Cell and Molecular Biology of Cancer of the Brain

Author(s):  
Øle Didrik Laerum
Keyword(s):  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Gazanfar Rahmathulla ◽  
Steven A. Toms ◽  
Robert J. Weil

Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM).


2001 ◽  
Vol 10 (4) ◽  
pp. 271
Author(s):  
Issam A. Awad ◽  
M Sc ◽  
FACS ◽  
MA(Hon)

2019 ◽  
Vol 1 (1) ◽  
pp. 1-16
Author(s):  
Paul Elliott

“I don’t believe that linguistics and psychoanalysis offer a great deal to the cinema. On the contrary, the biology of the brain – molecular biology – does.” Gilles DeleuzeModels of the brain are inextricably linked to the surrounding cultural episteme: whether it is viewed as a complex clockwork device, a computer, a self-regulating network or even a cinema screen, our understanding of neurophysiology has always relied on discourses and images taken from other fields. In turn, however, our knowledge of cerebral processes (such as sight for instance) has always, inevitably, affected the way that we approach artworks, literary texts and cultural artefacts.Based on this, this paper looks at how recent neuroscientific research on vision and cognition can help us better understand the processes inherent in film theory. Focussing mainly on the recently discovered concept of the mirror neuron but also citing synaesthesia and limbic perceptual processing, I suggest that neuroscience can provide us with a fertile new ground for thinking about areas such as spectatorship and the facilitation of emotional affect, it can also offer us alternatives to monolithic ideas like the Gaze and the patriarchal nature of visual pleasure.Prompted perhaps by a shift in scopic thinking, some recent neuroscientific research has even mirrored film and cultural theory by foregrounding notions such embodiment, cross-model perception and mimesis, adding to the dialogic relationship that exists between these two disciplines. This paper then is not only concerned with how different fields communicate but with how each can provide models, metaphors and frameworks for the other.


2000 ◽  
Vol 75 (1) ◽  
pp. 81-81
Author(s):  
Eric E. Turner
Keyword(s):  

1992 ◽  
Vol 5 (1) ◽  
pp. 49-73 ◽  
Author(s):  
E O Major ◽  
K Amemiya ◽  
C S Tornatore ◽  
S A Houff ◽  
J R Berger

Studies of the pathogenesis and molecular biology of JC virus infection over the last two decades have significantly changed our understanding of progressive multifocal leukoencephalopathy, which can be described as a subacute viral infection of neuroglial cells that probably follows reactivation of latent infection rather than being the consequence of prolonged JC virus replication in the brain. There is now sufficient evidence to suggest that JC virus latency occurs in kidney and B cells. However, JC virus isolates from brain or kidney differ in the regulatory regions of their viral genomes which are controlled by host cell factors for viral gene expression and replication. DNA sequences of noncoding regions of the viral genome display a certain heterogeneity among isolates from brain and kidney. These data suggest that an archetypal strain of JC virus exists whose sequence is altered during replication in different cell types. The JC virus regulatory region likely plays a significant role in establishing viral latency and must be acted upon for reactivation of the virus. A developing hypothesis is that reactivation takes place from latently infected B lymphocytes that are activated as a result of immune suppression. JC virus enters the brain in the activated B cell. Evidence for this mechanism is the detection of JC virus DNA in peripheral blood lymphocytes and infected B cells in the brains of patients with progressive multifocal leukoencephalopathy. Once virus enters the brain, astrocytes as well as oligodendrocytes support JC virus multiplication. Therefore, JC virus infection of neuroglial cells may impair other neuroglial functions besides the production and maintenance of myelin. Consequently our increased understanding of the pathogenesis of progressive multifocal leukoencephalopathy suggests new ways to intervene in JC virus infection with immunomodulation therapies. Perhaps along with trials of nucleoside analogs or interferon administration, this fatal disease, for which no consensus of antiviral therapy exists, may yield to innovative treatment protocols.


2018 ◽  
Vol 18 (1) ◽  
pp. 115-140
Author(s):  
Fu`ad Arif Noor

Neuroscience, are simply the science devoted to learning Neoron(nerve cells). Nerve cells make up the nervous system, both thecentral nervous system (brain and spinal cord) and the peripheralnerves (31 pairs and 12 pairs of spinal nerve head). A nerve cellitself is not the smallest unit away from the nerve cell, the smallestunit of nerve cells (neurons) are the synapses ie the meeting point oftwo nerve cells move and pass the information (neurotransmitters).At the level of molecular biology, the smallest unit is like genes(genetic studies). Generally, the neuroscientist focused on nervecells in the brain. In the Qur'an sense has a glorious position. It wasevident the word "reasonable" in the Qur'an is mentioned insignificant amounts. The word "reasonable" in the Qur'an is called49 times. All in the form mudhari deed '(a verb that indicates thecurrent and future), but one that is shaped madhi verb (a verb thatindicates the past).Although the Qur'an does not mention the "sense" in its form as' acertain part of the human self '(سفنلا ىف لاقتسم ارهوج), which becamethe source of the birth of any acts rationally, but the Qur'anmentions "reasonable" in its meaning as' activities reasonable use'(لقعتلا ةيلمع), the appeal that invites use of reason as the path to truth(لقعتلا), thinking (ركفتلا), watching (رظنلا), to understand and learn(هقفتلا), take the wisdom and lessons from each incident (رابتعلاا) andetc.


2016 ◽  
Author(s):  
Alex Gomez-Marin ◽  
Zachary F Mainen

Over the past decade neuroscience has been attacking the problem of cognition with increasing vigor. Yet, what exactly is cognition, beyond a general signifier of anything seemingly complex the brain does? Here, we briefly review attempts to define, describe, explain, build, enhance and experience cognition. We highlight perspectives including psychology, molecular biology, computation, dynamical systems, machine learning, behavior and phenomenology. This survey of the landscape reveals not a clear target for explanation but a pluralistic and evolving scene with diverse opportunities for grounding future research. We argue that rather than getting to the bottom of it, over the next century, by deconstructing and redefining cognition, neuroscience will and should expand rather than merely reduce our concept of the mind.


2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Neelima Mantha ◽  
Nandita G. Das ◽  
Sudip K. Das

Huntington’s disease is a genetically inherited neurodegenerative disease that is characterized by neuronal cell death in the brain. Molecular biology techniques to detect and quantify huntingtin protein in biological samples involve fluorescence imaging, western blotting, and PCR. Modified cell lines are widely used as models for Huntington’s disease for preclinical screening of drugs to study their ability to suppress the expression of huntingtin. Although worm and fly species have been experimented on as models for Huntington’s disease, the most successful animal models have been reported to be primates. This review critically analyses the molecular biology techniques for detection and quantitation of huntingtin and evaluates the various animal species for use as models for Huntington’s disease.


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