Cluster) sampling techniques, 1635 nomadic rural women from three cities of Kermanshah province (Sarpol-e Zahab (n = 609); Paveh (n = 480) and Kangavar (n = 546)) were volunteered. After filling out the consent form, the PAL and QOL questionnaires were completed and anthropometric parameters were measured. The PAL was assessed using the Baecke physical activity questionnaire, and the QOL was measured by the QoL Questionnaire (short-form-SF-12). Results: The findings showed that BW, BMI, BFP, and WHR were 68.01 ± 14.90, 27.46 ± 5.33, 29.41 ± 9.28, and 0.91 in Sarpol-e Zahab; 67.90 ± 15.56, 27.88 ± 17.85, 33.03 ± 11.97, and 0.93 in Paveh; and 69.24 ± 14.74, 28.31 ± 5.59, 30.91 ± 11.67, and 0.92 in Kangavar, respectively. In Paveh city, the PAL and QOL (14.37 ± 5.10; 23.08 ± 2.32; P = 0.001, respectively) were significantly higher than Kangavar (12.23 ± 3.18; 20.28 ± 3.32) and Sarpol-e-Zahab (10.57 ± 6.11; 16.24 ± 7.22) cities. A significant association was found between PAL and QOL (P = 0.001). Calculations: Based on the findings, increasing the PAL of middle-aged women might improve QoL and AC.


2020 ◽  
Vol 33 ◽  
Author(s):  
Maria Daniela Clementino ◽  
Rita Maria Monteiro Goulart

Abstract Introduction: Aging is a worldwide phenomenon that has favored an increase in people aged 80 years and older. Objective: To assess the influence of nutritional status (NS), measures of frailty, and physical activity level (PAL) on the quality of life (QoL) of long-lived people. Method: The study was carried out from Oct 2016 to Sept 2017 with 103 individuals aged 80 years or more. NS was classified according to the PAHO Health, Well-Being and Aging (SABE) survey; waist circumference (WC) and calf perimeter (CP) was based on the WHO classification; handgrip strength (HGS) and gait speed (GS) used the classification proposed by Lauretani; PAL was classified according to the IPAQ short form; the WHOQoL-bref and WHOQoL-old were applied to measure QOL. Variables were assessed using the Mann-Whitney U and t-tests. Results: 69.2% were women, with an average age of 82.75 (± 2.98) years, and only WC showed a significant association (p <0.001). The older women without dynapenia exhibited better QoL in the physical domain (p = 0.004), social relationships (p = 0.022), self-reported QoL (p = 0.017) of the WHOQoL-bref and social participation facet (p = 0.025) of WHOQOL-old. Comparison of QoL with NS and PAL showed a significant difference in self-reported QoL (p = 0.027) for the former and past, present and future activities for the latter (p = 0.050). Conclusion: Obesity and the absence of dynapenia were positively associated with the QoL of long-lived individuals. PAL was associated with positive QoL in one facet of the WHOQoL-old.


2021 ◽  
Vol 18 (3) ◽  
Author(s):  
Mahnaz Azmodeh ◽  
Rastegar Hoseini ◽  
Ehsan Amiri

Background: New coronavirus (COVID-19) has a major impact on the individual's physical activity level (PAL). The COVID-19 outbreak caused a decrease in the PAL, which might also affect the general health and quality of life (QoL). Objectives: This study aimed to evaluate the relationship of PAL with QoL and general health (GH) among COVID-19 recovered individuals (CRI). Methods: This is a descriptive-analytical study in which 890 CRI (men [n = 438] and women [n = 452]) were recruited from volunteers of different COVID-19 testing centers in Kermanshah Province. The participants were chosen by the multi-stage (Cluster) sampling techniques. The consent form and questionnaires (PAL, GH, and QoL) were filled out, and demographic information was evaluated. The short form of international physical activity questionnaire (IPAQ-SF), GHQ, and the short-form-SF-12 QoL questionnaires were used to appraise the PAL, GH, and QoL. Data were analyzed by independent t-test and Pearson correlation coefficient using SPSS version 24.0 at a significance level of P < 0.05. Results: The findings of the present study showed that men and women with COVID-19 had inadequate PAL (876.11 ± 40.23 and 739.08 ± 27.02, respectively), insufficient GH (50.13 ± 3.11 and 54.15 ± 4.28, respectively), and poor QoL (22.02 ± 2.28 and 19.23 ± 1.87, respectively). The results also showed that men had significantly higher PAL (P = 0.035), GH (P = 0.047), and QoL (P = 0.023) compared to women. Also, the results showed a significant inverse relationship between PAL and GH (men: r = -0.589, P = 0.038 and women: r = -0.685, P = 0.029) and a significant positive relationship between PAL and QoL (men: r = 0.792, P = 0.018 and women: r = 0.824, P = 0.001) in COVID-19 recovered individuals. Conclusions: Considering the prevalence of COVID-19 and its negative impact on GH and QoL, maintaining adequate PAL can be considered as one of the effective strategies for improving QoL and GH.


2020 ◽  
Author(s):  
Christian Arinze Okonkwo ◽  
Peter Olarenwaju Ibikunle ◽  
Izuchukwu Nwafor ◽  
Andrew Orovwigho

BACKGROUND Quality of life (QoL), physical activity (PA) level and psychological profile (PF) of patients with serious mental illness have been neglected during patient’s management OBJECTIVE The purpose of this study was to determine the effect of selected psychotropic drugs on the QoL, PA level and PF of patients with serious mental illness METHODS A cross sectional survey involving one hundred and twenty-four subject [62 Serious Mental Illness (SMI) and 62 apparently healthy subjects as control] using purposive and consecutive sampling respectively .Questionnaires for each of the constructs were administered to the participants for data collation. Analysis of the data was done using non parametric inferential statistics of Mann-Whitney U independent test and Spearman’s rho correlation with alpha level set as 0.05. RESULTS Significant difference was recorded in the QoL (p<0.05) of patient with SMI and apparently healthy psychotropic naive participants. There was a significant correlation between the QoL (p<0.05) and PF of participants with SMI. Participants with SMI had significantly lower QoL than apparently healthy psychotropic naive subject. QoL of the healthy psychotropic naive group was better than those of the participants with SMI. Female participants with SMI had higher PA than their male counterparts CONCLUSIONS Psychological profiles of male participants with SMI were lower than male healthy psychotropic naive participants. Clinicians should take precaution to monitor the QoL, PA level and PF because the constructs are relevant in evaluation of treatment outcome.


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1270.1-1270
Author(s):  
S. Baglan Yentur ◽  
D. C. Saraç ◽  
N. G. Tore ◽  
F. Sarİ ◽  
N. Atas ◽  
...  

Background:Behçet’s Disease (BD) is a chronic, inflammatory, rheumatic disease that is characterized by mucocutaneous lesions and can be seen major organ involvement such as eyes, musculoskeletal system, gastrointestinal system and central nervous system. Impaired quality of life, aerobic capacity, respiratory function and life satisfaction, sleep disorders, depression, anxiety and fatigue are seen commonly in BD patients like the other rheumatic diseases. Considering that regular physical activity effects survival for patients and healthy people, it is important to determine the factors affecting physical activity level and exercise barriers.Objectives:The aim of this study is to investigate physical activity level and exercise barriers in patients with BD.Methods:45 patients were included in the study. Physical activity level, exercise barriers, fatigue, depression, pain, quality of life and aerobic capacity were evaluated with International Physical Activity Questionnaire (IPAQ), Exercise Barriers and Benefits Scale (EBBS), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), Visual Analog Scale (VAS), Behçet’s Disease Quality of Life Questionnaire (BDQoL) and 6 minutes walk test, respectively. Spaerman’s Correlation Coefficient were used to investigate the relationships between exercise barriers and other parameters.Results:IPAQ demonstrated that 22 (48.8%) of the patients had low level physical activitiy. Additionally, physical activity levels significantly correlated with both exercise barriers (rho= -0.345) and exercise benefits (rho= 0.320) (p<0.05). BDQoL scores also correlated significantly with exercise barrier scores (rho= 0.338), (p<0.05). No significant relationships were observed for other parameters.Conclusion:Exercise and physical activity are of great importance because of its positive contribution to the musculoskeletal system for BD patients’ rehabilitation. Thinking of negative effects of physical inactivity, patients with Behçet disease should be encouraged to exercise. Also, reasons of physical inactivity should be investigated and treated.References:[1]Ilhan B, Can M, Alibaz-Oner F, Yilmaz-Oner S, Polat-Korkmaz O, Ozen G et al. Fatigue in patients with Behcet’s syndrome: relationship with quality of life, depression, anxiety, disability and disease activity. International journal of rheumatic diseases. 2018;21(12):2139-45.[2]Alder NM, Fisher M, Yazici Y. Behçet’s syndrome patients have high levels of functional disability, fatigue and pain as measured by a Multi-dimensional Health Assessment Questionnaire (MDHAQ). Clin Exp Rheumatol. 2008;26(Suppl 50):S110-3.Disclosure of Interests:None declared


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