RNAi targeting Caenorhabditis elegans α-arrestins marginally affects lifespan
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Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had small or no effects on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.
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2021 ◽
2005 ◽
Vol 25
(7)
◽
pp. 2583-2592
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2003 ◽
Vol 14
(7)
◽
pp. 2972-2983
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