Otomycosis in Turkey: predisposing factors, aetiology and therapy

2003 ◽  
Vol 117 (1) ◽  
pp. 39-42 ◽  
Author(s):  
K. Murat Ozcan ◽  
Muge Ozcan ◽  
Aydin Karaarslan ◽  
Filiz Karaarslan

Otomycosis usually requires long-term treatment and tends to recur. This study was performed on 87 patients with the clinical diagnosis of otomycosis and 20 controls in order to determine the pathogenic agents, predisposing factors and a cost-effective treatment. The predisposing factors included wearing head clothes (74.7 per cent), presence of dermatomycoses (34.5 per cent) and swimming (27.6 per cent). The most common pathogenic fungus was Aspergillus niger (44.8 per cent) in the otomycosis group. The only isolate was Candida albicans in the control group (2.5 per cent). We concluded that administration of four per cent boric acid solution in alcohol and frequent suction cleaning of the ear canal might be a cost-effective treatment for otomycosis since 77 per cent of the patients were treated effectively this way. Eighty per cent of the resistant cases had mixed fungal-bacterial infections, and 50 per cent of them had dermatomycoses. These resistant cases were treated by administration of tioconazole ointment.

2019 ◽  
Vol 8 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Muhammad R. Baig

Background: Treatment-resistant psychosis makes schizophrenia a disabling and costly illness. Clozapine is an effective treatment for treatment-resistant psychosis, though it is underutilized mainly due to prescribing providers’ fear of a serious yet uncommon complication, clozapine-induced neutropenia. Clozapine-induced neutropenia predisposes patients to potentially life-threatening infections leading prescribers to stop use when blood counts start to drop even well above the recommended cut-off point. Colonystimulating factors are effective options for reducing risk and duration of neutropeniarelated events though they add a significant cost burden to the patient and healthcare system. There is a great need for feasible and cost-effective pharmacotherapies in the mental health care setting for the management of clozapine-induced neutropenia. Objective: We evaluated adjunctive use of lithium when prescribed at a low-dose to stabilize dropping blood count in patients receiving clozapine for treatment-resistant psychosis. Methods & Results: A case series analysis of three patients who were followed in a mental health outpatient clinic for the management of schizophrenia. Blood counts of all the patients were stabilized by low-dose lithium treatment and continued to receive long term treatment of clozapine. Conclusion: Results suggest low-dose lithium as a feasible and cost-effective pharmacotherapeutic option enabling the continuation of clozapine, an effective treatment for treatment-resistant psychosis.


2021 ◽  
Vol 6 (2) ◽  
pp. 262-271
Author(s):  
Andi Maulana Kamri ◽  
◽  
Rachmat Kosman ◽  
Dian Rahayu

Hypertension is a chronic disease that requires long-term treatment and high cost. The research aimed to determine a more cost-effective treatment between amlodipine and captopril in hypertensive patients at Majene Hospital from January to June 2019. The sampling technique was purposive sampling with a cross-sectional method. The data collection was obtained from medical records and direct medical costs of hypertensive patients who take amlodipine or captopril. The Mann-Whitney statistical test was performed to determine the significant difference between the treatment groups. The results showed that the Average Cost Effectiveness Rasio (ACER) value of the 5 mg amlodipine and 12.5 mg captopril groups was Rp. 4233.3 and Rp. 4904 with an Incremental Cost Effectiveness rasio (ICER) value of Rp. 1063.5. Meanwhile, the Average Cost Effectiveness Rasio (ACER) value of the 10 mg amlodipine and 25 mg captopril group was Rp. 3764,7 and Rp. 4875.1. In conclusion, amlodipine is more cost effective than captopril.


2018 ◽  
Vol 66 (10) ◽  
pp. 1487-1491 ◽  
Author(s):  
Jean B Nachega ◽  
Nadia A Sam-Agudu ◽  
Lynne M Mofenson ◽  
Mauro Schechter ◽  
John W Mellors

Abstract Although significant progress has been made, the latest data from low- and middle-income countries show substantial gaps in reaching the third “90%” (viral suppression) of the UNAIDS 90-90-90 goals, especially among vulnerable and key populations. This article discusses critical gaps and promising, evidence-based solutions. There is no simple and/or single approach to achieve the last 90%. This will require multifaceted, scalable strategies that engage people living with human immunodeficiency virus, motivate long-term treatment adherence, and are community-entrenched and ‑supported, cost-effective, and tailored to a wide range of global communities.


2017 ◽  
Vol 69 ◽  
pp. 508-517 ◽  
Author(s):  
Adib Amini ◽  
Veronica Aponte-Morales ◽  
Meng Wang ◽  
Merrill Dilbeck ◽  
Ori Lahav ◽  
...  

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