scholarly journals Association of Ventricular Arrhythmias with Dementia: The Atherosclerosis Risk in Communities (ARIC) Study

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011122
Author(s):  
Faye L Norby ◽  
Alvaro Alonso ◽  
Mary R Rooney ◽  
Ankit Maheshwari ◽  
Ryan J Koene ◽  
...  
Keyword(s):  
Population Based ◽  
Recording Device ◽  
Cross Sectional ◽  
Premature Ventricular Contractions ◽  
Recording Time ◽  
Atherosclerosis Risk In Communities ◽  
Wide Complex Tachycardia ◽  
Underlying Mechanisms ◽  
Sectional Analysis ◽  
Aric Study

Objective–We performed a cross-sectional analysis to determine whether nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) were associated with dementia in a population-based study.Methods– We included 2517 (mean age 79; 26% black) participants who wore a 2-week ambulatory continuous ECG recording device in 2016-17. NSVT was defined as a wide complex tachycardia ≥ 4 beats with a rate >100 beats per minute. We calculated NSVT and PVC burden as the number of episodes per day. Dementia was adjudicated by experts. We used logistic regression to assess the associations of NSVT and PVCs with dementia.Results– The mean recording time of the Zio® XT Patch was 12.6 ± 2.6 days. There were 768 (31%) participants with NSVT; prevalence was similar in whites and blacks. There were 134 (6.5%) dementia cases (5% in whites; 10% in blacks). After multivariable adjustment, there was no overall association between NSVT and dementia; however, there was a significant race interaction (p<0.001). In blacks, NSVT was associated with a 3.67 times higher adjusted odds of dementia (95% CI = 1.92-7.02) compared to those without NSVT, whereas in whites NSVT was not associated with dementia [OR (95% CI) = 0.64 (0.37-1.10)]. In blacks only, a higher burden of PVCs was associated with dementia.Conclusions– Presence of NSVT and a higher burden of NSVT and PVCs are associated with dementia in elderly blacks. Further research to confirm this novel finding and elucidate the underlying mechanisms is warranted.

Abstract P275: Growth Differentiation Factor (gdf)-15 and Metabolic Outcomes: The ARIC Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Justin B Echouffo Tcheugui ◽  
Natalie R Daya ◽  
Kunihiro Matsushita ◽  
Chiadi E Ndumele ◽  
Ron C Hoogeveen ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Differentiation Factor ◽  
Metabolic States ◽  
Unit Increase ◽  
Sectional Analysis ◽  
Roche Diagnostics ◽  
Aric Study

Introduction: Mechanistic studies suggest an involvement of growth differentiation factor 15 (GDF-15) in metabolic dysregulation. However, the potential utility of GDF-15 as a marker of diabetes or metabolic syndrome (MetS) risk remains unclear, especially in older adults. Hypothesis: GDF-15 is positively associated with biomarkers of hyperglycemia, diabetes, and MetS. Methods: We conducted a cross-sectional analysis of older adults who attended visit 6 (2016-2017) of the Atherosclerosis Risk in Communities (ARIC) Study. GDF-15 was measured using electrochemiluminescence immunoassay (Elecsys, Roche Diagnostics). Linear regression was used to assess continuous outcomes after appropriate transformations, and multivariable-adjusted odds of diabetes or MetS by quartiles of GDF-15 were derived using logistic regression. Results: Among 3,792 participants (mean age 80 years, 59% women, 23% blacks and 77% whites), higher GDF-15 concentrations (per 1-unit increase in ln[GDF-15]) were associated with higher levels of fasting plasma glucose (mg/dL) (adjusted β coefficient : 10.98, 95% CI:8.86 - 13.09) and HbA 1C (%)(0.41, 95% CI: 0.35 - 0.48). Higher GDF-15 was associated with greater odds of diabetes (adjusted odds ratio [OR]: 5.81 for highest vs. lowest GDF-15 quartile, 95% CI 4.43-7.61) and of MetS syndrome (adjusted OR: 2.57, 95% CI 2.01-3.20) among individuals without diabetes (Figure). Conclusions: In this sample of older adults, elevated GDF-15 was strongly associated with diabetes and metabolic syndrome. These data strongly suggest that GDF-15 could be a robust biomarker of adverse metabolic states.

Abstract P022: The Association of Sleep Apnea With Atrial Fibrillation and Ectopy Using Ambulatory Electrocardiogram in the Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Kapuaola S Gellert ◽  
Alvaro Alonso ◽  
Lin Y Chen ◽  
Michelle L Meyer ◽  
Elsayed Z Soliman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sleep Apnea ◽  
Hospital Discharge ◽  
Poor Quality ◽  
Premature Ventricular Contractions ◽  
Recording Time ◽  
Atherosclerosis Risk In Communities ◽  
Inverse Variance ◽  
Study Population ◽  
Aric Study

Introduction: Sleep apnea (SA) is associated with burden of atrial fibrillation (AF), but studies of SA and ectopic beats, potential triggers of AF, are sparse. Our study contributes by examining the association of SA with AF, premature atrial contractions (PACs), and premature ventricular contractions (PVCs) from 48-hour continuous ambulatory electrocardiogram (aECG) monitoring. Methods: The study population includes 716 black and 438 white participants from the ARIC 48-hour aECG ancillary study, after excluding those with a paced rhythm (n=43) or poor quality measures (n=8). SA was defined as self-reported physician diagnosis or hospital discharge records with ICD-9-CM codes for SA. Prevalent AF was defined using 48-hour aECG monitoring, study visit ECGs, or hospital discharge code (427.3) since study baseline in 1986-1987. PACs and PVCs were defined if ectopy was present 1-5% (occasional) and >5% (frequent) of the recording time versus <1% of the recording time (referent). Multivariable logistic regression was used to examine this association with inverse variance weighting to account for the sampling and non-response. Results: Participants with SA (unweighted N=217) were more likely to be female (55%), white race (52%), current smokers (57%), have hypertension (82%), and be obese (57%). Participants with SA were 7.3 (95% CI: 3.7, 14.5) times more likely to have AF compared to those without SA after adjusting for covariates. Compared to participants without SA, the relative odds of occasional and frequent PACs versus the referent was increased by 20% and 50% respectively among participants with SA after adjusting for confounders, although not statistically significant. The association was similar and not statistically significant for frequent PVCs. Conclusions: In a community-based population using standardized 48-hour aECG monitoring, SA was associated with prevalent AF, but not significantly associated with PACs or PVCs. Further study is needed to establish mechanisms that link SA and cardiac arrhythmias.

scholarly journals The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiajing Jia ◽  
Ying Yang ◽  
Fangchao Liu ◽  
Minjin Zhang ◽  
Qin Xu ◽  
...  
Keyword(s):  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Population Based ◽  
Reproductive Age ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Serum Alanine Aminotransferase ◽  
Cross Sectional Analysis ◽  
Registration Data ◽  
Sectional Analysis

Abstract Background Inconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated the association between ALT and hypertension among Chinese reproductive-age population by utilizing registration data from National Free Pre-pregnancy Checkups Project in 2016–2017. Methods The 21,103,790 registered participants were eligible for analysis, including women who were 20–49 years old and men who were 20–59 years old with available data for ALT and blood pressure (BP). Logistic regression was conducted to estimate odds ratio (OR) for the association between ALT and hypertension as a binary outcome. Linear regression was used to examine the association between ALT and BP as a continuous outcome. Results In total, 4.21% of the participants were hypertensive, and 11.67% had elevated ALT (> 40 U/L). Hypertension prevalence was 3.63% and 8.56% among participants with normal and elevated ALT levels. A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders. The multivariable-adjusted ORs for hypertension were 1, 1.22 (1.21, 1.22), 1.67 (1.65 1.68), 1.78 (1.76, 1.80), and 1.92 (1.90, 1.94) in participants with ALT levels of ≤ 20, 20.01–40, 40.01–60, 60.01–80, and > 80 U/L, respectively. Systolic and diastolic BPs rose by 1.83 and 1.20 mmHg on average, for each 20 U/L increase in ALT (P for trend < 0.001). The association was consistent among subgroups and tended to be stronger among populations who are overweight (body mass index ≥ 24 kg/m2) (χ2 = 52,228, P < 0.001), alcohol drinking (χ2 = 100,730, P < 0.001) and cigarette smoking (χ2 = 105,347, P < 0.001). Conclusions Our cross-sectional analysis suggested a linear association between serum ALT and hypertension or BP, which indicated that abnormal liver metabolism marked by elevated serum ALT could play a role in hypertension or elevated BP condition.

Abstract 12385: Past Alcohol Consumption and Incident Atrial Fibrillation

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Shalini Dixit ◽  
Alvaro Alonso ◽  
Elsayed Z Soliman ◽  
Lin Y Chen ◽  
Gregory M Marcus
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Population Based ◽  
Self Report ◽  
Atherosclerosis Risk In Communities ◽  
Increased Risk ◽  
Before And After ◽  
Dietary Intake Assessment ◽  
Aric Study

Introduction: Although current alcohol consumption appears to be a risk factor for incident atrial fibrillation (AF), limitations related to self-reported alcohol use and confounding in observational studies limit the certainty of conclusions regarding causality. Whether cessation of alcohol consumption can protect against incident AF remains unknown. Methods: We examined all participants in the Atherosclerosis Risk in Communities (ARIC) study, a population-based cohort of 15,792 men and women aged 45-65, without prevalent AF. Past alcohol consumption was assessed via self-report during the baseline dietary intake assessment. Cases of incident AF were ascertained via study ECGs, hospital discharge ICD-9 codes, and death certificates. Results: Among 15,262 participants with complete survey data, 2,898 (19.0%) were former drinkers. During an average follow-up of 17.4 years, there were 380 cases of incident AF in former consumers. Both before and after adjustment for potential confounders, a longer duration of alcohol abstinence was associated with a lower risk of developing AF; previously consuming alcohol for a longer duration and consuming a greater quantity of alcohol were each associated with a higher risk of developing AF (Table). Conclusions: Among former drinkers, the number of years of drinking and the amount of alcohol consumed may each confer an increased risk of AF. Given that a longer duration of abstinence was associated with a decreased risk of AF, modification of alcohol use could potentially play a role in AF prevention.

Non-pharmacological management of adult asthma in Australia: cross-sectional analysis of a population-based cohort study

2018 ◽  
Vol 57 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Daniel J. Tan ◽  
John A. Burgess ◽  
Jennifer L. Perret ◽  
Dinh S. Bui ◽  
Michael J. Abramson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Cross Sectional ◽  
Pharmacological Management ◽  
Adult Asthma ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Comorbidities in adults with asthma: Population-based cross-sectional analysis of 1.4 million adults in Scotland

2017 ◽  
Vol 47 (10) ◽  
pp. 1246-1252 ◽  
Author(s):  
C. J. Weatherburn ◽  
B. Guthrie ◽  
S. W. Mercer ◽  
D. R. Morales
Keyword(s):  
Population Based ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

Abstract P047: Circulating Levels of the DDT Metabolite p,p'-DDE are Related to Prevalent Hypertension in the Elderly

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Monica Lind ◽  
Samira Salihovic ◽  
Bert v Bavel ◽  
Lars Lind
Keyword(s):  
Blood Pressure ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
The Elderly ◽  
Population Based ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Experimental Findings ◽  
Sectional Analysis ◽  
Circulating Levels

Background: Exposure to PCBs and dioxin to experimental animals increase blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample. Methods: 1016 subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Hypertension was defined as either use of antihypertensive treatment or blood pressure > 140/90 mmHg. Twenty-one different POPs, including 16 PCBs, three pesticides (HCB, DDE and TNK), one dioxin (OCDD) and one brominated compound (BDE47) were analyzed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS) at age 70. Results: 732 subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, several of the PCBs with a low number of chlorine atoms (PCB74, 99, 105, 118 and 138) were related to prevalent hypertension. Also the OC pesticides, HCB, TNK, pp-DDE, and the brominated compound BDE47 were related to hypertension. The strongest of these associations were seen for pp-DDE (OR 1.35 for a SD change, 95%CI 1.17-1.56, p<0.0001). Following further adjustment for serum cholesterol and triglycerides, BMI, smoking, education and exercise habits, only pp-DDE was still significant (OR 1.23 for a SD change, 95%CI 1.06- 1.43, p=0.006). Conclusion: In this cross-sectional analysis of an elderly population, high levels of circulating levels of pp-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure.

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