scholarly journals UNC-45A is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

2021 ◽  
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Cancer Patients ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Cancer Initiation

AbstractUNC-45A is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the acto-myosin system and as a Microtubule (MT)-destabilizing protein. UNC-45A is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug Paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment in highly proliferating and prone to remodeling cells and in microtubule-rich areas of in the ovaries and in neurons respectively. In both apparatuses UNC-45A is also abundantly expressed in the ciliated epithelium. Because regulators of acto-myosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development and in neurodegeneration.

scholarly journals UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1604
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Actomyosin Contractility ◽  
Cancer Initiation

UNC-45A (Protein unc-45 homolog A) is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the actomyosin system and a Microtubule (MT)-destabilizing protein, which is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment not only in highly proliferating and prone to remodeling cells, but also in microtubule-rich areas, of the ovaries and the nervous system, respectively. In both apparatuses, UNC-45A is also abundantly expressed in the ciliated epithelium. As regulators of actomyosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development, our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development as well as in neurodegeneration.

scholarly journals Non-Pulmonary Immune Functions of Surfactant Proteins A and D

2016 ◽  
Vol 9 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Sylvia Ujma ◽  
William G.C. Horsnell ◽  
Arieh A. Katz ◽  
Howard W. Clark ◽  
Georgia Schäfer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Innate Immune System ◽  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
The Body ◽  
Innate Immune ◽  
Surfactant Proteins ◽  
Immune Functions ◽  
Essential Components

Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites.

Central Nervous System Metastases from Primary Epithelial Ovarian Cancer

2003 ◽  
Vol 10 (3) ◽  
pp. 244-253 ◽  
Author(s):  
Lalit Kumar ◽  
Suchitra Barge ◽  
Ashok K. Mahapatra ◽  
Sanjay Thulkar ◽  
Gaura Kishore Rath ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Epithelial Ovarian Cancer ◽  
Central Nervous System Metastases ◽  
Primary Epithelial Ovarian Cancer

scholarly journals The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies

2021 ◽  
Author(s):  
Darren M. Brenner ◽  
Neal E. Slatkin ◽  
Nancy Stambler ◽  
Robert J. Israel ◽  
Paul H. Coluzzi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Opioid Withdrawal ◽  
Double Blind ◽  
Post Hoc Analysis ◽  
Pain Scores ◽  
Opioid Receptor Antagonists ◽  
Post Hoc

Abstract Purpose Peripherally acting μ-opioid receptor antagonists such as methylnaltrexone (MNTX, Relistor®) are indicated for the treatment of opioid-induced constipation (OIC). The structural properties unique to MNTX restrict it from traversing the blood-brain barrier (BBB); however, the BBB may become more permeable in patients with brain metastases. We investigated whether the presence of brain metastases in cancer patients compromises the central effects of opioids among patients receiving MNTX for OIC. Methods This post hoc analysis of pooled data from 3 randomized, placebo-controlled trials included cancer patients with OIC who received MNTX or placebo. Endpoints included changes from baseline in pain scores, rescue-free laxation (RFL) within 4 or 24 h of the first dose, and treatment-emergent adverse events (TEAEs), including those potentially related to opioid withdrawal symptoms. Results Among 356 cancer patients in the pooled population, 47 (MNTX n = 27; placebo n = 20) had brain metastases and 309 (MNTX n = 172; placebo n = 137) did not have brain metastases. No significant differences in current pain, worst pain, or change in pain scores from baseline were observed between patients treated with MNTX or placebo. Among patients with brain metastases, a significantly greater proportion of patients who received MNTX versus placebo achieved an RFL within 4 h after the first dose (70.4% vs 15.0%, respectively, p = 0.0002). TEAEs were similar between treatment groups and were generally gastrointestinal in nature and not related to opioid withdrawal. Conclusion Focal disruptions of the BBB caused by brain metastases did not appear to alter central nervous system penetrance of MNTX.

scholarly journals Central nervous system side-effects of 5-HT3-receptor antagonists in elderly cancer patients treated with chemotherapy

2004 ◽  
Vol 15 (6) ◽  
pp. 987-988 ◽  
Author(s):  
P. Tralongo ◽  
A. Dimari ◽  
G. Conti ◽  
R. Aiello ◽  
G. Mauceri
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Side Effects ◽  
Cancer Patients ◽  
Receptor Antagonists ◽  
Elderly Cancer Patients

Central Nervous System Infections in Cancer Patients

2003 ◽  
pp. 253-270
Author(s):  
Neil E. Anderson ◽  
Mark G. Thomas
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cancer Patients ◽  
Central Nervous System Infections

Investigating the Tissue Specific Expression Patterns of Murine Semaphorins 3C, 4D, 4G, 6A and 7A in Primary Lymphoid Tissues

2001 ◽  
Vol 7 (S2) ◽  
pp. 76-77
Author(s):  
Sreedevi Chalasani ◽  
David Matthes
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cell Survival ◽  
Neuronal Development ◽  
Expression Patterns ◽  
Human Neutrophils ◽  
Lymphoid Tissues ◽  
Specific Expression ◽  
Est Analysis

Semaphorins are primarily known for the important role they play in the guidance of growth cones during neuronal development. There is evidence, however, that semaphorins are expressed outside the nervous system as well, suggesting a wider scope for semaphorin function. The overall objective of our study is to identify the functions of semaphorins outside central nervous system especially in T cell development. Some of the 20 semaphorins have been shown to have extra-neural functions that include (for different semaphorins) bone differentiation, promotion of B-cell survival and aggregation, and activation of T-cells. Apart from central nervous system statement of most semaphorins, one semaphorin (CD 100) has transcripts in T cells, B cells, neutrophils, monocytes and granulocytes. EST analysis suggests that other semaphorins are expressed in lymphoid tissues such as thymus, spleen, tonsil, and the interfollicular areas and germinal centers of lymph nodes.Semaphorins have been related to several cell survival mechanisms, immunosuppression and promotion of cell death resistance. in preliminary studies our lab found that viral semaphorins inhibit the migration of human T cells and human SEMA3A can inhibit migration of human neutrophils.

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