scholarly journals TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42513 ◽  
Author(s):  
Chris Hough ◽  
Maria Radu ◽  
Jules J. E. Doré
Keyword(s):  
Tgf Beta ◽  
Linker Region ◽  
Smad Signaling ◽  
Erk Phosphorylation

scholarly journals SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 30919-30924
Author(s):  
Jinhang Zhang ◽  
Yanping Li ◽  
Qinhui Liu ◽  
Rui Li ◽  
Shiyun Pu ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathway ◽  
Inos Expression ◽  
Tgf Beta ◽  
Hepatocellular Injury ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Inos Inhibitor

NASH is characterized by hepatocellular injury accompanied by steatosis, inflammation and fibrosis. SKLB023 as a potent iNOS inhibitor, suppressed the activation of TGF-β/Smad signaling pathway by blocking iNOS expression to attenuate liver fibrosis in MCD diet-induced mice.

scholarly journals Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling

2019 ◽  
Vol Volume 12 ◽  
pp. 509-518 ◽  
Author(s):  
Zhitao Jiang ◽  
Qianyu Cao ◽  
Guoliang Dai ◽  
Jianchun Wang ◽  
Chundi Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tgf Beta ◽  
Smad Signaling
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