Cardiovascular Diseases Risk Factors During The First Year of Life 519

Objective. Early feeding and infant exposures have been suggested as potential risk factors for immunoglobulin E- (IgE-) mediated food allergy (FA). We aimed to evaluate the association between IgE-mediated FA in children and early exposures including the child’s nutritional status, breastfeeding and its duration, the age at which the solid food was first introduced, antibiotic exposure during the first year of life, and the child’s vitamin D status during infancy. Design. A case-control study. Setting and Subjects. Children aged 0–13 years were recruited from pediatric allergy and immunology clinics (PAICs) located at major government hospitals in Kuwait (total FA cases: n=100; boys = 67%), and healthy controls (n=100, boys 55%) were recruited from various vaccination units at primary healthcare centers. Results. Cow’s milk allergy was the most common type of FA. FA status was independently associated with the early exposures of exclusive breastfeeding (aOR = 15.55 (3.26–74.19), p=0.001), vitamin D deficiency or insufficiency during infancy (aOR = 5.42 (1.92–15.30), p=0.001), and antibiotic exposure during the first year of life (aOR = 5.00 (1.58–15.84), p=0.006). Conclusions. FA is highly prevalent among children in Kuwait, and our data indicate that early nutrition-related and antibiotic exposures are associated with FA risk.

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Epidemiology of Physician-Diagnosed Allergic Rhinitis in Childhood

PEDIATRICS ◽

10.1542/peds.94.6.895 ◽

1994 ◽

Vol 94 (6) ◽

pp. 895-901

Author(s):

Anne L. Wright ◽

Catharine J. Holberg ◽

Marilyn Halonen ◽

Fernando D. Martinez ◽

Wayne Morgan ◽

...

Keyword(s):

Risk Factors ◽

Allergic Rhinitis ◽

Immunoglobulin E ◽

Age At Onset ◽

First Year ◽

Healthy Children ◽

Early Introduction ◽

Maternal Cigarette Smoking ◽

History Of ◽

First Year Of Life

Objective. To investigate the natural history of and risk factors for allergic rhinitis in the first 6 years of life. Methods. Parents of 747 healthy children followed from birth completed a questionnaire when the child was 6 years old. Data were obtained regarding physician-diagnosed allergic rhinitis (PDAR), associated symptoms, and age at onset. Risk-factor data were taken from earlier questionnaires, and data regarding immunoglobulin E (IgE) and skin-test reactivity were obtained at age 6. Results. By the age of 6, 42% of children had PDAR. Children whose rhinitis began in the first year of life had more respiratory symptoms at age 6 and were more likely to have a diagnosis of asthma. Early introduction of foods or formula, heavy maternal cigarette smoking in the first year of life, and higher IgE, as well as parental allergic disorders, were associated with early development of rhinitis. Risk factors for PDAR that remained significant in a multivanate model included maternal history of physician-diagnosed allergy (odds ratio: 2.2, 95% confidence interval: 1.35-3.54), asthma in the child (4.06, 2.06-7.99), and IgE greater than 100 IU/mL at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were significantly higher only among those with high IgE and those who had dogs. Conclusion. Allergic rhinitis developing in the first years of life is an early manifestation of an atopic predisposition, which may be triggered by early environmental exposures.

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DOZ047.81: Neurodevelopmental outcome in infants with AE: developmental trajectories in the first year of life

Diseases of the Esophagus ◽

10.1093/dote/doz047.81 ◽

2019 ◽

Vol 32 (Supplement_1) ◽

Author(s):

F Bevilacqua ◽

B Ragni ◽

L Valfrè ◽

A Conforti ◽

A Braguglia ◽

...

Keyword(s):

Risk Factors ◽

Mechanical Ventilation ◽

Motor Development ◽

Developmental Trajectories ◽

Neurodevelopmental Outcome ◽

First Year ◽

Neurodevelopmental Outcomes ◽

Prospective Longitudinal Study ◽

First Year Of Life ◽

Prospective Longitudinal

Abstract Background Esophageal atresia (EA) prognosis have improved significantly over the past three decades. Research and clinical attention has shifted to neurodevelopmental outcomes and quality of life. Aim The aim of this study wasto examine neurodevelopmental outcomes and to identify clinical and sociodemographic risk factors in a cohort of infants with EA. Methods An observational prospective longitudinal study was conducted between 2009 and 2017. Neurodevelopment was assessed at 6 and 12 months by Bayley Scales of Infants and Toddler Development—3rd Edition. Clinical and sociodemographic variables included were gender, birthweight, gestational age, associated malformations, number of hospitalizations, surgeries and dilatations at 12 months, days of mechanical ventilation, parental age, education level, and socioeconomic status. Results Ninety-six infants were enrolled in the study at 6 months and 73 of them were evaluated also at 12 months. Analysis showed significant differences between motor development at 6 and 12 months (M6 = 95.39, SD = 15.71; M12 = 91.83, SD = 12.87; t = 0.245, P = 0.017); significant differences emerged also between cognitive development at 6 and 12 months (M6 = 91.80, SD = 11.70; M12 = 100.92, SD = 15.39; t = −5.10, p = .000). Infants with long-gap AE achieved the worst scores in cognitive (r = -.28, P < .01) and motor scales (r = -.36, P < .01) at 6 months and in motor scale at 12 months (r = −0.30, P < 0.05). More days of mechanical ventilation were related to a lower score in both the cognitive (6 months r = −0.26, P < 0.05; 12 months r = −0.26, P < 0.05) and motor scale (6 months: r = −0.38, P < 0.01; 12 months r = −0.42, P < 0.01). A major number of interventions in the first year of life were related to lower scores in the motor scale at 12 months (r = −0.43, P < 0.01). Conclusions Infants operated on for AE are at risk of neurodevelopmental impairment in the first year of life. Findings support the association between neurodevelopmental outcomes and clinical risk factors. Careful interdisciplinary follow-up is essential for early detection of neurodevelopmental delay.

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Neurodevelopmental outcome in infants with esophageal atresia: risk factors in the first year of life

Diseases of the Esophagus ◽

10.1093/dote/doaa102 ◽

2020 ◽

Author(s):

Bevilacqua Francesca ◽

Ragni Benedetta ◽

Conforti Andrea ◽

Braguglia Annabella ◽

Gentile Simonetta ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Cognitive Development ◽

Low Birth Weight ◽

Multiple Regression ◽

Esophageal Atresia ◽

Gestational Age ◽

Motor Development ◽

First Year ◽

First Year Of Life

Summary Data on neurodevelopmental outcomes of infants born with esophageal atresia (EA) are still scarce and controversial. The aims of our study were to evaluate motor and cognitive development during the first year of life, in patients operated on of EA and to investigate potential risk factors for motor and cognitive development both at 6 and 12 months. This is an observational prospective longitudinal study in a selected cohort of type C and D EA infants enrolled in our follow-up program from 2009 to 2017. In order to exclude possible confounding factors, the following exclusion criteria were applied: (i) gestational age ≤ 32 weeks and/or birth weight ≤ 1500 g; (ii) genetic syndrome or chromosomal anomaly known to be associated with neurodevelopmental delay; (iii) neurologic disease; (iv) esophageal gap ≥three vertebral bodies. Patients were evaluated at 6 and 12 months of life (corrected age for infants with a gestational age of 32–37 weeks) with the Bayley Scales of Infant and Toddler Development—3rd Edition. In our selected cohort of EA infants, 82 were evaluated at 6 months and 59 were reevaluated at 12 months. Both Motor and Cognitive average scores were within the norm at both time points. However, we report increased number of infants with motor delay with time: 14% at 6 months and 24% at 12 months. Multiple regression analysis for Motor scores at 6 [F(4,74) = 4.363, P = 0.003] and 12 months [F(6,50) = 2.634, P = 0.027] identified (i) low birth weight, (ii) longer hospital stay and (iii) weight < fifth percentile at 1 year as risk factors. Interestingly, average Cognitive scores also increased with time from 85.2% at 6 months and 96.6% at 12 months. Multiple regression models explaining variance of Cognitive scores at 6 [F(4, 73) = 2.458, P = 0.053] and 12 months [F(6, 49) = 1.232, P = 0.306] were nonsignificant. Our selected cohort of EA patients shows, on the average, Motor and Cognitive scores within the norm both at 6 and 12 months. Nevertheless, the percentage of infants with Motor scores below the average increases regardless gestational age. None of clinical and sociodemographic variables taken into consideration was able to predict cognitive development both at 6 and 12 months whereas risk factors for Motor development change during the first year of life. Healthcare providers should pay particular attention to patients with low birth weight, longer hospital stays and weight under fifth percentile at 1 year. Future studies should include long-term outcomes to reveal possible catch up in motor development and/or possible findings in Cognitive scores.

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Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort

Italian Journal of Pediatrics ◽

10.1186/s13052-015-0149-z ◽

2015 ◽

Vol 41 (1) ◽

Cited By ~ 39

Author(s):

Marcello Lanari ◽

◽

Federica Prinelli ◽

Fulvio Adorni ◽

Simona Di Santo ◽

...

Keyword(s):

Risk Factors ◽

Birth Cohort ◽

First Year ◽

First Year Of Life

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Wheezing in the First Year of Life: Prevalence and Risk Factors

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2007.12.580 ◽

2008 ◽

Vol 121 (2) ◽

pp. S158-S158

Author(s):

H CHONGNETO ◽

N ROSARIO

Keyword(s):

Risk Factors ◽

First Year ◽

First Year Of Life

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VITAMIN D PROVISION FOR CHILDREN AND ADULT POPULATION OF THE AMUR REGION

Bulletin physiology and pathology of respiration ◽

10.12737/20121 ◽

2016 ◽

Vol 1 (60) ◽

pp. 57-61 ◽

Cited By ~ 1

Author(s):

Романцова ◽

Elena Romantsova ◽

Борисенко ◽

Elena Borisenko ◽

Бабцева ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Respiratory Infections ◽

Adult Population ◽

Amur Region ◽

Preschool Age ◽

First Year ◽

First Year Of Life

The aim of the research is to study the availability of vitamin D among children of different age and pregnant women living in the Amur region. 339 residents of Blagoveshchensk (279 children of different age and 60 adults) were examined. Among them there were 129 toddlers, 90 children of preschool age of 3-6 years old, 60 adolescents of 15-17 years old and 60 adults (pregnant women) of 18-40 years old. In the blood serum the content of the metabolite of vitamin D [25(OH)D] was studied by high performance liquid chromatography. The assessment of risk factors for failure and deficiency of vitamin D was conducted by clinical and anamnestic data. The first results of the study have been presented. They indicate a high frequency of various vitamin D deficiency in the population of the Amur region. Among 339 residents of the Amur region 92 (27.1%) had an adequate availability of vitamin D, 144 (42.4%) had an insufficiency of 25(OH)D; at the same time vitamin D deficiency was identified in 90 (26.5%) with 1/3 of the child population and 1/4 of pregnant women. The level of 25(OH)D within normal limits found in 37.5% of children in the first year of life decreased till 3.6 % by 3 years old, with its deficit increasing from 29.1% to 50%, persisting at this level (45.5 percent) in 3-6 year-old children, declining till 23.3% in adolescents and till 23.3% in pregnant women. The average vitamin D in the studied age periods was the highest in the first year of life (36.14±4.3 ng/ml), and the lowest in 2-3 year-old children (19.31±14.68 ng/ml), with a gradual increase in 3-6 years old (21.77±0.96 ng/ml); in 15-17 years old (23.89±0.66 ng/ml) and in pregnant women it has reached a level of 27.75±0.18 ng/ml, remaining below normal values. Respiratory infections, digestion, bone and joint systems pathologies are the most important risk factors contributing to the low status of 25 (OH) D; their prevention, alongside with the correction of vitamin D deficiency can improve the health of the population of the Amur region.

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