scholarly journals A Minor (<50%) Signet-Ring Cell Component Associated with Poor Prognosis in Colorectal Cancer Patients: A 26-Year Retrospective Study in China

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121944 ◽  
Author(s):  
Yinuo Tan ◽  
Jianfei Fu ◽  
Xiaofen Li ◽  
Jiao Yang ◽  
Mengjie Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Signet Ring Cell ◽  
Cell Component ◽  
Signet Ring ◽  
Ring Cell ◽  
A Minor ◽  
Colorectal Cancer Patients

scholarly journals Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes

2021 ◽  
Vol 22 (23) ◽  
pp. 13108
Author(s):  
Pantea Pour Farid ◽  
Markus Eckstein ◽  
Susanne Merkel ◽  
Robert Grützmann ◽  
Arndt Hartmann ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Interobserver Reliability ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Tissue Sections ◽  
Signet Ring ◽  
Tumor Center ◽  
Ring Cell ◽  
Colorectal Cancer Patients

Peritumoral budding and intratumoral budding (ITB) are important prognostic factors for colorectal cancer patients. Scientists worldwide have investigated the role of budding in tumor progression and its prognosis, but guidelines for reliably identifying tumor buds based on morphology are lacking. In this study, next-generation tissue microarray (ngTMA®) construction was used for tumor bud evaluation, and highly detailed rule-out annotation was used for tumor definition in pancytokeratin-stained tissue sections. Initially, tissues of 245 colon cancer patients were evaluated with high interobserver reliability, and a concordance of 96% was achieved. It was shown that high ITB scores were associated with poor distant metastasis-free survival (p = 0.006 with a cut-off of ≥10 buds). This cut-off was defined as the best maximum value from one of two/three ngTMA® cores (0.6 mm diameter). ITB in 30 cases of mucinous, medullary, and signet ring cell carcinoma was analyzed for the subsequent determination of differences in tumor bud analyses between those subtypes. In conclusion, blinded randomized punched cores in the tumor center can be useful for ITB detection. It can be assumed that this method is suitable for its adoption in clinical routines.

scholarly journals Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape

2021 ◽  
Vol 11 ◽  
Author(s):  
Dong-Liang Lin ◽  
Li-Li Wang ◽  
Peng Zhao ◽  
Wen-Wen Ran ◽  
Wei Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Sequencing ◽  
Differential Gene Expression ◽  
Differentially Expressed Genes ◽  
Colorectal Adenocarcinoma ◽  
Signet Ring Cell ◽  
Cell Component ◽  
Signet Ring ◽  
Differential Gene ◽  
Ring Cell

Goblet cell adenocarcinoma (GCA) is a rare amphicrine tumor and difficult to diagnose. GCA is traditionally found in the appendix, but extra-appendiceal GCA may be underestimated. Intestinal adenocarcinoma with signet ring cell component is also very rare, and some signet ring cell carcinomas are well cohesive, having some similar morphological features to GCAs. It is necessary to differentiate GCA from intestinal adenocarcinomas with cohesive signet ring cell component (IACSRCC). The goal of this study is to find occurrence of extra-appendiceal GCA and characterize the histological, immunohistochemical, transcriptional, and immune landscape of GCA. We collected 12 cases of GCAs and 10 IACSRCCs and reviewed the clinicopathologic characters of these cases. Immunohistochemical stains were performed with synaptophysin, chromogranin A, CD56, somatostatin receptor (SSTR) 2, and Ki-67. Whole transcriptome RNA-sequencing was performed, and data were used to analyze differential gene expression and predict immune cell infiltration levels in GCA and IACSRCC. RNA-sequencing data for colorectal adenocarcinoma were gathered from TCGA data portal. Of the 12 patients with GCA, there were 4 women and 8 men. There were three appendiceal cases and nine extra-appendiceal cases. GCAs were immunohistochemically different from IACSRCC. GCA also had different levels of B-cell and CD8+ T-cell infiltration compared to both colorectal adenocarcinoma and cohesive IACSRCCs. Differential gene expression analysis showed distinct gene expression patterns in GCA compared to colorectal adenocarcinoma, with a number of cancer-related differentially expressed genes, including upregulation of TMEM14A, GOLT1A, DSCC1, and HSD17B8, and downregulation of KCNQ1OT1 and MXRA5. GCA also had several differentially expressed genes compared to IACSRCCs, including upregulation of PRSS21, EPPIN, RPRM, TNFRSF12A, and BZRAP1, and downregulation of HIST1H2BE, TCN1, AC069363.1, RP11-538I12.2, and REG4. In summary, the number of extra-appendiceal GCA was underestimated in Chinese patients. GCA can be seen as a distinct morphological, immunohistochemical, transcriptomic, and immunological entity. The classic low-grade component of GCA and the immunoreactivity for neuroendocrine markers are the key points to diagnosing GCA.

A STUDY OF HISTOPATHOLOGICAL DISTRIBUTION IN COLORECTAL CANCER

2021 ◽  
pp. 24-25
Author(s):  
Shipra Singh ◽  
Kailash Chand Jat ◽  
Ajit Singh ◽  
Kunal Purohit
Keyword(s):  
Colorectal Cancer ◽  
Surgical Techniques ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Lymph Node Status ◽  
Sex Distribution ◽  
Surgical Specimen ◽  
Signet Ring ◽  
Ring Cell ◽  
Causes Of Deaths

Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.

Sign in / Sign up

Export Citation Format

Share Document