scholarly journals MON-109 Modulator of Gut Barrier, Zonulin Was Associated with Waist to Height Ratio in Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ki Eun Kim ◽  
Ok-Hyang Kim ◽  
Sol Han ◽  
Youn-Ho Sheen ◽  
Soo-Yeon Kim
Keyword(s):  
Insulin Resistance ◽  
Tight Junction ◽  
Alanine Aminotransferase ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Multivariate Linear Regression Analysis ◽  
Z Score ◽  
Height Ratio ◽  
Waist Hip Ratio ◽  
Waist Height Ratio

Abstract Background: Zonulin is the endogenous protein known to control the permeability of intestinal tight junction reversibly. Zonulin is actively engaged in intestinal innate immunity and is over-expressed in autoimmune diseases where tight junction of intestine plays a pivotal role, such as celiac disease, malabsorption disorder, and type 1 diabetes. Waist-Height ratio was well known as one of indices of obesity and also Waist-Hip ratio was known of abdominal obesity. We investigated that the associations among Waist-Height, Waist-Height ratio, and the level of Zonulin by assessing obesity-related biomarkers, such as liver enzymes, lipid profiles, and insulin resistance, in a population of adolescents. Methods: The study included 198 adolescents aged 12-18 years; 92 were overweight/obese and 106 were of normal-weight. We assessed anthropometric and laboratory measures, including body mass index (BMI), BMI z-score, Waist-Height, Waist-Hip ratio, blood pressure, liver enzyme levels, lipid profiles, and insulin sensitivity. Serum Zonulin levels were measured using an enzyme-linked immunosorbent assay. Results: The mean age of the participants was 15.2±2.5 years. Circulating serum Zonulin levels were significantly increased in overweight/obese participants compared with those in normal-weight participants (P=0.042). Zonulin levels were significantly and positively associated with BMI, BMI z-score, alanine aminotransferase levels, triglyceride, fasting insulin, and insulin resistance as indicated by the homeostasis model assessment of insulin resistance (HOMA-IR) (all P<0.05). In multivariate linear regression analysis, alanine aminotransferase (P<0.0001), triglyceride (P<0.0001), and HOMA-IR (P=0.001) contributed independently to circulating Zonulin levels after controlling for the effect of BMI z-score. Zonulin levels were more strongly associated with Waist-Hip ratio rather than Waist-Height ratio. Conclusions: Zonulin was associated with indices of obesity. Waist-Hip ratio was more strongly associated with levels of Zonulin. The positive correlation between these parameters suggests putative pathophysiological mechanism linking Zonulin to metabolic dysfunction in adolescents.

Association between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution

2019 ◽  
Vol 13 (3) ◽  
pp. 2041-2047 ◽  
Author(s):  
Diego Urrunaga-Pastor ◽  
Luciana De La Fuente-Carmelino ◽  
Carlos J. Toro-Huamanchumo ◽  
Miriam Pérez-Zavala ◽  
Vicente A. Benites-Zapata
Keyword(s):  
Insulin Resistance ◽  
Waist Circumference ◽  
Educational Institution ◽  
Normal Weight ◽  
Height Ratio ◽  
Waist To Height Ratio

scholarly journals Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status

2020 ◽  
Vol 14 ◽  
Author(s):  
Maria Poessel ◽  
Nora Breuer ◽  
Akshita Joshi ◽  
André Pampel ◽  
Arno Villringer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Olfactory Bulb ◽  
Eating Behavior ◽  
Body Fat ◽  
Explanatory Models ◽  
Metabolic Health ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Height Ratio ◽  
Waist Height Ratio

Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin’ Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs.

scholarly journals Waist circumference, waist-hip ratio and waist-height ratio percentiles and central obesity among Pakistani children aged five to twelve years

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Muhammad Umair Mushtaq ◽  
Sibgha Gull ◽  
Hussain Muhammad Abdullah ◽  
Ubeera Shahid ◽  
Mushtaq Ahmad Shad ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Central Obesity ◽  
Height Ratio ◽  
Waist Hip Ratio ◽  
Waist Height Ratio

Insulin resistance is associated with elevated transaminases and low aspartate aminotransferase/alanine aminotransferase ratio in young adults with normal weight

2017 ◽  
Vol 29 (4) ◽  
pp. 435-440 ◽  
Author(s):  
Luis E. Simental-Mendía ◽  
Martha Rodríguez-Morán ◽  
Rita Gómez-Díaz ◽  
Niels H. Wacher ◽  
Heriberto Rodríguez-Hernández ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Young Adults ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Normal Weight ◽  
Elevated Transaminases

scholarly journals Insulin Resistance of Normal Weight Central Obese Adolescents in Korea Stratified by Waist to Height Ratio: Results from the Korea National Health and Nutrition Examination Surveys 2008–2010

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Won Kyoung Cho ◽  
Hyojin Kim ◽  
Hyun Young Lee ◽  
Kyung Do Han ◽  
Yeon Jin Jeon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
National Health ◽  
Central Obesity ◽  
Normal Weight ◽  
Female Adolescents ◽  
Height Ratio ◽  
Health And Nutrition ◽  
High Insulin ◽  
Waist To Height Ratio ◽  
Wbc Count

Background. To evaluate insulin resistance of normal weight central obese 13–18-year-old male and female adolescents stratified by waist to height ratio (WHR).Methods. Data were obtained from the Korea National Health and Nutrition Examination Survey (K-NHANES) conducted during 2008–2010. Central obesity was defined as that in the upper quartile of age and sex specific WHR. Subjects were classified into no central obesity normal weight (NW), central obesity normal weight (CONW), no central obesity overweight (OW), and central obesity overweight (COOW).Results. The prevalence of CONW was 9.6% (83/832) in female and 7.0% (61/909) in male. CONW showed higher levels of insulin (P<0.006), HOMA-IR (P<0.006), and ALT (P<0.001) than NW in female. CONW had higher levels of insulin (P<0.0001), HOMA-IR (P<0.0001), and WBC count (P<0.021) and lower level of HDL (P<0.0001) than NW in male. WHR and BMI had similar significant correlations with MS components. CONW showed 2.5 times (95% confidence interval, 1.21–5.00) more likelihood to have high insulin resistance than NW in male.Conclusions. Screening for central obesity using WHR in clinical setting is recommended.

scholarly journals Abdominal and gluteo-femoral markers of adiposity and risk of vascular-metabolic mortality in a prospective study of 150 000 Mexican adults

2021 ◽  
Author(s):  
Louisa Gnatiuc ◽  
Roberto Tapia-Conyer ◽  
Rachel Wade ◽  
Raúl Ramirez-Reyes ◽  
Diego Aguilar-Ramirez ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Prospective Study ◽  
Abdominal Adiposity ◽  
Reverse Causality ◽  
Hip Circumference ◽  
Height Ratio ◽  
Waist Hip Ratio ◽  
Mexican Adults ◽  
A Prospective Study ◽  
Waist Height Ratio

Abstract Aims Results of previous studies of abdominal adiposity and risk of vascular-metabolic mortality in Hispanic populations have been conflicting. We report results from a large prospective study of Mexican adults with high levels of abdominal adiposity. Methods and results A total of 159 755 adults aged ≥35 years from Mexico City were enrolled in a prospective study and followed for 16 years. Cox regression, adjusted for confounders, yielded mortality rate ratios (RRs) associated with three markers of abdominal adiposity (waist circumference, waist–hip ratio, and waist–height ratio) and one marker of gluteo-femoral adiposity (hip circumference) for cause-specific mortality before age 75 years. To reduce reverse causality, deaths in the first 5 years of follow-up and participants with diabetes or other prior chronic disease were excluded. Among 113 163 participants without prior disease and aged 35–74 years at recruitment, all adiposity markers were positively associated with vascular-metabolic mortality. Comparing the top versus bottom tenth of the sex-specific distributions, the vascular-metabolic mortality RRs at ages 40–74 years were 2.32 [95% confidence interval (CI) 1.84–2.94] for waist circumference, 2.22 (1.71–2.88) for the waist–hip ratio, 2.63 (2.06–3.36) for the waist–height ratio, and 1.58 (1.29–1.93) for hip circumference. The RRs corresponding to each standard deviation (SD) higher usual levels of these adiposity markers were 1.34 (95% CI 1.27–1.41), 1.31 (1.23–1.39), 1.38 (1.31–1.45), and 1.18 (1.13–1.24), respectively. For the markers of abdominal adiposity, the RRs did not change much after further adjustment for other adiposity markers, but for hip circumference the association was reversed; given body mass index and waist circumference, the RR for vascular-metabolic mortality for each one SD higher usual hip circumference was 0.80 (0.75–0.86). Conclusions In this study of Mexican adults, abdominal adiposity (and in particular the waist–height ratio) was strongly and positively associated with vascular-metabolic mortality. For a given amount of general and abdominal adiposity, however, higher hip circumference was associated with lower vascular-metabolic mortality.

scholarly journals Prevalence of hypertension and its association with anthropometric parameters in adult population of Raipur city, Chhattisgarh, India

2017 ◽  
Vol 5 (5) ◽  
pp. 2120 ◽  
Author(s):  
Prem S. Panda ◽  
Kamlesh K. Jain ◽  
Gopal P. Soni ◽  
Shubhra A. Gupta ◽  
Srishti Dixit ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Adult Population ◽  
Public Health Problem ◽  
Height Ratio ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Waist Hip Ratio ◽  
Waist Height Ratio

Background: Obesity is now an important emerging public health problem in India. It is one of the major risk factor for hypertension. Overweight persons have two to six fold increase in the risk of developing hypertension. This study was carried out with objective to find out prevalence of Hypertension and assess its association with four obesity-related indices- body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR).Methods: A cross-sectional community-based study was done among 640 study subjects of age group 25-59 years during July 2015 to June 2016. Multi stage random sampling method was used. Data collection was done using WHO STEPS instrument V 3.1. Privacy and confidentiality of data was maintained. Data was entered in the Microsoft excel, collected data was checked for its completeness and correctness before data analysis with the help of PSPP software.Results: Prevalence of hypertension among study subjects was found to be 22.19% (142 out of 640).With respect to body mass index, waist circumference, waist hip ratio and waist height ratio, 4.38%, 64.35%, 85.33%, 76.2% were found to be obese respectively. Hypertension was strongly associated with BMI (p<0.001), waist circumference (p<0.001), waist hip ratio (p<0.05), waist height ratio (p<0.05). Out of the four anthropometric variables waist hip ratio (WHR) was most strongly associated with hypertension (β=420.236, p=0.007).Conclusions: The study shows a rising burden of hypertension among study population. As WHR is the best indicator for measuring obesity, so measurement of WHR should be made compulsory in healthy life style clinics along with other parameters.

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