Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans
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Animals subjected to dietary restriction (DR) have reduced body size, low fecundity, slower development, lower fat content and longer life span. We identified lamin as a regulator of multiple dietary restriction phenotypes. Downregulation of lmn-1, the single Caenorhabditis elegans lamin gene, increased animal size and fat content, specifically in DR animals. The LMN-1 protein acts in the mTOR pathway, upstream to RAPTOR and S6K, key component and target of mTOR complex 1 (mTORC1), respectively. DR excludes the mTORC1 activator RAGC-1 from the nucleus. Downregulation of lmn-1 restores RAGC-1 to the nucleus, a necessary step for the activation of the mTOR pathway. These findings further link lamin to metabolic regulation.
2020 ◽
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2016 ◽
Vol 113
(32)
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pp. E4620-E4629
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2017 ◽
Vol 74
(8)
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pp. 1198-1205
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2017 ◽
Vol 72
(10)
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pp. 1311-1318
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