Safety considerations in complex airborne systems

2008 ◽  
pp. 2321-2330
2002 ◽  
Vol 2 (5-6) ◽  
pp. 209-216
Author(s):  
R. Sublet ◽  
A. Boireau ◽  
V.X. Yang ◽  
M.-O. Simonnot ◽  
C. Autugelle

Two lead removal water filters were developed to lower lead levels in drinking water below 10 μg.L-1 in order to meet the new regulation given by the European Directive 98-83, applicable in December 2013. An appropriate adsorbent was selected through a stringent research program among a wide range of media, and is composed of a synthetic zeolite and an activated carbon. Two prototypes were developed: the first is a faucet-mounted filter which contains a fixed bed of the adsorbent and a hollow fiber bundle, while the second is an under-sink cartridge made of a porous extruded block of carbon and adsorbent. Both are able to treat at least 1,000 litres of any water containing on average 100 to 150 μg Pb.L-1, by lowering the lead concentration below 10 μg.L-1. Once their safety considerations were addressed by an independent laboratory according to the French Ministry of Health recommendations, 20 prototypes were installed at consumers' taps in northeastern France. Their performance in terms of lead removal, HPC control and bad taste and odor reduction was followed for 6 months. This field testing program resulted in the validation of both prototypes which meet the new French Ministry of Health recommendations and assures that the filtered water is fully ED 98-83 compliant. Their commercialization will be launched first in France in middle 2002.


2017 ◽  
Vol 12 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Benjamin Maslin ◽  
Lawrence Lipana ◽  
Brandon Roth ◽  
Gopal Kodumudi ◽  
Nalini Vadivelu

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1135
Author(s):  
Kristin Entzian ◽  
Achim Aigner

Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and dose-limiting toxicity. Therefore, there is a need for novel therapeutics and formulations with higher efficacy, improved safety, and more favorable toxicological profiles. This has promoted the development of nanomedicines, including systems for drug delivery, but also for imaging and diagnostics. Nanoparticles loaded with drugs can be designed to overcome several biological barriers to improving efficiency and reducing toxicity. In addition, stimuli-responsive nanocarriers are able to release their payload on demand at the tumor tissue site, preventing premature drug loss. This review focuses on ultrasound-triggered drug delivery by nanocarriers as a versatile, cost-efficient, non-invasive technique for improving tissue specificity and tissue penetration, and for achieving high drug concentrations at their intended site of action. It highlights aspects relevant for ultrasound-mediated drug delivery, including ultrasound parameters and resulting biological effects. Then, concepts in ultrasound-mediated drug delivery are introduced and a comprehensive overview of several types of nanoparticles used for this purpose is given. This includes an in-depth compilation of the literature on the various in vivo ultrasound-responsive drug delivery systems. Finally, toxicological and safety considerations regarding ultrasound-mediated drug delivery with nanocarriers are discussed.


2021 ◽  
pp. 088626052110079
Author(s):  
Alison Gregory ◽  
Emma Johnson ◽  
Gene Feder ◽  
John Campbell ◽  
Judit Konya ◽  
...  

Experiences of sexual violence, childhood sexual abuse, and sexual assault are common across all societies. These experiences damage physical and mental health, coping ability, and relationships with others. Given the breadth and magnitude of impacts, it is imperative that there are effective, accessible services to support victim-survivors, ease suffering, and empower people to cope, recover and thrive. Service provision for this population in the United Kingdom is complex and has been hit substantially by austerity. Since positive social support can buffer against negative impacts, peer support may be an effective approach. The aim of this exploratory study was to capture the views and perspectives of professional stakeholders concerning service provision for victim-survivors, particularly perceptions of peer support. In-depth semistructured interviews were conducted in the UK during 2018 with six professional stakeholders, highly experienced in the field of service provision for victim-survivors of sexual violence and abuse. An abductive approach to analysis was used, applying principles from thematic analysis. Our sample comprised four females and two males, and their roles included psychiatrist, general practitioner, service improvement facilitator, and senior positions within victim-survivor organizations. Interviews highlighted models of peer support for this population, good practice and safety considerations, and a lack of uniformity regarding quality and governance standards across the sector. Findings indicated that current funding models impact negatively on victim-survivor services, and that provision is fragmented and insufficient across statutory and not-for-profit sectors. The influence of the medical model upon service provision was evident, which resulted in apprehension around support delivered in less-usual forms—including peer support. Further research is needed to explore the potential of peer support for victim-survivors of sexual violence and abuse.


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