Steroidogenic Enzyme Gene Expression in the Human Heart

2000 ◽  
Vol 85 (7) ◽  
pp. 2519-2525 ◽  
Author(s):  
K. M. Kayes-Wandover
Keyword(s):  
Gene Expression ◽  
Human Heart ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene

scholarly journals Steroidogenic Enzyme Gene Expression in the Human Heart1

2000 ◽  
Vol 85 (7) ◽  
pp. 2519-2525
Author(s):  
Kathleen M. Kayes-Wandover ◽  
Perrin C. White
Keyword(s):  
Gene Expression ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene

scholarly journals Evidence of a Steroidogenic Enzyme Gene Dose Effect on Adrenal Gene Expression in Hereditary Rabbit Congenital Adrenal Hyperplasia

1994 ◽  
Vol 36 (5) ◽  
pp. 660-666 ◽  
Author(s):  
Kotaro Iwamoto ◽  
Ximing Yang ◽  
Fraser M Rogerson ◽  
J Ian Mason ◽  
James Artwohl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Congenital Adrenal Hyperplasia ◽  
Dose Effect ◽  
Adrenal Hyperplasia ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene ◽  
Gene Dose

scholarly journals Steroidogenic Enzyme Gene Expression in Androgen Induced Polycystic Ovaries in the Rabbit

2001 ◽  
Vol 10 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Kotaro Iwamoto ◽  
J. Ian Mason ◽  
Jose Manaligod ◽  
K-Y Francis Pau ◽  
Harold G. Spies ◽  
...  
Keyword(s):  
Gene Expression ◽  
Polycystic Ovaries ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene

Steroidogenic enzyme gene expression profiles in the testis of cattle treated with illicit growth promoters

Steroids ◽  
2011 ◽  
Vol 76 (5) ◽  
pp. 508-516 ◽  
Author(s):  
Rosa M. Lopparelli ◽  
Vanessa Zancanella ◽  
Mery Giantin ◽  
Licia Ravarotto ◽  
Giandomenico Pozza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Growth Promoters ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene

scholarly journals The Effects of Leptin and Irisin on Steroidogenic Enzyme Gene Expression in Human Ovarian Granulosa Cells - Initial Studies

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A772-A773
Author(s):  
Dimiter Bogdanov Avtanski ◽  
Karina Ziskovich ◽  
Tomer Singer ◽  
Ariel Yeshua ◽  
Tal Cantor ◽  
...  
Keyword(s):  
Gene Expression ◽  
Energy Metabolism ◽  
Granulosa Cells ◽  
Pcr Analysis ◽  
Mrna Levels ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene ◽  
Ovarian Granulosa Cells ◽  
Brown Adipose

Abstract Fertility and energy metabolism are closely associated, and the cytokines produced by the adipose and muscle tissue play a role in this association. Leptin, predominantly produced by the white adipose tissue, and irisin, produced by the brown adipose and skeletal muscle tissues, are cytokines that are important in balancing energy metabolism. This study aimed to investigate the effects of leptin and irisin on steroidogenic enzyme gene expression in human ovarian granulosa cells in vitro. Granulosa cells were retrieved and isolated from ovarian follicular fluid during in vitro fertilization (IVF) procedures. Cells were placed in primary in vitro cultures and treated with increasing concentrations of leptin (25, 50, 100, 200, and 400 ng/ml) or irisin (125, 250, 500, 1,000, and 2,000 ng/ml) for 24, 48, and 72 hours. mRNA expression levels of CYP11A1, CYP19A1, CYP21A2, HSD3B1, and HSD17B3 were measured by qRT-PCR analysis. Leptin treatment of granulosa cells resulted in significant upregulation of CYP21A2 mRNA levels, while irisin significantly downregulated mRNA levels of CYP11A1, CYP19A1, and HSD3B1. Taken together, these early experiments demonstrate that leptin and irisin may affect steroid hormone production in the ovary by targeting the gene expression of key steroidogenic enzymes. Additional experiments are in progress.

scholarly journals Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells

1992 ◽  
Vol 43 (8) ◽  
pp. 895-906 ◽  
Author(s):  
A.H. Payne ◽  
G.L. Youngblood ◽  
L. Sha ◽  
M. Burgos-Trinidad ◽  
S.H. Hammond
Keyword(s):  
Gene Expression ◽  
Hormonal Regulation ◽  
Leydig Cells ◽  
Steroidogenic Enzyme ◽  
Enzyme Gene
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