Maintenance of multiplication rate stability by cell populations in the face of heterogeneity among individual cells

1988 ◽  
Vol 91 (4) ◽  
pp. 571-576 ◽  
Author(s):  
R. Grundel ◽  
H. Rubin
Keyword(s):  
Growth Rates ◽  
Cell Populations ◽  
Multiplication Rate ◽  
Population Growth Rates ◽  
Wide Range ◽  
Constant Multiplication ◽  
Embryo Cells ◽  
The Face ◽  
Nih 3T3 ◽  
Slow Growing

We addressed the question of how a population of cells can maintain a constant multiplication rate given the heterogeneity of its individual members. Using the NIH 3T3 line of mouse embryo cells, comparisons were made of multiplication rates between offspring subclones and the parental clones from which the subclones were derived. Parents at all levels of multiplication rate produced offspring with a wide range of multiplication rates. Offspring from parent cells with the highest growth rates rarely exceeded their parents in rate of multiplication. Offspring from slow-growing parents, however, often exceeded the parents. It is concluded that the multiplication of NIH 3T3 populations represents constant diversification in multiplication rate: heterogeneous parents producing heterogeneous offspring. Population growth rates can remain stable because the fastest-growing parents generally produce offspring that multiply slower than the parents while the slowest parents often produce offspring that multiply faster than the parents.

scholarly journals Estimates of regional annual abundance and population growth rates of white sharks off central California

2021 ◽  
Vol 257 ◽  
pp. 109104
Author(s):  
Paul E. Kanive ◽  
Jay J. Rotella ◽  
Taylor K. Chapple ◽  
Scot D. Anderson ◽  
Timothy D. White ◽  
...  
Keyword(s):  
Population Growth ◽  
Growth Rates ◽  
Central California ◽  
Population Growth Rates

scholarly journals Deeply Learned Pose Invariant Image Analysis with Applications in 3D Face Recognition

2019 ◽  
Vol 2019 ◽  
pp. 1-21 ◽  
Author(s):  
Naeem Ratyal ◽  
Imtiaz Ahmad Taj ◽  
Muhammad Sajid ◽  
Anzar Mahmood ◽  
Sohail Razzaq ◽  
...  
Keyword(s):  
Face Recognition ◽  
Superior Performance ◽  
Support Vector ◽  
Complex Nature ◽  
Alignment Algorithm ◽  
3D Face Recognition ◽  
3D Face ◽  
Norm Minimization ◽  
Wide Range ◽  
The Face

Face recognition aims to establish the identity of a person based on facial characteristics and is a challenging problem due to complex nature of the facial manifold. A wide range of face recognition applications are based on classification techniques and a class label is assigned to the test image that belongs to the unknown class. In this paper, a pose invariant deeply learned multiview 3D face recognition approach is proposed and aims to address two problems: face alignment and face recognition through identification and verification setups. The proposed alignment algorithm is capable of handling frontal as well as profile face images. It employs a nose tip heuristic based pose learning approach to estimate acquisition pose of the face followed by coarse to fine nose tip alignment using L2 norm minimization. The whole face is then aligned through transformation using knowledge learned from nose tip alignment. Inspired by the intrinsic facial symmetry of the Left Half Face (LHF) and Right Half Face (RHF), Deeply learned (d) Multi-View Average Half Face (d-MVAHF) features are employed for face identification using deep convolutional neural network (dCNN). For face verification d-MVAHF-Support Vector Machine (d-MVAHF-SVM) approach is employed. The performance of the proposed methodology is demonstrated through extensive experiments performed on four databases: GavabDB, Bosphorus, UMB-DB, and FRGC v2.0. The results show that the proposed approach yields superior performance as compared to existing state-of-the-art methods.

Lymphoedema after head and neck cancer treatment: an overview for clinical practice

2021 ◽  
Vol 26 (Sup4) ◽  
pp. S24-S29
Author(s):  
Claire Jeans ◽  
Bena Brown ◽  
Elizabeth C Ward ◽  
Anne E Vertigan
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Lymphatic System ◽  
Review Article ◽  
Psychological Issues ◽  
Wide Range ◽  
The Face ◽  
Protein Rich ◽  
The Impact

Lymphoedema is a disorder of the lymphatic system that presents as an atypical swelling and accumulation of protein-rich fluid within the interstitial spaces. Head and neck lymphoedema (HNL) is highly prevalent in patients who have been treated for head and neck cancer (HNC) and may manifest externally on the face and neck; internally within the oral cavity, pharynx or larynx; or as a combination of both. HNL is known to contribute to a wide range of physical, functional and psychological issues, and presents several unique challenges in terms of its management. This review article provides an overview of HNL for clinicians and aims to improve awareness of this condition and the impact it has on patients.

scholarly journals Role of carbon allocation efficiency in the temperature dependence of autotroph growth rates

2018 ◽  
Vol 115 (31) ◽  
pp. E7361-E7368 ◽  
Author(s):  
Bernardo García-Carreras ◽  
Sofía Sal ◽  
Daniel Padfield ◽  
Dimitrios-Georgios Kontopoulos ◽  
Elvire Bestion ◽  
...  
Keyword(s):  
Growth Rate ◽  
Temperature Dependence ◽  
Growth Rates ◽  
Carbon Allocation ◽  
Thermal Sensitivity ◽  
Potential Growth ◽  
Allocation Efficiency ◽  
Population Growth Rates ◽  
Performance Curves

Relating the temperature dependence of photosynthetic biomass production to underlying metabolic rates in autotrophs is crucial for predicting the effects of climatic temperature fluctuations on the carbon balance of ecosystems. We present a mathematical model that links thermal performance curves (TPCs) of photosynthesis, respiration, and carbon allocation efficiency to the exponential growth rate of a population of photosynthetic autotroph cells. Using experiments with the green alga, Chlorella vulgaris, we apply the model to show that the temperature dependence of carbon allocation efficiency is key to understanding responses of growth rates to warming at both ecological and longer-term evolutionary timescales. Finally, we assemble a dataset of multiple terrestrial and aquatic autotroph species to show that the effects of temperature-dependent carbon allocation efficiency on potential growth rate TPCs are expected to be consistent across taxa. In particular, both the thermal sensitivity and the optimal temperature of growth rates are expected to change significantly due to temperature dependence of carbon allocation efficiency alone. Our study provides a foundation for understanding how the temperature dependence of carbon allocation determines how population growth rates respond to temperature.

4D ARCHITEKTŪROJE

2011 ◽  
Vol 35 (1) ◽  
pp. 28-37 ◽  
Author(s):  
Kęstutis Lupeikis ◽  
Algimantas M. Mačiulis
Keyword(s):  
Modern Architecture ◽  
Fourth Dimension ◽  
Video Installation ◽  
Internal Structures ◽  
Wide Range ◽  
The Face ◽  
Intention To Change ◽  
Contemporary Architecture

Recently, among other processes in modern architecture, a lot more attention is expressed towards the fourth dimension (4D). This process is caused as an opposition to pragmatic functionalism, utilitarity, unification, formal deconstructyvism, sophistication. The expression of 4D in contemporary architecture is an intention to change the face of modern architecture, giving it more expressiveness, modern innovation. It results in specific aims and priorities of architectural expression. Architecture of today contains a variety of artistic areas (video, installation, painting, sculpture, graphics) as integral parts of its surface or internal structures. A building becomes an object of interdisciplinary art. The integration of interactive hypersurfaces in exteriors and interiors leads to various aspects of 4D in modern architecture. The paper discusses various aspects of 4D in architecture, excluding several marginal cases showing a wide range of aspects and priorities. Santrauka Pastaruoju metu, šalia kitų reiškinių, šiuolaikinėje architektūroje vis aktyviau reiškiasi ketvirtosios dimensijos vaidmuo. Šį procesą lemia priešprieša pragmatiškam funkcionalizmui, utilitarumui, unifikacijai, formaliam dekonstrukciniam laužymui, įmantrumui, daugžodžiavimui. 4D raišką šiuolaikinėje architektūroje formuoja siekis keisti architektūros „veidą“, suteikiant jai daugiau išraiškingumo, įtaigumo ir šiuolaikinio novatoriškumo. Tai lemia specifinius architektūrinės raiškos tikslus ir prioritetus. Šiuolaikinė architektūra įtraukia į save įvairių meno krypčių (videomenas, instaliacija, tapyba, skulptūra, grafika) elementus ne kaip atskirus meno objektus, o kaip neatsiejamus pastato paviršiaus ar vidaus struktūrinius darinius. Pastatas tampa tarpdisciplininiu meno objektu. Interaktyvių hiperpaviršių integravimasis eksterjere ir interjere lemia įvairius ketvirtosios dimensijos aspektus šiuolaikinėje architektūroje, kurie ir yra nagrinėjami šiame straipsnyje. Straipsnyje aptariami įvairūs ketvirtosios dimensijos šiuolaikinėje architektūroje aspektai ir sritys, išskiriami kraštutiniai, charakteringi atvejai, atspindintys platų tikslų ir prioritetų diapazoną. Aptariami, autorių manymu, charakteringiausi šios raiškos atvejai, daugiausiai dėmesio skiriant hiperpaviršių įtakai ketvirtosios dimensijos pasireiškimui šiuolaikinėje architektūroje.

scholarly journals Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF

2017 ◽  
Vol 24 (9) ◽  
pp. 459-474 ◽  
Author(s):  
W Imruetaicharoenchoke ◽  
A Fletcher ◽  
W Lu ◽  
R J Watkins ◽  
B Modasia ◽  
...  
Keyword(s):  
Colony Formation ◽  
Human Cancer ◽  
Soft Agar ◽  
Cellular Migration ◽  
3T3 Fibroblasts ◽  
Wide Range ◽  
Functional Consequences ◽  
Altered Cell ◽  
Proliferation Assays ◽  
Nih 3T3

Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and significantly associated with poorer oncological outcomes, such as early tumour recurrence, distant metastasis, extramural vascular invasion and decreased disease-specific survival. PBF transforms NIH 3T3 fibroblasts and induces tumours in nude mice, while mice harbouring transgenic thyroidal PBF expression show hyperplasia and macrofollicular lesions. Our assumption that PBF becomes an oncogene purely through increased expression has been challenged by the recent report of mutations in PBF within the Catalogue of Somatic Mutations in Cancer (COSMIC) database. We therefore sought to determine whether the first 10 PBF missense substitutions in human cancer might be oncogenic. Anisomycin half-life studies revealed that most mutations were associated with reduced protein stability compared to wild-type (WT) PBF. Proliferation assays narrowed our interest to two mutational events which significantly altered cell turnover: C51R and R140W. C51R was mainly confined to the endoplasmic reticulum while R140W was apparent in the Golgi apparatus. Both C51R and R140W lost the capacity to induce cellular migration and significantly reduced cell invasion. Colony formation and soft agar assays demonstrated that, in contrast to WT PBF, both mutants were unable to elicit significant colony formation or anchorage-independent growth. However, C51R and R140W retained the ability to repress radioiodide uptake, a functional hallmark of PBF. Our data reveal new insight into PBF function and confirm that, rather than being oncogenic, mutations in PBF are likely to be passenger effects, with overexpression of PBF the more important aetiological event in human cancer.

scholarly journals George Papanicolaou's Efforts to Develop Novel Cytologic Methods for the Early Diagnosis of Endometrial Carcinoma

2017 ◽  
Vol 61 (4-5) ◽  
pp. 281-298 ◽  
Author(s):  
R. Marshall Austin
Keyword(s):  
Tissue Culture ◽  
Early Diagnosis ◽  
Growth Rates ◽  
Female Genital Tract ◽  
Uterine Cavity ◽  
Diagnostic Procedures ◽  
Phagocytic Cells ◽  
The Face ◽  
Initial Focus ◽  
Female Genital

Toward the end of his career, Dr. George Papanicolaou became interested in human endometrial explants placed into tissue culture. The initial focus of his studies was on phagocytic cells emanating from endometrial explants and their role in cleansing the uterine cavity after each menstrual cycle and in sterilizing the uterine cavity in the face of infection. Papanicolaou also observed that growth rates of explanted normal and pathologic endometrial tissues differed considerably. Explants of endometrial malignancies exhibited not only increased growth rates but also visible proliferation of cells with readily identifiable cytologic features of malignancy. Acknowledging that cytologic screening for early diagnosis of intrauterine malignancies had up to that point not proven to be reliable as screening for cervical cancer, he hoped that the tissue culture explant technique could prove to be a new adjunctive diagnostic method for the diagnosis of endometrial and other female genital tract malignancies not readily detectible by other diagnostic procedures. Papanicolaou's untimely death in 1962 cut short his progress in this area of study.

scholarly journals Single-Cell Sequencing: Biological Insight and Potential Clinical Implications in Pediatric Leukemia

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5658
Author(s):  
Donát Alpár ◽  
Bálint Egyed ◽  
Csaba Bödör ◽  
Gábor T. Kovács
Keyword(s):  
High Resolution ◽  
Single Cell ◽  
Childhood Leukemia ◽  
Clinical Decision Making ◽  
Cellular Heterogeneity ◽  
Therapeutic Interventions ◽  
Cell Populations ◽  
Pediatric Leukemia ◽  
Single Cell Sequencing ◽  
Wide Range

Single-cell sequencing (SCS) provides high-resolution insight into the genomic, epigenomic, and transcriptomic landscape of oncohematological malignancies including pediatric leukemia, the most common type of childhood cancer. Besides broadening our biological understanding of cellular heterogeneity, sub-clonal architecture, and regulatory network of tumor cell populations, SCS can offer clinically relevant, detailed characterization of distinct compartments affected by leukemia and identify therapeutically exploitable vulnerabilities. In this review, we provide an overview of SCS studies focused on the high-resolution genomic and transcriptomic scrutiny of pediatric leukemia. Our aim is to investigate and summarize how different layers of single-cell omics approaches can expectedly support clinical decision making in the future. Although the clinical management of pediatric leukemia underwent a spectacular improvement during the past decades, resistant disease is a major cause of therapy failure. Currently, only a small proportion of childhood leukemia patients benefit from genomics-driven therapy, as 15–20% of them meet the indication criteria of on-label targeted agents, and their overall response rate falls in a relatively wide range (40–85%). The in-depth scrutiny of various cell populations influencing the development, progression, and treatment resistance of different disease subtypes can potentially uncover a wider range of driver mechanisms for innovative therapeutic interventions.

scholarly journals ATIVIDADE ACARICIDA DE ÓLEOS ESSENCIAIS SOBRE Tetranychus ludeni (Zacher) (Acari: Tetranychidae) EM DUAS CULTIVARES DE ALGODOEIRO

Nativa ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 469
Author(s):  
Yasmin Bruna de Siqueira Bezerra ◽  
José Vargas de Oliveira ◽  
Taciana Keila dos Anjos Ramalho ◽  
Douglas Rafael e Silva Barbosa ◽  
Carlos Romero Ferreira de Oliveira ◽  
...  
Keyword(s):  
Population Growth ◽  
Essential Oils ◽  
Growth Rates ◽  
Ocimum Basilicum ◽  
Alternative Control ◽  
Population Growth Rates ◽  
Colored Cotton ◽  
Potential Alternative ◽  
Tetranychus Ludeni ◽  
Corymbia Citriodora

O presente trabalho teve como objetivo avaliar os efeitos repelentes e as taxas de crescimento populacional de óleos essenciais de Corymbia citriodora, Ocimum basilicum e Myracroduon urundeuva sobre o ácaro vermelho Tetranychus ludeni (Zacher) em algodoeiro de fibra colorida. Para o teste de repelência, óleos de Corymbia citriodora, Ocimum basilicum e Myracroduon urundeuva foram testados em diferentes concentrações sobre fêmeas adultas de T. ludeni, assim como para o teste de crescimento populacional, onde as cultivares foram tratadas com óleos essenciais.  O efeito repelente foi verificado para todos os óleos testados nas duas cultivares de algodão colorida. As taxas instantâneas de crescimento populacional para T. ludeni nas cultivares de algodoeiro BRS Verde e BRS Rubi foram todas positivas (ri> 0), indicando que a população está em estado ascendente, no entanto, a população cresceu a uma taxa menor quando comparada ao controle. Os óleos essenciais de C. citriodora, O. basilicum e M. urundeuva apresentam efeito acaricida e potencial controle alternativo de T. ludeni em algodoeiro de fibras coloridas sem causar danos ao algodoeiro.Palavras-chave: ácaro vermelho; algodão colorido; controle alternativo; taxa instantânea de crescimento; repelência. ACARICIDAL ACTIVITY OF ESSENTIAL OILS ON RED MITETetranychus ludeni (Zacher) (Acari: Tetranychidae) IN TWO COTTON CULTIVARS ABSTRACT: The objective of this work was to evaluate the repellent and population growth rates of essential oils of Corymbia citriodora, Ocimum basilicum and Myracroduon urundeuva on the red mite Tetranychus ludeni (Zacher) in cotton fiber. For the repellency test, oils of Corymbia citriodora, Ocimum basilicum and Myracroduon urundeuva were tested in different concentrations on adult females of T. ludeni, as well as for the population growth test, where the cultivars were treated with essential oils. The repellent effect was verified for all tested oils the two cultivars of colored cotton. The instant population growth rates for T. ludeni in the cultivars BRS Verde and BRS Rubi were all positive (ri> 0), indicating that the population is in an upward, however, the population grew at a lower rate when compared to the control. The essential oils of C. citriodora, O. basilicum and M. urundeuva have an acaricidal effect and potential alternative control of T. ludeni in cotton from colored fibers without causing damage to the cotton.Keywords: Red mite; colored cotton; essential oils; instant growth rate; repellency.

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