scholarly journals Anticlastogenic Effect of Ginkgo Biloba Extract in Graves’ Disease Patients Receiving Radioiodine Therapy

2007 ◽  
Vol 92 (11) ◽  
pp. 4286-4289 ◽  
Author(s):  
A. Dardano ◽  
M. Ballardin ◽  
M. Ferdeghini ◽  
E. Lazzeri ◽  
C. Traino ◽  
...  
Keyword(s):  
Placebo Group ◽  
Clinical Outcome ◽  
Ginkgo Biloba ◽  
Radioiodine Therapy ◽  
Statistical Significance ◽  
Ginkgo Biloba Extract ◽  
131I Therapy ◽  
Graves Disease ◽  
Egb 761 ◽  
Significant Difference

Abstract Background: Chromosomal damage, as assessed by clastogenic factors (CFs) and micronuclei (MN) appearance, after radioiodine therapy of Graves’ disease has been reported. Objective and Methods: Our objective was to evaluate the effect of Ginkgo biloba extract (EGb 761) supplementation on the time course (up to 120 d) of CFs and MN appearance in lymphocytes from patients with Graves’ disease after iodine-131 (131I) therapy. Patients were randomly assigned to EGb 761 or placebo, in a blinded manner. Results: In the placebo group, MN increased early (P < 0.001) after 131I, peaking at the 21st day (P = 0.0003) and declining thereafter. In EGb 761-treated patients, MN increased early (P < 0.05), while returning toward baseline value thereafter. Therefore, mean MN increment was significantly higher in the placebo group as compared with EGb 761-treated patients (P < 0.01). Moreover, an early (P < 0.0001) and sustained (up to 35 d; P < 0.001) MN increase induced by CFs was observed in the placebo group. Conversely, in EGb 761-treated patients, MN increase induced by CFs never reached the statistical significance; therefore, the mean of the MN increments was significantly lower than in placebo (P < 0.05). A significant positive correlation between MN maximum increment and the bone marrow dose was observed in the placebo group only (P = 0.03). No significant difference was observed in clinical outcome between the two groups. Conclusions: EGb 761 supplementation neutralized genotoxic damage induced by radioiodine treatment, without affecting the clinical outcome. Although 131I therapy is generally safe, our data suggest that Gingko biloba extracts may prevent genetic effects of radioiodine therapy for hyperthyroid Graves’ disease.

The Effect of Ginkgo biloba Extract (EGb 761) on Hepatic Sinusoidal Endothelial Cells and Hepatic Microcirculation in CCl4 Rats

2004 ◽  
Vol 32 (01) ◽  
pp. 21-31 ◽  
Author(s):  
Chunqing Zhang ◽  
Juren Zu ◽  
Hengmei Shi ◽  
Jiyong Liu ◽  
Chengyong Qin
Keyword(s):  
Endothelial Cells ◽  
Ginkgo Biloba ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ginkgo Biloba Extract ◽  
Egb 761 ◽  
Sinusoidal Endothelial Cells ◽  
Hepatic Microcirculation ◽  
Significant Difference ◽  
Hepatic Sinusoidal Endothelial Cells

It has been shown that Ginkgo biloba Extract (EGb 761) increases peripheral and cerebral blood flow and microcirculation and improves myocardial ischemia reperfusion injury. This study was designed to investigate the effect of EGb 761 on hepatic endothelial cells and hepatic microcirculation. Sixty male Wister rats were divided into normal, carbon tetrachloride ( CCl 4) and EGb groups, and were given normal saline, CCl 4 and CCl 4 plus EGb 761, respectively, for 10 weeks. Samples were taken from the medial lobe of the rat livers ten weeks later. Hepatic sinusoidal endothelial cells and other parameters of hepatic microcirculation were observed under transmission electron microscopy (TEM). The amount of malondialdehyde (MDA), endothelin (ET-1), platelet-activating factor (PAF) and nitric oxide (NO) in liver tissue was determined by spectrophotometry and radioimmunoassay, respectively. Compared with the CCl 4 group, aggregation of blood cell or micro thrombosis in hepatic sinusoids, deposition of collagen in hepatic sinusoids and space of Disse, injury of endothelial cells and capillization of hepatic sinusoid was significantly reduced in the EGb group. The amount of MDA, ET-1 and PAF was markedly reduced in the EGb group than in the CCl 4 group, while no significant difference in the amount of NO was observed between the two groups. The results demonstrate that EGb 761 has protective effect on hepatic endothelial cells and hepatic microcirculation in rats with chronic liver injury induced by CCl 4. The mechanisms may involve its inhibition on ET-1, PAF and lipid peroxidation.

Downregulation of Agonist-Induced Nitric Oxide Synthesis and Cell-Cell Adhesion by Ginkgo biloba Extract EGb 761

1999 ◽  
pp. 359-370
Author(s):  
Sashwati Roy ◽  
Hirotsugu Kobuchi ◽  
Chandan K. Sen ◽  
Marie-Thérèse Droy-Lefaix ◽  
Lester Packer
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Egb 761 ◽  
Nitric Oxide Synthesis ◽  
Cell Cell

Ginkgo biloba extract (EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice

Neuroreport ◽  
1999 ◽  
Vol 10 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Sandrine Pierre ◽  
Isabelle Jamme ◽  
Marie-Thérèse Droy-Lefaix ◽  
André Nouvelot ◽  
Jean-Michel Maixent
Keyword(s):  
Cerebral Ischemia ◽  
Atpase Activity ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Egb 761

Ginkgo Biloba Extract (Egb 761) Modulates Bleomycin-induced Acute Lung Injury in Rats

2001 ◽  
Vol 87 (6) ◽  
pp. 417-422 ◽  
Author(s):  
Aiman S El-Khatib ◽  
Adel M Moustafa ◽  
Abdel-Aziz H Abdel-Aziz ◽  
Othman A Al-Shabanah ◽  
Hassan A El-Kashef
Keyword(s):  
Alkaline Phosphatase ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Artery ◽  
Lung Tissue ◽  
Ginkgo Biloba ◽  
Biochemical Markers ◽  
Ginkgo Biloba Extract ◽  
Slight Reduction ◽  
Egb 761

The effect of Ginkgo biloba extract (EGb 761) on bleomycin (BLM)-induced acute lung injury was studied in rats. The responsiveness of isolated pulmonary arterial rings to 5-hydroxytryptamine (5-HT) as well as the levels of some relevant biochemical markers in the lung tissue were taken as evidence for the acute lung injury. BLM was given intraperitoneally at a dose of 15 mg/kg/day for five consecutive days. It was found that BLM treatment attenuated the vasoconstrictor effect of 5-HT on the isolated pulmonary arteries. In lung tissues BLM also elevated the level of lipid peroxides and enhanced the activity of glutathione peroxidase. On the other hand, the level of glutathione and the activity of alkaline phosphatase were reduced. Body weight, lung weight and tissue glutathione-S-transferase activity were, however, not altered. Oral administration of EGb 761 at a dose of 100 mg/kg/day for five consecutive days did not alter any of the chosen biochemical parameters in the lung tissue except for a slight reduction in alkaline phosphatase activity. However, treatment with EGb 761 reduced the responsiveness of the pulmonary artery to 5-HT. Administration of EGb 761 (100 mg/kg/day; po) two hours prior to BLM (15 mg/kg/day; ip), for five consecutive days blunted the occurrence of further reduction in the vasoconstrictor response of the pulmonary artery to 5-HT. Furthermore, EGb 761 tended to normalize BLM-induced alterations in the measured biochemical markers in the lung tissue. The apparent modulatory influence of EGb 761 on BLM-induced acute lung injury stems, at least in part, from its beneficial free radical scavenging properties that provide the extract with antioxidant activity.

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