Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts

AbstractContext: Outdoor temperature and bright sunlight may directly and/or indirectly modulate systemic metabolism.Objective: We assessed the associations between outdoor temperature and bright sunlight duration with metabolomics.Design: meta-analysis of two cross-sectional studies.Setting: Two population-based European cohort studies.Patients or other participants: Non-diabetic individuals from the Oxford BioBank (OBB; N=6,368; mean age 47.0 years, males 44%) and the Netherlands Epidemiology of Obesity (NEO; N=5,916; mean age 55.6 years, males 43%) studies.Intervention(s): Data on mean outdoor bright sunlight and temperature collected from local weather stations in the week prior to blood sampling.Main Outcome Measure(s): Serum levels of 148 metabolites measured using NMR spectroscopy, including 14 lipoprotein subclasses.Statistical analyses: Multivariable linear regression analyses adjusted for age, sex, body mass index, season and either outdoor temperature or bright sunlight. Summary statistics from the OBB and NEO cohorts were combined using fixed-effect meta-analyses.Results: A higher mean outdoor temperature was associated with increased concentrations of lipoprotein (sub)particles and certain amino acids such as phenylalanine and leucine. In contrast, longer mean hours of bright sunlight were specifically associated with lower concentrations of very low density lipoprotein (sub)particles. The direction of effects was consistent between the OBB and NEO, although effect sizes were generally larger in the OBB.Conclusions: Increased bright sunlight duration is associated with an improved metabolic profile whilst higher outdoor temperature may adversely impact cardiometabolic health.

Download Full-text

Predicting sentinel node positivity in melanoma patients: external validation of a risk‐prediction calculator (the MIA nomogram) using a large European population‐based patient cohort

British Journal of Dermatology ◽

10.1111/bjd.19895 ◽

2021 ◽

Author(s):

M.A. El Sharouni ◽

A.H.R. Varey ◽

A.J. Witkamp ◽

T. Ahmed ◽

V. Sigurdsson ◽

...

Keyword(s):

Sentinel Node ◽

Risk Prediction ◽

External Validation ◽

Population Based ◽

European Population ◽

Patient Cohort ◽

Melanoma Patients

Download Full-text

Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts

European Journal of Epidemiology ◽

10.1007/s10654-021-00754-4 ◽

2021 ◽

Author(s):

Silvia Alemany ◽

Claudia Avella-García ◽

Zeyan Liew ◽

Raquel García-Esteban ◽

Kosuke Inoue ◽

...

Keyword(s):

Attention Deficit ◽

Clinical Symptoms ◽

Meta Analysis ◽

Collaborative Study ◽

Population Based ◽

Autism Spectrum ◽

European Population ◽

Autism Spectrum Conditions ◽

Adhd Symptoms ◽

Postnatal Exposure

AbstractThe potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative study of six European population-based birth/child cohorts. A total of 73,881 mother–child pairs were included in the study. Prenatal and postnatal (up to 18 months) acetaminophen exposure was assessed through maternal questionnaires or interviews. ASC and ADHD symptoms were assessed at 4–12 years of age using validated instruments. Children were classified as having borderline/clinical symptoms using recommended cutoffs for each instrument. Hospital diagnoses were also available in one cohort. Analyses were adjusted for child and maternal characteristics along with indications for acetaminophen use. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. The proportion of children having borderline/clinical symptoms ranged between 0.9 and 12.9% for ASC and between 1.2 and 12.2% for ADHD. Results indicated that children prenatally exposed to acetaminophen were 19% and 21% more likely to subsequently have borderline or clinical ASC (OR = 1.19, 95% CI 1.07–1.33) and ADHD symptoms (OR = 1.21, 95% CI 1.07–1.36) compared to non-exposed children. Boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys. Postnatal exposure to acetaminophen was not associated with ASC or ADHD symptoms. These results replicate previous work and support providing clear information to pregnant women and their partners about potential long-term risks of acetaminophen use.

Download Full-text