scholarly journals Minireview: Intrinsic and Extrinsic Factors in Thyroid Gland Development: An Update

Endocrinology ◽  
2011 ◽  
Vol 152 (8) ◽  
pp. 2948-2956 ◽  
Author(s):  
Mario De Felice ◽  
Roberto Di Lauro
Keyword(s):  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Small Group ◽  
Extrinsic Factors ◽  
Recent Developments ◽  
Endodermal Cells ◽  
Gland Development ◽  
Intrinsic And Extrinsic Factors

In vertebrates the portion of the thyroid gland synthesizing the thyroid hormones develops from a small group of endodermal cells in the foregut. The nature of the signals that lead to the biochemical and morphogenetic events responsible for the organization of these cells into the adult thyroid gland has only recently become evident. In this review we summarize recent developments in the understanding of these processes, derived from evidence collected in several organisms.

scholarly journals From Endoderm to Progenitors: An Update on the Early Steps of Thyroid Morphogenesis in the Zebrafish

2021 ◽  
Vol 12 ◽  
Author(s):  
Federica Marelli ◽  
Giuditta Rurale ◽  
Luca Persani
Keyword(s):  
Developmental Stages ◽  
Developmental Process ◽  
Experimental Models ◽  
Extrinsic Factors ◽  
Comprehensive Picture ◽  
Central Interest ◽  
Endodermal Cells ◽  
Gland Development ◽  
Early Developmental ◽  
Developmental Windows

The mechanisms underlying thyroid gland development have a central interest in biology and this review is aimed to provide an update on the recent advancements on the early steps of thyroid differentiation that were obtained in the zebrafish, because this teleost fish revealed to be a suitable organism to study the early developmental stages. Physiologically, the thyroid precursors fate is delineated by the appearance among the endoderm cells of the foregut of a restricted cell population expressing specific transcription factors, including pax2a, nkx2.4b, and hhex. The committed thyroid primordium first appears as a thickening of the pharyngeal floor of the anterior endoderm, that subsequently detaches from the floor and migrates to its final location where it gives rise to the thyroid hormone-producing follicles. At variance with mammalian models, thyroid precursor differentiation in zebrafish occurs early during the developmental process before the dislocation to the eutopic positioning of thyroid follicles. Several pathways have been implicated in these early events and nowadays there is evidence of a complex crosstalk between intrinsic (coming from the endoderm and thyroid precursors) and extrinsic factors (coming from surrounding tissues, as the cardiac mesoderm) whose organization in time and space is probably required for the proper thyroid development. In particular, Notch, Shh, Fgf, Bmp, and Wnt signaling seems to be required for the commitment of endodermal cells to a thyroid fate at specific developmental windows of zebrafish embryo. Here, we summarize the recent findings produced in the various zebrafish experimental models with the aim to define a comprehensive picture of such complicated puzzle.

THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: THE STATE OF THE PROBLEM AND THE WAYS OF SOLVING

2018 ◽  
Vol 22 (4) ◽  
pp. 40-49 ◽  
Author(s):  
A. R. Volkova ◽  
O. D. Dygun ◽  
B. G. Lukichev ◽  
S. V. Dora ◽  
O. V. Galkina
Keyword(s):  
Chronic Kidney Disease ◽  
Thyroid Gland ◽  
Kidney Disease ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
The Body ◽  
Type I ◽  
Low T3 ◽  
Iodine Excretion

Disturbance of the thyroid function is often detected in patients with different profiles. A special feature of patients with chronic kidney  disease is the higher incidence of various thyroid function  disturbances, especially hypothyroidism. It is known that in patients  with chronic kidney disease (CKD) iodine excretion from the body is  violated, since normally 90% of iodine is excreted in urine.  Accumulation of high concentrations of inorganic iodine leads to the  formation of the Wolf-Chaikoff effect: suppression of iodine  organization in the thyroid gland and disruption of the thyroid  hormones synthesis. Peripheral metabolism of thyroid hormones is  also disturbed, namely, deiodinase type I activity is suppressed and  peripheral conversion of T4 into T3 is inhibited (so-called low T3  syndrome). Therefore, patients with CKD are often diagnosed with  hypothyroidism, and the origin of hypothyroidism is not always  associated with the outcome of autoimmune thyroiditis. The article  presents an overview of a large number of population studies of  thyroid gland dysfunction in patients with CKD, as well as  experimental data specifying the pathogenetic mechanisms of  thyroid dysfunction in patients with CKD. Therapeutic tactics are still  not regulated. However, in a number of studies, replacement therapy with thyroid hormones in patients with CKD had some advantages.

scholarly journals Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors

2012 ◽  
Vol 21 (3) ◽  
pp. 327-338 ◽  
Author(s):  
J. J. Phillips ◽  
Y. Javadi ◽  
C. Millership ◽  
E. R. G. Main
Keyword(s):  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors

Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review

2021 ◽  
Vol 325 ◽  
pp. 110859
Author(s):  
Caterina Raffone ◽  
Miriam Baeta ◽  
Nicole Lambacher ◽  
Eva Granizo-Rodríguez ◽  
Francisco Etxeberria ◽  
...  
Keyword(s):  
Skeletal Remains ◽  
Extrinsic Factors ◽  
Dna Preservation ◽  
Intrinsic And Extrinsic Factors

scholarly journals Conceptualizing Mobility Inequality: Mobility and Accessibility for the Marginalized

2021 ◽  
pp. 088541222110128
Author(s):  
Isti Hidayati ◽  
Wendy Tan ◽  
Claudia Yamu
Keyword(s):  
Conceptual Understanding ◽  
Thought Experiments ◽  
Future Research ◽  
Planning Practice ◽  
Extrinsic Factors ◽  
Research Directions ◽  
Future Research Directions ◽  
Intrinsic And Extrinsic Factors

The burgeoning landscape of literature on mobility inequalities has led to discrepancies between a conceptual understanding of mobility inequalities and its implementation in planning practice. Reviewing 270 publications across five decades, this article identifies intrinsic and extrinsic factors and approaches for understanding and analyzing mobility inequality. Using two thought experiments to critically locate variations in factors and approaches, dilemmas and challenges in addressing mobility inequality for the marginalized are exposed. The article concludes with future research directions for investigating mobility inequality.

scholarly journals Effect of Intrinsic and Extrinsic Factors on Global and Regional Cortical Thickness

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96429 ◽  
Author(s):  
Koushik A. Govindarajan ◽  
Leorah Freeman ◽  
Chunyan Cai ◽  
Mohammad H. Rahbar ◽  
Ponnada A. Narayana
Keyword(s):  
Cortical Thickness ◽  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors

Modulation of both intrinsic and extrinsic factors additively promotes rewiring of corticospinal circuits after spinal cord injury

2021 ◽  
pp. JN-RM-2649-20
Author(s):  
Yuka Nakamura ◽  
Masaki Ueno ◽  
Jesse K. Niehaus ◽  
Richard A Lang ◽  
Yi Zheng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Extrinsic Factors ◽  
Cord Injury ◽  
Intrinsic And Extrinsic Factors

scholarly journals Prevalence of postural deviations and associated factors in children and adolescents: a cross-sectional study

2016 ◽  
Vol 29 (4) ◽  
pp. 777-786 ◽  
Author(s):  
Mariana Vieira Batistão ◽  
Roberta de Fátima Carreira Moreira ◽  
Helenice Jane Cote Gil Coury ◽  
Luis Ernesto Bueno Salasar ◽  
Tatiana de Oliveira Sato
Keyword(s):  
Physical Activity ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Associated Factors ◽  
Multiple Logistic Regression Analysis ◽  
Extrinsic Factors ◽  
Cross Sectional ◽  
Postural Changes ◽  
Intrinsic And Extrinsic Factors

Abstract Introduction: Postural deviations are frequent in childhood and may cause pain and functional impairment. Previously, only a few studies have examined the association between body posture and intrinsic and extrinsic factors. Objective: To assess the prevalence of postural changes in school children, and to determine, using multiple logistic regression analysis, whether factors such as age, gender, BMI, handedness and physical activity might explain these deviations. Methods: The posture of 288 students was assessed by observation. Subjects were aged between 6 and 15 years, 59.4% (n = 171) of which were female. The mean age was 10.6 (± 2.4) years. Mean body weight was 38.6 (± 12.7) kg and mean height was 1.5 (± 0.1) m. A digital scale, a tapeline, a plumb line and standardized forms were used to collect data. The data were analyzed descriptively using the chi-square test and logistic regression analysis (significance level of 5%). Results: We found the following deviations to be prevalent among schoolchildren: forward head posture, 53.5%, shoulder elevation, 74.3%, asymmetry of the iliac crests, 51.7%, valgus knees, 43.1%, thoracic hyperkyphosis, 30.2%, lumbar hyperlordosis, 37.2% and winged shoulder blades, 66.3%. The associated factors were age, gender, BMI and physical activity. Discussion: There was a high prevalence of postural deviations and the intrinsic and extrinsic factors partially explain the postural deviations. Conclusion: These findings contribute to the understanding of how and why these deviations develop, and to the implementation of preventive and rehabilitation programs, given that some of the associated factors are modifiable.

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