Analysis of Risk Factors of Osteoporosis in the Middle-Aged and Elderly Population in Fuzhou and the Relationship between TCM Syndromes and Bone Mineral Density

2020 ◽  
Vol 09 (06) ◽  
pp. 468-474
Author(s):  
斌 吴
2020 ◽  
Author(s):  
Jie-Yu Liu ◽  
Jia-Xiang Wang ◽  
Li Xu ◽  
Shu-Feng Lei ◽  
Fei-Yan Deng

AbstractOsteoporosis is a systemic chronic skeletal disease, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs). OFs are associated with high mortality and morbidity, and seriously affect the life quality of patients. Osteoporosis is prevalent in the middle-aged and elderly population, especially the postmenopausal women. With population aging, osteoporosis becomes a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing OFs. In light of the high heritability and complex pathogenesis of OP, comprehensive consideration of significant biological/biochemical factors is necessary for accurate risk evaluation. For this purpose, we reviewed recent research progress on moleculars which are diagnostic and/or predictive of OFs risk. Future integrative analyses and systematic evaluation of these moleculars may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence to contribute to preventing OFs in the world.Graphical AbstractOsteoporosis, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs), is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. We focused on several types of important molecules, including proteins/peptides, RNAs, lipids, to gain comprehensive understanding and to generate novel perspectives in predicting and diagnosing OFs.


Author(s):  
Seok-Hee KIM ◽  
Jooyoung KIM

Background: The risk factors of metabolic syndrome (MetS) in menopausal women are potential causes of osteoporosis. However, there is no consensus on this. We aimed to determine the relationship between risk factors of MetS and bone mineral density (BMD) in menopausal Korean women. Methods: We enrolled 205 menopausal Korean women who visited a health promotion center in Seoul in 2015 and divided them into the following two groups according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria with modified waist-circumference criteria: the non-MetS group (Group 1, n=90) and the MetS group (Group 2, n=115). Anthropometric parameters and clinical parameters, including blood pressure, blood lipid profile (cholesterol, triglycerides), and fasting blood sugar levels were recorded for all participants. BMD at the lumbar spine was determined using dual-energy X-ray absorptiometry (DEXA). The relationship between the risk factors of MetS and bone mineral density was analyzed by statistical methods. Results: There was no significant difference in risk factors of MetS between the groups. In correlation tests, waist circumference showed a significant association with body surface area (BSA) (r = -0.242, P < 0.001). Diastolic blood pressure was correlated with BSA (r = 0.186, P < 0.01) and bone mineral content (BMC) (r = 0.161, P < 0.05). However, multiple regression analysis showed no significant relationship between MetS risk factors and BMD. Conclusion: The risk factors of MetS did not affect BMD in menopausal Korean women. Follow-up studies with a larger study population are necessary size to allow the investigation of other research variables.


2016 ◽  
Vol 22 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Münevver Serdaroğlu Beyazal ◽  
Erhan Çapkın ◽  
Murat Karkucak ◽  
Mustafa Güler ◽  
Haşim Çakırbay ◽  
...  

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1198.1-1199
Author(s):  
C. Thurston ◽  
R. Tribbick ◽  
J. Kerns ◽  
F. Dondelinger ◽  
M. Bukhari

Background:A decreased body mass index (BMI) is associated with poorer bone health, a decreased bone mineral density (BMD), and an increased fracture risk. Cardiovascular (CVS) data has shown that the waist:hip ratio is a more robust measurement for CVS outcomes than BMI (1). Waist:hip ratio has never been evaluated as an outcome measure for bone health. Dual-energy x-ray absorptiometry (DEXA) has the capacity to measure average percentage fat in the L1-L4 region and at the hip, and directly relates to the measurement of waist:hip ratio.Objectives:To evaluate the relationship between BMD and average percent fat in a cohort referred for DEXA scanning.Methods:We analysed data routinely collected from patients referred for DEXA between 2004 and 2010 at the Royal Lancaster Infirmary in the North of England. Data collected for these patients included DEXA scans of BMD at the left and right hip, and at the lumbar spine, as well as average percent far and other risk factors for osteoporosis, including the FRAX risk factors. We used only the measures collected at baseline (time of first scan). We modelled the T scores of the BMD measurements using a linear regression model including percentage fat and BMI as explanatory variables, and adjusting for gender, age at scan, and other known risk factors for osteoporosis, including the FRAX risk factors. BMI and average percent fat were standardised.Results:The number of patients included was 33037, (82% female). Results of both regression models are shown in table 1 below. We show the standardised effect size estimates for average percent fat and BMI.Anatomical locationEffect size estimate for average percent fat (95% confidence intervals)P valueEffect size estimate for BMI (95% confidence intervals)P valueLeft neck-0.156 (-0.171, -0.141)<0.001-0.0255 (-0.0441, -0.00701)0.00692Left total-0.225 (-0.241, -0.208)<0.001-0.0680 (-0.0882, -0.0477)<0.001Left Ward’s-0.181 (-0.196, -0.166)<0.001-0.0268 (-0.0456, -0.00813)0.00493Left trochanter-0.263 (-0.281, -0.246)<0.001-0.0667 (-0.0882, -0.0451)<0.001Right neck-0.139 (-0.154, -0.124)<0.001-0.0131 (-0.0317, 0.00549)0.167Right total-0.221 (-0.237, -0.204)<0.001-0.0611 (-0.0811, -0.0411)<0.001Right Ward’s-0.180 (-0.196, -0.165)<0.001-0.0193 (-0.0381, -0.000586)0.0433Right trochanter-0.261 (-0.278, -0.243)<0.001-0.0598 (-0.0810, -0.0386)<0.001Spine (averaged L1-L4)0.219 (0.195, 0.242)<0.001-0.00846 (-0.0379, 0.0206)0.563Conclusion:The analysis shows that average percent fat is a statistically significant predictor for BMD at different anatomical locations, and a larger predictor in comparison to BMI when evaluated in the same model. In the right hip neck and the spine, BMI was not predictive of changes in BMD. Higher average percent fat increases the BMD in the spine, compared to a decline at the hip. Further research is needed to characterise the relationship more precisely and identify whether there is a causal link.References:[1]Obes Rev. 2012 Mar;13(3):275-86. doi: 10.1111/j.1467-789X.2011.00952.xDisclosure of Interests:None declared


2021 ◽  
pp. 64-67
Author(s):  
Yevheniia Luk’ianets

Osteoporosis is the fourth most common after cardiovascular, cancer and endocrine diseases. According to WHO experts, due to the aging population and the impact of negative environmental factors, the incidence of osteoporosis will increase further. The objective: determining the relationship between ultrasound densitometry data on the heel cyst and the risk of fractures in older women from different regions of the country. Materials and methods. The study was based on a survey of women in major cities of Ukraine – Kyiv, Kharkiv, Odessa. 116 women aged 40 to 79 years were included. The average age of the subjects was 56±9,62 years, the average body weight was 74,5±12,9 kg, height 163,1±5,62 cm, the average body mass index (BMI) was 28±4,90. Normal (BMI) 20–24,9 had 35 women (30,2%), rates of preobesity and clinical obesity were in 81 surveyed women (69,8%). All subjects were divided into 4 groups by age: 40–49 years, 50–59 years, 60–69 years, 70–79 years. Results. Decrease in bone mineral density was found in 59,5% of examined women, of which osteopenia was in 57%, osteoporosis in 2,5% of women, the norm in 40,5% of women. The number of women with low BMD increased with age. Analyzing the risk factors in women after 40 years revealed a high incidence of hypertension 40,5%, the frequency of previous fractures in the anamnesis was 22,% of respondents, fractures of the femur and other fractures in parents noted 33,6% of women, a decrease in growth by 3 cm during life occurred in 13,7%, early menopause (up to 45 years) in 16,3% of women. Physical activity less than 30 minutes a day was noted by 27,5%. The risk of FRAX and Q-fracture fractures is significantly correlated with densitometry. Conclusions. Early detection of osteoporosis risk factors in the practice of a family doctor will help prevent an epidemic of this disease in our country and will prevent negative medical and social consequences. All of the above should be considered for planning preventive measures for osteoporosis and its complications, as well as for subsequent diagnostic steps for early detection of the disease.


2005 ◽  
Vol 63 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Ki Won Oh ◽  
Won Young Lee ◽  
Eun Jung Rhee ◽  
Ki Hyun Baek ◽  
Kun Ho Yoon ◽  
...  

2008 ◽  
Vol 21 (02) ◽  
pp. 147-151 ◽  
Author(s):  
S. Loebcke ◽  
M. Skalicky ◽  
S. Grampp ◽  
D. Lorinson ◽  
K. Lorinson

SummaryThe objective was to determine signalment-related differences in bone mineral content (BMC) and bone mineral density (BMD) in dogs. Unilateral appendicular bones were harvested from 62 canine cadavers. Middiaphyseal regions of interest (ROIs) were scanned using a Hologic® DXA device Braincon, Vienna, Austria). BMC and BMD were calculated within this region. Middle-aged dogs (3 . 10 years) revealed the highest BMC and BMD levels. Mean BMC and BMD were higher in males compared to females. Furthermore, bodyweight of the male dogs was significantly higher compared to the females (P<0.0001). Body weight and bone length were significantly associated with BMC and BMD (P.0.023) in all bones but the radius. These data suggest that BMC and BMD appear to be highest in male large-breed dogs with a body weight greater than 30 kg. These results may help determine risk factors in fracture development and healing.


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