scholarly journals Assessing the impact of physical exercise on cognitive function in older medical patients during acute hospitalization: Secondary analysis of a randomized trial

PLoS Medicine ◽  
2019 ◽  
Vol 16 (7) ◽  
pp. e1002852 ◽  
Author(s):  
Mikel L. Sáez de Asteasu ◽  
Nicolás Martínez-Velilla ◽  
Fabricio Zambom-Ferraresi ◽  
Álvaro Casas-Herrero ◽  
Eduardo L. Cadore ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Physical Exercise ◽  
Randomized Trial ◽  
Secondary Analysis ◽  
Medical Patients ◽  
Acute Hospitalization ◽  
The Impact

scholarly journals The impact of DECISION+2 on patient intention to engage in shared decision making: secondary analysis of a multicentre clustered randomized trial

2014 ◽  
Vol 18 (6) ◽  
pp. 2629-2637 ◽  
Author(s):  
Nicolas Couët ◽  
Michel Labrecque ◽  
Hubert Robitaille ◽  
Stéphane Turcotte ◽  
France Légaré
Keyword(s):  
Decision Making ◽  
Randomized Trial ◽  
Shared Decision Making ◽  
Secondary Analysis ◽  
Shared Decision ◽  
The Impact

scholarly journals Behavioural interventions targeting physical activity improve psychocognitive outcomes in COPD

2019 ◽  
Vol 5 (4) ◽  
pp. 00013-2019 ◽  
Author(s):  
Kim L. Lavoie ◽  
Maria Sedeno ◽  
Alan Hamilton ◽  
Pei-Zhi Li ◽  
Dorothy De Sousa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Exercise Capacity ◽  
Secondary Analysis ◽  
Depression Scale ◽  
Daily Physical Activity ◽  
Cognitive Outcomes ◽  
Double Blind ◽  
Patient Health ◽  
The Impact

This study explored the impact of a self-management behaviour modification (SMBM) programme with/without bronchodilators and with/without exercise training (ExT) to improve daily physical activity on psychological and cognitive outcomes in COPD patients as a secondary analysis of the PHYSACTO trial.A 12-week, four-group, randomised, partially double-blind, placebo-controlled, parallel-group trial of SMBM in addition to tiotropium 5 µg, tiotropium/olodaterol 5/5 µg, tiotropium/olodaterol 5/5 µg plus ExT, or placebo was conducted in 304 patients. Outcomes included anxiety (Hospital Anxiety and Depression Scale (HADS)-A), depression (HADS-D and Patient-Health Questionnaire (PHQ)-9) and cognitive function (Montreal Cognitive Assessment (MoCA)).All outcomes showed statistically and clinically significant improvements after 12 weeks independent of treatment group. However, greater improvements in HADS-A and MoCA were seen in patients who exhibited greater increases in physical activity and exercise capacity, respectively, whereas greater improvements in HADS-D and PHQ-9 were seen in patients who exhibited increases in either physical activity or exercise capacity.The results indicate that SMBM with/without bronchodilators or ExT was associated with improved psychological and cognitive functioning. Anxiety reduced with increased physical activity, cognitive function improved with increased exercise capacity, and depression reduced with increases in either physical activity or exercise capacity. Interventions that increase daily physical activity or exercise capacity may improve psychological and cognitive outcomes in COPD.

scholarly journals Brain Vitalization Gymnastics Improved Cognitive Function Marked by Increased BDNF, Decreased Serum Interleukin-6 and Decreased S-100β Expression among Elderly in West Denpasar Primary Health Clinic

2019 ◽  
Vol 7 (21) ◽  
pp. 3596-3602 ◽  
Author(s):  
Anak Agung Ayu Putri Laksmidewi ◽  
Anak Agung Raka Sudewi ◽  
Nyoman Adiputra ◽  
Dwi Antari ◽  
Oka Suliani
Keyword(s):  
Cognitive Function ◽  
Physical Exercise ◽  
Brain Plasticity ◽  
The Elderly ◽  
Time Frame ◽  
Health Clinic ◽  
Control Group ◽  
Post Test ◽  
The Impact ◽  
Bodily Movements

Background: Brain vitalization gymnastics (BVG) is a form of physical exercise which attempts to synchronize bodily movements with cognition within the same time frame. This study aims to prove BVG can improve cognitive function among the elderly. BACKGROUND: Brain vitalisation gymnastics (BVG) is a form of physical exercise which attempts to synchronise bodily movements with cognition within the same time frame. AIM: This study aims to prove BVG can improve cognitive function among the elderly. METHODS: The impact of BVG was evaluated as opposed to elderly gymnastics (regarded as a control group) for a 4-week study period. Outcomes measured were improvements of cognitive function assessed by MoCA-Ina questionnaire, as well as the difference in serum levels of BDNF, IL-6, and S100β. An experimental pretest-posttest control design was applied to evaluate BDNF and IL-6 levels, while the post-test only designed to evaluate S100β levels. Parametric data were tested for normality before being proceeded into either parametric (independent student’ t) or non-parametric (Mann Whitney) test. RESULTS: BVG significantly improved cognitive function better than elderly gymnastics with MoCA-Ina score of 1.53 ± 1.58 dan 0.11 ± 2.54, respectively (p ≤ 0.047). BVG group also had increased BDNF levels when compared with control (-6020.58 ± 7857.22 dan 0.11 ± 2.54; p = 0.027). Whereas BVG had lower IL-6 levels as opposed to the control group (median pre-test IL-6: 2212, median post-test IL-6: 3197.50; p = 0.004). Meanwhile, S100β levels were found lower among BVG when compared with the control group, although statistically insignificant (p = 0.40). CONCLUSION: BVG programme for 4 weeks improved: (1) brain plasticity as shown by increased serum BDNF and S100β levels (although the latter was statistically not-significant), as well as marked decrease of IL-6 levels, (2) cognitive function as proven by an increase of MoCA-Ina score when compared with elderly gymnastics.  

scholarly journals The Impact of Physical Exercise on Brain-Derived Neurotrophic Factor (BDNF) Level in Elderly Population

2019 ◽  
Vol 7 (10) ◽  
pp. 1618-1620
Author(s):  
Fauziah Nuraini Kurdi ◽  
Rostika Flora
Keyword(s):  
Cognitive Function ◽  
Physical Exercise ◽  
Health Problem ◽  
Neurotrophic Factor ◽  
Memory Function ◽  
Brain Derived Neurotrophic Factor ◽  
Exercise Group ◽  
Bdnf Level ◽  
Major Health Problem ◽  
The Impact

BACKGROUND: Memory function disorder is a major health problem in geriatric patients. Physical exercise has the potency to decrease the incidence of many degenerative and chronic health problem, related to cognitive deterioration (dementia). AIM: This research aimed to observe the effect of physical exercise in various doses and duration on memory function by analysing the role of Brain-Derived Neurotrophic Factor (BDNF) as a regulatory protein affected by exercise. METHODS: This was an analytical observational study with a cohort design. Thirty participants were included in each group, classified as exercise and non-exercise group. The exercise was in the form of jogging for at least fifteen minutes every day. The observation was done for sixty days. Cognitive function assessment was done by using the Mini-Mental State Examination (MMSE) questionnaire. Meanwhile, the BDNF level was assessed by ELISA. Statistical analysis was done using Independent T-test. RESULTS: Exercise group showed better MMSE score (28.56 ± 1.76), and a higher concentration of BDNF (235.34 ± 12.56 pg/mL), both were statistically significant. CONCLUSION: Physical exercise was able to maintain geriatric cognitive function performance by BDNF protein regulation.

scholarly journals Utility of suPAR and NGAL for AKI Risk Stratification and Early Optimization of Renal Risk Medications among Older Patients in the Emergency Department

2021 ◽  
Vol 14 (9) ◽  
pp. 843
Author(s):  
Anne Byriel Walls ◽  
Anne Kathrine Bengaard ◽  
Esben Iversen ◽  
Camilla Ngoc Nguyen ◽  
Thomas Kallemose ◽  
...  
Keyword(s):  
Early Detection ◽  
Secondary Analysis ◽  
Kidney Injury ◽  
Discriminatory Power ◽  
Medical Patients ◽  
Urokinase Plasminogen Activator Receptor ◽  
Plasminogen Activator Receptor ◽  
Neutrophil Gelatinase ◽  
The Impact

Diagnosis of acute kidney injury (AKI) based on plasma creatinine often lags behind actual changes in renal function. Here, we investigated early detection of AKI using the plasma soluble urokinase plasminogen activator receptor (suPAR) and neutrophil gelatinase-sssociated lipocalin (NGAL) and observed the impact of early detection on prescribing recommendations for renally-eliminated medications. This study is a secondary analysis of data from the DISABLMENT cohort on acutely admitted older (≥65 years) medical patients (n = 339). Presence of AKI according to kidney disease: improving global outcomes (KDIGO) criteria was identified from inclusion to 48 h after inclusion. Discriminatory power of suPAR and NGAL was determined by receiver-operating characteristic (ROC). Selected medications that are contraindicated in AKI were identified in Renbase®. A total of 33 (9.7%) patients developed AKI. Discriminatory power for suPAR and NGAL was 0.69 and 0.78, respectively, at a cutoff of 4.26 ng/mL and 139.5 ng/mL, respectively. The interaction of suPAR and NGAL yielded a discriminatory power of 0.80, which was significantly higher than for suPAR alone (p = 0.0059). Among patients with AKI, 22 (60.6%) used at least one medication that should be avoided in AKI. Overall, suPAR and NGAL levels were independently associated with incident AKI and their combination yielded excellent discriminatory power for risk determination of AKI.

The Oxford Handbook of Adult Cognitive Disorders

2019 ◽  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Neurodevelopmental Disorders ◽  
Brain Aging ◽  
Cognitive Disorders ◽  
Diverse Range ◽  
Medical Specialties ◽  
Psychiatric Illnesses ◽  
Medical Disorders ◽  
The Impact

The prevalence of cognitive impairment caused by neurodegenerative diseases and other neurologic disorders associated with aging is expected to rise dramatically between now and year 2050, when the population of Americans aged 65 or older will nearly double. Cognitive impairment also commonly occurs in other neurologic conditions, as well as in non-neurologic medical disorders (and their treatments), idiopathic psychiatric illnesses, and adult neurodevelopmental disorders. Cognitive impairment can thus infiltrate all aspects of healthcare, making it necessary for clinicians and clinical researchers to have an integrated knowledge of the spectrum of adult cognitive disorders. The Oxford Handbook of Adult Cognitive Disorders is meant to serve as an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders (e.g., cardiovascular, liver, pulmonary) and psychiatric illnesses (e.g., depression and bipolar disorder) on cognitive function, adult neurodevelopmental disorders (e.g., Down Syndrome, Attention Deficit/Hyperactivity Disorder), as well as the various neurological conditions (e.g., Alzheimer’s disease, chronic traumatic encephalopathy, concussion). A section of the Handbook is also dedicated to unique perspectives and special considerations for the clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. The target audience of this Handbook includes: (1) clinicians, particularly psychologists, neuropsychologists, neurologists (including behavioral and cognitive neurologists), geriatricians, and psychiatrists (including neuropsychiatrists), who provide clinical care and management for adults with a diverse range of cognitive disorders; (2) clinical researchers who investigate cognitive outcomes and functioning in adult populations; and (3) graduate level students and post-doctoral trainees studying psychology, clinical neuroscience, and various medical specialties.

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