scholarly journals Recent advances in Japanese encephalitis

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 259 ◽  
Author(s):  
Anirban Basu ◽  
Kallol Dutta
Keyword(s):  
Clinical Trials ◽  
Global Health ◽  
Southeast Asia ◽  
Japanese Encephalitis ◽  
The South ◽  
Active Vaccination ◽  
Recent Advances ◽  
Vaccination Campaigns

Japanese encephalitis is a flaviviral disease that is endemic to the South, Southeast Asia, and Asia Oceania regions. Given that about 60% of the world’s population (about 7.4 billion) resides in this region (about 4.4 billion), this disease poses a significant threat to global health. Active vaccination campaigns conducted in endemic countries have led to a decrease in the number of reported cases over the years. In this article, we strive to briefly highlight recent advances in understanding the role of microRNAs in disease pathology, focus on providing brief summaries of recent clinical trials in the field of Japanese encephalitis therapeutics, and review the current prophylactic strategies.

scholarly journals Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Sylvie Hermouet ◽  
Edith Bigot-Corbel ◽  
Betty Gardie
Keyword(s):  
Clinical Trials ◽  
Chronic Inflammation ◽  
Molecular Diagnosis ◽  
Molecular Mechanisms ◽  
Myeloproliferative Neoplasms ◽  
Heterogeneous Group ◽  
Genetic Defects ◽  
Jak Inhibitor ◽  
Recent Advances

Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with mutation(s) in theJAK2, MPL,orCALRgenes. Yet the roles played by these mutations in the pathogenesis and main complications of the different subtypes of MPNs are not fully elucidated. Importantly, chronic inflammation has long been associated with MPN disease and some of the symptoms and complications can be linked to inflammation. Moreover, the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients even in the absence of significant decrease in theJAK2-V617F mutant load. These observations suggested that part of the inflammation observed in patients withJAK2-mutated MPNs may not be the consequence ofJAK2mutation. The aim of this paper is to review the different aspects of inflammation in MPNs, the molecular mechanisms involved, the role of specific genetic defects, and the evidence that increased production of certain cytokines depends or not on MPN-associated mutations, and to discuss possible nongenetic causes of inflammation.

Nation Building and the Vietnam War

2005 ◽  
Vol 74 (3) ◽  
pp. 441-456 ◽  
Author(s):  
CHRISTOPHER T. FISHER
Keyword(s):  
United States ◽  
Southeast Asia ◽  
Vietnam War ◽  
Nation Building ◽  
The United States ◽  
Modernization Theory ◽  
The South ◽  
Quiet Revolution ◽  
The Vietnam War

The literature on U.S. participation in the Vietnam War has recently undergone a quiet revolution due to use of the concept of nation building. Since the early 1950s nation building has been the subtext, if not the excuse, for U.S. intervention in Southeast Asia, but in the last ten years it has also become useful as a method of inquiry. This article contends that new insights regarding the signi�cance of ideologies and paradigms, particularly modernization theory, enabled the transformation. Understanding modernization theory as an ideology broke with the tradition among diplomatic historians that minimized the role of ideas in policy decisions. It also settled longstanding questions about the nature of paci�cation as either development or counterinsurgency: Counterinsurgency and development were simply different expressions of the same impulse for the United States and the South Vietnamese.

Bridging the Knowledge Gaps in Arrhythmogenic Cardiovascular Conditions: The Critical Role of Registries

2016 ◽  
Vol 10 (2) ◽  
pp. 1 ◽  
Author(s):  
Melody Hermel ◽  
Rebecca Duffy ◽  
Alexander Orfanos ◽  
Isabelle Hack ◽  
Shayna McEnteggart ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Risk Stratification ◽  
Critical Role ◽  
Knowledge Gaps ◽  
Level Of Evidence ◽  
The Future

Cardiac registries have filled many gaps in knowledge related to arrhythmogenic cardiovascular conditions. Despite the less robust level of evidence available in registries when compared with clinical trials, registries have contributed a range of clinically useful information. In this review, the authors discuss the role that registries have played – related to diagnosis, natural history, risk stratification, treatment, and genetics of arrhythmogenic cardiovascular conditions – in closing knowledge gaps, and their role in the future.

When People Come First

2013 ◽  
Keyword(s):  
Global Health ◽  
Scale Up ◽  
Moral Economy ◽  
Health Science ◽  
Health It ◽  
Left Behind ◽  
New Research ◽  
Health Enterprise ◽  
Conceptual Work

This book critically assesses the expanding field of global health. It brings together an international and interdisciplinary group of scholars to address the medical, social, political, and economic dimensions of the global health enterprise through vivid case studies and bold conceptual work. The book demonstrates the crucial role of ethnography as an empirical lantern in global health, arguing for a more comprehensive, people-centered approach. Topics include the limits of technological quick fixes in disease control, the moral economy of global health science, the unexpected effects of massive treatment rollouts in resource-poor contexts, and how right-to-health activism coalesces with the increased influence of the pharmaceutical industry on health care. The chapters explore the altered landscapes left behind after programs scale up, break down, or move on. We learn that disease is really never just one thing, technology delivery does not equate with care, and biology and technology interact in ways we cannot always predict. The most effective solutions may well be found in people themselves, who consistently exceed the projections of experts and the medical-scientific, political, and humanitarian frameworks in which they are cast. This book sets a new research agenda in global health and social theory and challenges us to rethink the relationships between care, rights, health, and economic futures.

PD-L1 Inhibitors for the Treatment of Prostate Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 1558-1565
Author(s):  
Matteo Santoni ◽  
Francesco Massari ◽  
Liang Cheng ◽  
Alessia Cimadamore ◽  
Marina Scarpelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
T Lymphocytes ◽  
Chronic Inflammation ◽  
Immune Cells ◽  
Response To Therapy ◽  
Complex Series

The carcinogenesis of prostate cancer (PCa) results from a complex series of events. Chronic inflammation and infections are crucial in this context. Infiltrating M2 type macrophages, as well as neutrophils and T lymphocytes, contribute to PCa development, progression and response to therapy. The preliminary findings on the efficacy of immunotherapy in patients with PCa were not encouraging. However, a series of studies investigating anti-PD-L1 agents such as Atezolizumab, Avelumab and Durvalumab used alone or in combination with other immunotherapies, chemotherapy or locoregional approaches are in course in this tumor. In this review, we illustrate the role of immune cells and PD-L1 expression during PCa carcinogenesis and progression, with a focus on ongoing clinical trials on anti-PD-L1 agents in this context.

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