Micronized progesterone as a neuroprotector in pregnant women with post-trauma brain syndrome

The present article is concerned with the study of glial fibrillary acidic protein (GFAP) level in the blood serum of pregnant women with post–trauma brain injury syndrome (post-TBI syndrome) as the marker of hematoencephalic barrier status and predictor of obstetric and perinatal complications development.

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A novel time-resolved fluorescent lateral flow immunoassay for quantitative detection of the trauma brain injury biomarker-glial fibrillary acidic protein

Sensors & Diagnostics ◽

10.1039/d1sd00021g ◽

2022 ◽

Author(s):

Satheesh Natarajan ◽

Jayaraj Joseph

Keyword(s):

Brain Injury ◽

Glial Fibrillary Acidic Protein ◽

Lateral Flow ◽

Acidic Protein ◽

Lateral Flow Immunoassay ◽

Quantitative Detection ◽

Time Resolved ◽

Highly Sensitive ◽

Mild Brain Injury ◽

Trauma Brain Injury

A highly sensitive time-resolved fluorescence lateral flow immunoassay (TRF-LFIA) was developed to quantify glial fibrillary acidic protein (GFAP), a trauma brain injury (TBI) biomarker in blood, for the purpose of providing a diagnosis of mild brain injury.

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Faculty Opinions recommendation of Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718326742.793539000 ◽

2017 ◽

Author(s):

W Dalton Dietrich

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Glial Fibrillary Acidic Protein ◽

Acidic Protein ◽

Autoantibody Response

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PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN

Wiadomości Lekarskie ◽

10.36740/wlek202110210 ◽

2021 ◽

Vol 74 (10) ◽

pp. 2585-2587

Author(s):

Vitaliy V. Maliar

Keyword(s):

Vitamin D ◽

Blood Serum ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Test System ◽

Perinatal Complications ◽

Pregnancy And Childbirth ◽

Wide Range ◽

Pregnancy And Delivery

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack. Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women. Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section. Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.

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Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury

Journal of Neurotrauma ◽

10.1089/neu.2018.5952 ◽

2019 ◽

Vol 36 (10) ◽

pp. 1551-1560 ◽

Cited By ~ 14

Author(s):

Iftakher Hossain ◽

Mehrbod Mohammadian ◽

Riikka S.K. Takala ◽

Olli Tenovuo ◽

Linnéa Lagerstedt ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Glial Fibrillary Acidic Protein ◽

Mild Traumatic Brain Injury ◽

Acidic Protein ◽

Neurofilament Light

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Acute Biomarkers of Traumatic Brain Injury: Relationship between Plasma Levels of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein

Journal of Neurotrauma ◽

10.1089/neu.2013.3040 ◽

2014 ◽

Vol 31 (1) ◽

pp. 19-25 ◽

Cited By ~ 192

Author(s):

Ramon Diaz-Arrastia ◽

Kevin K.W. Wang ◽

Linda Papa ◽

Marco D. Sorani ◽

John K. Yue ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Glial Fibrillary Acidic Protein ◽

Plasma Levels ◽

Acidic Protein

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Modern view on the problem of optimization of therapy in pregnant women with functional cervical insufficiency

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2018-22(1)-33 ◽

2018 ◽

Vol 22 (1) ◽

pp. 173-177

Author(s):

V. F. Oleshko

Keyword(s):

Blood Serum ◽

Pregnant Women ◽

Main Group ◽

Control Group ◽

Cervical Insufficiency ◽

Progesterone Concentration ◽

Therapeutic Dosage ◽

Hormonal Balance ◽

Magnesium Orotate ◽

Micronized Progesterone

A functional cervical insufficiency plays an important role in the etiology of miscarriage and premature birth. The aim of research was to estimate the hormonal balance indexes during the course of pregnancy in pregnant women with functional cervical insufficiency and to correct the revealed violations in order to prevent obstetric complications. 101 pregnant women with confirmed diagnosis of a functional cervical insufficiency in term of gestation 22–32 weeks of pregnancy (the main group) and 34 pregnant women and women in labor with physiological condition of the cervix (the control group) were examined. The content of estradiol, progesterone, cortisol and prolactin was examined in the blood serum. On the second stage of examination 63 pregnant women obtained general basic therapy (I main group) and 38 pregnant women (II main group) received a developed treatment complex which included progesterone support by the micronized progesterone 200–400 mg twice a day up to 34–35 weeks of pregnancy, magnesium support by the magnesium orotate dehydrate in the therapeutic dosage and arginine glutamate in the therapeutic dosage. The correction of cervical insufficiency was performed with the help of a cervical pessary (according to indications). The examination of hormonal balance revealed an accurate decease of progesterone concentration on the background of high concentration of estradiol and increased levels of stress-associated hormones. Propitious influence of the developed therapy is proved by increase of progesterone concentration in the blood serum, normalization in stress-associated hormones balance according to gestational age. All this provideded the decrease of specific weight of threatened preterm labors, placental dysfunction, vaginitis, bacterial vaginosis and delay the labors up to 38–39 weeks of gestation in 97,4% of pregnant women (82,5% in the I main group). Prescription of micronized progesterone, magnesium orotate dehydrate, arginine glutamate to pregnant women with a cervical insufficiency is reasonable and effective one comparing with general and traditional therapy.

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Influence of pregnancy on iron and copper exchange rates in women with normal body weight and women with obesity

Russian Clinical Laboratory Diagnostics ◽

10.51620/0869-2084-2021-66-4-205-209 ◽

2021 ◽

Vol 66 (4) ◽

pp. 205-209

Author(s):

E. L. Makarova ◽

N. A. Terekhina

Keyword(s):

Body Weight ◽

Blood Serum ◽

Pregnant Women ◽

Copper Metabolism ◽

The Body ◽

Reproductive Age ◽

Perinatal Complications ◽

Effective Prevention ◽

Normal Body ◽

Normal Body Weight

The number of obese pregnant women increases annually and reaches 20-30%. The metabolism of hormones and minerals changes in the presence of a large amount of adipose tissue in the body of a pregnant woman, which leads to a number of obstetric and perinatal problems. The aim of the work is to study and compare the influence of the gestational process on the indicators of iron and copper metabolism in the blood serum of women with normal body weight and women with obesity. In the blood serum of 125 women of reproductive age, the content of hemoglobin, iron, transferrin, ferritin, copper and ceruloplasmin was determined. The influence of pregnancy on the indicators of iron and copper metabolism in the blood serum of women was revealed. Pregnancy in women with normal body weight increases the content of transferrin and ceruloplasmin. Correlation of ceruloplasmin and ferritin content with body mass index of obese pregnant women was revealed. In pregnancy with concomitant obesity, hyperferritinemia is formed with a reduced content of hemoglobin and serum iron. Knowledge of the indicators of iron and copper metabolism is necessary to optimize the observation of pregnant women, effective prevention and prediction of obstetric and perinatal complications.

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