scholarly journals Experimental Research on Therapeutic Efficacy of Traditional Chinese Medicine Shengjing Capsule Extracts in Treating Spermatogenesis Impairment Induced by Oxidative Stress

2016 ◽  
Vol 22 ◽  
pp. 50-56 ◽  
Author(s):  
Shaohu Zhou ◽  
Zhiwei Wen ◽  
Aijun Liang ◽  
Shuting Zhang
Keyword(s):  
Oxidative Stress ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Experimental Research ◽  
Therapeutic Efficacy ◽  
Spermatogenesis Impairment

scholarly journals The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Xinyu Yang ◽  
Tianmai He ◽  
Songjie Han ◽  
Xiaoyu Zhang ◽  
Yang Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antioxidant Treatment ◽  
Molecular Systems ◽  
Artery Disease ◽  
Signal Activation

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. There are several kinds of antioxidative and small molecular systems of antioxidants, such as β-carotene, ascorbic acid, α-tocopherol, and reduced glutathione (GSH). Studies have shown that antioxidant treatment was effective and decreased the risk of CHD, but the effect of the treatment varies greatly. Traditional Chinese medicine (TCM) has been utilized for thousands of years in China and is becoming increasingly popular all over the world, especially for the treatments of cardiovascular diseases. This review will concentrate on the evidence of the action mechanism of TCM in preventing CHD by modulating oxidative stress-related signaling pathways.

scholarly journals Psychological Stress-Induced Oxidative Stress as a Model of Sub-Healthy Condition and the Effect of TCM

2007 ◽  
Vol 4 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Lei Wang ◽  
Gong Muxin ◽  
Hiroshi Nishida ◽  
Chieko Shirakawa ◽  
Shinji Sato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Protein Carbonyl ◽  
Chinese Medicine Formula ◽  
Traditional Chinese Medicine Theory ◽  
Locomotive Activity ◽  
Carbonyl Formation ◽  
Chinese Medicine Theory ◽  
Herbal Mixtures

Distress-mediated tissue oxidative stress was examined as a model of sub-healthy condition defined in traditional Chinese medicine theory. Mice were subjected to psychologically stressful conditions by whiskers removal. Under this condition, spontaneous locomotive activity was significantly enhanced in the dark (P< 0.05 versus the control mice in three different movements), and granulocytes/lymphocytes balance shifted to granulocytes. At the same time, peroxynitrite level in blood plasma increased to ∼180% from that of the control mice at 6 h after removal of the whiskers (P< 0.01), and was maintained even after 12 h. Both protein carbonyl formation and lipid peroxidation were significantly increased under this condition in brain, heart, liver and spleen at 6 h after removal of whiskers (P< 0.05 orP< 0.01), and these levels were maximized after 12 h (increased to 120–160%,P< 0.05 orP< 0.01). The oxidative tissue injuries observed at 12 h after the removal of the whiskers were effectively prevented by two traditional Chinese medicine formula: Shengmai San (SMS) and Ling Gui Zhu Gan Tang (LGZGT), when administered for 5 days before the removal of the whiskers. Therefore, this stress model is considered useful in assessing the preventive potential of antioxidants and antioxidant-based herbal mixtures in treating the pathophysiology associated with psychological or emotional distress.

Ganoderma lucidum Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

2014 ◽  
Vol 675-677 ◽  
pp. 1577-1579
Author(s):  
Lin Luo ◽  
Feng Yan ◽  
Bei Bei Wang
Keyword(s):  
Oxidative Stress ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ganoderma Lucidum ◽  
Antioxidant Defense ◽  
Defense Systems ◽  
Medicinal Fungus ◽  
Traditional Remedy ◽  
Antioxidant Defense Systems ◽  
Exercise Induced

Ganoderma lucidum(G. lucidum), a medicinal fungus called ‘‘Lingzhi’’ in China is one of the most famous fungi in traditional Chinese medicine. For hundreds of years, this mushroom has been known as a traditional remedy for treatment of several diseases, such as hepatitis, hypertension, chronic bronchitis, bronchial asthma, cancer and others. Polysaccharide is an important pharmacological ingredient extracted from fruit bodies and mycelium ofG. lucidum. It has been extensively documented thatG. lucidumpolysaccharides (Gl-PS) had wide bioactivities, such as anti-aging, anti-tumor, hypoglycemic, immunomodulatory and immunotherapeutic activities [1]. In our previous studies, Gl-PS has been proven to have significant anti-hypoxia and anti-fatigue effects in mice [2], which suggesting that it might be beneficial to exercise-induced oxidative stress. Therefore, the purpose of this study was to investigate the effects of Gl-PS against exercise-induced oxidative stress in liver of mice.

scholarly journals Therapeutic Efficacy of Fuzheng-Huayu Tablet Based Traditional Chinese Medicine Syndrome Differentiation on Hepatitis-B-Caused Cirrhosis: A Multicenter Double-Blind Randomized Controlled Trail

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ya-Nan Song ◽  
Ji-Jia Sun ◽  
Yi-Yu Lu ◽  
Lie-Ming Xu ◽  
Yue-Qiu Gao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hepatitis B ◽  
Therapeutic Efficacy ◽  
Life Quality ◽  
Classification Model ◽  
Syndrome Differentiation ◽  
Double Blind ◽  
Forecasting Method ◽  
Tcm Syndrome

Aim. To evaluate and predict the therapeutic efficacy of Fuzheng-Huayu tablet (FZHY) based traditional Chinese Medicine (TCM) syndrome differentiation or TCM symptoms on chronic hepatitis B caused cirrhosis (HBC).Methods.The trial was designed according to CONSORT statement. It was a multi-center, double-blind, randomized, placebo-controlled trail. Several clinical parameters, Child-Pugh classification and TCM symptoms were detected and evaluated. The FZHY efficacy was predicted by an established Bayes forecasting method following the Bayes classification model.Results.The levels of HA and TCM syndrome score in FZHY group were significantly decreased (P<0.05) compared to placebo group, respectively. The efficacy of FZHY on TCM syndrome score in HBC patients with some TCM syndromes was better. In TCM syndrome score evaluation, there were 53 effective and 22 invalid in FZHY group. TCM symptoms predicted FZHY efficacy on HBC were close to Child-Pugh score prediction.Conclusion.FZHY decreases the levels of HA and TCM syndrome scores, improves the life quality of HBC patients. Moreover, there were different therapeutic efficacies among different TCM syndromes, indicating that accurate TCM syndrome differentiation might guide the better TCM treatment. Furthermore, the FZHY efficacy was able to predict by Bayes forecasting method through the alteration of TCM symptoms.

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