Pesticide Use and Lung Cancer Risk in the Korea National Cancer Center Community-Based Cohort Study: A Propensity Score Matching Analysis

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Byungmi Kim ◽  
Eunyoung Park ◽  
Jinsun Kim ◽  
Eunjung Park ◽  
Jin-Kyoung Oh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Propensity Score ◽  
Cancer Risk ◽  
Propensity Score Matching ◽  
Lung Cancer Risk ◽  
Cancer Center ◽  
Pesticide Use ◽  
Community Based ◽  
Propensity Score Matching Analysis

scholarly journals Relationship Between Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol and Lung Cancer Risk in the General Population: A Community-Based Prospective Cohort Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Eun Young Park ◽  
Min Kyung Lim ◽  
Eunjung Park ◽  
Jin-Kyoung Oh ◽  
Do-Hoon Lee
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
General Population ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Proportional Hazards ◽  
Lung Cancer Risk ◽  
Cox Proportional Hazards ◽  
Community Based

No published studies have prospectively evaluated the association between urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels and lung cancer risk in the general population. Here, we conducted a prospective community-based cohort study in the Republic of Korea to evaluate the relationship between urinary NNAL levels and lung cancer risk using prediagnostic urine samples. This prospective cohort study was based on the Korean National Cancer Center Community Cohort. During the follow-up period, 173 primary lung cancer cases were identified. Total urinary NNAL levels were measured by liquid chromatography-tandem mass spectrometry, and data were analyzed using multivariable Cox proportional hazards regression models. The risk of lung cancer was significantly increased per unit of natural log-transformed urinary NNAL (HR, 1.27; 95% CI, 1.09–1.48), after adjusting for age, region, entry year into the cohort, education achievement, alcohol consumption status, BMI, smoking status, and urinary cotinine levels. Cox proportional-hazards models with NNAL quartiles also showed positive dose-response relationships with risk of lung cancer. A significantly increased risk of lung cancer was found in the fourth quartile of urinary NNAL levels (HR, 3.27; 95% CI, 1.37–7.79, P for trend < 0.01). After stratification with sex, the significant association remained in only men. Urinary NNAL levels are associated with the risk of lung cancer in the general population, and this association is independent from the quantification of cigarette smoking and nicotine uptake.

scholarly journals Adherence to the Mediterranean diet and risk of lung cancer in the Netherlands Cohort Study

2018 ◽  
Vol 119 (6) ◽  
pp. 674-684 ◽  
Author(s):  
Maya Schulpen ◽  
Piet A. van den Brandt
Keyword(s):  
Lung Cancer ◽  
Cancer Research ◽  
Cohort Study ◽  
Cancer Risk ◽  
The Netherlands ◽  
Mediterranean Diet ◽  
Dietary Habits ◽  
Lung Cancer Risk ◽  
Cox Regression ◽  
The Mediterranean

AbstractThe evidence on a cancer-protective effect of the Mediterranean diet (MD) is still limited. Therefore, we investigated the association between MD adherence and lung cancer risk. Data were used from 120 852 participants of the Netherlands Cohort Study (NLCS), aged 55–69 years. Dietary habits were assessed at baseline (1986) using a validated FFQ and alternate and modified Mediterranean diet scores (aMED and mMED, respectively), including and excluding alcohol, were calculated. After 20·3 years of follow-up, 2861 lung cancer cases and 3720 subcohort members (case-cohort design) could be included in multivariable Cox regression analyses. High (6–8) v. low (0–3) aMED excluding alcohol was associated with non-significantly reduced lung cancer risks in men and women with hazard ratios of 0·91 (95 % CI 0·72, 1·15) and 0·73 (95 % CI 0·49, 1·09), respectively. aMED-containing models generally fitted better than mMED-containing models. In never smokers, a borderline significant decreasing trend in lung cancer risk was observed with increasing aMED excluding alcohol. Analyses stratified by the histological lung cancer subtypes did not identify subtypes with a particularly strong inverse relation with MD adherence. Generally, the performance of aMED and World Cancer Research Fund/American Institute for Cancer Research dietary score variants without alcohol was comparable. In conclusion, MD adherence was non-significantly inversely associated with lung cancer risk in the NLCS. Future studies should focus on differences in associations across the sexes and histological subtypes. Furthermore, exclusion of alcohol from MD scores should be investigated more extensively, primarily with respect to a potential role of the MD in cancer prevention.

Radon exposure and lung cancer risk — Czech cohort study on residential radon

2001 ◽  
Vol 272 (1-3) ◽  
pp. 43-51 ◽  
Author(s):  
L Tomášek ◽  
E Kunz ◽  
T Müller ◽  
J Hůlka ◽  
A Heribanová ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Radon Exposure ◽  
Residential Radon

Reproductive factors and lung cancer risk among never-smoking Japanese women with 21 years of follow-up: a cohort study

2021 ◽  
pp. cebp.1399.2020
Author(s):  
Calistus Wilunda ◽  
Norie Sawada ◽  
Taiki Yamaji ◽  
Motoki Iwasaki ◽  
Manami Inoue ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Reproductive Factors ◽  
Japanese Women

scholarly journals Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update

2019 ◽  
Vol 111 (8) ◽  
pp. 811-819 ◽  
Author(s):  
Daniel O Stram ◽  
S Lani Park ◽  
Christopher A Haiman ◽  
Sharon E Murphy ◽  
Yesha Patel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
African Americans ◽  
Cancer Risk ◽  
Racial Differences ◽  
Lung Cancer Risk ◽  
Native Hawaiians ◽  
Japanese Americans ◽  
Urinary Biomarker ◽  
Multiethnic Cohort

Abstract Background We previously found that African Americans and Native Hawaiians were at highest lung cancer risk compared with Japanese Americans and Latinos; whites were midway in risk. These differences were more evident at relatively low levels of smoking intensity, fewer than 20 cigarettes per day (CPD), than at higher intensity. Methods We apportioned lung cancer risk into three parts: age-specific background risk (among never smokers), an excess relative risk term for cumulative smoking, and modifiers of the smoking effect: race and years-quit smoking. We also explored the effect of replacing self-reports of CPD with a urinary biomarker—total nicotine equivalents—using data from a urinary biomarker substudy. Results Total lung cancers increased from 1979 to 4993 compared to earlier analysis. Estimated excess relative risks for lung cancer due to smoking for 50 years at 10 CPD (25 pack-years) ranged from 21.9 (95% CI = 18.0 to 25.8) for Native Hawaiians to 8.0 (95% CI = 6.6 to 9.4) for Latinos over the five groups. The risk from smoking was higher for squamous cell carcinomas and small cell cancers than for adenocarcinomas. Racial differences consistent with earlier patterns were seen for overall cancer and for cancer subtypes. Adjusting for predicted total nicotine equivalents, Japanese Americans no longer exhibit a lower risk, and African Americans are no longer at higher risk, compared to whites. Striking risk differences between Native Hawaiians and Latinos persist. Conclusions Racial differences in lung cancer risk persist in the Multiethnic Cohort study that are not easily explained by variations in self-reported or urinary biomarker-measured smoking intensities.

scholarly journals Investigating the associations of glycemic load and glycemic index with lung cancer risk in the Southern Community Cohort Study

2020 ◽  
Vol 31 (12) ◽  
pp. 1069-1077
Author(s):  
Xiang Shu ◽  
Danxia Yu ◽  
Xiao-ou Shu ◽  
Heather M. Munro ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Glycemic Index ◽  
Lung Cancer Risk ◽  
Glycemic Load
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