Antisperm , Anticardiolipin and Antithyroglobulin Antibodies in Sera and Cervical Secretions among Women with Unexplained Infertility Attending Gynecological and Obstetric Department of Benha University Hospital

2012 ◽  
Vol 21 (2) ◽  
pp. 1-10
Author(s):  
Amal M. Saeed ◽  
Sherin Mohammed Emam ◽  
Ayman A. Shedid
Keyword(s):  
Unexplained Infertility ◽  
University Hospital ◽  
Antithyroglobulin Antibodies ◽  
Obstetric Department

scholarly journals ICSI Does Not Improve Live Birth Rates but Yields Higher Cancellation Rates Than Conventional IVF in Unexplained Infertility

2021 ◽  
Vol 7 ◽  
Author(s):  
Jianyuan Song ◽  
Tingting Liao ◽  
Kaiyou Fu ◽  
Jian Xu
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertilization Rate ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
University Hospital ◽  
Miscarriage Rate ◽  
Birth Rates ◽  
Live Birth Rates

Objectives: Unexplained infertility has been one of the indications for utilization of intracytoplasmic sperm injection (ICSI). However, whether ICSI should be preferred to IVF for patients with unexplained infertility remains an open question. This study aims to determine if ICSI improves the clinical outcomes over conventional in vitro fertilization (IVF) in couples with unexplained infertility.Methods: This was a retrospective cohort study of 549 IVF and 241 ICSI cycles for patients with unexplained infertility at a fertility center of a university hospital from January 2016 and December 2018. The live birth rate and clinical pregnancy rate were compared between the two groups. Other outcome measures included the implantation rate, miscarriage rate, and fertilization rate.Results: The live birth rate was 35.2% (172/488) in the IVF group and 33.3% (65/195) in ICSI group, P = 0.635. The two groups also had similar clinical pregnancy rates, implantation rates, and miscarriage rates. The fertilization rate of IVF group was significantly higher than that of ICSI group (53.8 vs. 45.7%, P = 0.000, respectively). Sixty-one and 46 patients did not transfer fresh embryos in IVF and ICSI cycles, respectively. Patients with IVF cycles had lower cancellation rates than those with ICSI (11.1 vs. 19.1%, P = 0.003, respectively).Conclusion: ICSI does not improve live birth rates but yields higher cancellation rates than conventional IVF in the treatment of unexplained infertility.

scholarly journals Role of Endometrial Scratch in UnExplained infertility (RESCUE); A Randomized Clinical Trial

2021 ◽  
Author(s):  
reham elkhateeb ◽  
Haitham Bahaa ◽  
Alaa Gamal ◽  
Mahmoud Ibrahim ◽  
Nisreen Toni ◽  
...  
Keyword(s):  
Natural Killer ◽  
Pregnancy Rate ◽  
Ovulation Induction ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Endometrial Scratch

Abstract Background Endometrial natural killer (NK) is thought to play a role in implantation and maintenance of a healthy pregnancy. However, their immunological role in unexplained infertility is yet unknown. The aim of the current study was to investigate the role of endometrial injury in treatment of unexplained infertility and to have more insight on the potential underlying mechanisms of its action methodology randomized controlled trial (RCT) done at Minia university hospital, diagnostic laparoscopy was done for both study and control group, study group had gentle scratch and specimens were sent for histopathological examination while control group had Laparoscopy only .Patients in both groups were followed up at the outpatient clinic for 3 months to assess if pregnancy achieved or not. Patients in the study group who had not achieved pregnancy had a repeated scratch using a pipelle sampler which was also sent for histopathology. Patients were counselled for intrauterine insemination (IUI) with ovulation induction while patient in control group had been counselled for IUI and ovulation induction only. Patients in both groups were followed up for further 3 months to assess patients who achieved pregnancy either naturally or after IUI . Results Baseline characteristics were comparable in both groups. Clinical pregnancy rate (CPR) was significantly higher in scratch group compared with the control group (22%; vs. 7.4%, P = 0.001) in the first three months of follow up. After second scratch and IUI cycles cumulative pregnancy rate was significantly higher in the scratch group compared with the control group (36.7% , vs. 16.2%,, P = 0.001). The mean time achieve pregnancy was found to be significantly shorter in the scratch group as compared to the control group (102 days vs.49.5 days, P = 0.01). Conclusion: Endometrial natural killer cells might play a crucial role in endometrial receptivity and therefore embryo implantation. Endometrial scratch could promote the recruitment of endometrial NK cells and give a more favourable results as regard clinical pregnancy in patients with unexplained infertility. Registration number PACTR201604001405465

scholarly journals ECLAMPSIA

2009 ◽  
Vol 16 (04) ◽  
pp. 583-588
Author(s):  
FARHANA YOUSUF ◽  
AMBREEN HAIDER ◽  
GULFAREEN HAIDER ◽  
Nasirudin Muhammad
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Perinatal Outcome ◽  
Maternal Morbidity ◽  
Neonatal Period ◽  
Mode Of Delivery ◽  
University Hospital ◽  
Set Up ◽  
Obstetric Department ◽  
Duration Of Pregnancy

Objectives: The purpose of our study was to find the outcome, frequency, maternal morbidity and perinatal outcome due toeclampsia in our set up. Design: Descriptive study. Place and Duration of Study: This study was conducted in the department of obstetricsand gynae from 1 st January 2007 to 1 st January 2008, in Gynecology & obstetric department: unit 1 of Liaquat University hospital Hyderabad.Patients and Methods: Total 39 patient's who had eclampsia were included in this study while other obstetric patient's who had no eclampsiawere excluded from the study. After an informed consent information was recorded on predesigned proforma regarding maternal age, parity,duration of pregnancy, B.P at admission, mode of delivery, maternal morbidity and perinatal outcome. Results were analyzed through computersoftware programme SPSS version 11 and percentages were used to describe the data. Results: Total 1415 deliveries were conducted duringthe study period. Out of these, 39 patients had eclampsia. So the frequency of eclampsia was 2.7%. Majority of patient's i.e. 15(38.4%) wereless than 20 years .Out of 39 patient's, 32(82.0%) patient's were primigravida while 4(10.2%) were multigravida and 3(7.6%) patient's weregrandmultigravida. Majority of the patient's i.e. 28(71.7%) were unbooked. 18(46.1%) patient's had fit during antenatal period, 14(35.8%)patient's had fit in postpartum period one case with eclampsia was received on 6th postnatal day. Serious maternal morbidity was pulmonaryedema seen in 6(15.3%) HELLP Syndrome in 3 (7.6%) and acute renal failure in 4(10.2%) patient's. Regarding perinatal outcome, 28(71.7%)babies were born alive, out of these 11 (39.2%) were died in early neonatal period.8 (20.5%) babies born, were still birth while 3(7.6%) weremacerated IUD. Conclusion: In our study majority of patient's who developed eclampsia were young and primigravida. Major maternalmorbidity was pulmonary edema, chest infection and acute renal failure. Perinatal mortality was also high.

scholarly journals Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hussam H. Alhawari ◽  
Yousef S. Khader ◽  
Hussein H. Alhawari ◽  
Amal F. Alomari ◽  
Hiba N. Abbasi ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Reports ◽  
University Hospital ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid ◽  
Thyroid Uptake ◽  
Antithyroglobulin Antibodies ◽  
And Gender ◽  
Study Participants

Purpose.The association between autoimmune diseases and keratoconus (KC) has been proposed based on previous retrospective studies and case reports. The aim of our study is to investigate whether KC is associated with autoimmune thyroid disease. Methods.A comparative study was conducted on 131 adult subjects from September 2015 to May 2017 at Jordan University Hospital, Amman, Jordan. Subjects were classified into 2 groups: subjects with autoimmune thyroid disease, including Graves’ disease and Hashimoto’s thyroiditis (n=68), and a healthy group for comparison (n=63). Subjects with any other conditions known to be associated with KC were excluded. The diagnosis of KC was based on clinical and corneal topographic findings utilizing the Oculus-Pentacam machine. In addition, TSH and total T4 levels as well as thyroid peroxidase antibodies were measured in all study participants. Antithyroglobulin antibodies, thyroid stimulating immunoglobulin, thyroid ultrasound, and thyroid uptake and scan were also selectively performed in some participants.Results.This study included a total of 131 participants (101 females and 30 males), including patients and controls. In the multivariate analysis, autoimmune disease was not significantly associated with keratoconus (OR = 1.1; 95% confidence interval: 0.3, 3.8;pvalue = 0.353) after adjusting for age and gender.Conclusion.This study did not show a statistically significant association between autoimmune thyroid disease and KC.

scholarly journals The Role of Diagnostic Laparoscopy in the Unexplained Infertility Cases

2021 ◽  
Vol 2 (4) ◽  
pp. 57-63
Author(s):  
Ibrahim Arafa I. Hamed ◽  
Nahla Waer Shady ◽  
Abdu Saeed Ait-Allah
Keyword(s):  
Diagnostic Laparoscopy ◽  
Semen Analysis ◽  
Diagnostic Technique ◽  
Unexplained Infertility ◽  
University Hospital ◽  
Cross Sectional ◽  
Uterosacral Ligaments ◽  
Pelvic Ultrasonography ◽  
Infertility Patients

Purpose: The study examines how useful laparoscopy is in finalizing the diagnosis of unexplained infertility. Materials: The study included 50 women with 1 year or 2 years of infertility,  who had a regular marital life with unprotected intercourse for more than a year, normal husband's semen analysis, normal ovulation by folliculometry, normal hormonal profile, and normal hysterosalpingogram at the department of Obstetrics and Gynecology at Aswan University Hospital from January to December 2019. Methods: This is a cross-sectional observational study involving 50 women who underwent diagnostic laparoscopy after investigations and imaging failed to reveal the cause of infertility. During the procedure, the pelvis was inspected for any pathology, including the uterus, fallopian tubes, round ligaments, ureterovesical pouch, uterosacral ligaments, Douglas pouch, and ovarian fossae. Results: Diagnostic laparoscopy helped uncover abnormal pathologies such as endometriosis, adhesions, and tubal pathologies in 30 women (60%) of the 50 included in the study, whereas no abnormality was detected in the remaining 20 (40%). Conclusion: Laparoscopy is not only a crucial diagnostic technique in infertility patients, but it can also help with treatment selections. Conducting laparoscopy in cases of unexplained infertility is linked to both peritubular adhesions and pelvic endometriosis. These pelvic disorders might not be appropriately detected or treated without laparoscopy, and hysterosalpingography and basic imaging such as pelvic ultrasonography are frequently ignored.

An Ultrastructural Study of the Proliferation Patterns of the Reserve Cells of the Human Cervix Uteri

1972 ◽  
Vol 30 ◽  
pp. 80-81
Author(s):  
Takanori Sohda ◽  
Hiroshi Saito ◽  
Goro Asano ◽  
Katsunari Fukushi ◽  
Katsuya Suzuki ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Age Groups ◽  
Point Of View ◽  
University Hospital ◽  
Cervix Uteri ◽  
Morphological Aspect ◽  
Functional Aspect ◽  
Pathological Conditions ◽  
Human Cervix ◽  
Morphological Patterns

Recently, the functional aspect as well as morphological aspect of the reserve cells in the cervix uteri drew much attention in view of the carcinogenesis in squamocolumunar junction. In this communication, the authors elucidate the ultrastructural features of the reserve cells in patients of various age groups visiting our university hospital and affiliated hospital.From conventional light microscopic point of view, the reserve cells tend to be pronounced in various pathological conditions, such as the persisting inflammation, proliferative disorders and irritation of hormones. The morphological patterns of the reserve cells from various stage and degree of irritation were observed.

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