scholarly journals Protective effects of folic acid on colon carcinogenesis induced by azoxymethane in mice

2021 ◽  
Vol 22 (3) ◽  
pp. 111-120
Author(s):  
Ji Yun Sohn ◽  
Eun Young Kim ◽  
Jae-Hwang Jeong ◽  
Dae Joong Kim ◽  
Sang Yoon Nam ◽  
...  
Keyword(s):  
Folic Acid ◽  
Colon Carcinogenesis ◽  
Protective Effects

Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid

2019 ◽  
Vol 130 ◽  
pp. 379-396 ◽  
Author(s):  
Omar Emiliano Aparicio-Trejo ◽  
Laura María Reyes-Fermín ◽  
Alfredo Briones-Herrera ◽  
Edilia Tapia ◽  
Juan Carlos León-Contreras ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Kidney Damage ◽  
Protective Effects ◽  
Acetyl Cysteine

Lack of chemoprevention of dietary Agaricus blazei against rat colonic aberrant crypt foci

2008 ◽  
Vol 27 (6) ◽  
pp. 505-511 ◽  
Author(s):  
L Ziliotto ◽  
LF Barbisan ◽  
MAM Rodrigues
Keyword(s):  
Folk Medicine ◽  
Colon Carcinogenesis ◽  
Distal Colon ◽  
Edible Mushroom ◽  
Aberrant Crypt Foci ◽  
Nuclear Antigen ◽  
Rat Colon ◽  
Protective Effects ◽  
Agaricus Blazei ◽  
Initiation Stage

The mushroom Agaricus blazei ( Ab) has been widely used in folk medicine to treat various diseases including cancer. No information is available on its possible protective effects on the development of colon cancer. The potential blocking effect of Ab intake on the initiation stage of colon carcinogenesis was investigated in a short-term (4-week) bioassay using aberrant crypt foci (ACF) as biomarker. Male Wistar rats were given four subcutaneous injections of the carcinogen 1,2-dimethylhydrazine (DMH, 40 mg/kg bw, twice a week), during 2 weeks to induce ACF. The diet containing Ab at 5% was given 2 weeks before and during carcinogen treatment to investigate the potential beneficial effects of this edible mushroom on DMH-induced ACF. All groups were killed at the end of the fourth week. The colons were analyzed for ACF formation in 1% methylene blue whole-mount preparations and for cell proliferation in histological sections immunohistochemically stained for the proliferating cell nuclear antigen (PCNA). All DMH-treated rats developed ACF mainly in the middle and distal colon. Agaricus blazei intake at 5% did not alter the number of ACF induced by DMH or the PCNA indices in the colonic mucosa. Thus, the results of the present study did not confirm a chemopreventive activity of Ab on the initiation stage of rat colon carcinogenesis.

Protective effects of sodium selenite and selenium nanoparticles against experimental colon carcinogenesis in mice

2016 ◽  
Vol 40 (3) ◽  
pp. 101-108 ◽  
Author(s):  
Do-Youn Jang ◽  
◽  
Sung-June Kim ◽  
Jae-Hwang Jeong ◽  
Sang Yoon Nam ◽  
...  
Keyword(s):  
Sodium Selenite ◽  
Colon Carcinogenesis ◽  
Selenium Nanoparticles ◽  
Protective Effects

scholarly journals Effectiveness of Bioactive Food Components in Experimental Colon Carcinogenesis

2009 ◽  
Vol 78 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Emília Hijová ◽  
Anna Chmelárová ◽  
Alojz Bomba
Keyword(s):  
Bile Acid ◽  
High Fat Diet ◽  
Colon Carcinogenesis ◽  
Control Group ◽  
Serum Bile Acid ◽  
Protective Effects ◽  
High Fat ◽  
Bile Acid Concentration ◽  
Food Components ◽  
Bioactive Food Components

The aim of the present study was the evaluation of possible protective effects of selected bioactive food components in experimental N,N-dimethylhydrazine (DMH)-induced colon carcinogenesis. Wistar albino rats (n = 92) were fed a high fat diet or conventional laboratory diet. Two weeks after the beginning of the trial, DMH injections were given to six groups of rats at the dose of 20 mg/kg b.w. twice weekly. The activity of bacterial enzymes in faeces and serum bile acid concentrations were determined. High fat diet, DMH injections, and their combination significantly increased the activies of β-galactosidase, β-glucuronidase, and α-glucosidase (p < 0.001) compared to the control group of rats. Treatment with the prebiotic inulin, Hyppocastani extractum siccum and Lini oleum virginale significantly decreased the activity of β-galactosidase, β-glucuronidase, and α-glucosidase (p < 0.001), as well as the bile acid concentration compared to the group at the highest risk. The protective effects of selected bioactive food components in experimentally induced colon carcinogenesis allow for their possible use in cancer prevention or treatment.

Protective effects of folic acid on DNA damage and DNA methylation levels induced by N-methyl-N′-nitro-N-nitrosoguanidine in Kazakh esophageal epithelial cells

2018 ◽  
Vol 37 (12) ◽  
pp. 1258-1267
Author(s):  
Y Chen ◽  
H Feng ◽  
D Chen ◽  
K Abuduwaili ◽  
X Li ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Damage ◽  
Folic Acid ◽  
Epithelial Cells ◽  
Methylenetetrahydrofolate Reductase ◽  
Folate Receptor ◽  
Protective Effects ◽  
Genome Wide ◽  
Esophageal Epithelial Cells

The protective effects of folic acid on DNA damage and DNA methylation induced by N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) in Kazakh esophageal epithelial cells were investigated using a 3 × 3 factorial design trial. The cells were cultured in vitro and exposed to media containing different concentrations of folic acid and MNNG, after which growth indices were detected. DNA damage levels were measured using comet assays, and genome-wide DNA methylation levels (MLs) were measured using high-performance liquid chromatography. The DNA methylation of methylenetetrahydrofolate reductase (MTHFR) and folate receptor- α (FR α) genes was detected by bisulfite sequencing polymerase chain reaction (PCR). The results showed significant increases in tail DNA concentration, tail length, and Olive tail moment ( p < 0.01); a significant reduction of genome-wide DNA MLs ( p < 0.01); and an increase in the methylation frequencies of MTHFR and FR α genes. In particular, significant differences were observed in the promoter regions of both genes ( p < 0.01). Our study indicated that a reduction in folic acid concentration promotes DNA damage and DNA methylation in Kazakh esophageal epithelial cells upon MNNG exposure. Thus, sufficient folic acid levels could play a protective role against the damage induced by this compound.

Protective effects of calcium from nonfat dried milk against colon carcinogenesis in rats

1996 ◽  
Vol 25 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Barbara C. Pence ◽  
Dale M. Dunn ◽  
Christina Zhao ◽  
Vijay Patel ◽  
Stephanie Hunter ◽  
...  
Keyword(s):  
Colon Carcinogenesis ◽  
Protective Effects

scholarly journals The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

2019 ◽  
Vol 97 (9) ◽  
pp. 893-901 ◽  
Author(s):  
Slavica Mutavdzin ◽  
Kristina Gopcevic ◽  
Sanja Stankovic ◽  
Jovana Jakovljevic Uzelac ◽  
Milica Labudovic Borovic ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Folic Acid ◽  
Matrix Metalloproteinase ◽  
Acid Treatment ◽  
Cardiac Tissue ◽  
Physiological Saline ◽  
Diabetic Rats ◽  
Fibrinogen Concentration ◽  
Protective Effects ◽  
Creatinine Concentration

Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. There were 4 groups: control (physiological saline 1 mL/kg, i.p., 28 days), DM (streptozotocin [STZ] 100 mg/kg in physiological saline, i.p., 1 day), folic acid (FA; 5 mg/kg, i.p., 28 days), and DM+FA (STZ 100 mg/kg, i.p., 1 day and folic acid 5 mg/kg, i.p., 28 days). Our results demonstrated increased aminotransferase and alkaline phosphatase activity, urea and creatinine concentration, and decreased albumin and fibrinogen concentration in the DM group. MMP-2 relative activity was elevated in the DM and FA groups; MMP-9 was decreased in the DM and increased in the FA group. The folic acid treatment of diabetic rats did not change aminotransferase activity; it alleviated the increase in alkaline phosphatase and the decrease in albumin and fibrinogen concentration, and reduced MMP-2 activity; however, it increased urea and creatinine concentration. In conclusion, folic acid treatment of diabetic rats has cardio- and hepato-protective effects. However, its dosing should be carefully considered because of possible renal damage.

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