scholarly journals Model of personalized non-pharmacological program of cognitive disorder correction in patients with epilepsy and the assessment of its efficacy

2021 ◽  
Vol 11 (2) ◽  
pp. 208-221
Author(s):  
I. Blazhyna
Keyword(s):  
Quality Of Life ◽  
Cognitive Training ◽  
Cognitive Functions ◽  
Cognitive Assessment ◽  
Montreal Cognitive Assessment ◽  
Depression Symptoms ◽  
Statistical Research ◽  
Quality Of Life Scale ◽  
Patients With Epilepsy

Cognitive dysfunction shows higher incidence in people, suffering from epilepsy, than in general population and most likely they are related to common patho-biological processes. The use of medication in patients with epilepsy for treating cognitive functions is limited due to the potential risk of more frequent seizures. Therefore, non-pharmacological methods of cognitive correction are becoming especially important for this category of patients.Aim. The aim of the research is to study the specifics of non-dementia cognitive disorders in patients with epilepsy and to develop a set of activities for their prevention and non-pharmacological correction.Materials and methods. The study included 146 patients (61 women and 85 men), their average age was 40,73. We applied clinical anamnestic, sociodemographic, clinical-psychopathological, psycho-diagnostic and statistical research methods. The following psycho-diagnostic techniques were used: Montreal Cognitive Assessment (MoCA), Munsterberg test, MiniMult test, Hamilton depression and anxiety rating scales (HRDS, HARS) and the quality of life scale. 63 patients completed a 3-month computerized online cognitive training with daily sessions, out of which 33 patients also participated in psychoeducational activities.Results. The findings of studying patients with epilepsy using the Montreal Cognitive Assessment (MoCA) showed low levels of all parameters while the total score in the patients with epilepsy with cognitive non-dementia disorders was 20,72 versus27,36 in healthy persons; the analysis of HRDS, HARS showed high anxiety and depression symptoms levels, lower quality of life level was also observed, the average indicator was 69,45, whereas in the control group the level of life quality was 78,60. There was marked adherence to cognitive training in the patients with epilepsy compared to the healthy group.Conclusion. Reliable improvement of cognitive functioning was found in the patients under consideration after 3 months of the training. The computerized cognitive functions training in current conditions showed its benefits owing to the opportunity to complete it online. It may be advised to be introduced as a part of the social rehabilitation system for patients with epilepsy, who have cognitive non-dementia disorders.

scholarly journals Cognitive impairments in patients with treatment resistant epilepsy and complex rehabilitation

2021 ◽  
Vol 8 (2) ◽  
pp. 123-129
Author(s):  
Volodymyr Korostiy ◽  
Iryna Blazhina
Keyword(s):  
Quality Of Life ◽  
Cognitive Decline ◽  
Cognitive Training ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Cognitive Impairments ◽  
Control Group ◽  
Quality Of Life Scale ◽  
Patients With Epilepsy

Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation. Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation. Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety. Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction. Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.

Features and methods of assessing health-related quality of life and cognitive functions in patients with glial tumors

2020 ◽  
pp. 47-56
Author(s):  
Vera Arsenyeva ◽  
Boris Martynov ◽  
Gennadiy Bulyshchenko ◽  
Dmitriy Svistov ◽  
Boris Gaydar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Functions ◽  
Well Being ◽  
Health Related Quality ◽  
Number Of Patients ◽  
Related Quality ◽  
Health Related ◽  
Eortc Qlq ◽  
Patients With Epilepsy

Gliomas make up about 8 cases per 100,000 population and the number of patients with this disease is only increasing. There can be not only various types of neurological deficits among the symptoms, but also personal and emotional changes, that seriously affects the quality of life. The modern model of health care includes not only recovery of the patient’s physical functions, but also his or her psychosocial well-being. In particular, the assessment and study of the characteristics of health-related quality of life, as well as cognitive functions in patients with gliomas, is increasingly recognized as an important criterion when considering the effectiveness of treatment. To date, the features of health related quality of life and cognitive functions of patients with epilepsy and acute cerebral circulation disorders have been studied sufficiently, and, as a result, techniques have been developed that accurately assess the QOL and CF in patients with these diseases. These are QOLIE-31 and QOLIE-AD-48 questionnaires for patients with epilepsy. This is the National Institutes of Health Stroke Scale (NIHSS), Orgogozo stroke scale (OSS), World Federation of Neurological Surgeons (WFNS) scale for the clinical assessment of subarachnoid hemorrhage (SAH) for patients with acute cerebrovascular accident. At the same time, there are no generally accepted methods for assessing quality of life and neurocognitive functions that are sensitive to changes in the condition of patients with gliomas in the early postoperative period by the time of discharge from the hospital. As a result, there is no systematic information on the dynamics of the quality of life of such patients, their neurocognitive functioning. The purpose of this article was to study the literature on QOL and CF in patients affected by neurological and neurosurgical disorders for the further selection of optimal methods for assessing dynamics of the condition of patients with glial brain tumors before and after surgery. At the moment, such requirements are only partially met by the EORTC QLQ-C30 questionnaire and its application EORTC QLQ-BN20.

scholarly journals Prevalence of symptoms and quality of life of cancer patients

2020 ◽  
Vol 73 (2) ◽  
Author(s):  
Marina de Góes Salvetti ◽  
Caroline Silva Pereira Machado ◽  
Suzana Cristina Teixeira Donato ◽  
Adriana Marques da Silva
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Negative Correlation ◽  
Physical Symptoms ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Positive Correlation ◽  
Quality Of Life Scale ◽  
Loss Of Appetite

ABSTRACT Objectives: to analyze the prevalence of symptoms and their relationship with the quality of life of cancer patients. Methods: this is a cross-sectional study with 107 patients evaluated using a sociodemographic instrument, the hospital anxiety and depression scale (HADS) and the quality of life scale (EORTC-QLQ-C30). Pearson’s correlation test was used to evaluate the relationship between symptoms and quality of life. Results: prevalence of female patients (56.1%), 55 years as the mean age and 10 years of schooling. Fatigue (76.6%), insomnia (47.7%), pain (42.1%), loss of appetite (37.4%), anxiety (31.8%) and depression (21.5%) were identified. Anxiety and depression symptoms presented a negative correlation with quality of life and positive correlation with physical symptoms. Conclusions: fatigue, insomnia, pain and loss of appetite were the most common and most intense symptoms. Anxiety and depression symptoms presented a negative correlation with quality of life and positive correlation with physical symptoms.

Efficacy and impact on cognitive functions and quality of life of perampanel as first add-on therapy in patients with epilepsy: A retrospective study

2019 ◽  
Vol 98 ◽  
pp. 139-144 ◽  
Author(s):  
Raffaele Rea ◽  
Enea Traini ◽  
Rosaria Renna ◽  
Francesco Pagliuca ◽  
Marianna Pezzella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retrospective Study ◽  
Cognitive Functions ◽  
Patients With Epilepsy

scholarly journals IMPACTS OF COMPUTERIZED COGNITIVE TRAINING FOR OLDER ADULTS IN A COVID-19 PANDEMIC CONTEXT

2021 ◽  
Author(s):  
Cristiane Viviani ◽  
Karen Jardim ◽  
Jonatas Borges ◽  
Beatriz Aparecida Gutierrez ◽  
Tiago Ordonez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Cognitive Training ◽  
Training Group ◽  
Cognitive Intervention ◽  
Life Assessment ◽  
Computerized Cognitive Training ◽  
Memory Complaints ◽  
Quality Of Life Scale

Background: Healthy aging it is possible to compensate for normative changes in cognitive performance, such as during digital learning, in which processes can benefit the global cognition and mood of healthy older adults. Objective: To verify the impacts of computerized cognitive training through an online platform, on mood, frequency of forgetfulness, memory complaints and quality of life of active older adults. Methods: 66 healthy elderly people were invited and divided into two groups, training group (n=32) and control group (n=34). Protocol: a sociodemographic questionnaire, the Memory Complaint Questionnaire (MAC-Q), a MAC-Nair forgetfulness frequency scale, the Geriatric Depression Scale (GDS-15), the Geriatric Anxiety Inventory (GAI), and a questionnaire of Quality of Life Assessment Control, Autonomy, Selfrealization and Pleasure (CASP-19). Results: Elderly aged 60 to 92 years, who attended higher education (39.39%) and postgraduate education (42.42%). Participants in the training group had a reduction in the MAC-Q, MAC-Nair and GAI scores, post-cognitive intervention, and the deltas of the scores (Post – Pre). Additionally, there were significant differences between groups, in the total quality of life scale - CASP 19 - in the posttest. Conclusion: That participating in a computerized cognitive intervention made it possible to reduce memory complaints, reduce the frequency of forgetfulness, reduce anxiety symptoms and improve self-reported quality of life.

scholarly journals Caffeine as symptomatic treatment for Parkinson disease (Café-PD)

Neurology ◽  
2017 ◽  
Vol 89 (17) ◽  
pp. 1795-1803 ◽  
Author(s):  
Ronald B. Postuma ◽  
Julius Anang ◽  
Amelie Pelletier ◽  
Lawrence Joseph ◽  
Mariana Moscovich ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Cognitive Assessment ◽  
Rating Scale ◽  
Montreal Cognitive Assessment ◽  
Class I ◽  
Symptomatic Therapy ◽  
Motor Symptoms ◽  
Secondary Outcomes

Objective:To assess effects of caffeine on Parkinson disease (PD).Methods:In this multicenter parallel-group controlled trial, patients with PD with 1–8 years disease duration, Hoehn & Yahr stages I–III, on stable symptomatic therapy were randomized to caffeine 200 mg BID vs matching placebo capsules for 6–18 months. The primary research question was whether objective motor scores would differ at 6 months (Movement Disorder Society–sponsored Unified Parkinson's Disease Rating Scale [MDS-UPDRS]–III, Class I evidence). Secondary outcomes included safety and tolerability, motor symptoms (MDS-UPDRS-II), motor fluctuations, sleep, nonmotor symptoms (MDS-UPDRS-I), cognition (Montreal Cognitive Assessment), and quality of life.Results:Sixty patients received caffeine and 61 placebo. Caffeine was well-tolerated with similar prevalence of side effects as placebo. There was no improvement in motor parkinsonism (the primary outcome) with caffeine treatment compared to placebo (difference between groups −0.48 [95% confidence interval −3.21 to 2.25] points on MDS-UPDRS-III). Similarly, on secondary outcomes, there was no change in motor signs or motor symptoms (MDS-UPDRS-II) at any time point, and no difference on quality of life. There was a slight improvement in somnolence over the first 6 months, which attenuated over time. There was a slight increase in dyskinesia with caffeine (MDS-UPDRS-4.1+4.2 = 0.25 points higher), and caffeine was associated with worse cognitive testing scores (average Montreal Cognitive Assessment = 0.66 [0.01, 1.32] worse than placebo).Conclusion:Caffeine did not provide clinically important improvement of motor manifestations of PD (Class I evidence). Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects.Clinicaltrials.gov identifier:NCT01738178.Classification of evidence:This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations.

Impact of hormone-therapy used in CRPC patients: Evaluation of abiraterone acetate/prednisone or enzalutamide on activity and cognitive functions in aged castrated mice.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e16526-e16526
Author(s):  
Hélène Castel ◽  
Tareq Al Sagheer ◽  
Martine Dubois ◽  
Cynthia Campart ◽  
Laurence Desrues ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spontaneous Activity ◽  
Cognitive Functions ◽  
Emotional Reactivity ◽  
Abiraterone Acetate ◽  
Depression Symptoms ◽  
Major Public Health Problem ◽  
Oral Agents ◽  
The Impact

e16526 Background: Prostate cancer (PC) is a major public health problem and represents the most frequent cancer in elderly male patients. Although most patients initially respond to androgen deprivation therapy (ADT) through inhibition of gonadal testosterone biosynthesis, the majority of these patients will progress to metastatic castration-resistant PC (mCRPC). Novel oral agents targeting androgen signaling axis, abiraterone acetate (AA)+prednisone (P) and enzalutamide (ENZ) are available and used in mCRPC patients in addition to ADT, but their impact on cognition is not well understood. Recently, the AQUARiUS study (Thiery-Vuillemin et al., ESMO Open, 2018) showed that after treatment, median Quality of life score improved with AAP. Additionally, results from a phase 2 trial showed that a worsening of depression symptoms were more often detected in ENZ- than in AAP-treated patients (Khalaf et al., Eur Urol, 2018). Methods: Here we developed a preclinical animal model to clarify the potential impact of AAP or ENZ on emotional reactivity and cognitive functions including spontaneous activity, anxiety-like and depression-like behaviors or spatial memory and learning. Results: In aged castrated mice receiving per os vehicle or AAP or ENZ, we showed that, in contrast to AAP, exposure to ENZ reduced spontaneous activity and increased depressive-like behaviors. AAP-treated mice displayed diminished self-grooming suggesting lower arousal in a novel environment. None of the treatments provoked anxiety-like behavior, learning and memory deficits. However, the swimming strategies (Morris-water maze) in AAP and ENZ groups were slightly altered. Analysis of plasma from treated mice revealed a detectable level of corticosterone only in AAP group. Conclusions: These data establish the impact of ENZ on emotional reactivity and of both ENZ and AAP on subtle cognitive functions in castrated aged male subjects. It paves the road for future effective research that could lead to better management of quality of life in mCRPC.

scholarly journals The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment

2020 ◽  
pp. 030802262095099
Author(s):  
Talia Maeir ◽  
Mor Nahum ◽  
Chen Makranz ◽  
Afik Hoba ◽  
Tamar Peretz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Cancer Survivors ◽  
Cognitive Training ◽  
Cognitive Functions ◽  
Treatment Intervention ◽  
Occupational Performance ◽  
Combined Model

Introduction The purpose of this study was to test the feasibility of a telehealth intervention combining computerised cognitive training and occupation-based treatment among adult cancer survivors experiencing cancer-related cognitive impairment. Method This was a single-arm study including six cancer survivors with cancer-related cognitive impairment. Participants completed the computerised retraining and functional treatment intervention consisting of 10 hours of computerised cognitive training (BrainHQ) and approximately 10 1:1 remote sessions with an occupational therapist using an occupation-based approach. Feasibility was measured in terms of recruitment, adherence, acceptability and potential effectiveness. Assessments were administered at baseline, post-intervention and at 3-month follow-up and included measures of occupational performance, objective cognitive functions, quality of life and mood questionnaires. Results From the nine participants enrolled in the study, six completed 8–13 weeks of computerised retraining and functional treatment intervention and reported high satisfaction levels. Positive and significant improvements were found in occupational performance, useful field of view and social quality of life (all P < 0.05). The positive gains were maintained at the 3-month follow-up. Conclusion A combined model of computerised cognitive training and occupation-based treatment delivered remotely to adults with cancer-related cognitive impairment was found feasible and may improve occupational performance, cognitive functions and quality of life.

scholarly journals Mood Disturbances, Anxiety, and Impact on Quality of Life in Patients Admitted to Epilepsy Monitoring Units

2021 ◽  
Vol 12 ◽  
Author(s):  
Rodrigo Rocamora ◽  
Beatriz Chavarría ◽  
Eva Pérez ◽  
Carmen Pérez-Enríquez ◽  
Ainara Barguilla ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Refractory Epilepsy ◽  
Depression Scale ◽  
Epileptic Seizures ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Patients With Epilepsy ◽  
Anxiety Depression ◽  
Epilepsy Monitoring

Introduction: The overall combined prevalence of anxiety and depression in patients with epilepsy has been estimated at 20.2 and 22.9%, respectively, and is considered more severe in drug-refractory epilepsy. Patients admitted to epilepsy monitoring units constitute a particular group. Also, patients with psychogenic non-epileptic seizures can reach more than 20% of all admissions. This study aims to characterize these symptoms in a large cohort of patients admitted for evaluation in a tertiary epilepsy center.Materials and Methods: The study was conducted among 493 consecutive patients (age: 38.78 ± 12.7, 57% females) admitted for long-term video EEG from January 2013 to February 2021. Demographic, clinical, and mood disorder patients' data were collected. Anxiety and depression symptoms were assessed through the Hospital Anxiety Depression Scale (HADS-A and HADS-D), the State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI-II). Quality of life was determined using the QOLIE-10. Patients were divided into three groups: patients with epilepsy (n = 395), psychogenic non-epileptic seizures (PNES) (n = 56), and combined (n = 33). A univariate and multivariate regression analysis was performed for variables associated with quality of life.Results: Of 493 patients, 45.0% had structural etiology, and considering epilepsy classification, 43.6% were of temporal lobe origin. In addition, 32.45% of patients had a previous psychiatric history, 49.9% of patients had depressive symptoms in BDI, and 30.9% according to HADS-D; 56.42 and 52.63% of patients presented pathological anxiety scores in STAI-T and STAI-S, respectively; and 44.78% according to HADS-A. PNES and combined groups revealed a higher incidence of pathologic BDI scores (64.29 and 78.79%, p &lt; 0.001) as well as pathologic HADS-A scores (p = 0.001). Anxiety and depression pathologic results are more prevalent in females, HADS-A (females = 50.7%, males = 36.8%; p = 0.0027) and BDI &gt; 13 (females = 56.6%, males = 41.0%; p = 0.0006). QOLIE-10 showed that 71% of the patients had their quality of life affected with significantly higher scores in the combined group than in the epilepsy and PNES groups (p = 0.0015).Conclusions: Subjective anxiety, depression, and reduced quality of life are highly prevalent in patients with refractory epilepsy. These symptoms are more evident when PNES are associated with epilepsy and more severe among female patients. Most of the cases were not previously diagnosed. These factors should be considered in everyday clinical practice, and specific approaches might be adapted depending on the patient's profile.

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