Meta-analysis suggests small stroke benefit with vitamin B

Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers. We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery. The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP). Study bias was analyzed using the Cochrane risk-of-bias tool. Statistical analyses were performed using Review Manager. The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%. A majority of the studies showed a low or moderate risk of bias. Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P=0.02). There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P=0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P=0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P=0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P=0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P=0.93). The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12. This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.

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Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis

Neurology ◽

10.1212/wnl.0b013e3182a823cc ◽

2013 ◽

Vol 81 (15) ◽

pp. 1298-1307 ◽

Cited By ~ 54

Author(s):

Y. Ji ◽

S. Tan ◽

Y. Xu ◽

A. Chandra ◽

C. Shi ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Meta Analysis ◽

Vitamin B

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A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

Public Health Nutrition ◽

10.1017/s136898001500261x ◽

2015 ◽

Vol 19 (8) ◽

pp. 1446-1456 ◽

Cited By ~ 10

Author(s):

Nai-Hui Sun ◽

Xuan-Zhang Huang ◽

Shuai-Bo Wang ◽

Yuan Li ◽

Long-Yi Wang ◽

...

Keyword(s):

Colorectal Cancer ◽

Dose Response ◽

Meta Analysis ◽

Dietary Vitamin ◽

Vitamin B ◽

Response Relationship ◽

Dose Response Relationship ◽

Total Vitamin ◽

Linear Dose ◽

Non Linear

AbstractObjectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.DesignThe PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.SettingThe meta-analysis included seventeen studies.SubjectsA total of 10 601 patients.ResultsThe non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).ConclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

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The preventive efficacy of vitamin B supplement on the cognitive decline of elderly adults: a systematic review and meta-analysis

10.21203/rs.3.rs-50598/v2 ◽

2020 ◽

Author(s):

Shufeng Li ◽

Yuchen Guo ◽

Jie Men ◽

Hanlin Fu ◽

Ting Xu

Keyword(s):

Cognitive Impairment ◽

Cognitive Decline ◽

Meta Analysis ◽

Mean Difference ◽

Controlled Trials ◽

Vitamin B ◽

Cochrane Central Register ◽

Elderly Adults ◽

Preventive Medication ◽

Preventive Efficacy

Abstract Background: The irreversibility of cognitive impairment of Alzheimer’s disease (AD) prompts that preventing or delaying the onset of AD should be a public health priority. Vitamin B supplement can lower the serum homocysteine (Hcy) level, but whether it can prevent cognitive decline or not remains unclear. We aimed to evaluate the preventive efficacy of vitamin B supplement on the cognitive decline of elderly adults.Methods: We searched PubMed, Embase, The Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus, Science Direct, PsycINFO from inception to December 1, 2019, and then updated the retrieved results on June 1, 2020. The randomized controlled trials (RCTs) which evaluated the efficacy of vitamin B in mild cognitive impairment (MCI) patients or elderly adults without cognitive impairment were selected. Standardized mean difference (SMD) or mean difference (MD) as well as their 95% confidence interval (CI) were calculated by performing random effects models or fixed effects models.Results: A total of 21 RCTs involving 7571 participants were included for meta-analysis. The forest plots showed that there is significant effect in global cognitive function (15 RCTs, SMD: 0.36; 95% CI: 0.18 to 0.54, P < 0.01) and Hcy (11 RCTs, MD: -4.59; 95%CI: -5.51 to -3.67, P < 0.01), but there is no effect in information processing speed (10 RCTs, SMD: 0.06; 95% CI: -0.12 to 0.25, P = 0.49), episodic memory (15 RCTs, SMD: 0.10; 95% CI: -0.04 to 0.25, P = 0.16), executive function (11 RCTs, SMD: -0.21; 95% CI: -0.49 to 0.06, P = 0.13). The value of effect size and heterogeneity did not vary apparently when excluding the low-quality studies, so we could believe that the results of meta-analysis were robust.Conclusions: Vitamin B supplement might delay or maintain the cognitive decline of elderly adults. We can recommend that the vitamin B supplement should be considered as a preventive medication to MCI patients or elderly adults without cognitive impairment. More well-designed RCTs with large sample sizes were required to clarify the preventive efficacy in the future.

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Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis

Cancer Management and Research ◽

10.2147/cmar.s168413 ◽

2018 ◽

Vol Volume 10 ◽

pp. 5395-5410 ◽

Cited By ~ 7

Author(s):

Jun-Li Ma ◽

Yan Zhao ◽

Chen-Yang Guo ◽

Hong-Tao Hu ◽

Lin Zheng ◽

...

Keyword(s):

Esophageal Cancer ◽

Meta Analysis ◽

Dietary Vitamin ◽

Vitamin B

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Meta-analysis reveals protective effects of vitamin B on stroke patients

Translational Neuroscience ◽

10.1515/tnsci-2015-0014 ◽

2015 ◽

Vol 6 (1) ◽

pp. 150-156 ◽

Cited By ~ 4

Author(s):

Liping Wang ◽

Weiwei Cui ◽

Guangxian Nan ◽

Yang Yu

Keyword(s):

Acute Stroke ◽

Meta Analysis ◽

Clinical Importance ◽

Systemic Review ◽

Cochrane Library ◽

Stroke Recurrence ◽

Vitamin B ◽

Protective Effects ◽

Stroke Patients ◽

Vascular Events

AbstractStroke is the loss of brain function due to a disturbance in the blood supply to the brain resulting from either ischemia or hemorrhage. Previous studies have evaluated the clinical importance of nutritional interventions such as vitamin B supplementation in the management of acute strokes. However, it is still inconclusive whether or not vitamin B supplementation will benefit patients with acute strokes. Therefore, a meta-analysis was performed to assess the efficacy of vitamin B supplementation in the treatment of stroke patients. Medline, Embase, Scopus, and Cochrane Library databases were searched (from 1960 to June 2015) and forest plots were generated to illustrate the treatment effects. A systemic review of the electronic databases yielded 12 eligible studies consisting of 7474 patients. Forest plots from the meta-analyses of the included studies illustrated that vitamin B supplementation significantly lowered the plasma concentration of total homocysteine (SMD = -0.82; 95% CI: -0.77; Z = -29.06, p < 0.0001) and resulted in significant reduction in stroke recurrence (OR = 0.86%; 95% CI: 0.76, 0.97; Z = -2.41; p = 0.016) as well as a combined incidence of vascular events, including recurrent strokes, myocardial infarctions and vascular deaths (OR = 0.87%; 95% CI: 0.79, 0.96; Z= -2.73; p = 0.0063). Additionally, the nearly-symmetrical funnel plot (Egger’s test, t = −1.705, p = 0.1224) indicated the absence of publication bias regarding the meta-analysis that examined the effect of vitamin B supplementation on the plasma levels of homocysteine in acute stroke patients. These findings suggested that vitamin B supplementation presents a potential addition to the armamentarium for the management of acute stroke patients.

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Plasma total homocysteine status of vegetarians compared with omnivores: a systematic review and meta-analysis

British Journal Of Nutrition ◽

10.1017/s000711451200520x ◽

2013 ◽

Vol 109 (5) ◽

pp. 785-794 ◽

Cited By ~ 49

Author(s):

Derek Obersby ◽

David C. Chappell ◽

Andrew Dunnett ◽

Amalia A. Tsiami

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin B ◽

Elevated Plasma ◽

Cross Sectional ◽

Animal Products ◽

Plasma Thcy ◽

Total Homocysteine ◽

Plasma Total Homocysteine

There is strong evidence indicating that elevated plasma total homocysteine (tHcy) levels are a major independent biomarker and/or a contributor to chronic conditions, such as CVD. A deficiency of vitamin B12can elevate homocysteine. Vegetarians are a group of the population who are potentially at greater risk of vitamin B12deficiency than omnivores. This is the first systematic review and meta-analysis to appraise a range of studies that compared the homocysteine and vitamin B12levels of vegetarians and omnivores. The search methods employed identified 443 entries, from which, by screening using set inclusion and exclusion criteria, six eligible cohort case studies and eleven cross-sectional studies from 1999 to 2010 were revealed, which compared concentrations of plasma tHcy and serum vitamin B12of omnivores, lactovegetarians or lacto-ovovegetarians and vegans. Of the identified seventeen studies (3230 participants), only two studies reported that vegan concentrations of plasma tHcy and serum vitamin B12did not differ from omnivores. The present study confirmed that an inverse relationship exists between plasma tHcy and serum vitamin B12, from which it can be concluded that the usual dietary source of vitamin B12is animal products and those who choose to omit or restrict these products are destined to become vitamin B12deficient. At present, the available supplement, which is usually used for fortification of food, is the unreliable cyanocobalamin. A well-designed study is needed to investigate a reliable and suitable supplement to normalise the elevated plasma tHcy of a high majority of vegetarians. This would fill the gaps in the present nutritional scientific knowledge.

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