Emergence of Complex Phenomena in a Simple Reversible Cellular Space

2020 ◽  
pp. 108-126
Author(s):  
Kenichi Morita
Keyword(s):  
Cellular Space ◽  
Complex Phenomena

Defects of Platelet Function Recognized by X-Ray Imaging and Scanning Electron Microscopy

1985 ◽  
Vol 43 ◽  
pp. 610-613
Author(s):  
M.G. Baldini ◽  
S. Morinaga ◽  
D. Minasian ◽  
R. Feder ◽  
D. Sayre ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Biology ◽  
Imaging Technique ◽  
Human Platelets ◽  
X Rays ◽  
X Ray ◽  
X Ray Imaging ◽  
Complex Phenomena ◽  
Scanning Electron

Contact X-ray imaging is presently developing as an important imaging technique in cell biology. Our recent studies on human platelets have demonstrated that the cytoskeleton of these cells contains photondense structures which can preferentially be imaged by soft X-ray imaging. Our present research has dealt with platelet activation, i.e., the complex phenomena which precede platelet appregation and are associated with profound changes in platelet cytoskeleton. Human platelets suspended in plasma were used. Whole cell mounts were fixed and dehydrated, then exposed to a stationary source of soft X-rays as previously described. Developed replicas and respective grids were studied by scanning electron microscopy (SEM).

Motility of leukemic lymphocytes

1990 ◽  
Vol 48 (3) ◽  
pp. 368-369
Author(s):  
Manoj Raje ◽  
Karvita B. Ahluwalia
Keyword(s):  
Quantitative Data ◽  
Laser Doppler Velocimetry ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Cellular Space ◽  
Differentiated Cells ◽  
Poorly Differentiated ◽  
Solid Tissues ◽  
Well Differentiated ◽  
Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

Influence of Flexible Side-Chains on the Breathing Phase Transition of Pillared Layer MOFs: A Force Field Investigation

2020 ◽  
Author(s):  
Julian Keupp ◽  
Johannes P. Dürholt ◽  
Rochus Schmid
Keyword(s):  
First Principles ◽  
Good Accuracy ◽  
Field Investigation ◽  
Square Lattice ◽  
Side Chain ◽  
Second Step ◽  
Side Chains ◽  
Dynamics Simulations ◽  
Complex Phenomena ◽  
Closed Pore

The prototypical pillared layer MOFs, formed by a square lattice of paddle-<br>wheel units and connected by dinitrogen pillars, can undergo a breathing phase<br>transition by a “wine-rack” type motion of the square lattice. We studied this not<br>yet fully understood behavior using an accurate first principles parameterized force<br>field (MOF-FF) for larger nanocrystallites on the example of Zn 2 (bdc) 2 (dabco) [bdc:<br>benzenedicarboxylate, dabco: (1,4-diazabicyclo[2.2.2]octane)] and found clear indi-<br>cations for an interface between a closed and an open pore phase traveling through<br>the system during the phase transformation [Adv. Theory Simul. 2019, 2, 11]. In<br>conventional simulations in small supercells this mechanism is prevented by periodic<br>boundary conditions (PBC), enforcing a synchronous transformation of the entire<br>crystal. Here, we extend this investigation to pillared layer MOFs with flexible<br>side-chains, attached to the linker. Such functionalized (fu-)MOFs are experimen-<br>tally known to have different properties with the side-chains acting as fixed guest<br>molecules. First, in order to extend the parameterization for such flexible groups,<br>1a new parametrization strategy for MOF-FF had to be developed, using a multi-<br>structure force based fit method. The resulting parametrization for a library of<br>fu-MOFs is then validated with respect to a set of reference systems and shows very<br>good accuracy. In the second step, a series of fu-MOFs with increasing side-chain<br>length is studied with respect to the influence of the side-chains on the breathing<br>behavior. For small supercells in PBC a systematic trend of the closed pore volume<br>with the chain length is observed. However, for a nanocrystallite model a distinct<br>interface between a closed and an open pore phase is visible only for the short chain<br>length, whereas for longer chains the interface broadens and a nearly concerted trans-<br>formation is observed. Only by molecular dynamics simulations using accurate force<br>fields such complex phenomena can be studied on a molecular level.

scholarly journals A NuSTAR confirmation of the 36 ks hard X-ray pulse-phase modulation in the magnetar 1E 1547.0 − 5408

2021 ◽  
Vol 502 (2) ◽  
pp. 2266-2284
Author(s):  
Kazuo Makishima ◽  
Teruaki Enoto ◽  
Hiroki Yoneda ◽  
Hirokazu Odaka
Keyword(s):  
Time Lapse ◽  
Phase Behaviour ◽  
Modulation Amplitude ◽  
Axial Deformation ◽  
Physical Processes ◽  
Arrival Times ◽  
Pulse Phase ◽  
Phase Variations ◽  
Complex Phenomena ◽  
Made In

ABSTRACT This paper describes an analysis of the NuSTAR data of the fastest-rotating magnetar 1E 1547 − 5408, acquired in 2016 April for a time lapse of 151 ks. The source was detected with a 1–60 keV flux of 1.7 × 10−11 erg s−1 cm−2, and its pulsation at a period of 2.086710(5) s. In 8–25 keV, the pulses were phase-modulated with a period of T = 36.0 ± 2.3 ks, and an amplitude of ∼0.2 s. This reconfirms the Suzaku discovery of the same effect at $T=36.0 ^{+4.5}_{-2.5}$ ks, made in the 2009 outburst. These results strengthen the view derived from the Suzaku data, that this magnetar performs free precession as a result of its axial deformation by ∼0.6 × 10−4, possibly caused by internal toroidal magneti fields (MFs) reaching ∼1016 G. Like in the Suzaku case, the modulation was not detected in energies below ∼8 keV. Above 10 keV, the pulse-phase behaviour, including the 36 ks modulation parameters, exhibited complex energy dependencies: at ∼22 keV, the modulation amplitude increased to ∼0.5 s, and the modulation phase changed by ∼65° over 10–27 keV, followed by a phase reversal. Although the pulse significance and pulsed fraction were originally very low in &gt;10 keV, they both increased noticeably, when the arrival times of individual photons were corrected for these systematic pulse-phase variations. Possible origins of these complex phenomena are discussed, in terms of several physical processes that are specific to ultrastrong MFs.

scholarly journals Child Sexual Abuse, Self-esteem, and Delinquent Behaviors During Adolescence: The Moderating Role of Gender

2021 ◽  
pp. 088626052110014
Author(s):  
Amélie Gauthier-Duchesne ◽  
Martine Hébert ◽  
Martin Blais
Keyword(s):  
Sexual Abuse ◽  
High School Students ◽  
Child Sexual Abuse ◽  
Self Esteem ◽  
School Students ◽  
Delinquent Behaviors ◽  
Male Adolescents ◽  
Moderated Mediation Model ◽  
Increased Risk ◽  
Complex Phenomena

To reflect the complex phenomena of child sexual abuse (CSA), studies should examine possible gender specificities and explore potentially explanatory mechanisms. The current study aimed to test the moderating effect of gender in the mediated relationship between CSA, self-esteem, and delinquency during adolescence. A moderated mediation model was tested among a representative sample of 8,194 high school students (57.8% girls and 42.2% boys) age 14 to 18 in the province of Quebec in Canada. Results showed that self-esteem has an indirect effect on the relationship between CSA and delinquency. Gender (being a boy) was associated with a higher level of self-esteem and an increased risk of delinquent behaviors. Among victims of CSA, boys reported lower levels of self-esteem than girls, which was associated with an increased risk of displaying delinquent behaviors. Self-esteem may be an important target of intervention for sexually abused youth, especially for boys. Focusing on promoting positive self-esteem may also reduce the risk for male adolescents struggling with the deleterious consequences of delinquency.

Designing an Emergency Management Simulation Testbed to Investigate Incident Management Team Performance

2020 ◽  
Vol 64 (1) ◽  
pp. 1881-1885
Author(s):  
Changwon Son ◽  
Farzan Sasangohar ◽  
S. Camille Peres ◽  
Jukrin Moon
Keyword(s):  
Emergency Management ◽  
Team Performance ◽  
Real Life ◽  
Management Team ◽  
Future Research ◽  
Incident Management ◽  
Emergency Operations ◽  
Management Domain ◽  
Qualitative Approaches ◽  
Complex Phenomena

Investigating real-life disasters and crises has been challenging due to accompanying difficulties and risks posed by these complex phenomena. Previous research in the emergency management domain has largely relied on qualitative approaches to describe the event after it occurred. To facilitate investigations for more generalizable findings, this paper documents ongoing efforts to design an emergency management simulation testbed called Team Emergency Operations Simulation (TEOS) in which an incident management team (IMT) is situated. First, we describe the design process based on our previous work. Next, we present the overall description of TEOS including representative roles, tasks, and team environments. We also propose measures of team performance of the IMT and propose future research that can be realized through TEOS.

Sleep Phenomena from the Perspectives of Islam and Science

2014 ◽  
Vol 67 (1) ◽  
Author(s):  
Farahwahida Mohd Yusof ◽  
Siti Norlina Muhamad ◽  
Arieff Salleh Rosman ◽  
Sarimah Noor Ahmad ◽  
Nor Farhah Razak ◽  
...  
Keyword(s):  
20Th Century ◽  
Advanced Technology ◽  
Complex Phenomena ◽  
Scientific Facts ◽  
The Relationship ◽  
The Brain ◽  
Taking Care

This article discusses the phenomenon of sleep, with emphasized to its importance, sleeping times, sleeping positions and even the etiquette of sleeping, from the views of Islam and Science. The Quran and Science are inseparable and the relationship between the two is highly balanced. Scientists have said that the phenomena of sleep is a miracle that deserves to be analysed and studied in depth, as it is a complex phenomena. Glory and Praise to be Allah Almighty has decreed in the Quran of the importance of sleep in the day and night, and that sleep is one of the signs of Allah’s Almighty power and is a miracle to be studied by each individual. Islam places great importance on taking care of one’s body and sleep is one need that has to be fulfilled. Scientists have stressed that sleep is needed to rest the brain, improve memory, and increase one’s energy. This shows that Islam places great importance on having productivity and alertness in each individual’s deed. Many scientific facts that had been clearly stated in a fundamental manner in the Quran could only be analysed with the advanced technology of the 20th century. These facts were not known when they were first revealed and are proof that the Quran is the book of Allah Almighty. The view of Islam on the sleep phenomenon is in line with and is according to the findings of contemporary scien

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