In-situ chemical analysis for life cycle health management

2008 ◽  
pp. 149-151
Author(s):  
M Ghandehari
Keyword(s):  
Life Cycle ◽  
Chemical Analysis ◽  
Health Management

Canaries Development via Combinatorial Materials Science Techniques for Prognostics and Health Management in Electronics Systems

2010 ◽  
Author(s):  
Pedro O. Quintero Aguilo ◽  
Ricky Valentin ◽  
Pablo Caceres Valencia
Keyword(s):  
Life Cycle ◽  
Materials Science ◽  
Health Management ◽  
Fault Tolerant ◽  
Cycle Monitoring ◽  
Combinatorial Materials ◽  
Combinatorial Materials Science ◽  
Selection Of

The design of a canary in a system aims at the detection of failures without causing an error in the system. The idea behind a canary is to have a system that will provide an early warning in a way that a fault-tolerant system will continue its intended function despite the potential presence of hardware errors. This paper presents methods to collect and analyze life-cycle environmental and usage data for in-situ health assessments. The FARM method is also provided to develop a canary life cycle monitoring plan, that encompasses the selection of environmental and usage parameters. The multidimensional failure space of a system is analyzed with combinatorial material science. A case study is presented to illustrate the methodology.

Solid Phase Excitation-Emission Matrix Spectroscopy for In-Situ Chemical Analysis of Combustion Aerosols

2020 ◽  
Author(s):  
Gaurav Mahamuni ◽  
Jiayang He ◽  
Jay Rutherford ◽  
Byron Ockerman ◽  
Edmund Seto ◽  
...  
Keyword(s):  
Chemical Analysis ◽  
Cigarette Smoke ◽  
Forest Fires ◽  
Solid Phase ◽  
Incident Angle ◽  
Personal Exposure ◽  
Traffic Emission ◽  
Excitation Emission Matrix ◽  
Internal Excitation

<p>Exposure to combustion generated aerosols such as PM from residential woodburning, forest fires, cigarette smoke, and traffic emission have been linked to adverse health outcomes. It is important to assess the chemical composition of PM to examine personal exposure. Excitation-emission matrix (EEM) spectroscopy has been shown as a sensitive and cost-effective technique for evaluation of combustion PM composition and as a source apportionment tool. However, EEM measurements are hindered by a solvent extraction step and a need for benchtop instrumentation. Here, we present a methodology that eliminates this labor-intensive sample preparation and allows to automate and miniaturize the detection platform. A miniature electrostatic collector deposits PM sample onto transparent polydimethylsiloxane (PDMS) coated substrate, where PAH components are extracted into solid-phase (SP) solvent and analyzed using EEM spectroscopy in-situ. We evaluated external and internal excitation schemes to optimized signal to noise ratio. Analysis of woodsmoke and cigarette smoke samples showed good agreement with liquid extraction EEM spectra. Internal excitation is hindered by fluorescent interference from PDMS at λ<250nm. The external excitation EEM spectra are dependent on the incident angle; ranges of 30-40⁰ and 55-65⁰ showed the best results. The proposed SP-EEM technique can be used for development of miniaturized sensors for chemical analysis of combustion generated PM. </p>

Observing microscopic phases of lichen life cycles on transparent substrata placed in situ

2005 ◽  
Vol 37 (5) ◽  
pp. 373-382 ◽  
Author(s):  
William B. SANDERS
Keyword(s):  
Life Cycle ◽  
Developmental Stages ◽  
Life Cycles ◽  
Potential Significance ◽  
Free Living ◽  
Lichen Community ◽  
One Year ◽  
The One ◽  
Observation Period

The utility of plastic cover slips as a substratum for in situ study of lichen developmental stages is further explored in a neotropical foliicolous lichen community and in a European temperate corticolous community. Twenty-one months after placement in the tropical forest, the cover slips bore foliicolous lichen thalli with several species producing characteristic ascocarps and ascospores, indicating the suitability of the substratum for completion of the life cycle of these lichens. On cover slips placed within the temperate corticolous community, lichen propagules anchored to the substratum with relatively short attachment hyphae but did not develop further within the one year observation period. Intimately intermixed microbial communities of short-celled, mainly pigmented fungi and chlorophyte algae developed upon the transparent substratum. Among the algae, Trebouxia cells, often in groups showing cell division and without associated lichenizing hyphae, were commonly observed. The potential significance of the free-living populations in the life cycle of Trebouxia and in those of Trebouxia-associated lichen fungi is discussed.

Molecular Cytogenetic Classification of Down Syndrome and Screening of Somatic Aneuploidy in Mothers

2021 ◽  
pp. 1-9
Author(s):  
Sushil Kumar Jaiswal ◽  
Ashok Kumar ◽  
Amit Kumar Rai
Keyword(s):  
Down Syndrome ◽  
Peripheral Blood ◽  
Trisomy 21 ◽  
Health Management ◽  
Chromosome 21 ◽  
Robertsonian Translocations ◽  
Significant Difference ◽  
And Control

Down Syndrome (DS) caused by trisomy 21 results in various congenital and developmental complications in children. It is crucial to cytogenetically diagnose the DS cases early for their proper health management and to reduce the risk of further DS childbirths in mothers. In this study, we performed a cytogenetic analysis of 436 suspected DS cases using karyotyping and fluorescent in situ hybridization. We detected free trisomies (95.3%), robertsonian translocations (2.4%), isochromosomes (0.6%), and mosaics (1.2%). We observed a slightly higher incidence of DS childbirth in younger mothers compared to mothers with advanced age. We compared the somatic aneuploidy in peripheral blood of mothers having DS children (MDS) and control mothers (CM) to identify biomarkers for predicting the risk for DS childbirths. No significant difference was observed. After induced demethylation in peripheral blood cells, we did not observe a significant difference in the frequency of aneuploidy between MDS and CM. In conclusion, free trisomy 21 is the most common type of chromosomal abnormality in DS. A small number of DS cases have translocations and mosaicism of chromosome 21. Additionally, somatic aneuploidy in the peripheral blood from the mother is not an effective marker to predict DS childbirths.

In situ observations of Akashiwo sanguinea (Dinophyceae) displaying life cycle stages during blooms in a subtropical estuary

2017 ◽  
Vol 60 (6) ◽  
Author(s):  
Susan Badylak ◽  
Edward J. Phlips ◽  
Ashley Loren Mathews ◽  
Karen Kelley
Keyword(s):  
Life Cycle ◽  
Algal Bloom ◽  
Harmful Algal Bloom ◽  
Life Cycle Stages ◽  
Subtropical Estuary ◽  
In Situ Observations ◽  
Akashiwo Sanguinea

AbstractThis study reports on the harmful algal bloom (HAB) dinoflagellate

Laboratory Experience with In Situ Detection of Beryllium in Biological Specimens

1968 ◽  
Vol 22 (6) ◽  
pp. 758-760 ◽  
Author(s):  
Solomon F. Brokeshoulder ◽  
Farrel R. Robinson
Keyword(s):  
Chemical Analysis ◽  
Laser Beam ◽  
Tissue Thickness ◽  
Laboratory Experience ◽  
Laser Microprobe ◽  
Medium Concentration ◽  
Embedding Medium ◽  
In Situ Detection

Suitable microspectrochemical techniques have been devised for the laser microprobe made by the Jarrell—Ash Co. to detect beryllium in histologic structures. Density and type of tissue, thickness of the specimen, character of the embedding medium, concentration and localization of the element, and the penetrability of the laser beam must be considered in preparing biological specimens for chemical analysis by the microspectrochemical technique. Advantages of this technique are the identification of specific elements in situ and the correlation of the presence of the element with a specific histologic structure.

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