Prevalence of iron deficiency in cancer patients: The French prospective CARENFER study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15617-e15617
Author(s):  
Elisabeth Luporsi ◽  
Aurelien Carnot ◽  
Vincent Massard ◽  
Sophie Morin ◽  
Bruno Chauffert ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Cancer Patients ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Malignant Tumors ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Ferritin Concentration

e15617 Background: Despite the potential deleterious consequences of iron deficiency (ID) in patients with cancer, under-diagnosis is frequent and existence of ID based on both serum ferritin concentration and transferrin coefficient saturation (TSAT) index is rarely determined. The CARENFER Study aimed to assess prospectively the prevalence of ID, anemia and iron deficiency anemia (IDA) in cancer patients. Methods: The study was conducted in France from May to July 2019, as a prospective cross-sectional survey carried out in 15 oncology units. The analysis focused on 1221 patients with different types of solid malignant tumors. Serum ferritin and iron concentrations, TSAT index and hemoglobin (Hb) level were determined. Based on ESMO 2018 Guidelines, ID was defined as ferritin < 100 μg/L or TSAT < 20%, and then categorized as either absolute ID (ferritin < 100 μg/L) or functional ID (ferritin ≥ 100μg/L and TSAT < 20%). Anemia was defined as Hb level ≤ 11 g/dL. Iron deficiency anemia (IDA) was defined according to ESMO 2018 Guidelines. The prevalence of ID, anemia and IDA was estimated using Agresti-Coull 95% confidence interval. Results: Patient’s median age was 63 years (55% women and 45% men). 89.4% of patients were currently under treatment for their cancer, mainly by chemotherapy (75.4%). The proportion of cancer patients with ferritin level < 100 μg/L was 20.5% [18.3-22.9] and 50.6% [47.8-53.4] of patients had a TSAT index < 20%. Overall, ID was found in 57.9% [55.1-60.6] of patients, with absolute ID accounting for 36% of all ID cases. 36.0% of patients were anemic and among them, IDA was reported in 21.8% [19.6-24.2] of patients. The type of cancer treatment did not influence the ID status as ID was also present in 57.4% of untreated cancer patient. Conclusions: This study highlights the high prevalence of ID in cancer patients, whether or not concomitantly associated with anemia or treatment. These results emphasize the need to better management of ID in cancer thereby optimizing overall patient care. Clinical trial information: NCT03924271.

Evaluation of serum electrolyte levels in iron deficiency anemia patients.

2021 ◽  
Vol 28 (05) ◽  
pp. 691-696
Author(s):  
Maryam Rafiq ◽  
Amna Arooj ◽  
Qurrat-ul-Ain Tahir ◽  
Nudrat Fayyaz ◽  
Afra Samad ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Close Monitoring ◽  
Cross Sectional ◽  
Mean Values ◽  
Medical College ◽  
Complete Blood Counts

Objectives: To evaluate electrolytes levels in patients suffering from iron deficiency anemia and to compare it with patients without anemia. Study Design: Descriptive Cross Sectional study. Setting: Department of Pathology, Sahiwal Medical College Sahiwal. Period: November, 2019 to May, 2020. Material & Methods: After taking informed consent, five milliliter of blood was drawn from each patient. Blood sample was analyzed for electrolytes, complete blood counts and serum ferritin levels. Results were compared in normal and iron deficiency anemic groups. Results: A total of 287 clinically anemic suspects including 181 (63.0%) female and 106 (37.0%) male with mean age of patients as 36.11±12.23 were included in this study. A total of 205 (71.4%) of the suspects had anemia whereas frequency of anemia remained higher among females (78.5%) as compared to males (59.5%) in this study. On the basis of serum ferritin levels a total of 178 (62.0%) patients had iron deficiency. Mean values of Sodium (130.41±0.59) and Bicarbonate (24.10±0.31) remained low while mean Potassium (4.33±0.07) and Chloride (103.93±0.47) levels of Iron Deficiency Anemia (IDA) group remained high as compared to non-anemic group. Conclusion: Levels of sodium and bicarbonate are found to be on the lower side while potassium and chloride remained on higher side in patients with Iron deficiency Anemia in this study. Thus these findings indicate close monitoring of electrolytes to evade impediments during management of patients.

scholarly journals Prevalence and causes of iron deficiency anemias in infants aged 9 to 12 months in Estonia

Medicina ◽  
2007 ◽  
Vol 43 (12) ◽  
pp. 947 ◽  
Author(s):  
Neve Vendt ◽  
Heli Grünberg ◽  
Sirje Leedo ◽  
Vallo Tillmann ◽  
Tiina Talvik
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Mean Corpuscular Volume ◽  
Ferritin Level ◽  
Solid Food ◽  
Deficiency Anemia ◽  
Corpuscular Volume ◽  
Main Risk Factor ◽  
Ferritin Concentration

Objective. To investigate the prevalence and causes of iron deficiency anemia in infants aged 9 to 12 months in Estonia. Material and methods. Every second child aged 9–12 months was randomly selected from primary medical centers in seven counties from all over Estonia. A questionnaire concerning eating habits and lifestyle was sent to their parents. Sixty-five percent (n=195) of contacted families agreed to participate in the study. Mean corpuscular volume and hemoglobin, serum ferritin, and soluble transferrin receptor levels were measured in 171 infants. Anemia was defined when hemoglobin level was lower than 105 g/L, and iron deficiency when ferritin level and mean corpuscular volume were lower than 12 µg/L and 74 fL, respectively. Results. The prevalence of iron deficiency was 14.0% and iron deficiency anemia 9.4%. Birthweight less than 3000 g was the main risk factor for iron deficiency (OR=9.4; P<0.0005). Infants fed with breast milk and solid food had lower ferritin concentration (18.5 µg/L, 95% CI 14.0–23.0) than infants fed with formula and solid food (32.8 µg/L, 95% CI 26.6–39) (P<0.005). Conclusion. Iron deficiency anemia is common among 9–12-month-old Estonian infants. The main risk factor for iron deficiency was birthweight less than 3000 g.

scholarly journals Lactoferrin Levels in the Gastric Tissue ofHelicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yaşar Doğan ◽  
Tülay Erkan ◽  
Zerrin Önal ◽  
Merve Usta ◽  
Gülen Doğusoy ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Antral Mucosa ◽  
Gastric Tissue ◽  
Negative Controls

Aim. To determine gastric tissue lactoferrin (Lf) levels ofHelicobacter pylori-(Hp-) positive and -negative patients and its effect on anemia.Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.Results. The study included 64 cases (average: years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were % and , respectively. Hp-negative cases showed significantly different values of % and , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were /dL and /mL, but these were comparable with Hp-negative cases (/dL and /mL).Conclusions.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

scholarly journals Incidence of iron deficiency anemia among the children with febrile seizures.

2021 ◽  
Vol 29 (01) ◽  
pp. 121-125
Author(s):  
Samina Batool ◽  
Nadia Qamar ◽  
Akasha Islam ◽  
Saman Jamal ◽  
Qurat-ul-Ain Rana
Keyword(s):  
Socioeconomic Status ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Rural Areas ◽  
Ferritin Level ◽  
Demographic Data ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Duration Of Symptoms

Objective: To determine frequency of iron deficiency anemia among the children having febrile seizures. Study Design: Descriptive Cross Sectional study. Setting: Pediatric Unit Allama Iqbal Memorial Teaching Hospital Sialkot. Period: September 2020 to February 2021. Material & Methods: Total 70 children were studied with age six months to 10 years with either gender presenting with febrile seizures. All data of the patients was documented including demographic data like age, gender, residential area, educational status, socioeconomic status and clinical findings at the time of presentation like fever, fits and duration of symptoms etc. Blood hemoglobin and ferritin level were tested of each patient to evaluate iron deficiency anemia. Results: There were 65.7% male and 34.3% female cases in this study. Age range of the patients was 6 months to 10 years with mean age of 4.36 ± 2.71 years. Most of the children (60%) were below three years of age. Mostly children belonged to low and middle socioeconomic status with the frequency of 42.8% and 45.7% respectively. Iron deficiency anemia was found in 38.6% cases. Majority of the mothers were illiterate (65%). There were 44.3% cases from rural areas and 55.7% from urban area. Conclusion:  Iron deficiency anemia is a common problem among children with febrile seizures, younger than 03 years and belonging to rural areas. Illiterate mothers, is an important risk factor of iron deficiency anemia in their children.

scholarly journals Prevalence of Iron Deficiency Anemia among Adolescent Girls in the City of Saravan -

2020 ◽  
Vol 10 (2) ◽  
pp. 68-73
Author(s):  
Omid Sabet Ghadam ◽  
Mohammad Fararouei ◽  
Mansour Shahraki   ◽  
Zahra Sohrabi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Parental Education ◽  
Ferritin Level ◽  
Demographic Data ◽  
Good Practice ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Increased Risk ◽  
Prevalence Of Anemia

Background and Objective: Iron deficiency anemia (IDA) is the most common type of micronutrient deficiency in the world. Numerous reports indicated that adolescence is a period which has an increased risk of development of IDA. Given the importance of IDA and lack of studies in Saravan, a city of Iran, this study was performed to assess the prevalence of IDA among adolescent girls.Methods: In this cross-sectional study, 460 high-school girls were randomly selected. Demographic data was collected using a questionnaire. Knowledge, attitude and practice of participants with regard to iron deficiency anemia was measured at the beginning of the interview. Accordingly, five cc of blood sample was drawn from each student to determine the prevalence of anemia, which was defined by a hemoglobin level lower than 12 mg / dL. The level of ferritin was analyzed to confirm the IDA for students diagnosed with anemia. Ferritin level lower than 12 ?g / dl was considered as IDA. Data was analyzed using SPSS software version 22.Results: Prevalence of anemia and IDA was 24% (n = 111) and 12.6% (n = 58), respectively. Results showed that 37 % of students had good knowledge, 45. 5 % good attitude, and 6.7 % had good practice. Also, there was no significant association between IDA and socio-economic status including parental education, job, and household income (P>0.05).Conclusion: The findings of this study showed that the prevalence of IDA was moderate in Saravan city. Given the importance of IDA and its complications, further studies are needed, especially in high risk populations for IDA such as children.

scholarly journals Iron Deficiency Anemia as a Factor in Male Infertility: Awareness in Health College Students in the Jazan Region of Saudi Arabia

2021 ◽  
Vol 18 (24) ◽  
pp. 12866
Author(s):  
Mohammad S. Akhter ◽  
Hassan A. Hamali ◽  
Johar Iqbal ◽  
Abdullah A. Mobarki ◽  
Hina Rashid ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Male Infertility ◽  
Iron Deficiency Anemia ◽  
Female Students ◽  
Deficiency Anemia ◽  
P Value ◽  
Inclusion Criteria ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Total P

Male contribution towards couple infertility is increasing but is less discussed. We aimed to assess the knowledge about iron deficiency anemia (IDA) as a contributor to male infertility in students at health colleges of Jazan University. A multicentric, cross-sectional survey included 910 participants and 768 participants qualified as per our inclusion criteria. The questions were categorized as: Model 1—knowledge about IDA-induced male infertility; Model 2—knowledge about IDA. The average knowledge of IDA causing male infertility is very low among students. The 18–20 years age group had a lesser score for either knowledge of IDA (M2; p-value = 0.047) or total (p-value < 0.0001) compared to the older group. In addition, female students were significantly more likely to be better in achieving higher total scores (p-value = 0.023) as well as M2 scores (p-value < 0.0001) when compared to the respective male category. On the other hand, males were significantly better in scoring for M1 (p-value = 0.004) compared to females. Awareness about iron deficiency anemia as a factor in male infertility may reduce the infertility burden, arising from a preventable factor, in the Jazan region.

scholarly journals Zinc protoporphyrin as screening test in female blood donors

1998 ◽  
Vol 44 (4) ◽  
pp. 800-804 ◽  
Author(s):  
Else J Harthoorn-Lasthuizen ◽  
Jan Lindemans ◽  
Mart M A C Langenhuijsen
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Blood Donors ◽  
Deficiency Anemia ◽  
Zinc Protoporphyrin ◽  
Ferritin Concentration ◽  
Iron Deficient ◽  
Serum Ferritin Concentration ◽  
Low Serum

Abstract Erythrocyte zinc protoporphyrin (ZPP) was measured in 102 women blood donors to evaluate its usefulness in screening for evolving iron deficiency anemia, a reason for the deferral of donors. The results were compared with serum ferritin determinations. Five women were deferred before their first donation and eight women were deferred after one or two donations. Women with increased ZPP values all had low serum ferritin concentrations, indicating iron-deficient erythropoiesis that was caused by iron depletion. The positive predictive value of an increased ZPP in predicting deferral of the donor after one or two donations was 75%, whereas a serum ferritin concentration ≤12 μg/L predicted deferral in 26% of the donors. The results indicate that the ZPP test can be recommended as a feasible and inexpensive predonation test to determine a subset of donors with iron-deficient erythropoiesis at risk of developing iron deficiency anemia.

scholarly journals Relationship of Menstrual Patterns with Serum Ferritin Levels in Brides-to-Be in Padang City

2021 ◽  
Vol 8 (12) ◽  
pp. 45-53
Author(s):  
Rahmani Welan ◽  
Verty Ratna Monika ◽  
Yulistini .
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
T Test ◽  
Deficiency Anemia ◽  
Bivariate Analysis ◽  
Women Of Childbearing Age ◽  
Childbearing Age

Background: Among the causes of high Maternal Mortality Rate (MMR) in Indonesia is anemia. Iron deficiency anemia, the most common type of anemia, frequently occurs in women of childbearing age because they experience menstruation each month. To diagnose iron deficiency, serum ferritin level could be used as one of the indicators. This study aims to know whether there is an association between menstruation patterns and serum ferritin level in brides-to-be in Padang. Method: This study was conducted using an analytic observational method with a cross-sectional design. A Total of seventy samples of brides-to-be aged 20-30 years were gathered using a consecutive sampling technique. This study was conducted from November 2019 until April 2020. Data on menstruation patterns were collected through a questionnaire. Data of serum ferritin levels were acquired from venous blood sampling and measurement of serum ferritin levels with The Electro Chemiluminescence Immuno Assay (ECLIA) method. Bivariate analysis of this study used Independent T-test. Results: This study showed sixty-eight point six percent of respondents were experiencing abnormal menstruation patterns while the mean of serum ferritin levels was normal (sixty-two point zero seven ± thirty-nine point forty-five ng/ml). The Independent T-test showed p-value = 0,921. Conclusion: There was no significant association between menstruation pattern and serum ferritin level in brides-to-be in Padang. Keywords: iron deficiency anemia, women of childbearing age, menstruation patterns, serum ferritin levels.

Serum Ferritin and Anemia in Trained Female Athletes

1998 ◽  
Vol 8 (3) ◽  
pp. 223-229 ◽  
Author(s):  
Michael J. Ashenden ◽  
David T. Martin ◽  
Geoffrey P. Dobson ◽  
Colin Mackintosh ◽  
Allan G. Hahn
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Female Athletes ◽  
Weight Bearing ◽  
Hemoglobin Concentration ◽  
Background Information ◽  
Deficiency Anemia ◽  
Mean Corpuscular Hemoglobin ◽  
Ferritin Concentration

The aim of this study was to establish whether extremely low serum ferritin values in female athletes were associated with indications of iron deficiency anemia and whether serum ferritin values were influenced by the type of training or participants' body size. Hematological data collected during 6 years at the Australian Institute of Sport were reviewed to quantify changes in serum ferritin concentration associated with training and to establish whether decrements in serum ferritin were associated with any change in hemoglobin concentration, mean corpuscular volume, or mean corpuscular hemoglobin concentration. Mean serum ferritin concentrations of 7.5 μg ⋅ L−1 were not associated with any indication of iron-deficiency anemia. Serum ferritin declined by approximately 25% with the onset of rigorous daily training (p <.01) whether training was predominantly weight-bearing or non-weight-bearing. Rowers had significantly higher ferritin concentrations than basketball players of similar stature (p = .02). We conclude that considerable background information such as the stage of training, specific sport, and previous blood results should be sought when interpreting serum ferritin concentrations in female athletes.

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