scholarly journals Neonatal osteofibrous dysplasia: Synchronous tibial and fibular involvement is common

2022 ◽  
Author(s):  
Harsimran Laidlow-Singh ◽  
Pranai Buddhdev ◽  
Mark Latimer ◽  
Pearl Wou ◽  
Amaka C. Offiah

Osteofibrous dysplasia is a rare non-malignant fibro-osseous bone tumour, first described and characterised under this name by Campanacci (1976). It is most commonly encountered in the tibia of children and young adults, but less frequently seen in the neonate with only few prior reports in the literature. We report a case of neonatal congenital osteofibrous dysplasia, presenting with unilateral limb deformity at birth. Radiographs demonstrated well-defined mixed lytic-sclerotic lesions, in a previously unreported distribution in this age-group, confined to the distal metadiaphysis of the affected tibia and fibula. Open surgery was performed for deformity correction, with tissue biopsy confirming the radiographically-suspected diagnosis. We present the up-to-date clinical, radiological, and pathological findings in this case of a rare pathology with some novel features, within this age group, in disease distribution and consequent radiographic appearances. OFD should be considered in the differential of similar congenital deforming bone lesions of the lower limb. We also review the small number of previously published cases of congenital OFD in the neonate, noting in particular that the frequency of ipsilateral fibular involvement appears to be higher than that observed in older patients.

2010 ◽  
Vol 23 (04) ◽  
pp. 273-276 ◽  
Author(s):  
M. Hilbe ◽  
S. Ohlert ◽  
K. Nuss ◽  
T. Schmid

SummaryThe clinical, radiographical and histo-pathological findings of a chondrosarcoma in the humerus of a goat are discussed. An 11-year-old female Saanen goat was admitted for evaluation of chronic, progressive left forelimb lameness. Clinical examination revealed signs of pain in the shoulder region. Radiographs of the scapulohumeral joint showed a large lytic lesion of the proximal third of the humerus with cortical destruction, intralesional calcification and marked periosteal reactions. Differential diagnoses included aggressive bone lesions as seen with osteomyelitis or a primary bone tumour, such as osteosarcoma, chondrosarcoma or fibrosarcoma. The goat was euthanatized for humane reasons because of the poor prognosis. On the basis of the histopathological findings, the lesion was diagnosed as grade II chondrosarcoma. The tumour had already spread to the lungs and the left prescapular lymph node at the time of diagnosis.


2019 ◽  
Vol 70 (4) ◽  
Author(s):  
Marianna Faggiani ◽  
Selena Desayeux ◽  
Giovanni Martino ◽  
Eraclite Petruccelli ◽  
Alessandro Aprato ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Anitha Sen ◽  
Jiji Valsalamony ◽  
Jubie Raj

Abstract Objectives Cervical component of thymus is noted more in children and young adults than in older age group. CT texture (lobules of soft tissue interspersed with fat), similarity with CT density of mediastinal thymus and continuity with mediastinal thymus on sagittal/coronal images, are given as the criteria for diagnosis of the cervical thymus. But CT densities of cervical and mediastinal components of the thymus may vary. The purpose of our study was to compare CT densities of cervical and mediastinal parts of the thymus, in cases where ultrasonography correlation was available. Methods We retrospectively identified 22 patients who had undergone CT between May 2015 and May 2017 and in whom ultrasonography (USG) correlation was available. CT densities of cervical and mediastinal components of thymus were measured. Results CT density of cervical thymus is lower than the CT density of mediastinal thymus by ~ 25 HU. There is a moderate positive correlation between CT densities of cervical and mediastinal parts of the thymus. CT densities of both cervical and mediastinal thymus were found to reduce with age, but the reduction was statistically significant only in the cervical thymus in this study. Conclusions CT densities of cervical and mediastinal components of the thymus may vary, with CT density of cervical thymus being lower. There is a positive correlation between CT densities of cervical and mediastinal parts of the thymus. CT density of cervical thymus reduces with age. Understanding these may help avoid confusion on CT and avoid the need for correlative USG, saving time and effort.


2009 ◽  
Vol 80 (3) ◽  
pp. 338-343 ◽  
Author(s):  
Hubert J Oostenbroek ◽  
Ronald Brand ◽  
Peter M van Roermund

Author(s):  
Thu Koskas ◽  
Karamo Souaré ◽  
Tarik Ouahabi ◽  
Dominique Porquet ◽  
Didier Chevenne

AbstractWe measured serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin concentrations on a bioMérieux Mini Vidas system in a pediatric population ranging in age from 1 to 19 years. Reference intervals were established separately for females and males, with stratification by age group and by Tanner's pubertal stage. FSH values were higher in females than in males, and were lowest in both sexes of age class 2 (4–8 years), increasing thereafter to the upper limit for stage PIV (females) and stage PV (males). LH values showed a similar pattern of change: concentrations were lowest for class 1 (1–3 years) and class 2 (4–8 years), and highest for stage PII (females) and stage PV (males). No significant difference was observed according to gender. Prolactin values did not differ markedly according to gender or pubertal status.Clin Chem Lab Med 2007;45:541–5.


PEDIATRICS ◽  
1949 ◽  
Vol 4 (6) ◽  
pp. 805-809
Author(s):  
W. M. KELSEY ◽  
L. B. LEINBACH

Values for total serum base in 96 normal children under 12 years of age as determined by the conductivity method fell between 143 to 160.5 mEq./l. The mean was 153. Standard deviations for each age group are given. The values in 73 normal persons above the age of 12 varied from 142 to 160.5 mEq./l. The mean was 147 mEq./l. A statistically significant difference between the total serum base in children and adults was found.


2014 ◽  
Vol 23 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Hubert J. Oostenbroek ◽  
Ronald Brand ◽  
Peter M. van Roermund ◽  
René M. Castelein

2021 ◽  
Vol 27 (3) ◽  
pp. 291-295
Author(s):  
S. Qin ◽  
◽  
J. Zang ◽  
B. Guo ◽  
◽  
...  

The Ilizarov technology was honored as a "milestone" in the history of orthopedics in the 20th century, benefiting tens of thousands of patients around the world, including Chinese patients. The paper presents an analysis of the integration of the method into Chinese medicine, taking into account national traditions, culture and clinical thinking. Ilizarov technology has revolutionized the orthopaedic surgery and clinical limb regeneration medicine in China. Ilizarov's methodology arose suddenly and brought about revolutionary changes in terms of theoretical guidance, methods of thinking, tools used and medical procedures. For the first time, Ilizarov's discovery made people realize that the human body, natural selection in biology and joint symbiotic evolutionary characteristics are common, namely, as long as the levers activate the tissue regeneration switch and changes in regulation, any tissue at any age and to any degree can complete the self-healing process in according to the requirements of doctors and the expectations of patients, similar to the growth of children. The process of working with an external Ilizarov fixator is like playing chess and changing a kaleidoscope, and the countless number of free combinations of stress configurations can be changed in accordance with the needs of the treatment. In China, Qin Xihe integrated the Chinese culture into the Ilizarov technology, thus forming the Chinese Ilizarov technology. He proposed new concepts such as the concept of natural reconstruction, evolutionary orthopedics, interpretation of body language, one walk, two lines, the principle of three balances, happy orthopedics, etc., which were introduced into clinical practice in the field of limb deformity correction and functional reconstruction. As of December 31, 2018, 35,075 cases of various deformities and disorders of the limbs were entered into the Qinsihe orthopedic database, of which 8113 cases were treated with external fixation (Ilizarov technology). The statistics of a large number of cases showed striking results: diseases treated with this technique covered almost all sections of orthopedic pathology and more than 10 sections of non-orthopedic and traumatological pathology, including vascular, nervous, genetic, metabolic, and skin diseases. In addition to orthopedic, there are more than 170 diseases in total. When Ilizarov's technology is applied, it can magically transform the old into the young. Therefore it is known as a "lifeboat". Conclusion Over the past 70 years, Ilizarov's ideas and technologies have been preserved, updated and augmented. Ilizarov's technology serves as an evolutionary phenomenon that transcends bone science. If you understand this technique, you will understand the direction of modern orthopedic surgery and regenerative medicine. Professor Ilizarov's morale and the spirit of fighting to alleviate the suffering of patients were transferred to the Chinese medical community. This awakened many Chinese doctors who followed the norms of the old and stereotyped medicine. After celebrating the centenary of the birth of Professor Ilizarov, ASAMI China will also prepare for the “Sixth ASAMI & ILLRS-BR World Conference (Beijing – 2023)”. We believe that orthopedics and allied disciplines around the world have a bright future.


2017 ◽  
Vol 8 (1) ◽  
pp. 6-9
Author(s):  
Tabassum Tahmin Sajani ◽  
Tanjila Tahmin Sarnali ◽  
Md Atiqur Rahman ◽  
Shoib Ahmed

Background: Endometrial diseases ranked among the most common gynecological disorders that affect women globally. This study was undertaken to identify the most common pathologies identified in hysterectomy specimens.Materials & Methods: The present study was conducted in the Department of Pathology, Anwer Khan Modern Medical College, Dhaka over a period of 6 months from July to December 2013. Ninety eight (98) hysterectomy specimens were received by the pathology department during this period. On receiving the hysterectomy specimens, the gross features were noted. A detailed microscopic examination was done to arrive at an accurate diagnosis.Result: Most of the women 54% were 40-49 years age group followed by 25% in 30-39 years age group. Chronic cervicitis and adenomyosis were the commonest pathological findings in (80.6%) and (32.7%) respectively. Other pathologies identified include Leiomyoma (23.5%), endometrial hyperplasia (17.4%), endometrial polyp (4.1%) and PID with hemorrhagic infection (1.0%). Two cases of carcinoma cervix (2.0%), two local invasion of tumors (2.0%) and one adenocarcima (1.0%) was found. Type of operation most common is total hysterectomy with oophorectomy (51.0%).Conclusion: Hysterectomy still remains the widely used treatment modality even in developed countries. The ultimate diagnosis is only on histology, so every hysterectomy specimen should be subjected to histopathological examination. Benign pathologies are more common than their malignant counterparts and the most common pathologies identified in hysterectomy specimens are chronic cervicitis, adenomyosis and leiomyoma.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 6-9


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