scholarly journals SUN-049 Male Pattern Baldness and Waist-Hip Ratio as Markers of Arterial Stiffness in Transgender Men Undergoing Long-Term Testosterone Therapy

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Leonardo Azevedo Mobilia Alvares ◽  
Flávia Siqueira Cunha ◽  
Tainã Aci Amaral Oliveira ◽  
Berenice Bilharinho Mendonca ◽  
Elaine Maria Frade Costa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pharmacological Treatment ◽  
Treatment Duration ◽  
Body Hair ◽  
Testosterone Therapy ◽  
Male Pattern Baldness ◽  
Androgen Treatment ◽  
Male Pattern

Abstract Introduction: Association between male pattern baldness, also called androgenetic alopecia (AGA) and risk of coronary artery disease has been suggested by several epidemiological studies. Exogenous testosterone (T) therapy in transgender men (TM) promotes the development of alopecia in genetically susceptible individuals, and increases facial and body hair, muscle mass (MM) and visceral fat. The outcome of a long-term androgenic therapy over the functional properties of large arteries and the cardiovascular system of TM are not well stablished. Objective: To investigate the possible association between AGA and arterial stiffness assessed by measurement of carotid-femoral pulse wave velocity (VOPcf) and intima-media thickness carotid artery (cIMT) in TM receiving long-term T therapy. Methods: Forty-six TM (mean age: 43 ± 10 yo) undergoing T therapy (mean time of treatment duration: 13 ± 10 y; mean serum T levels: 611 ± 439 ng/dL) were evaluated in a cross-sectional study. Hair pattern (Ferriman & Gallway scale), grades of male pattern baldness (Hamilton-Norwood scale) and waist-hip ratio (WHR) were analyzed. Subjects were considered to have AGA if they have vertex alopecia (grade ≥ 3). Arterial Hypertension was defined as systolic blood pressure > 140 and/or diastolic blood pressure > 90mmHg or under pharmacological treatment, and dyslipidemia as total cholesterol ≥ 240 mg/dL and/or LDL-c≥ 160 mg/dL and/or HDL-c < 40 mg/dL and/or triglycerides > 200 mg/dL, or under pharmacological treatment. Current smoking has been investigated. The aortic stiffness, assessed by VOPcf and cIMT, was measured using the Complior® device and carotid ultrasound, respectively. Results: TM’s Ferriman degree was 21 ± 6 and AGA was identified in 70% of them. The WHR was 0.9 ± 0.1. TM with AGA showed higher cIMT than TM without AGA (0.66 ± 0.1mm vs. 0.54 ± 0.07mm, p = 0.001), as well as higher WHR (0.93 ± 0.08 vs.0.87 ± 0.04, p = 0.02), higher score in terminal body hair (Ferriman 23 ± 6 vs. 18 ± 6, p = 0.007) and higher frequency of hypertension (94% vs. 6%, p = 0.01). The cIMT positively correlated with age (p = 0.01) and WHR (p = 0.002). The VOPcf was positively correlated with the age (p = 0.0001), androgen treatment duration (p = 0.01) and WHR (p = 0.04). There was a positive correlation between androgen treatment duration and WHR (p = 0.01). There was no difference in the VOPcf values, age, T treatment duration, serum T levels, frequency of dyslipidemia and smoking between the groups. Conclusion: The severe vertex AGA pattern may be considered a possible marker of arterial stiffness in TM undergoing long-term testosterone therapy.

Long-term efficacy of topical minoxidil in male pattern baldness

1987 ◽  
Vol 16 (3) ◽  
pp. 711-718 ◽  
Author(s):  
Harry Irving Katz ◽  
Ngo T. Hien ◽  
Steven E. Prawer ◽  
Sandra J. Goldman
Keyword(s):  
Male Pattern Baldness ◽  
Term Efficacy ◽  
Topical Minoxidil ◽  
Male Pattern

scholarly journals Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Pieter M. Jansen ◽  
Koen Verdonk ◽  
Ben P. Imholz ◽  
A. H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Essential Hypertension ◽  
Primary Aldosteronism ◽  
Treatment Duration ◽  
Uncontrolled Hypertension ◽  
Receptor Antagonists ◽  
Aldosterone Receptor

Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported.Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available.Results. Systolic BP decreased by22±20and diastolic BP by9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was33±20and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response.Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.

scholarly journals Long-Term Burden of Higher Body Mass Index and Adult Arterial Stiffness Are Linked Predominantly Through Elevated Blood Pressure

Hypertension ◽  
2019 ◽  
Vol 73 (1) ◽  
pp. 229-234 ◽  
Author(s):  
Yang Liu ◽  
Yinkun Yan ◽  
Xiangjun Yang ◽  
Shengxu Li ◽  
Lydia Bazzano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Arterial Stiffness ◽  
Body Mass ◽  
Elevated Blood Pressure ◽  
Elevated Blood

Association between long-term blood pressure control and ten-year progression in carotid arterial stiffness among hypertensive individuals

2017 ◽  
Vol 35 (4) ◽  
pp. 862-869 ◽  
Author(s):  
Yacob G. Tedla ◽  
Adam D. Gepner ◽  
Dhananjay Vaidya ◽  
Laura Colangelo ◽  
James H. Stein ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Carotid Arterial

scholarly journals Improved glycaemic control and reduced incidence of myocardial infarctions, strokes, and mortality in men with hypogonadism and type 2 diabetes, with and without long-term testosterone therapy

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
F Saad ◽  
A Haider ◽  
K S Haider ◽  
G Doros ◽  
A Traish
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Fasting Glucose ◽  
Testosterone Therapy ◽  
Testosterone Undecanoate ◽  
Long Term Treatment ◽  
Improved Glycaemic Control

Abstract Introduction Guidelines by the ESC and EASD state that patients with diabetes have a two-fold excess risk of vascular outcomes. An increasing number of studies suggests that testosterone therapy (TTh) has cardiometabolic benefits in men with hypogonadism and type 2 diabetes (T2DM). Methods In a registry of men with hypogonadism in a urological office, 361 men had T2DM and received standard diabetes treatment including lifestyle recommendations and coaching in a diabetes center. 183 men received TTh with testosterone undecanoate injections 1000 mg/12 weeks following an initial 6-week interval (T-group). 178 men opted against TTh and served as controls (CTRL). Changes over time between groups were compared and adjusted for age, weight, waist circumference, fasting glucose, blood pressure, lipids and quality of life to account for baseline differences between the two groups. 12-year analyses of 3149 patient-years are reported. Results Mean (median) follow-up 8.2±3.2 (8) years in the T-group, 9.2±2.8 (10) years in CTRL, baseline age: 60.6±5.4 (T-group) and 63.5±5.0 (CTRL) years (p<0.0001). All but 7 patients were overweight or obese. 70 patients (38.3%) in the T-group and 70 (39.3%) in CTRL had a history of cardiovascular disease (myocardial infarction MI, stroke, or coronary artery disease diagnosis) (p=0.8341). Baseline smoking prevalence was 41.0% (75 men) in the T-group and 38.2% (68 men) in CTRL (p=0.5161). The T-group had significantly worse baseline risk factor profile than CTRL: BMI (36.5±4.5 vs. 33.4±5.3 kg/m2), systolic blood pressure (163.0±13.5 vs. 145.6±14.6 mmHg), LDL (4.7±0.9 vs. 4.1±1.4 mmol/L), HbA1c 9.4±1.4 vs. 7.8±0.7% (p<0.0001 for all). HbA1c progressively decreased by 3.7±0.2% at 12 years in the T-group and increased in CTRL by 3.2±0.2%, estimated adjusted difference between groups: −6.9% [95% CI: −7.4; −6.4] (p<0.0001 for all). Fasting glucose decreased in the T-group by 1.9±0.1 and increased in CTRL by 1.8±0.1 mmol/L, estimated adjusted difference: −3.6 mmol/L [95% CI: −4.0; −3.3] (p<0.0001 for all). Men in the T-group lost 19.7±0.4% weight, men in CTRL gained 9.1±0.4%, estimated adjusted difference: −28.8% [95% CI: −30.2; −27.4] (p<0.0001 for all). During the observation period, 15 patients (8.2%) died in the T-group vs. 61 (34.3%) in CTRL (p<0.0001). In the T-group, there were no cases of MI or stroke. In CTRL, there were 56 cases of MI (31.5%) and 56 cases of stroke (31.5%). 35 patients (19.7%) suffered a MI and a stroke. Medication adherence to testosterone was 100% as all injections were administered in the medical office and documented. Conclusions Long-term treatment with TU in men with hypogonadism and T2DM significantly reduces mortality, compared to untreated controls. Improved glycaemic control and weight loss may have contributed to these outcomes. FUNDunding Acknowledgement Type of funding sources: Private company. Main funding source(s): Bayer AG, Berlin, Germany

scholarly journals Blood Pressure and Arterial Stiffness in Association With Aircraft Noise Exposure: Long-Term Observation and Potential Effect of COVID-19 Lockdown

Hypertension ◽  
2021 ◽  
Author(s):  
Wiktoria Wojciechowska ◽  
Andrzej Januszewicz ◽  
Tomasz Drożdż ◽  
Marta Rojek ◽  
Justyna Bączalska ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Noise Exposure ◽  
Pulse Wave ◽  
Aircraft Noise ◽  
Unexposed Group

In a cross-sectional analysis of a case-control study in 2015, we revealed the association between increased arterial stiffness (pulse wave velocity) and aircraft noise exposure. In June 2020, we evaluated the long-term effects, and the impact of a sudden decline in noise exposure during the coronavirus disease 2019 (COVID-19) lockdown, on blood pressure and pulse wave velocity, comparing 74 participants exposed to long-term day-evening-night aircraft noise level > 60 dB and 75 unexposed individuals. During the 5-year follow-up, the prevalence of hypertension increased in the exposed (42% versus 59%, P =0.048) but not in the unexposed group. The decline in noise exposure since April 2020 was accompanied with a significant decrease of noise annoyance, 24-hour systolic (121.2 versus 117.9 mm Hg; P =0.034) and diastolic (75.1 versus 72.0 mm Hg; P =0.003) blood pressure, and pulse wave velocity (10.2 versus 8.8 m/s; P =0.001) in the exposed group. Less profound decreases of these parameters were noticed in the unexposed group. Significant between group differences were observed for declines in office and night-time diastolic blood pressure and pulse wave velocity. Importantly, the difference in the reduction of pulse wave velocity between exposed and unexposed participants remained significant after adjustment for covariates (−1.49 versus −0.35 m/s; P =0.017). The observed difference in insomnia prevalence between exposed and unexposed individuals at baseline was no more significant at follow-up. Thus, long-term aircraft noise exposure may increase the prevalence of hypertension and accelerate arterial stiffening. However, even short-term noise reduction, as experienced during the COVID-19 lockdown, may reverse those unfavorable effects.

scholarly journals Pengendalian Hipertensi Menggunakan Tanaman Obat Keluarga di Kelurahan Lebak Bandung

2021 ◽  
Vol 3 (3) ◽  
pp. 346
Author(s):  
Fithriyani Fithriyani ◽  
Vevi Suryenti Putri
Keyword(s):  
Blood Pressure ◽  
High Risk ◽  
Medicinal Plants ◽  
Pulmonary Edema ◽  
High Blood Pressure ◽  
Kidney Failure ◽  
Pharmacological Treatment ◽  
Heart Attack

Hypertension or high blood pressure is characterized by increased blood pressure. The incidence of hypertension continues to increase, the dangers of complications that arise, and the risks of long-term pharmacological treatment. The prevalence of hypertension tends to increase recently. Hypertension that is not treated properly has a high risk of complications including stroke, pulmonary edema, heart attack, and kidney failure. One of the efforts to prevent complications of hypertension is by controlling blood pressure regularly and controlling hypertension, one of which is by using family medicinal plants (TOGA) which are widely grown around residents' homes. The method of activities carried out is in the form of socialization by providing counseling on how to control hypertension by utilizing TOGA. Implementation of activities carried out on residents in the Lebak Bandung Village, Jambi City. The purpose of this activity is to provide an understanding to residents about how to control hypertension through TOGA and can apply it in their respective yards

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