scholarly journals Optical coherence tomography’s current clinical medical and dental applications: a review

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 310
Author(s):  
Saqib Ali ◽  
Saqlain Bin Syed Gilani ◽  
Juzer Shabbir ◽  
Khalid S. Almulhim ◽  
Amr Bugshan ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Root Canals ◽  
Advantages And Disadvantages ◽  
Non Invasive ◽  
Initial Application ◽  
Investigative Technique ◽  
Imaging Detection ◽  
Dental Applications

Optical coherence tomography (OCT) is a non-invasive investigative technique that is used to obtain high-resolution three-dimensional (3D) images of biological structures. This method is useful in diagnosing diseases of specific organs like the eye, where a direct biopsy cannot be conducted. Since its inception, significant advancements have been made in its technology. Apart from its initial application in ophthalmology for retinal imaging, substantial technological innovations in OCT brought by the research community have enabled its utilization beyond its original scope and allowed its application in many new clinical areas. This review presents a summary of the clinical applications of OCT in the field of medicine (ophthalmology, cardiology, otology, and dermatology) and dentistry (tissue imaging, detection of caries, analysis of dental polymer composite restorations, imaging of root canals, and diagnosis of oral cancer). In addition, potential advantages and disadvantages of OCT are also discussed.

scholarly journals Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06645
Author(s):  
Charlotte Theresa Trebing ◽  
Sinan Sen ◽  
Stefan Rues ◽  
Christopher Herpel ◽  
Maria Schöllhorn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Performance ◽  
Three Dimensional ◽  
Oral Epithelium ◽  
Optical Coherence ◽  
Non Invasive

Intraluminal three-dimensional optical coherence tomography – a tool for imaging of the Eustachian tube?

2019 ◽  
Vol 133 (2) ◽  
pp. 87-94 ◽  
Author(s):  
R Schuon ◽  
B Mrevlje ◽  
B Vollmar ◽  
T Lenarz ◽  
G Paasche
Keyword(s):  
Optical Coherence Tomography ◽  
Eustachian Tube ◽  
Cross Sections ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Diagnostic Value ◽  
Optical Coherence ◽  
Experimental Conditions ◽  
Non Invasive ◽  
Tube Dysfunction

AbstractObjectivesThe cause of Eustachian tube dysfunction often remains unclear. Therefore, this study aimed to examine the feasibility and possible diagnostic use of optical coherence tomography in the Eustachian tube ex vivo.MethodsTwo female blackface sheep cadaver heads were examined bilaterally. Three conditions of the Eustachian tube were investigated: closed (resting position), actively opened and stented. The findings were compared (and correlated) with segmented histological cross-sections.ResultsIntraluminal placement of the Eustachian tube with the optical coherence tomography catheter was performed without difficulty. Regarding the limited infiltration depth of optical coherence tomography, tissues can be differentiated. The localisation of the stent was accurate as was the lumen.ConclusionThe application of optical coherence tomography in the Eustachian tube under these experimental conditions is considered to be a feasible, rapid and non-invasive diagnostic method, with possible diagnostic value for determining the luminal shape and superficial lining tissue of the Eustachian tube.

scholarly journals The methods used for the diagnosis and evaluation of scoliosis

2016 ◽  
Vol 9 (17) ◽  
pp. 36-41 ◽  
Author(s):  
Ana-Maria Vutan ◽  
Erwin-Christian Lovasz ◽  
Mihaela Amarandei ◽  
Valentin Ciupe
Keyword(s):  
Three Dimensional ◽  
Growth Period ◽  
Small Scale ◽  
X Rays ◽  
Hematopoietic Tissue ◽  
X Ray ◽  
Advantages And Disadvantages ◽  
Non Invasive ◽  
Three Dimensional Mapping ◽  
Clinical Control

Abstract In recent years there multiple studies have been carried out on early diagnosis of scoliosis on school and preschool children. The diagnosis and evaluation of scoliosis is done by carrying out X-rays. A protocol is implemented for tracking the evolution of a scoliosis which involves both clinical control and imaging (X-ray) every 6 months, until the end of the growth period of the child. Because investigations such as X-ray and CT, can have harmful effects on the child's growing body (recent studies have shown that X-ray affects the skin, eyes, hematopoietic tissue, gonads and may cause cancer), new methods for diagnosing and tracking the evolution in time were researched. The present paper tries to present the current methods used in the diagnosis and assessment of scoliosis evolution in time, pointing out the main advantages and disadvantages of each method. There are a few methods developed in recent years in Germany by Zebris Medical Gmbh (using mapping with ultrasonic digital equipment), in Canada by InSpeck (using three-dimensional mapping through digital image acquisition) but used on a small scale. The newly developed methods have the advantage of being non-invasive, painless, non-irradiating and they can be used regardless of health status or gender. Although medical technology has developed very rapidly in recent years, radiology remains the most common method of investigation used for scoliosis. Certainly, in the near future the methods presented in this paper could be used more widely, for the benefits arising from their use.

scholarly journals Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography

Micromachines ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 35 ◽  
Author(s):  
Meng-Tsan Tsai ◽  
Bo-Huei Huang ◽  
Chun-Chih Yeh ◽  
Kin Fong Lei ◽  
Ngan-Ming Tsang
Keyword(s):  
Optical Coherence Tomography ◽  
Cancer Cell ◽  
Cellular Response ◽  
Tumor Development ◽  
Three Dimensional ◽  
Cancer Cell Line ◽  
Optical Coherence ◽  
Non Invasive

Investigation of tumor development is essential in cancer research. In the laboratory, living cell culture is a standard bio-technology for studying cellular response under tested conditions to predict in vivo cellular response. In particular, the colony formation assay has become a standard experiment for characterizing the tumor development in vitro. However, quantification of the growth of cell colonies under a microscope is difficult because they are suspended in a three-dimensional environment. Thus, optical coherence tomography (OCT) imaging was develop in this study to monitor the growth of cell colonies. Cancer cell line of Huh 7 was used and the cells were applied on a layer of agarose hydrogel, i.e., a non-adherent surface. Then, cell colonies were gradually formed on the surface. The OCT technique was used to scan the cell colonies every day to obtain quantitative data for describing their growth. The results revealed the average volume increased with time due to the formation of cell colonies day-by-day. Additionally, the distribution of cell colony volume was analyzed to show the detailed information of the growth of the cell colonies. In summary, the OCT provides a non-invasive quantification technique for monitoring the growth of the cell colonies. From the OCT images, objective and precise information is obtained for higher prediction of the in vivo tumor development.

scholarly journals Wavefront Shaping Concepts for Application in Optical Coherence Tomography—A Review

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7044
Author(s):  
Jonas Kanngiesser ◽  
Bernhard Roth
Keyword(s):  
Optical Coherence Tomography ◽  
Scattered Light ◽  
Three Dimensional ◽  
Medical Diagnostics ◽  
Optical Coherence ◽  
Scattering Media ◽  
Destructive Testing ◽  
Non Invasive ◽  
Wavefront Shaping ◽  
Micrometer Scale

Optical coherence tomography (OCT) enables three-dimensional imaging with resolution on the micrometer scale. The technique relies on the time-of-flight gated detection of light scattered from a sample and has received enormous interest in applications as versatile as non-destructive testing, metrology and non-invasive medical diagnostics. However, in strongly scattering media such as biological tissue, the penetration depth and imaging resolution are limited. Combining OCT imaging with wavefront shaping approaches significantly leverages the capabilities of the technique by controlling the scattered light field through manipulation of the field incident on the sample. This article reviews the main concepts developed so far in the field and discusses the latest results achieved with a focus on signal enhancement and imaging.

scholarly journals Optical Coherence Tomography Angiography of Choroidal Neovascularisation

2016 ◽  
Vol 10 (01) ◽  
pp. 29 ◽  
Author(s):  
Lorenzo Iuliano ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Three Dimensional ◽  
Choroidal Neovascularisation ◽  
Diagnostic Tools ◽  
Retinal Diseases ◽  
Optical Coherence ◽  
Promising Technique ◽  
Non Invasive ◽  
Dimensional Reconstruction

Optical coherence tomography angiography (OCTA) is a new promising technique able to provide a rapid, dyeless and non-invasive three-dimensional reconstruction of perfused vessels of retina and choroid. OCTA has been recently added to the diagnostic tools of retinal experts, and its role is still being explored in different retinal diseases. Chorodial neovascularisations (CNVs) are among the most significant disorders where OCTA is enhancing our diagnostic and classification skills, since it demonstrates an excellent capacity to identify and characterise each specific subtype of CNV.

scholarly journals A review on Cone Beam Computed Tomography in dentistry

2021 ◽  
pp. 003-007
Author(s):  
Patel Nimeshkumar ◽  
Mistry Ekta
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Dental Treatment ◽  
Low Cost ◽  
Three Dimensional ◽  
Cone Beam ◽  
Root Canals ◽  
Dental Practices ◽  
Dental Applications ◽  
Dimensional Assessment

Introduction: Cone Beam Computed Tomography (CBCT) has transformed the manner in which radiological evaluation is performed. Methods: This article discusses the different aspects of CBCT, common dental applications of CBCT for diagnosis and treatment in different dental specialties from the current literature. Results: CBCT has been widely accepted into different dental practices. The main reasons are the decreased size, low cost, less exposure to radiation as compared to computed tomography. CBCT enables the three dimensional assessment of the region of maxilla, mandible, cranium, and associated structures. Conclusions: Dentists and dental specialists can utilize three dimensional radiography- CBCT for a comprehensive diagnosis. CBCT can also help in identifying the structures such as root canals, bifurcated canals, supernumerary teeth, impacted teeth in different planes and thus are a valuable tool for dental treatment planning.

scholarly journals First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

2019 ◽  
Vol 12 ◽  
pp. 175628641984304 ◽  
Author(s):  
Karl Hartmann ◽  
Klaus-Peter Stein ◽  
Belal Neyazi ◽  
Ibrahim Erol Sandalcioglu
Keyword(s):  
Optical Coherence Tomography ◽  
Subarachnoid Space ◽  
Brain Cortex ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Pia Mater ◽  
Anatomical Structures ◽  
Non Invasive ◽  
The Brain

The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients ( n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures.

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