Serum 25-Hydroxyvitamin D and Insulin Resistance in Apparently Healthy Adolescents

INTRODUCTION: Obesity represents the major risk factor for development of insulin resistance during childhood and adolescents. In obesity, adipose tissue release free fatty acids, various hormones, and cytokines, resulting in insulin resistance. This study aimed to establish the correlation between vitamin D deficiency and the incidence of insulin resistance in obese children. DESIGN AND METHOD: This analytical cross-sectional study was arranged from December 2019 - February 2020 included 96 students aged 11 - 17 years old from junior and senior high school who met the criteria for obesity in Makassar. The study subjects were parted into two groups, obese children with vitamin D deficiency (levels of 25-hydroxyvitamin D ≤ 20 ng/ml) and obese children without vitamin D deficiency group (levels of 25-hydroxyvitamin D > 20 ng/ml). Data were analyzed using univariate and bivariate analysis. RESULTS: The frequency of insulin resistance in obese children with vitamin D deficiency was 28 (54.9%), while obese children without vitamin D deficiency was 10 (22.2%). Based on statistical analysis, the frequency of the occurrence of insulin resistance in vitamin D deficiency obese children was higher than in obese children without vitamin D deficiency with OR = 4.261 (95% CI 1.744 – 10.411), p = 0.001. CONCLUSION: The risk of insulin resistance in obese children with vitamin D deficiency is 4.261 times higher than obese children without vitamin D deficiency.

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The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

Journal of Nutrition ◽

10.3945/jn.115.220541 ◽

2015 ◽

Vol 145 (12) ◽

pp. 2683-2689 ◽

Cited By ~ 11

Author(s):

Christian S Wright ◽

Eileen M Weinheimer-Haus ◽

James C Fleet ◽

Munro Peacock ◽

Wayne W Campbell

Keyword(s):

Insulin Resistance ◽

Central Adiposity ◽

Obese Adults ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Public Health Nutrition ◽

10.1017/s1368980014002845 ◽

2014 ◽

Vol 18 (12) ◽

pp. 2211-2219 ◽

Cited By ~ 8

Author(s):

Ji-Chang Zhou ◽

Yu-Mei Zhu ◽

Zheng Chen ◽

Jun-Luan Mo ◽

Feng-Zhu Xie ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Parathyroid Hormone ◽

Vitamin D Supplementation ◽

Normal Weight ◽

Vitamin D Status ◽

Intervention Trial ◽

Oral Vitamin ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

AbstractObjectiveTo examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city.DesignAn intervention trial.SettingShenzhen City, Guangdong Province, China.SubjectsFrom a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18–69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.ResultsFor the survey, there was no significant difference (P>0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P=0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P<0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men.ConclusionsFor obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.

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A Novel Approach Localizes the Association of Vitamin D Status With Insulin Resistance to One Region of the 25-Hydroxyvitamin D Continuum

Advances in Nutrition ◽

10.3945/an.113.003731 ◽

2013 ◽

Vol 4 (3) ◽

pp. 303-310 ◽

Cited By ~ 34

Author(s):

Robert P. Heaney ◽

Christine B. French ◽

Stacie Nguyen ◽

Mia Ferreira ◽

Leo L. Baggerly ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Novel Approach ◽

25 Hydroxyvitamin D

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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

British Journal Of Nutrition ◽

10.1017/s0007114516001185 ◽

2016 ◽

Vol 115 (11) ◽

pp. 1994-2002 ◽

Cited By ~ 12

Author(s):

Lucinda J. Black ◽

Sally Burrows ◽

Robyn M. Lucas ◽

Carina E. Marshall ◽

Rae-Chi Huang ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Vitamin D ◽

Cardiometabolic Risk ◽

Hdl Cholesterol ◽

Cardiometabolic Risk Factors ◽

Inverse Association ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Over Time

AbstractEvidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient −0·01; 95 % CI −0·03, −0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient −0·002; 95 % CI −0·003, −0·001; P<0·001) and positively associated with log-TAG in females (coefficient 0·002; 95 % CI 0·0008, 0·004; P=0·003). These associations did not vary over time. There were no significant associations between serum 25(OH)D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.

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