scholarly journals Protocol for a comparison study of 1-day (single dose) versus 2-day prophylactic antibiotic administration in Holmium Laser enucleation of the prostate (HoLEP): a randomized controlled trial

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 161
Author(s):  
Katsumi Shigemura ◽  
Fukashi Yamamichi ◽  
Kento Nishimoto ◽  
Koichi Kitagawa ◽  
Masato Fujisawa
Keyword(s):  
Infectious Disease ◽  
Single Dose ◽  
Surgical Site Infection ◽  
Prophylactic Antibiotic ◽  
University Hospital ◽  
Holmium Laser ◽  
Occurrence Rate ◽  
Antibiotic Administration ◽  
Site Infection ◽  
Prostate Hyperplasia

Background: The best method of antimicrobial prophylaxis administration for surgical site infection (SSI) in transurethral holmium laser resection and enucleation of the prostate (HoLEP)/bipolar transurethral enucleation (TUEB) remains controversial. The purpose of this study is to compare one-day and two-day cefazolin in a randomized 2nd-phase study to help establish a protocol with a 95% confidence interval (CI) for SSI prevention. Methods: Patients undergoing HoLEP/TUEB for benign prostate hyperplasia without preoperative pyuria will be enrolled and randomized to receive prophylactic antibiotic administration for HoLEP/TUEB in two groups, 1-day (single dose) cefazolin and 2-day cefazolin. The primary endpoint is the occurrence rate of postoperative urinary tract infection or urogenital infection within 30 days after HoLEP/TUEB with a statistical 95% CI in comparison between those groups. Secondary outcomes include the kind of infectious disease and evidence of diagnosis, day of diagnosis of infectious disease, performance of urine or blood culture, detection of bacteria, treatments, duration of treatments, AEs other than surgical site infection, and drug-induced AEs. Discussion: The results of this study will provide evidence for defining the optimal duration of cefazolin prophylactic antibiotic administration for SSI. Trial registration: This study was registered in the University Hospital Medical Information Network-Clinical Trial Registry (UMIN000027955) based on recommendations from the International Committee of Medical Journal Editors (ICMJE) on July 1st 2017.

scholarly journals Protocol for a comparison study of 1-day versus 2-day prophylactic antibiotic administration in Holmium Laser enucleation of the prostate (HoLEP): a randomized controlled trial

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 161
Author(s):  
Katsumi Shigemura ◽  
Fukashi Yamamichi ◽  
Kento Nishimoto ◽  
Koichi Kitagawa ◽  
Masato Fujisawa
Keyword(s):  
Infectious Disease ◽  
Surgical Site Infection ◽  
Antimicrobial Prophylaxis ◽  
Prophylactic Antibiotic ◽  
University Hospital ◽  
Holmium Laser ◽  
Occurrence Rate ◽  
Antibiotic Administration ◽  
Site Infection ◽  
Prostate Hyperplasia

Background: The best method of antimicrobial prophylaxis administration for surgical site infection (SSI) in transurethral holmium laser resection and enucleation of the prostate (HoLEP)/bipolar transurethral enucleation (TUEB) remains controversial. The purpose of this study is to compare one-day and two-day cefazolin in a randomized 2nd-phase study to help establish a protocol with a 95% confidence interval (CI) for SSI prevention. Methods: Patients undergoing HoLEP/TUEB for benign prostate hyperplasia without preoperative pyuria will be enrolled and randomized to receive prophylactic antibiotic administration for HoLEP/TUEB in two groups, 1-day cefazolin and 2-day cefazolin. The primary endpoint is the occurrence rate of postoperative urinary tract infection or urogenital infection within 30 days after HoLEP/TUEB with a statistical 95% CI in comparison between those groups. Secondary outcomes include the kind of infectious disease and evidence of diagnosis, day of diagnosis of infectious disease, performance of urine or blood culture, detection of bacteria, treatments, duration of treatments, AEs other than surgical site infection, and drug-induced AEs. Discussion: The results of this study will provide evidence for defining the optimal duration of cefazolin prophylactic antibiotic administration for SSI. Trial registration: This study was registered in the University Hospital Medical Information Network-Clinical Trial Registry (UMIN000027955) based on recommendations from the International Committee of Medical Journal Editors (ICMJE) on July 1st 2017.

scholarly journals Intra-incisional versus intravenous route of antibiotic administration in preventing surgical site infections: a randomized controlled trial

2018 ◽  
Vol 5 (4) ◽  
pp. 1438
Author(s):  
Aditya N. Patil ◽  
Veerendra M. Uppin
Keyword(s):  
Single Dose ◽  
Surgical Site Infection ◽  
Tertiary Care ◽  
Surgical Site Infections ◽  
Intravenous Route ◽  
Antibiotic Administration ◽  
Site Infection ◽  
Open Appendicectomy ◽  
Group A ◽  
Group B

Background: Surgical site infection (SSI) is one of the most common postoperative complications following abdominal surgeries. Whilst the use of prophylactic antibiotics has been shown to reduce postoperative wound infection, controversy still remains as to the optimum route of administration and the duration of treatment. This study aims to compare the efficacy of a preoperative single dose of a cephalosporin antibiotic (cefotaxime) administered intraincisionally versus that administered intravenously, in preventing postoperative surgical site infections following appendicectomy.Methods: Sixty consecutive cases diagnosed as uncomplicated appendicitis who consented for open appendicectomy at a tertiary care institute were included in the study. Cases were randomized to 2 comparable groups of 30 patients each. Preoperatively, patients in Group A received a single dose of Inj. Cefotaxime 1g intraincisionally while those in Group B received the same intravenously. Incision sites were examined every alternative day starting on postoperative day 3 until removal of sutures. Signs of surgical site infection, if any, were recorded and outcomes were statistically tested for significance.Results: One patient in Group A (3.3%) and 4 patients in Group B (13.3%) showed signs of postoperative surgical site infection (p >0.05) during the follow up period which prolonged their hospital stay.Conclusions: This study showed that a single dose preoperative intraincisional administration of cefotaxime was as effective as intravenous administration for prevention of postoperative surgical site infection after open appendicectomy. Although the difference was not statistically significant, there was a reduced incidence of SSI in individuals who received intraincisional antibiotic. These results are encouraging for a way forward in reducing unnecessary burdening of systemic antibiotics in patients undergoing abdominal surgeries. 

Abstract P1-20-09: Does a single-dose of pre-operative prophylactic antibiotic reduce surgical site infection following wire-localized lumpectomy?

2020 ◽  
Author(s):  
Gabrielle Bergeron Giguère ◽  
Brigitte Poirier ◽  
Louise Provencher ◽  
Dominique Boudreau ◽  
Dominique Leblanc ◽  
...  
Keyword(s):  
Single Dose ◽  
Surgical Site Infection ◽  
Prophylactic Antibiotic ◽  
Site Infection

scholarly journals Antibiotic Prophylaxis In Preventing Surgical Site Infection In Patients Undergoing Lichtenstein’s Hernioplasty

2018 ◽  
Vol 08 (03) ◽  
pp. 147-150
Author(s):  
Rizwanullah Junaid Bhanbhro ◽  
Khalil Ahmed Almani ◽  
Sadia Kazi
Keyword(s):  
Inguinal Hernia ◽  
Surgical Site Infection ◽  
Antibiotic Prophylaxis ◽  
Prophylactic Antibiotic ◽  
University Hospital ◽  
Site Infection ◽  
Inguinal Hernioplasty ◽  
Exclusion Criteria ◽  
Antibiotic Group ◽  
Low Incidence

Objective: To determine the antibiotic prophylaxis in preventing surgical site infection in patients undergoing Lichtenstein’s hernioplasty. Study design: Observational study Place and Duration: Department of surgery, ISRA University Hospital, Hyderabad. from December 2015 to March 2017. Materials and Methods: 120 cases of inguinal hernia planned for Lichtenstein’s hernioplasty were selected according to exclusion criteria and divided into control and antibiotic group. Pre- operative patient history, physical examination and inguinal hernia examination was performed. Prophylactic antibiotic ceftriaxone (1000 mg) was given over night of surgical procedure. Statistical software SPSS 21.0 was used for data analysis at 95% CI (P <0.05). Results: Mean± SD age was noted as 39.51 ± 7.56 years (15 – 61 years). Of 120, who underwent Lichtenstein’s hernioplasty the direct and indirect hernias were noted in 35 (29.16%) and 33 (27.5%) & 25 (20.83%) and 27 (22.5%) of control and antibiotic groups respectively. Of 120 subjects, the SSI was noted in 17 (14.1%) in control and 5 (4.16%) in antibiotic group. Cumulative SSI in 120 cases was 22 (18.33%). Conclusion: The present study reports low incidence of surgical site infection with antibiotic prophylaxis in Lichtenstein’s mesh repair in open inguinal hernioplasty.

scholarly journals Comparative study on prophylactic antibiotic versus empirical antibiotic in prevention of surgical site infection

2019 ◽  
Vol 9 (2) ◽  
pp. 9-13
Author(s):  
S Rajarajan ◽  
T.H. Sreelekshmi Devi ◽  
Neeshma Mariam Simon ◽  
K.R. Navin Shankar ◽  
V. Ganesan
Keyword(s):  
Single Dose ◽  
Comparative Study ◽  
Surgical Site Infection ◽  
Hospital Stay ◽  
Prophylactic Antibiotic ◽  
Operative Therapy ◽  
Prophylactic Antibiotics ◽  
Control Group ◽  
P Value ◽  
Site Infection

The main aim of the study was to comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotics in prevention of surgical site infection. The study was a prospective observational study conducted over a period of 8months. A total of 100 number of surgery cases were selected randomly, to groups of 50 each. The study group received a single dose of antibiotic preoperatively while the control group received 3 to 5 days of empirical antibiotic therapy. Data analysis and statistical analysis was done with the help of graph pad prism trial version software. Student t test was carried out for paired analysis to find P value. There was no significant association of surgical site infection, grades of infection, and other complications. The hospital stay of patients, cost to the patients, and number of antibiotics used in patients were significantly more. The single dose prophylactic antibiotics are better than empirical post operative therapy in reducing the hospital stay and hospital cost to patients. Since the complete eradication of surgical site infection is not possible, only the reduction in infection rate can be achieved to a minimal level. Keywords: Prophylactic antibiotics, surgical site infection, surgical complications, post operative antibiotics.

scholarly journals Role of antibiotics in elective clean surgeries: limiting its use to single shot preoperative dose

2020 ◽  
Vol 7 (4) ◽  
pp. 1186
Author(s):  
P. T. Jamdade ◽  
Meghraj J. Chawada ◽  
Apurva Samant
Keyword(s):  
Single Dose ◽  
Antibiotic Therapy ◽  
Surgical Site Infection ◽  
Financial Burden ◽  
Prophylactic Antibiotic ◽  
Control Group ◽  
Study Group ◽  
Single Shot ◽  
Site Infection ◽  
Management Protocol

Background: Conventional antibiotic therapy during operation not only increases the financial burden on patient, not only increases chances of adverse reactions among them but also not effective in reducing the infection rate after surgery. Single dose prophylactic antibiotic or maximum 24 hours dosing during or before surgery was found to be equally effective. Objective was the to study utility of single shot antibiotic prophylaxis in patients undergoing surgeryMethods: This prospective study includes 100 clean elective surgical cases randomized to groups of 50 each. Single dose prophylactic antibiotic was given to cases in the study group and conventional antibiotic therapy was given to cases in the control group. Study group cases received Injection Ceftriaxone in the dose of 2 gm intravenously. This was given at induction or half an hour before the incision was given. Second dose was given if there was delay in starting the surgery for more than three hours. Dose of the antibiotic was adjusted for children, underweight and obese persons. For cases in the control group. Injection ceftriaxone 1 gm was given intravenously twice a day for three days. Surgical site infection incidence was recorded.Results: Both the groups were comparable for age, sex, diagnosis and hence the type of surgery performed. The incidence of fever, redness, swelling and wound discharge which are the signs of surgical site infection after surgery was not found to be statistically significantly different. Management protocol was also not significantly different after the surgery.Conclusions: Single shot antibiotic before surgery is equally effective in reducing the incidence of surgical site infections (SSIs) compared to conventional antibiotic therapy.

scholarly journals Efficacy of Single Dose versus Multiple Dose of Pre-Operative Antibiotic: Teaching Hospital Based Study

2020 ◽  
Vol 3 (2) ◽  
pp. 25-29
Author(s):  
Kamta Prasad Gupta ◽  
Dinesh Pratap Singh
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Single Dose ◽  
Surgical Site Infection ◽  
Prophylactic Antibiotic ◽  
Invasive Procedure ◽  
Anesthesia Induction ◽  
Site Infection ◽  
Time Period ◽  
Study Results ◽  
Elective Laparoscopic Cholecystectomy

Background: The major crisis in any type of surgery is understood to be Surgical Site Infection (SSI). Although laparoscopic cholecystectomy is a nominally invasive procedure, there is a dominant prevalence of SSI in patients. It is also believed that prophylactic antibiotic has major impact in reducing SSI. Subjects & Methods: Seventy cases were enrolled in this study with knowledgeable consent. The study was carried out over a time period of ten months. The subjects acknowledge for elective laparoscopic cholecystectomy were incorporated in our study. Results: Out of the 70 randomized patients, 35 were allotted in single dose (SD group) while 35 patients were allotted in multiple doses (MD group), who got planned treatments and were then investigated. Of the 70 patients, female patients were 58(82.9%) and males were 12(17.1%). Total 43.62 12.18 years was the mean age of patients having symptomatic cholelithiasis, with 18 years as minimum and 77 years as maximum age. The peak of disease was documented in the age group of 30 to 39 years (28.6%). Conclusion: Utility of single antibiotic dose before anesthesia induction in laparoscopic cholecystectomy was likewise efficient as the use of multiple antibiotics doses in surgical site infection of postoperative periods.

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