Fluid Dynamics and Hemorheology in Vivo: The Interactions of Hemodynamic Parameters and Hemorheological “Properties” in Determining the Flow Behavior of Blood in Microvascular Networks

2019 ◽  
pp. 129-219 ◽  
Author(s):  
H. Schmid-Schönbein
Keyword(s):  
Fluid Dynamics ◽  
Flow Behavior ◽  
Hemodynamic Parameters ◽  
Microvascular Networks

Effect of Outer Fin Axial Gap on the Sealing Effectiveness and Fluid Dynamics of Radial Rim Seal

2017 ◽  
Author(s):  
Zhigang Li ◽  
Jun Li ◽  
Liming Song ◽  
Qing Gao ◽  
Xin Yan ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Flow Rate ◽  
Gas Turbines ◽  
Flow Behavior ◽  
Three Dimensional ◽  
Numerical Approach ◽  
Coolant Flow ◽  
Coolant Flow Rate ◽  
Navier Stokes ◽  
Hot Gas

The modern gas turbine is widely applied in the aviation propulsion and power generation. The rim seal is usually designed at the periphery of the wheel-space and prevented the hot gas ingestion in modern gas turbines. The high sealing effectiveness of rim seal can improve the aerodynamic performance of gas turbines and avoid of the disc overheating. Effect of outer fin axial gap of radial rim seal on the sealing effectiveness and fluid dynamics was numerically investigated in this work. The sealing effectiveness and fluid dynamics of radial rim seal with three different outer fin axial gaps was conducted at different coolant flow rates using three-dimensional Reynolds-Averaged Navier-Stokes (RANS) and SST turbulent model solutions. The accuracy of the presented numerical approach for the prediction of the sealing performance of the turbine rim seal was demonstrated. The obtained results show that the sealing effectiveness of radial rim seal increases with increase of coolant flow rate at the fixed axial outer fin gap. The sealing effectiveness increases with decrease of the axial outer fin gap at the fixed coolant flow rate. Furthermore, at the fixed coolant flow rate, the hot gas ingestion increases with the increase of the axial outer fin gap. This flow behavior intensifies the interaction between the hot gas and coolant flow at the clearance of radial rim seal. The preswirl coefficient in the wheel-space cavity is also illustrated to analyze the flow dynamics of radial rim seal at different axial outer fin gaps.

scholarly journals Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Nadia Afsheen ◽  
Khalil-ur-Rehman ◽  
Nazish Jahan ◽  
Misbah Ijaz ◽  
Asad Manzoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Medicinal Plants ◽  
Plasmid Dna ◽  
Research Work ◽  
Antioxidant Potential ◽  
Piper Nigrum ◽  
Coronary Artery Ligation ◽  
Hemodynamic Parameters ◽  
Metabolomic Profiling

In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. The C. oxyacantha and T. arjuna showed maximum antioxidant potential, while the E. cardamom showed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2. The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters. The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal. The histopathological examination also confirmed the cardioprotective potential of HC4. Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.

Acoustic patterning of endothelial cells in vivo to produce microvascular networks

2021 ◽  
Vol 150 (4) ◽  
pp. A57-A57
Author(s):  
Diane Dalecki ◽  
Eric S. Comeau ◽  
Melinda A. Vander Horst ◽  
Carol H. Raeman ◽  
Denise C. Hocking
Keyword(s):  
Endothelial Cells ◽  
Microvascular Networks

Abstract 372: The Endothelial Glycocalyx Promotes Homogenous Blood Flow Distribution within the Microvasculature

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
P Mason McClatchey
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Blood Viscosity ◽  
Tissue Perfusion ◽  
Microvascular Perfusion ◽  
Endothelial Glycocalyx ◽  
Heterogeneous Distribution ◽  
Disease States

Introduction: Impaired tissue oxygenation is observed in many disease states including congestive heart failure, diabetes, cancer and aging. Decreased tissue perfusion and heterogeneous distribution of blood flow in the microvasculature contributes to this pathology. The physiological mechanisms regulating homogeneity/heterogeneity of microvascular perfusion are presently unknown. We hypothesized that microfluidic properties of the glycocalyx would promote perfusion homogeneity. Methods: To test our hypothesis, we used established empirical formulations for modelling blood viscosity in vivo (blood vessels) and in vitro (glass tubes). We first assess distribution of blood flow in idealized arteriolar networks. We next simulated distribution of blood flow at an idealized capillary bifurcation. Finally, we simulated velocity profiles and pressure gradients within the vessel lumen with varying glycocalyx properties using a computational fluid dynamics approach. Results: We found that transit time heterogeneity (as assessed by STD to mean ratio) was increased approximately 9x (6.9x-10.6x) using in vitro formulations of blood viscosity relative to in vivo formulations. This effect was mathematically accounted for by increased effective blood viscosity in smaller arterioles. We also found that distribution of blood flow at an idealized microvascular bifurcation was more symmetric using the in vivo formulation than the in vitro formulation (approximately 2x greater disparity between flow in downstream vessels). This effect was mathematically accounted for by an increased hematocrit dependence of blood viscosity. Both the diameter- and hematocrit-based changes in blood viscosity were entirely predictable from fluid dynamics simulations incorporating a space-filling, semi-permeable glycocalyx layer. Summary: Our simulations indicate that the mechanical properties of the endothelial glycocalyx promote homogeneous microvascular perfusion. Conclusions: The literature provides evidence of both glycocalyx degradation and impaired tissue perfusion in the same disease states. Preservation or restoration of normal glycocalyx properties may be a viable strategy for improving tissue perfusion in a wide variety of diseases.

Abstract WP121: An Evaluation of Hemodynamics Across Intracranial Steno-occlusive Lesions by Computational Fluid Dynamics

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Florence SY Fan ◽  
Vincent HL Ip ◽  
Alexander YL Lau ◽  
Anne YY Chan ◽  
Lisa WC Au ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Pressure Gradient ◽  
Pressure Difference ◽  
Pressure Ratio ◽  
Velocity Ratio ◽  
Strongly Correlated ◽  
Hemodynamic Parameters ◽  
Moderate Correlation ◽  
Anterior Circulation

Introduction: Intracranial atherosclerotic steno-occlusive disease (ICAS) is a major cause of stroke worldwide and portends a high risk of recurrence. Computational fluid dynamics (CFD) is a novel technique developed to solve and analyze the dynamic effects of fluid flow. We aimed to analyse hemodynamics across ICAS using CFD on processed CTA images and explore the correlation between the degree of arterial stenosis and hemodynamic flow status. Methods: We recruited patients with symptomatic ICAS from Acute Stroke Unit, Prince of Wales Hospital. All patients received CTA and DSA as vascular workup. Using CFD analysis of processed CTA images, we first defined the hemodynamic parameters, including pressure difference, pressure ratio, pressure gradient, shear strain rate ratio (SSR), wall shear stress (WSS) ratio and velocity ratio, across the stenosed vessels, and then we correlated the severity of stenosis as defined by DSA, with these parameters. Results: Among the 53 recruited patients (mean age 62.9 years, 69.8% males), 45 (85%) had lesions in the anterior circulation. The severity of stenosis showed a weak-to-moderate correlation with pressure difference (rs=0.392, p=0.004), pressure ratio (rs=-0.429, p=0.001) and pressure gradient (rs=0.419, p=0.002). There was no significant correlation between the severity of stenosis with SSR ratio, WSS ratio and velocity ratio. Among patients with anterior circulation stroke or TIA, the severity of stenosis showed a weak to moderate correlation with pressure difference (rs=0.381, p=0.01), pressure ratio (rs=-0.426, p=0.004) and pressure gradient (rs=0.407, p=0.005). For patients with posterior circulation stroke or TIA, the severity of stenosis was strongly correlated with pressure difference (rs=0.714, p=0.047) and pressure ratio (rs=-0.714, p=0.047); and very strongly correlated with velocity ratio (rs=0.833, p=0.01). Conclusions: The severity of ICAS showed only weak-to-moderate correlation with hemodynamic parameters across the culprit lesion. Thus, risk stratification and treatment based solely on stenotic severity may be inadequate. Our findings may guide further research in estimating stroke risks and selection of high-risk patients who may benefit from adjunctive treatments.

Fish-friendly design of an axial flow pump impeller based on a blade strike model

2019 ◽  
Vol 234 (2) ◽  
pp. 173-186 ◽  
Author(s):  
Qiang Pan ◽  
Weidong Shi ◽  
Desheng Zhang ◽  
BPM van Esch ◽  
Ruijie Zhao
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Flow Behavior ◽  
Integrated Design ◽  
Axial Flow ◽  
Hydraulic Performance ◽  
Fish Mortality ◽  
Computational Fluid Dynamics Analysis ◽  
Axial Flow Pump ◽  
Flow Pump

With environmental awareness growing in many countries, governments are taking measures to reduce mortality of migrating fish in pumping stations. Manufacturers seek to develop pumps that are less damaging to fish and still provide good hydraulic performance, but little is known about the implications design modifications may have on internal flow characteristics and overall hydraulic performance. In this paper, an integrated design method is proposed that combines a validated blade strike model for fish damage and a computational fluid dynamics method to assess the pump performance. A redesign of an existing, conventional, axial flow pump is presented as an example in this paper. It shows how the design of the impeller blades was modified stepwise in order to reduce fish mortality while its hydraulic performance was monitored. Computational fluid dynamics analysis of the flow near the hub of the highly skewed blades indicated that unconventional design modifications were required to ensure optimum flow behavior. In the final fish-friendly design, the risk of fish mortality has reduced considerably while the hydraulic performance of the pump is still acceptable for practical application.

In vivo chemotactic properties and spatial expression of PDGF in developing mesenteric microvascular networks

2001 ◽  
Vol 280 (5) ◽  
pp. H2116-H2125 ◽  
Author(s):  
Peter J. Zeller ◽  
Thomas C. Skalak ◽  
Ana M. Ponce ◽  
Richard J. Price
Keyword(s):  
Smooth Muscle ◽  
Paracrine Signaling ◽  
Microvascular Networks ◽  
Cell Recruitment ◽  
Perivascular Cell ◽  
Fibroblast Migration ◽  
Pdgf Signaling ◽  
And Control

The recruitment of perivascular cells to developing microvessels is a key component of microvessel assembly. Whereas platelet-derived growth factor (PDGF) signaling is critical for this process during embryonic development, its role from the postnatal stages through adulthood remains unclear. We investigated the potential role of PDGF signaling during microvessel assembly by measuring in vivo the migration of labeled fibroblasts to PDGF in mesenteric connective tissue and by examining PDGF-B and PDGF receptor-β (PGDFR-β) expression in microvascular networks during normal maturation. PDGF-B homodimer (PDGF-BB; 30 ng/ml) application elicited a significant ( P < 0.05) increase (7.8 ± 4.1 cells) in labeled fibroblasts within 100 μm of the source micropipette after 2 h. PDGF-A homodimer (30 ng/ml) application and control solution did not elicit directed migration. PDGF-B was expressed in microvessel endothelium and smooth muscle, whereas PDGFR-β was expressed in endothelium, smooth muscle, and interstitial fibroblasts. Given that PDGF-BB elicits fibroblast migration in the mesentery and that PDGF-B and PDGFR-β are expressed in a pattern that indicates paracrine signaling from microvessels to the interstitium, the results are consistent with a role for PDGF-B in perivascular cell recruitment to microvessels.

Multiphase flow experiment and simulation for cells-on-a-chip devices

2019 ◽  
Vol 233 (4) ◽  
pp. 432-443 ◽  
Author(s):  
Meihua Zhang ◽  
Amy Zheng ◽  
Zhongquan C Zheng ◽  
Michael Zhuo Wang
Keyword(s):  
Multiphase Flow ◽  
Soft Lithography ◽  
Particle Deposition ◽  
Fluid Dynamic ◽  
Flow Behavior ◽  
Density Ratio ◽  
Simulation Method ◽  
Quantitative Agreement ◽  
Geometry Model

A microfluidic-based microscale cell-culture device, or a cells-on-a-chip device, provides a well-controlled environment with physiologically realistic factors that emulate the organ-to-organ network of human body. In the microsystem, the in vivo situation can be resembled closely by controlling the chip geometry model, medium flow behavior, medium-to-cell density ratio, and other fluid dynamic parameters. This study is to develop multiphase models to carry out experiments and simulate flow in such devices. A standard soft lithography method is used to build the three-dimensional microfluidic chips. A definitely good qualitative and reasonably good quantitative agreement is obtained between the experimental and simulation results for particle velocity in the microfluidic chip, which validates the numerical simulation method. The cell deposition rate influenced by the flow shear is studied. The influence of gravity, inlet velocity, and cell injection number on cell concentrations are also investigated. Comparisons of different designs of cells-on-a-chip devices are addressed in the study. The physics of flow dynamics and related cell particle motion due to each of the above-mentioned variables are discussed. The results show that the multiphase flow model is promising to be used for simulating cell particle deposition and concentration for the purpose of design of cells-on-a-chip devices.

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