Influence of pregnancy on iron and copper exchange rates in women with normal body weight and women with obesity

2021 ◽  
Vol 66 (4) ◽  
pp. 205-209
Author(s):  
E. L. Makarova ◽  
N. A. Terekhina
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Pregnant Women ◽  
Copper Metabolism ◽  
The Body ◽  
Reproductive Age ◽  
Perinatal Complications ◽  
Effective Prevention ◽  
Normal Body ◽  
Normal Body Weight

The number of obese pregnant women increases annually and reaches 20-30%. The metabolism of hormones and minerals changes in the presence of a large amount of adipose tissue in the body of a pregnant woman, which leads to a number of obstetric and perinatal problems. The aim of the work is to study and compare the influence of the gestational process on the indicators of iron and copper metabolism in the blood serum of women with normal body weight and women with obesity. In the blood serum of 125 women of reproductive age, the content of hemoglobin, iron, transferrin, ferritin, copper and ceruloplasmin was determined. The influence of pregnancy on the indicators of iron and copper metabolism in the blood serum of women was revealed. Pregnancy in women with normal body weight increases the content of transferrin and ceruloplasmin. Correlation of ceruloplasmin and ferritin content with body mass index of obese pregnant women was revealed. In pregnancy with concomitant obesity, hyperferritinemia is formed with a reduced content of hemoglobin and serum iron. Knowledge of the indicators of iron and copper metabolism is necessary to optimize the observation of pregnant women, effective prevention and prediction of obstetric and perinatal complications.

Features of the course of acute pancreatitis in patients with obesity

2019 ◽  
Vol 91 (5) ◽  
pp. 1-5 ◽  
Author(s):  
Andriy Kebkalo ◽  
Olha Tkachuk ◽  
Adrian Reyti
Keyword(s):  
Acute Pancreatitis ◽  
Body Weight ◽  
Mortality Rate ◽  
The Body ◽  
Obese Patients ◽  
Correlation Relationship ◽  
Systemic Complications ◽  
Key Words Acute Pancreatitis ◽  
Normal Body ◽  
Normal Body Weight

Abstract The purpose of the study is to investigate the course of acute pancreatitis in obese patients, the development of local and systemic complications and mortality rates. Materials and methods We have taken and analyzed 482 histories of acute pancreatitis, who has been treatmented at Kyiv Regional Clinical Hospital from January 1, 2011 to February 2, 2019. The data were statistically processed in the Exel 2010 program using a descriptive method using relative , absolute numbers, mean square deviations and their errors. A correlation relationship between variables was studied using the Pearson criterion (R2). Testing the significance of the difference between the two independent groups was carried out with the help of the t-criterion of the Student. Results In our study we had 482 patients, 260 patients (54%) had obesity (the study group), for comparison, a control group of patients with normal body weight was chosen, the total number of which was 222 (46%) patients. Obesity patients had a higher average age (55.4 ± 9.4 years, p = 0.01), also they had statistically greater percentage of severe cases of acute pancreatitis (85 (32.7%) vs 16 (7.2%); p = 0.01 *). We note the increase in the percentage of the course of severe pancreatitis in patients with weight gain from 10.20% to 53.93% (p = 0.03) *. Obesity patients had the longer bed-days in the hospital than in patients with normal body weight. In addition, they observed an increase of twice the bed in the reanimation and intensive care unit (5.8 ± 0.8 vs 2.7 ± 0.5 days, p = 0.01 *). When investigating the mortality rate, it should be noted that the main cause of death was the progression of organ failure of 30 (6.3%), pulmonary embolism (TB) - 15 (3.1%) and DIC 18 (3.7%) . Conclusions. The presence of obesity in patients involves a high risk of severe acute pancreatitis, this risk increases with an increase in the body mass index. In addition, in obese patients we have a higher bed-day in-patient and in-patient-care settings, which increases the total cost of treatment and requires a cost-effective algorithm in the future. A high mortality rate in obese patients requires improved treatment algorithm. Key words: acute pancreatitis, obesity.

scholarly journals Osteodensitometric Characteristics of Bone Tissue in Women with Normal Body Weight

2021 ◽  
Vol 10 (3) ◽  
pp. 108-111
Author(s):  
I. G. Pashkova
Keyword(s):  
Body Weight ◽  
Bone Tissue ◽  
Muscle Mass ◽  
Bone Mineralization ◽  
Lumbar Vertebrae ◽  
The Body ◽  
Mineral Density ◽  
Normal Body ◽  
Age Related ◽  
Normal Body Weight

The aim of the study was to investigate age-related changes in bone mineralization indicators in the lumbar vertebrae in women with normal body weight living in the conditions of the Northern region.Material and methods. A complex somatometric examination and quantitative assessment of the bone tissue mineral density in the lumbar vertebrae were performed according to dual-energy X-ray absorptiometry of a group of Slavic women (n=127) with a normal body weight (BMI values from 18.5 to 24.9 kg/m2) aged 20 to 87 years, permanently residing in the Republic of Karelia. Statistical processing of the material was performed using the program "STATISTICA 6.0".Results. The BMI values in women increased significantly every decade of life. Direct correlations of mineral bone density (MBD) with the body length (r=0.46, p<0.001), with the body surface area (r=0.46, p<0.001), with absolute muscle mass (MM) (r=0.39, p<0.001), and with body mass (r=0.29, p<0.001) were revealed. No significant correlation with the adipose mass was found. The incidence of low MBD of the lumbar vertebrae was 48%: osteopenia was in 29%, osteoporosis was in 19% of women. The analysis of the component composition of the body in women with different levels of bone mass showed significant differences in the absolute content of muscle mass.Conclusion. In women with a normal BMI, body weight and muscle mass play an essential role in maintaining lumbar vertebrae bone mineral density.

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

scholarly journals Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns

2019 ◽  
Vol 4 (4) ◽  
pp. 58-63
Author(s):  
O. B. Karelina ◽  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
T. Yu. Marochko ◽  
M. N. Surina
Keyword(s):  
Body Weight ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Thyroid Stimulating Hormone ◽  
Obese Women ◽  
Third Trimester ◽  
Normal Body ◽  
Normal Body Weight ◽  
Chemiluminescent Immunoassay ◽  
Stimulating Hormone

Aim: To study the level of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns.Materials and Methods. We consecutively recruited 40 pregnant women and their newborns. Blood sampling in pregnant women was carried out at the end of the third trimester 12 hours after the last meal while in newborns it was conducted immediately after birth. Measurement of serum thyroid-stimulating hormone, thyroxine, triiodothyronine, and free thyroxine was performed using chemiluminescent immunoassay.Results. Thyroid disease was significantly more common in pregnant women with obesity. Clinical and latent hypothyroidism in obese pregnant women was observed 1.5-fold more frequently as compared with those having normal body weight. In keeping with these findings, goiter and elevated thyroxine were also more common in obese pregnant women. Newborns from obese women were more often characterized by a transient hypothyroidism in combination with an augmented thyroid-stimulating hormone.Conclusion. Levels of thyroid-stimulating and thyroid hormones in obese pregnant women and their newborns significantly differ from the patients with normal body weight.

scholarly journals COMPOSITIONAL COMPOSITION OF THE BODY IN OBESE CHILDREN AND ADOLESCENTS

2019 ◽  
Vol 6 (1) ◽  
pp. 51-57 ◽  
Author(s):  
O. A. Gerasimchik ◽  
Ya. V. Girsh
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Fat Mass ◽  
Dynamic Control ◽  
Overweight And Obesity ◽  
The Body ◽  
Excess Body Weight ◽  
Sequential Effects ◽  
Normal Body ◽  
Normal Body Weight

Background. The steady growth of obesity in the children’s age group determines the need for integrated modern approaches to diagnosis and therapy.Objective. To determine the body composition of adolescents with different body mass for the quantitative analysis of the internal environment of the organism using the method bioimpendancemetria.Design and methods. To determine the composition of the body, 121 adolescents aged 10–17 years were examined, the average age was 13.9 years (± 2.1). Evaluation of anthropometric data and determination of BMI at the 1st stage of the study allowed to identify 3 groups of patients: group 1 — adolescents with normal body weight, 40 people (33 %), group 2 — overweight, 48 people (40 %) and group 3 — obese, 33 adolescents (27 %). At stage 2nd, the analysis of the body structure using computer impedance, which allows to determine the composition of the body in a percentage.Results. When assessing the structure of the body, in group with normal body weight, the content of adipose tissue corresponds to the normal value. In adolescents overweight and obesity in 100 % of cases there was an increased content of fat mass. In the group of adolescents with normal body weight, the percentage deviation of AKM is 16–17 %, in the group with excess body weight 12–40 %. Insufficient as well as excessive percentage of AKM causes hunger. The higher AKM in full adolescents, the more difficult the process of weight loss. During the evaluation of the main metabolism it was found that in the group of obese patients the indicators exceeded those in the groups with normal and overweight.Conclusion. The use of bioimpedance analysis allows to create an optimal set of sequential effects aimed at correcting the fat mass, water composition and muscle mass of the patient, which determines a more directed and effective weight loss and the possibility of dynamic control.

scholarly journals Influence of mass and distribution of adipose tissue on the content of leptin in pregnant women at different periods gestations

2019 ◽  
Vol 16 (1) ◽  
pp. 55-61
Author(s):  
Natalya B. Chabanova ◽  
Tatiana N. Vasilkova ◽  
Valentina A. Polyakova ◽  
Sergey I. Mataev
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Blood Serum ◽  
Body Mass ◽  
Fat Mass ◽  
First Trimester ◽  
Fat Deposition ◽  
The Body ◽  
Normal Body ◽  
Increased Risk

BACKGROUND: Currently, obesity is one of the most global problem in the world. Redundant accumulation of adipose tissue accompanied by metabolic disorders including high secretion of leptin may lead to an increased risk of gestational complications. AIMS: To assess the level of leptin in pregnant womens blood serum depending on their body weight and the character of content of adipose tissue in different terms of gestation. MATERIALS AND METHODS: We investigated 211 women with single pregnancies, which came in natural cycles and finished with urgent parturitions. All of them got anthropometric study, assessment of adipose tissues weight by bioimpedanceometry, character of fat deposition by ultrasound investigation of adipose tissue, determination of the level of whey leptin at 1014, 2428, 3638 weeks of pregnancy. RESULTS: Established, that the level of leptin increases in proportion to pregestational body mass index from the first trimester. Women with excess body mass and with obesity had higher concentrations of leptin all over gestation, than women with normal body mass (р0.001). The higher term of pregnancy was, the higher the level of whey leptin was in all groups, independently of character of fat deposition. In the end of third trimester, women with normal body mass had the largest value of absolute and relative increase of body mass and fatty mass, what accompanied by enlargement of the concentration of leptin more than in 3 times for the pregestational level. CONCLUSIONS: In this way, high content of leptin in pregnant womens (with excess body mass and obesity) blood serum in the first trimester is explained by redundant accumulation of the adipose tissue. The largest value of gestational increase of body mass and fat mass in group where women had normal initial weight is accompanied by the great increase of the level of leptin on the body weight unit and fat mass. These data indicate, that control and limitation of excessive weight gain while pregnancy can be a measure of prevention of the redundant leptins secretion and different gestational complications related with it.

scholarly journals Hepcidin and Feritin Levels in Obese Pregnant Women and Normal Body Weight before Pregnancy

2018 ◽  
Vol 3 (1) ◽  
pp. 22-26
Author(s):  
Hadiyatur Rahma ◽  
◽  
Sarma N Lumbanraja ◽  
Zulfikar Lubis ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Pregnant Women ◽  
Normal Body ◽  
Normal Body Weight

Morphofunctional indices and motor qualities in younout g students with different levels of body mass deficit

2020 ◽  
Vol 99 (4) ◽  
pp. 399-404
Author(s):  
Mikhail M. Kolokol’cev
Keyword(s):  
Higher Education ◽  
Body Weight ◽  
Young Men ◽  
Education Institution ◽  
Normal Weight ◽  
Educational Process ◽  
The Body ◽  
Normal Body ◽  
Normal Body Weight ◽  
Different Levels

Introduction. The body weight of the person characterizes features of the exchange, power, hormonal, etc. the processes happening in a human body. Deviations from normal parameters of body weight affects somatic, physical, mental human health. The analysis of morfofunctsional characteristics and motive features of youth students with insufficient body weight is relevant in connection with insufficient study of the matter. Material and methods. 1514 students of the Irkutsk University at the age of 17-21 years are examined. Anthropometrical and physiometric examination was preformed, the maintenance of muscle and fatty bulk in a body was determined, motive qualities of young men with the normal body weight and deficiency of weight with gradation “below an average” and “low” are considered. Results. The deficiency of body weight is revealed at 209 examined young men (13.8%), out of them 134 students (64.1%) have gradation of deficiency of body weight “below an average” and value of an index in the range of a sigma deviation from M = -1 σ to M = -2 σ and 75 young (35.9%) men - gradation “low” where value of an index less than A M = -2 σ. Reliable differences between morfofunctional indices and results in motive tests of the students having deficiency of body weight and normal weight students are established. Indices of anthropometrical and physiometric characteristics, motive tests, the maintenance of muscle and fatty bulk in a body of all young men having deficiency of body weight are lower in comparison with indices of the young men having normal body weight (p <0.05). The dependence between decrease in the level of development of motive qualities and reduction of body weight of students is noted. Conclusions. The received results allow correcting educational process on valeological and physical training of students of higher education institution with the use of integrative pedagogical methods and methods of training.

Characteristics of markers of metabolic syndrome and features of the course of early gestation in pregnant women with the threat of miscarriage, depending on the body weight of the pregnant woman

2017 ◽  
pp. 69-76
Author(s):  
Yu.M. Duka ◽  
Keyword(s):  
Body Weight ◽  
Pregnant Women ◽  
Diagnostic Algorithm ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
The Body ◽  
Clinical Group ◽  
Perinatal Complications ◽  
Early Gestation ◽  
Perinatal Center

The article gives a scientific and practical justification for the expansion of the diagnostic algorithm in pregnant women with the threat of miscarriage, taking into account the woman’s phenotype. The objective: was to study the basic patterns of the formation and disruption of the reproductive system in pregnant women with overweight and obesity and to evaluate possible criteria for the formation of endocrine and metabolic disorders for the timely diagnosis and prevention of perinatal complications in pregnant women, depending on their phenotype. Materials and methods. Clinical groups comprised 175 pregnant women of different body weight (120 women with overweight and obesity, who were observed from a small gestation period on the basis of the department of fetal medicine and the pathology of early pregnancy of the communal institution «Dnepropetrovsk Regional Perinatal Center with a hospital» in the city of Dnepr (I clinical group) and 55 pregnant women with normal body weight (II clinical group – comparison group)). Results. The dependence of the detection of menstrual cycle disorders in women with overweight and obesity is 1.5 times more often than in women with normal weight. The course of early gestation was analyzed. The necessity of lipid and carbohydrate profile estimation in these patients is substantiated. Authentic criteria of violations of carbohydrate metabolism are specified. Сonclusion. It is necessary to move from the assessment of the effects of obesity to the «Body Mass Index-Oriented Approach» to the assessment based on the «complicity approach». This will make it possible to individualize therapeutic tactics in pregnant women depending on their phenotype and reduce the incidence of gestational complications and perinatal losses. Key words: phenotype, pregnancy, loss of pregnancy, obesity, phenotype, carbohydrate profile, lipid profile, hormonal characteristics.

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