scholarly journals Effects of Petroselinum crispum Extract on Pancreatic B Cells and Blood Glucose of Streptozotocin-Induced Diabetic Rats

2003 ◽  
Vol 26 (8) ◽  
pp. 1206-1210 ◽  
Author(s):  
Refiye Yanardağ ◽  
Şehnaz Bolkent ◽  
Ayse Tabakoğlu-Oğuz ◽  
Özlem Özsoy-Saçan
Keyword(s):  
Blood Glucose ◽  
B Cells ◽  
Diabetic Rats ◽  
Petroselinum Crispum ◽  
Pancreatic B Cells

scholarly journals The Effect of Endurance Training Intensity on the Expression of Perlipin a Protein of Subcutaneous Adipose Tissue and Pancreatic B cells Function in Diabetic Rats

2020 ◽  
Author(s):  
Hadi Ghaedi
Keyword(s):  
B Cells ◽  
Endurance Training ◽  
High Intensity ◽  
Subcutaneous Adipose Tissue ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
P Value ◽  
Low Intensity ◽  
Pancreatic B Cells ◽  
Subcutaneous Adipose

Objective: The aim of this study was to compare the three endurance training intensities on the expression of Perlipin A protein in subcutaneous adipose tissue and pancreatic B-cells function in male diabetic rats. Materials and Methods: In this study, 40 healthy male wistar rats were divided into five groups, including diabetic with low intensity endurance training, diabetic with moderate intensity endurance training, diabetic with high intensity endurance training, diabetic control and healthy control. After diabetic induction with streptozotocin, endurance training was performed with low intensity, moderate and severe for eight weeks, three sessions per week. The relative expression of Perilipin A was measured by western blot technique. Results: The results indicated a significant effect of endurance training with three intensities on serum levels of insulin and glucose and pancreatic B-cells function ( P -value: 0.001). Also the results showed that there was no significant difference between Perlipin A expression in healthy and diabetic control groups with endurance training groups (with low, moderate and high intensity) ( P -value: 0.07). Conclusion: However, Moderate and high intensity endurance training compared to low-intensity training can compensate for the loss caused by diabetes in the expression of the Perlipin A protein but the difference was not significant. It seems that more intensity endurance training lead to more increase in Perlipin A expression in diabetic rats.

The effects of acarbose and Rumex patientia L. on ultrastructural and biochemical changes of pancreatic B cells in streptozotocin-induced diabetic rats

2005 ◽  
Vol 97 (3) ◽  
pp. 555-559 ◽  
Author(s):  
Irfan Degirmenci ◽  
M. Cengiz Ustuner ◽  
Yusuf Kalender ◽  
Suna Kalender ◽  
Hasan Veysi Gunes
Keyword(s):  
B Cells ◽  
Diabetic Rats ◽  
Biochemical Changes ◽  
Pancreatic B Cells

PENGENDALIAN KADAR GLUKOSA DARAH OLEH TEH HIJAU DAN ATAU TEH DAUN MURBEI PADA TIKUS DIABETES

2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Feed Consumption ◽  
Font Size ◽  
High Prevalence ◽  
The Difference ◽  
Control Diabetes

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

Effect of Saengmaec-san on the Level of Blood Glucose and Serum Components in Streptozocin-Induced Diabetic Rats

2009 ◽  
Vol 38 (9) ◽  
pp. 1179-1186 ◽  
Author(s):  
Hyeong-Jin Kim ◽  
Hye-Jin Yang ◽  
Mi-Hwan Kim ◽  
Gi-Hyung Ryu ◽  
Ji-Youn Jung
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Serum Components

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

2020 ◽  
Vol 20 (7) ◽  
pp. 1117-1132
Author(s):  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ismaeel Bin-Jaliah ◽  
Medhat Taha ◽  
Lashin S. Lashin
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Caspase 3 ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Control Group ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic

Background and Aims: In the current work, we studied the effects of exercise and stevia rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible underlying mechanisms. Methods: : Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c) DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts: type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues were measured. Results: T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2 and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05). On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05). Conclusion: Both exercise and methanolic stevia R extracts showed cardioprotective effects against DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.

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