scholarly journals In vitro anti oxidant activity and acute oral toxicity of Terminalia paniculata bark ethanolic extract on Sprague Dawley rats

2014 ◽  
Vol 4 (4) ◽  
pp. 294-298 ◽  
Author(s):  
Ramgopal Mopuri ◽  
Balaji Meriga
Keyword(s):  
Ethanolic Extract ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Anti Oxidant ◽  
Terminalia Paniculata

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

scholarly journals Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats

2021 ◽  
Author(s):  
Saad Alkahtani ◽  
Md Saquib Hasnain ◽  
Hamzah Algamdy ◽  
Nada H. Aljarba ◽  
Abdullah AlKahtane
Keyword(s):  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Lagerstroemia Speciosa ◽  
Sprague Dawley Rats

scholarly journals Acute oral toxicity study of wound healing drink from Ocimum tenuiflorum on adult female Sprague-Dawley rats

Food Research ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 390-393
Author(s):  
Rohini J. ◽  
Rabeta M.S. ◽  
Wan Ezumi M.F.
Keyword(s):  
Wound Healing ◽  
Histopathological Examination ◽  
Microscopy Study ◽  
Toxicity Study ◽  
Histopathological Study ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Ocimum Tenuiflorum

In this study, the extract of Ocimum tenuiflorum was formulated to promote wound healing and no acute toxicity study has been reported on this type of formulation. Acute oral toxicity results of the rats after administration of 5000 mg/kg body weight (BW) formulation showed no toxic effects and behavioural changes of the rats after 14 days of observation. On day 14, the rats were anaesthetized to collect the vital organs for histopathological examination. The microscopy study of the visceral organs of wound healing powder group shows no sign of toxicity in comparison to untreated rats organs. In conclusion, the result of the acute oral toxicity test of wound healing drink showed no sign of toxicity, as corroborated by a histopathological study.

scholarly journals Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats

2015 ◽  
Vol 7 (1) ◽  
pp. 38 ◽  
Author(s):  
MallikarjunaRao Pichika ◽  
MadhuKatyayani Balijepalli ◽  
Velan Suppaiah ◽  
An-me Chin ◽  
AyubaSunday Buru ◽  
...  
Keyword(s):  
Acute Oral Toxicity ◽  
Swietenia Macrophylla ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Sprague Dawley Rats

scholarly journals Acute Oral Toxicity Testing of Ethyl Acetate Fraction from Garcinia mangostana Linn Extract in Sprague-Dawley Rats

2016 ◽  
Vol 10 (3) ◽  
pp. 261-264 ◽  
Author(s):  
F. Rahmayanti ◽  
D.F. Suniarti ◽  
Z.A. Mas`ud ◽  
B.M. Bachtiar ◽  
Y.S. Wimardhani ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Toxicity Testing ◽  
Ethyl Acetate Fraction ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Garcinia Mangostana ◽  
Sprague Dawley Rats

scholarly journals Annona muricata's Leaves Ethanolic Extract Enhance p53 Expression in Rat Hepatic Cells Induced by Dimethylbenz(a)Anthracene (DMBA)

2013 ◽  
Vol 4 (1) ◽  
pp. 483 ◽  
Author(s):  
Rosa Adelina ◽  
Intan Sari Oktoberia ◽  
Putri Reno Intan
Keyword(s):  
Ethanolic Extract ◽  
Annona Muricata ◽  
Sprague Dawley ◽  
Independent Manner ◽  
P53 Expression ◽  
Hepatic Cells ◽  
Sprague Dawley Rats ◽  
Induction Process

Annona muricata or soursop contains acetogenin which can induce apoptosis in vitro and has cytotoxic effect. The study has been done to examine soursop leaves extract’s potency in vivo especially to induce apoptosis in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced Sprague Dawley rats. The induction process was done twice a week for five weeks. The soursop leaves extract were given in three dosages, that are 200, 400, and 800 mg/kgBW for seventeen days after two weeks DMBA induction. Data analysis showed that Annona muricata leaves ethanolic extract could enhance p53 pathway significantly with a dose independent manner in DMBA-induced rats.Keywords: Proapoptosis,  Annona muricata leaves ethanolic extract, hepatoma

scholarly journals ACUTE ORAL TOXICITY, DERMAL IRRITATION AND EYE IRRITATION STUDY OF ECLIPTA ALBA AQUEOUS EXTRACT IN SPRAGUE DAWLEY RATS AND NEWZEALAND WHITE RABBITS

2016 ◽  
Vol 7 (6) ◽  
pp. 103-109 ◽  
Author(s):  
Arakere C Udayashankar ◽  
Sollepura B Rajini ◽  
Murali Nandhini ◽  
Y S Suhas ◽  
Siddapura R Niranjana ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Eye Irritation ◽  
Eclipta Alba ◽  
Dermal Irritation ◽  
Sprague Dawley Rats

scholarly journals Effects of a Proprietary StandardizedOrthosiphon stamineusEthanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A2AReceptors

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Vandana Kotak Choudhary ◽  
Praveen Bommu ◽  
...  
Keyword(s):  
Social Memory ◽  
Recognition Task ◽  
Ethanolic Extract ◽  
Social Recognition ◽  
Sprague Dawley ◽  
Short Term ◽  
Antagonist Activity ◽  
Age Related ◽  
Sprague Dawley Rats

The aim of the study was to explore a propriety standardized ethanolic extract from leaves ofOrthosiphon stamineusBenth in improving impairments in short-term social memoryin vivo,possibly via blockade of adenosine A2Areceptors (A2AR). The ethanolic extract ofO. stamineusleaves showed significantin vitrobinding activity of A2AR with 74% inhibition at 150 μg/ml and significant A2AR antagonist activity with 98% inhibition at 300 μg/mL. A significant adenosine A1receptor (A1R) antagonist activity with 100%inhibition was observed at 300 μg/mL. Its effect on learning and memory was assessed via social recognition task using Sprague Dawley rats whereby the ethanolic extract ofO. stamineusshowed significant (p<0.001) change in recognition index (RI) at 300 mg/kg and 600 mg/kg p.o and 120 mg/kg i.p., respectively, compared to the vehicle control. In comparison, the ethanolic extract ofPolygonum minusaerial parts showed small change in inflexion; however, it remained insignificant in RI at 200 mg/kg p.o. Our findings suggest that the ethanolic extract ofO. stamineusleaves improves memory by reversing age-related deficits in short-term social memory and the possible involvement of adenosine A1and adenosine A2Aas a target bioactivity site in the restoration of memory.

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