scholarly journals NIS Mediates Iodide Uptake in the Female Reproductive Tract and Is a Poor Prognostic Factor in Ovarian Cancer

2014 ◽  
Vol 99 (7) ◽  
pp. E1199-E1208 ◽  
Author(s):  
Garcilaso Riesco-Eizaguirre ◽  
Suzana Garcia Leoni ◽  
Marta Mendiola ◽  
Maria Angeles Estevez-Cebrero ◽  
Marta Ines Gallego ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factor ◽  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
Iodide Uptake ◽  
Poor Prognostic Factor

scholarly journals Co-expression of CD44/MyD88 is a poor prognostic factor in advanced epithelial ovarian cancer

2019 ◽  
Vol 7 (5) ◽  
pp. 91-91
Author(s):  
Yi Zhu ◽  
Hongtao Zhang ◽  
Guonan Zhang ◽  
Yu Shi ◽  
Jianming Huang
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factor ◽  
Epithelial Ovarian Cancer ◽  
Poor Prognostic Factor ◽  
Advanced Epithelial Ovarian Cancer

scholarly journals A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuangfeng Chen ◽  
Yuebo Li ◽  
Lili Qian ◽  
Sisi Deng ◽  
Luwen Liu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Reproductive Tract ◽  
Molecular Subtypes ◽  
Female Reproductive Tract ◽  
Molecular Characteristics ◽  
The Novel ◽  
Endometrioid Ovarian Carcinoma ◽  
Endometrioid Ovarian Cancer ◽  
Prediction Of Prognosis ◽  
Novel Therapeutic Strategies

Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.

Old age as a poor prognostic factor in epithelial ovarian cancer: What is the best age cutoff?

2019 ◽  
Vol 154 ◽  
pp. 108-109
Author(s):  
W.Y. Kim ◽  
J. Kim ◽  
T. Song ◽  
S.Y. Jeong ◽  
E.S. Paik ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factor ◽  
Epithelial Ovarian Cancer ◽  
Old Age ◽  
Poor Prognostic Factor

scholarly journals UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1604
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Actomyosin Contractility ◽  
Cancer Initiation

UNC-45A (Protein unc-45 homolog A) is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the actomyosin system and a Microtubule (MT)-destabilizing protein, which is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment not only in highly proliferating and prone to remodeling cells, but also in microtubule-rich areas, of the ovaries and the nervous system, respectively. In both apparatuses, UNC-45A is also abundantly expressed in the ciliated epithelium. As regulators of actomyosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development, our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development as well as in neurodegeneration.

Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer

2016 ◽  
Vol 140 (3) ◽  
pp. 545-553 ◽  
Author(s):  
Thi My Hien Nguyen ◽  
In-Whoan Shin ◽  
Tae Jin Lee ◽  
Junsoo Park ◽  
Jae Hyung Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Prognostic Factor ◽  
Tumor Suppressor ◽  
Epithelial Ovarian Cancer ◽  
Cell Cycle Arrest ◽  
M Cell ◽  
Poor Prognostic Factor ◽  
Cycle Arrest

scholarly journals Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3801
Author(s):  
Tabea L. Bauer ◽  
Katrin Collmar ◽  
Till Kaltofen ◽  
Ann-Katrin Loeffler ◽  
Lorena Decker ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cell Lines ◽  
Reproductive Tract ◽  
Genetic Resistance ◽  
Female Reproductive Tract ◽  
Nurd Complex ◽  
Nucleosome Remodeling ◽  
Independent Prognostic Marker ◽  
Novel Biomarkers

Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and FGF10), which gained large enhancer clusters in resistant EOC cell lines, could provide novel biomarkers for early patient stratification with statistical independence for JAK1. To modulate the enhancer remodeling process and prevent the acquisition of cPt resistance in EOC cells, we performed a chromatin-focused RNAi screen in the presence of cPt. We identified subunits of the Nucleosome Remodeling and Deacetylase (NuRD) complex as critical factors sensitizing the EOC cell line A2780 to platinum treatment. Suppression of the Methyl-CpG Binding Domain Protein 3 (MBD3) sensitized cells and prevented the establishment of resistance under prolonged cPt exposure through alterations of H3K27ac at enhancer regions, which are differentially regulated in cPt-resistant cells, leading to a less aggressive phenotype. Our work establishes JAK1 as an independent prognostic marker and the NuRD complex as a potential target for combinational therapy.

scholarly journals UNC-45A is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

2021 ◽  
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Cancer Patients ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Cancer Initiation

AbstractUNC-45A is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the acto-myosin system and as a Microtubule (MT)-destabilizing protein. UNC-45A is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug Paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment in highly proliferating and prone to remodeling cells and in microtubule-rich areas of in the ovaries and in neurons respectively. In both apparatuses UNC-45A is also abundantly expressed in the ciliated epithelium. Because regulators of acto-myosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development and in neurodegeneration.

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