World Health Organization Grade II Gliomas and Subventricular Zone: Anatomic, Genetic, and Clinical Considerations

Neurosurgery ◽  
2011 ◽  
Vol 68 (5) ◽  
pp. 1293-1299 ◽  
Author(s):  
Francesco Vergani ◽  
Juan Martino ◽  
Catherine Gozé ◽  
Valérie Rigau ◽  
Hugues Duffau
Keyword(s):  
World Health Organization ◽  
Subventricular Zone ◽  
Magnetic Resonance Images ◽  
World Health ◽  
Allelic Loss ◽  
Grade Ii ◽  
Group 2 ◽  
Health Organization ◽  
The Relationship ◽  
Group 1

Abstract BACKGROUND: Recent studies suggest a possible origin of human gliomas from subventricular zone (SVZ) stem cells. OBJECTIVE: To evaluate the relationship of World Health Organization grade II gliomas (GIIGs) with the SVZ and to investigate the presence of different genetic patterns, depending on their relationship with the SVZ. METHODS: Forty-three consecutive patients were operated on for GIIG. Preoperative fluid-attenuated inversion recovery-weighted magnetic resonance images were reviewed to assess the presence of cortical involvement and the relationship between gliomas and the SVZ. Patients were divided into 2 groups: group 1, tumors in contact with the SVZ; and group 2, tumors not in contact with the SVZ. Preoperative and postoperative tumor volumes were calculated. Genetic analysis was performed to study 1p19q allelic loss. RESULTS: Twenty-four patients were in group 1 and 19 in group 2. All tumors were in contact with the cortex. Preoperative volume was significantly larger in group 1 than in group 2 (P = .003). The proportion of total and subtotal resections was higher in group 2 (P = .01). Insular tumors never showed 1p19q codeletions. Noninsular tumors exhibited a significantly different incidence of complete 1p19q codeletion, with allelic loss more common in group 1 (P = .03). CONCLUSION: GIIGs showed a constant relationship with the cortex and a larger volume when they came in contact with the ventricles. A distinct genetic pattern was found in noninsular SVZ GIIGs. This parameter can be considered for therapeutic management.

Association between fluorine-18–labeled fluorodeoxyglucose uptake and 1p and 19q loss of heterozygosity in World Health Organization Grade II gliomas

2007 ◽  
Vol 106 (4) ◽  
pp. 633-637 ◽  
Author(s):  
Florian Stockhammer ◽  
Ulrich-Wilhelm Thomale ◽  
Michail Plotkin ◽  
Christian Hartmann ◽  
Andreas von Deimling
Keyword(s):  
World Health Organization ◽  
Fdg Pet ◽  
Magnetic Resonance Images ◽  
World Health ◽  
Low Grade ◽  
Who Grade ◽  
Fdg Uptake ◽  
Grade Ii ◽  
Health Organization ◽  
Who Grade Ii Gliomas

Object Oligodendroglial tumors harboring combined 1p and 19q loss (1p/19q LOH) are characterized by a favorable prognosis and response to chemotherapy and radiotherapy, but detection of 1p/19q LOH relies on postoperative procedures. The authors investigated the potential of fluorine-18–labeled fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) to predict 1p/19q LOH preoperatively in tumors whose appearance on initial magnetic resonance images was consistent with that of low-grade glioma. Methods The study population comprised 25 patients who had undergone preoperative FDG-PET followed by tumor resection. Neuronavigation ensured a precise match of FDG uptake wi th the site of biopsy. All tumor specimens were graded according to the World Health Organization (WHO) classification system. Microsatellite analysis was used to identify 1p/19q LOH. In this series, 16 of 25 gliomas corresponded to WHO Grade II. In eight of these 16, 1p/19q LOH was detected. Raised glucose utilization within the tumor was seen in the six of eight WHO Grade II gliomas with 1p/19q LOH and in none of the WHO Grade II gliomas without this genetic alteration (p = 0.003). Conclusions These findings demonstrate the potential of FDG-PET to predict 1p/19q LOH in WHO Grade II gliomas.

scholarly journals How Experts React: The World Health Organization’s Appraisal of COVID-19 via Communication Patterns

2021 ◽  
pp. 0261927X2110263
Author(s):  
David M. Markowitz
Keyword(s):  
World Health Organization ◽  
Cognitive Processing ◽  
Communication Patterns ◽  
World Health ◽  
Working Through ◽  
The World ◽  
Internal States ◽  
Health Organization ◽  
The Relationship ◽  
Health Experts

How do COVID-19 experts psychologically manage the pandemic and its effects? Using a full year of press briefings (January 2020–January 2021) from the World Health Organization ( N = 126), this paper evaluated the relationship between communication patterns and COVID-19 cases and deaths. The data suggest as COVID-19 cases and deaths increased, health experts tended to think about the virus in a more formal and analytic manner. Experts also communicated with fewer cognitive processing terms, which typically indicate people “working through” a crisis. This report offers a lens into the internal states of COVID-19 experts and their organization as they gradually learned about the virus and its daily impact.

scholarly journals Health and fertility in World Health Organization group 2 anovulatory women

2012 ◽  
Vol 18 (5) ◽  
pp. 586-599 ◽  
Author(s):  
◽  
D. T. Baird ◽  
A. Balen ◽  
H. F. Escobar-Morreale ◽  
J. L. H. Evers ◽  
...  
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Group 2 ◽  
Health Organization

scholarly journals When to resume bariatric surgery after COVID-19 pandemic?: results of patients’ and surgeons’ survey

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alicja Dudek ◽  
Michał Wysocki ◽  
Maciej Walędziak ◽  
Jacek Szeliga ◽  
Monika Proczko-Stepaniak ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Body Mass Index ◽  
World Health ◽  
Online Surveys ◽  
The World ◽  
Bariatric Patients ◽  
Group 2 ◽  
Health Organization ◽  
Current Body Mass Index ◽  
Group 1

Abstract Background Coronavirus Disease 2019 is affecting most countries around the world, including Poland. In response, all elective surgeries have been postponed. We asked patients and surgeons when they want bariatric surgery to resume after pandemic. The main aim of the study was to determine patients’ and surgeons’ expectations about when to resume bariatric surgery regarding COVID-19 pandemic state. Methods The study was conducted in two groups: Group 1—bariatric patients; Group 2—bariatric surgeons. Two online surveys were distributed. Results A total of 895 patients, 299 before, 596 after surgery and 32 surgeons took part in survey. All patients and surgeons declared willingness to resume bariatric surgeries after pandemic and responded that they should be resumed immediately the World Health Organization announces end of pandemic (42%). The majority of patients before surgery answered that bariatric procedures should be resumed immediately the number of daily incidents begins to decrease (53%). In the patient group, current body mass index (p < 0.001) and contact with COVID+/quarantined persons (p < 0.001) had impact on the response to resumption of bariatric procedures. Conclusions Patients opted to wait for bariatric surgery until the oncological queue has become shorter. Surgeons presented a readiness to resume both procedures in parallel.

Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas

2006 ◽  
Vol 60 (3) ◽  
pp. 380-383 ◽  
Author(s):  
Johan Pallud ◽  
Emmanuel Mandonnet ◽  
Hugues Duffau ◽  
Michèle Kujas ◽  
Rémy Guillevin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
World Health Organization ◽  
Growth Rates ◽  
Prognostic Value ◽  
World Health ◽  
Resonance Imaging ◽  
Grade Ii ◽  
Health Organization

Differentiating Diffuse World Health Organization Grade II and IV Astrocytomas With Ex Vivo Magnetic Resonance Spectroscopy

Neurosurgery ◽  
2013 ◽  
Vol 72 (2) ◽  
pp. 186-195 ◽  
Author(s):  
Riyas Vettukattil ◽  
Michel Gulati ◽  
Torill E. Sjøbakk ◽  
Asgeir S. Jakola ◽  
Nadja A.M. Kvernmo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
World Health Organization ◽  
Ex Vivo ◽  
World Health ◽  
Resonance Spectroscopy ◽  
Grade Ii ◽  
Health Organization

scholarly journals Analysing Tuberculosis Trends in South Asia

2018 ◽  
Vol 8 (6) ◽  
pp. 5245
Author(s):  
Kumar Abhishek ◽  
M. P Singh ◽  
Md. Sadik Hussain
Keyword(s):  
Sri Lanka ◽  
World Health Organization ◽  
South Asia ◽  
Causes Of Death ◽  
Temporal Variations ◽  
World Health ◽  
Spatial And Temporal Variations ◽  
The World ◽  
Health Organization ◽  
The Relationship

<p>Tuberculosis (TB) has been one of the top ten causes of death in the world. As per the World Health Organization (WHO) around 1.8 million people have died due to tuberculosis in 2015. This paper aims to investigate the spatial and temporal variations in TB incident in South Asia (India, Bangladesh, Pakistan, Maldives, Nepal, and Sri-Lanka). Asia had been counted for the largest number of new TB cases in 2015. The paper underlines and relates the relationship between various features like gender, age, location, occurrence, and mortality due to TB in these countries for the period 1993-2012.</p>

scholarly journals When to Resume Bariatric Surgery after COVID-19 Pandemic? – Results of Patients’ and Surgeons’ Survey.

2020 ◽  
Author(s):  
Aicja Dudek ◽  
Alicja Dudek ◽  
Michał Wysocki ◽  
Maciej Walędziak ◽  
Jacek Szeliga ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Body Mass Index ◽  
World Health ◽  
Online Surveys ◽  
The World ◽  
Bariatric Patients ◽  
Group 2 ◽  
Health Organization ◽  
Current Body Mass Index ◽  
Group 1

Abstract BackgroundCOVID-19 is affecting most countries around the world, including Poland. In response, all elective surgeries have been postponed. We asked patients and surgeons when they want bariatric surgery to resume after pandemic. The main aim of the study was to determine patients’ and surgeons’ expectations about when to resume bariatric surgery regarding COVID-19 pandemic state.MethodsThe study was conducted in two groups: Group 1 – bariatric patients; Group 2 – bariatric surgeons. Two online surveys were distributed.Results A total of 895 patients, 299 before, 596 after surgery and 32 surgeons took part in survey. All patients and surgeons declared willingness to resume bariatric surgeries after pandemic and responded that they should be resumed immediately the World Health Organization announces end of pandemic (42%). The majority of patients before surgery answered that bariatric procedures should be resumed immediately the number of daily incidents begins to decrease (53%). In the patient group, current body mass index (p<0.001) and contact with COVID+/quarantined persons (p<0.001) had impact on the response to resumption of bariatric procedures.ConclusionsPatients opted to wait for bariatric surgery until the oncological queue has become shorter. Surgeons presented a readiness to resume both procedures in parallel.

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