scholarly journals Functional monopolar spindles caused by mutation in mgr, a cell division gene of Drosophila melanogaster

1988 ◽  
Vol 89 (1) ◽  
pp. 39-47 ◽  
Author(s):  
C. Gonzalez ◽  
J. Casal ◽  
P. Ripoll
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Division ◽  
Genetic Analysis ◽  
Normal Chromosome ◽  
Phenotypic Traits ◽  
Polyploid Cells ◽  
A Cell

Mutation in the gene merry-go-round (mgr) of Drosophila causes a variety of phenotypic traits in somatic and germinal tissues, such as polyploid cells, metaphasic arrest, postmeiotic cysts with 16 nuclei, and spermatids with four times the normal chromosome content. The most characteristic phenotype is the appearance of mitotic and meiotic figures where all chromosomes are arranged in a circle. Treatment with anti-mitotic drugs and the phenotype of double mutants mgr asp (asp being a mutation altering the spindle) show that these circular figures need a functional spindle for their formation. These abnormal figures are caused by monopolar spindles similar to those observed after different treatments in several organisms. All mutant traits indicate that mgr performs a function necessary for the correct behaviour of centrosomes, thus opening this organelle to genetic analysis.

scholarly journals The Lethal Effect of a Benzamide Derivative, 3-Methoxybenzamide, Can Be Suppressed by Mutations within a Cell Division Gene, ftsZ, in Bacillus subtilis

1999 ◽  
Vol 181 (4) ◽  
pp. 1348-1351 ◽  
Author(s):  
Yoshiaki Ohashi ◽  
Yoshie Chijiiwa ◽  
Koichiro Suzuki ◽  
Kouki Takahashi ◽  
Hideaki Nanamiya ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Cell Division ◽  
Genetic Analysis ◽  
Vegetative Growth ◽  
Lethal Effect ◽  
Primary Target ◽  
A Cell ◽  
Resistant Mutants ◽  
Adp Ribosyltransferase ◽  
Division System

ABSTRACT 3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

Analysis of gene expression during development in the homeotic mutant Contrabithorax of Drosophila melanogaster

Development ◽  
1975 ◽  
Vol 34 (1) ◽  
pp. 19-31
Author(s):  
Gines Morata
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Genetic Analysis ◽  
Normal Level ◽  
X Rays ◽  
Wild Type ◽  
Homeotic Transformation ◽  
Homeotic Mutant ◽  
A Cell ◽  
Final Expression

Contrabithorax, a mutant of the bithorax system in Drosophila melanogaster produces a partial homeotic transformation of mesothorax (wing) into metathorax (haltere). The wing of a fly homozygous or heterozygous for the mutant is a mosaic of wing and haltere structures. A genetic analysis of the mutant suggests that its phenotype is due to some form of derepression in the wing of two other genes of the bithorax system (bithorax and postbithorax) which are not normally active there. This repression is not complete. The activity of the two genes is below the normal level resulting in only a partial transformation of wing into haltere. Clones of marked cells were generated by X-rays and were found to include both transformed (haltere) and untransformed (wing) territory; this was true even for those generated late in development. Thus the final expression of a cell depends not on its immediate ancestry but perhaps on the level of the products of the wild-type alleles of bithorax and postbithorax.

scholarly journals A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females.

Genetics ◽  
1995 ◽  
Vol 139 (4) ◽  
pp. 1649-1661 ◽  
Author(s):  
B A Chase ◽  
B S Baker
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Analysis ◽  
Sexual Differentiation ◽  
Point Mutations ◽  
Regulatory Genes ◽  
Sexually Dimorphic ◽  
Specific Product ◽  
Sex Type ◽  
A Cell ◽  
Female Specific

Abstract Sex-type in Drosophila melanogaster is controlled by a hierarchically acting set of regulatory genes. At the terminus of this hierarchy lie those regulatory genes responsible for implementing sexual differentiation: genes that control the activity of target loci whose products give rise to sexually dimorphic phenotypes. The genetic analysis of the intersex (ix) gene presented here demonstrates that ix is such a terminally positioned regulatory locus. The ix locus has been localized to the cytogenetic interval between 47E3-6 and 47F11-18. A comparison of the morphological and behavioral phenotypes of homozygotes and hemizygotes for three point mutations at ix indicates that the null phenotype of ix is to transform diplo-X animals into intersexes while leaving haplo-X animals unaffected. Analysis of X-ray induced, mitotic recombination clones lacking ix+ function in the abdomen of diplo-X individuals indicates that the ix+ product functions in a cell-autonomous manner and that it is required at least until the termination of cell division in this tissue. Taken together with previous analyses, our results indicate that the ix+ product is required to function with the female-specific product of doublesex to implement appropriate female sexual differentiation in diplo-X animals.

scholarly journals A GENETIC ANALYSIS OF THE KILLER-PRUNE (K-pn) LOCUS OF DROSOPHILA MELANOGASTER

Genetics ◽  
1969 ◽  
Vol 62 (2) ◽  
pp. 353-358
Author(s):  
Eliezer Lifschytz ◽  
Raphael Falk
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Analysis

scholarly journals THE SELECTION OF S. CEREVISIAE MUTANTS DEFECTIVE IN THE START EVENT OF CELL DIVISION

Genetics ◽  
1980 ◽  
Vol 95 (3) ◽  
pp. 561-577 ◽  
Author(s):  
Steven I Reed
Keyword(s):  
Cell Division ◽  
Genetic Analysis ◽  
Linkage Map ◽  
Nuclear Genes ◽  
Temperature Sensitive ◽  
Restrictive Temperature ◽  
Mating Pheromone ◽  
Preliminary Characterization ◽  
Complementation Groups ◽  
Selection Of

ABSTRACT Thirty-three temperature-sensitive mutations defective in the start event of the cell division cycle of Saccharomyces cereuisiae were isolated and subjected to preliminary characterization. Complementation studies assigned these mutations to four complementation groups, one of which, cdc28, has been described previously. Genetic analysis revealed that these complementation groups define single nuclear genes, unlinked to one another. One of the three newly identified genes, cdc37, has been located in the yeast linkage map on chromosome IV, two meiotic map units distal to hom2.—Each mutation produces stage-specific arrest of cell division at start, the same point where mating pheromone interrupts division. After synchronization at start by incubation at the restrictive temperature, the mutants retain the capacity to enlarge and to conjugate.

scholarly journals The gene responsible for Werner syndrome may be a cell division "counting" gene.

1993 ◽  
Vol 90 (24) ◽  
pp. 12030-12034 ◽  
Author(s):  
R. G. Faragher ◽  
I. R. Kill ◽  
J. A. Hunter ◽  
F. M. Pope ◽  
C. Tannock ◽  
...  
Keyword(s):  
Cell Division ◽  
Werner Syndrome ◽  
A Cell

Inhibition of DNA synthesis and cell division by a cell surface sialoglycopeptide

1989 ◽  
Vol 139 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Heideh Fattaey ◽  
Terry C. Johnson ◽  
Hsin-Hwei Chou
Keyword(s):  
Cell Division ◽  
Cell Surface ◽  
Dna Synthesis ◽  
A Cell ◽  
Inhibition Of Dna Synthesis
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