scholarly journals Analysis of New Piperidine Substituted Benzothiazole Crystalline Derivatives

2021 ◽  
Vol 37 (5) ◽  
pp. 1158-1166
Author(s):  
S.Syed Shafi ◽  
R. Rajesh ◽  
R. Subaash ◽  
S.Senthil kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Photoluminescence Spectra ◽  
Chemical Structures ◽  
Good Antibacterial Activity ◽  
Biological Studies ◽  
Crystalline Nature

Recently, heterocyclic compounds play important role in drug industries. The benzothiazole (BTA) is a bicyclic compound in heterocyclic because of their biological properties. In this paper the synthesis and characterization of benzothiazole were reported. The chemical structures of synthesized compounds were established based on spectral data of 1HNMR, 13CNMR, and IR. The mass of the novel compounds was established with the help of the LCMS test. The formation of the crystal was confirmed by powder XRD and the sharp peaks show the purity and crystalline nature of the samples. The photoluminescence spectra explain the optical property of the compound. The biological studies of synthesized compounds show that compound 5c possesses good antibacterial activity and compound 5d has good antifungal activity.

Synthesis and Biological Properties of New Piperidine Substituted Benzothiazole Derivatives

2021 ◽  
Vol 6 (3) ◽  
pp. 181-185
Author(s):  
S. Syed Shafi ◽  
R. Rajesh ◽  
S. Senthilkumar
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Carboxylic Acid ◽  
Biological Properties ◽  
The Novel ◽  
Photoluminescence Spectra ◽  
Benzothiazole Derivatives ◽  
Chemical Structures ◽  
Good Antibacterial Activity ◽  
Biological Studies

In present work, ethyl 2-aminobenzo[d]thiazole-6-carboxylate was reacted to piperidine using copper(II) bromide to get ethyl 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylate. The reaction of ethyl 2-(piperidin- 1-yl)benzo[d]thiazole-6-carboxylate with NaOH produces 2-(piperidin-1-yl)benzo[d]thiazole-6- carboxylic acid. The inter-mediate 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylic acid have been isolated as stable compounds. The chemical structures of synthesized compounds were established based on the 1H & 13C NMR and IR spectral data. The mass of the novel compounds was established with the help of the LC-MS technique. The photoluminescence spectra explain the optical property of the compound. The biological studies of synthesized compounds show that the compound 5e possesses good antibacterial activity and compound 5d has good antifungal activity.

Synthesis and Characterization of Chemical Structures, Thermal Decomposition and Biological Properties of Novel Copper (II) Bio- Based Surfactants

2020 ◽  
Vol 10 (3) ◽  
pp. 213-228
Author(s):  
Asha Meena ◽  
Rashmi Sharma ◽  
Vandana Sukhadia
Keyword(s):  
Staphylococcus Aureus ◽  
Thermal Degradation ◽  
Edible Oils ◽  
Waste Water Treatment ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
Chemical Structures

Background: Thermal degradation has attracted the attention of scientific community throughout the world due to its multiple applications in environment, energy, waste water treatment, pollution control, green chemistry, etc. Objective: The present work deals with the study of synthesis and characterization of thermal and biological properties of novel copper complex. Methods: Chemical structures of copper (II) sesame 2-amino-6-ethoxy benzothiazole complex were confirmed by IR, NMR, and ESR techniques. Thermal and biological properties were analysed by Thermogravimetry (TGA) and antimicrobial activity determination against Staphylococcus aureus. Results: The TGA study reveals that copper (II) sesame 2-amino-6-ethoxy benzothiazole complex undergoes stepwise thermal degradation of ligand-soap bond of complex and unsaturated and saturated fatty acid components of edible oils. The complex exhibit significant antimicrobial activities against Staphylococcus aureus. Conclusion: This study provides relevant basic information on the thermal and antimicrobial properties of new copper (II) bio-based surfactants, as well as an explicit relationship structure-biological activity for their potential use as safe and green chemicals.

scholarly journals Chemical design of onion-like carbon-silicon diimide polymer composites

2021 ◽  
Vol 2 ◽  
Author(s):  
Kaili Wang ◽  
Gabriela Mera
Keyword(s):  
Polymer Composites ◽  
Argon Atmosphere ◽  
Polymerization Reaction ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Uv Absorbance ◽  
Photoluminescence Spectra ◽  
Chemical Design ◽  
3D Matrix

Abstract Herein, we report the synthesis and characterization of a novel class of polymer composites based on onion-like carbons (OLCs)-silicon diimide by a salt-free polycondensation reaction. The pyridine-catalyzed polymerization reaction was carried out in the presence of various contents (0.1, 0.5, 1, and 2 wt%) of carboxyl-functionalized OLCs in argon atmosphere to provide composites with well-dispersed and covalently incorporated 0D nanocarbons throughout the 3D matrix of silicon diimide polymer. A strong dependency of the optical properties (UV absorbance and the photoluminescence spectra) on the content of functionalized OLCs incorporated within the polymer matrix was observed. The novel polymer composites are suitable precursors for the design of advanced and multifunctional 0D-nanocarbon–containing Si3N4-based ceramic nanocomposites.

Synthesis and Characterization of Some New Esters Containing Heterocyclic and Derived From Azo Dyes

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Zena G. Alrecabi ◽  
Zainab Amer ◽  
Naeemah Al-Lami
Keyword(s):  
Schiff Base ◽  
13C Nmr ◽  
Azo Dyes ◽  
Spectral Methods ◽  
Anthranilic Acid ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
Cooh Group ◽  
Molecular Weights

This study including prepared new colored esters containing heterocyclic with high molecular weights. In the first part of work we synthesized azo dyes [1,2] from the reaction p-toluidine with β-naphthol and o-nitro phenol, thin we synthesized Schiff bases [3,4] by the reaction anthranilic acid with benzaldehyde and dimethyl benzaldehyde. The reaction azo dyes (contain OH group) with Schiff base (contain COOH group) these led to produce the new colored esters [A1-A4]. The second part of work was modification the (C=N-) group in esters to heterocyclic compounds by reacting with phenyl iso cyanide to produce new β-lactam [B1-B4] and with anthranilic acid to get new hydroquinazoline [C1-C4]. All these compounds were characterized by physical properties and spectral methods FTIR, 1H-NMR and 13C-NMR.

scholarly journals Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4488
Author(s):  
Aboagye Kwarteng Dofuor ◽  
Temitayo Samson Ademolue ◽  
Cynthia Mmalebna Amisigo ◽  
Kwaku Kyeremeh ◽  
Theresa Manful Gwira
Keyword(s):  
Structural Modification ◽  
Spectroscopic Analysis ◽  
Microscopic Analysis ◽  
The Novel ◽  
Chemical Derivatization ◽  
African Trypanosomiasis ◽  
Chemical Structures ◽  
Normal Ratio

The search for novel antitrypanosomals and the investigation into their mode of action remain crucial due to the toxicity and resistance of commercially available antitrypanosomal drugs. In this study, two novel antitrypanosomals, tortodofuordioxamide (compound 2) and tortodofuorpyramide (compound 3), were chemically derived from the natural N-alkylamide tortozanthoxylamide (compound 1) through structural modification. The chemical structures of these compounds were confirmed through spectrometric and spectroscopic analysis, and their in vitro efficacy and possible mechanisms of action were, subsequently, investigated in Trypanosoma brucei (T. brucei), one of the causative species of African trypanosomiasis (AT). The novel compounds 2 and 3 displayed significant antitrypanosomal potencies in terms of half-maximal effective concentrations (EC50) and selectivity indices (SI) (compound 1, EC50 = 7.3 μM, SI = 29.5; compound 2, EC50 = 3.2 μM, SI = 91.3; compound 3, EC50 = 4.5 μM, SI = 69.9). Microscopic analysis indicated that at the EC50 values, the compounds resulted in the coiling and clumping of parasite subpopulations without significantly affecting the normal ratio of nuclei to kinetoplasts. In contrast to the animal antitrypanosomal drug diminazene, compounds 1, 2 and 3 exhibited antioxidant absorbance properties comparable to the standard antioxidant Trolox (Trolox, 0.11 A; diminazene, 0.50 A; compound 1, 0.10 A; compound 2, 0.09 A; compound 3, 0.11 A). The analysis of growth kinetics suggested that the compounds exhibited a relatively gradual but consistent growth inhibition of T. brucei at different concentrations. The results suggest that further pharmacological optimization of compounds 2 and 3 may facilitate their development into novel AT chemotherapy.

scholarly journals The synthesis and characterization of some new diazoamino derivatives

2010 ◽  
Vol 16 (1) ◽  
pp. 89-95
Author(s):  
Mihaela Mocanu
Keyword(s):  
1H Nmr ◽  
Bioactive Compounds ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
Elemental Analysis Data ◽  
Spectral Measurements ◽  
Inflammatory Processes

The sulfonamidic moiety is much encountered in structures of bioactive compounds. In the present paper the studies on the sulfonamidated aryloxyalkylcarboxylic acids are extended by their attaching on certain substrata able to confer some special biological properties to the final products, such as anti-tumor and antioxidant actions useful in treating inflammatory processes, ulcer, convulsions and diabetes, as well as a herbicidal action. The stepwise syntheses of the sulfonamidated aryloxyalkylcarboxylic acid derivatives and their characterization by elemental analysis data and IR, 1H-NMR and UV-Vis spectral measurements are described. The newly obtained compounds could show potential pharmaceutical and herbicide properties.

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