scholarly journals Uric Acid Is Independently Associated with Diabetic Kidney Disease: A Cross-Sectional Study in a Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129797 ◽  
Author(s):  
Dandan Yan ◽  
Yinfang Tu ◽  
Feng Jiang ◽  
Jie Wang ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Chinese Population ◽  
Diabetic Kidney Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney

scholarly journals Diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Randa I. Farah ◽  
Mohammed Q. Al-Sabbagh ◽  
Munther S. Momani ◽  
Asma Albtoosh ◽  
Majd Arabiat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Type 2 Dm

Abstract Aim Diabetic kidney disease (DKD) is a major long-term complication of diabetes mellitus (DM). Given the paucity of data on DKD in Jordan, we aimed to evaluate the prevalence, characteristics and correlates of DKD in Jordanian patients with type 2 DM. Methods This cross-sectional study included 1398 adult patients with type 2 DM who sought medical advice in the endocrinology clinic between March and September 2019. Demographic, clinical and laboratory data were reviewed. DKD was defined as reduced eGFR, and/or albuminuria. Three regression models were constructed to identify factors associated with CKD stages, albuminuria and DKD. Results Overall, 701 (50.14%) patients had DKD, with a median age of 59.71 ± 11.36  years. Older age, high triglycerides, and low high-density lipoprotein were associated with DKD (multivariable odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.01–1.03, p < 0.01; OR: 1.1, 95% CI: 1.01–1.2; and OR: 0.98, 95% CI: 0.97–0.99, p < 0.01 respectively). Metformin and renin-angiotensin system blockers were negatively associated with albuminuria and chronic kidney disease stages (p < 0.01). Conclusion Our study demonstrated that approximately one half of patients with type 2 DM had DKD. Further studies are necessary to understand this high prevalence and the underlying factors. Future research are needed to assess implementing targeted community-based intervention.

scholarly journals Prevalence and Associated Factors of Diabetic Kidney Disease in Senegalese Patients: A Cross-Sectional Study in Saint-Louis

2020 ◽  
Vol 10 (01) ◽  
pp. 23-33
Author(s):  
Sidy Mohamed Seck ◽  
Dominique Doupa ◽  
Seraphin Ahou ◽  
Serigne Gueye ◽  
Macia Engerran ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Associated Factors ◽  
Diabetic Kidney Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Saint Louis

scholarly journals SP361THE RELATIONSHIP BETWEEN SOLUBLE KLOTHO AND DIFFERENT BIOMARKERS OF DIABETIC KIDNEY DISEASE- A CROSS-SECTIONAL STUDY

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii233-iii233
Author(s):  
Flaviu Bob ◽  
Adalbert Schiller ◽  
Romulus Timar ◽  
Daniel Lighezan ◽  
Oana Schiller ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney

scholarly journals PROPORTION OF ISOMORPHIC ERYTROCYTE URINE IN DIABETIC KIDNEY DISEASE WITH FLOW CYTOMETRY METHODS

2019 ◽  
Vol 25 (1) ◽  
pp. 1
Author(s):  
Erica Catarina ◽  
Coriejati Rita ◽  
Basti Andriyoko ◽  
Ida Parwati
Keyword(s):  
Flow Cytometry ◽  
Kidney Disease ◽  
Conventional Method ◽  
Diabetic Kidney Disease ◽  
Cross Sectional Study ◽  
Urine Samples ◽  
Sectional Study ◽  
Cross Sectional ◽  
Erythrocyte Morphology ◽  
Diabetic Kidney

Hematuria can be found in diabetic kidney disease. Urinary erythrocytes morphology can differentiate hematuria in diabetic kidney disease from other glomerular disorders. Different etiologies need different management. Urinalysis with flowcytometry method can directly give information about urine erythrocyte morphology which is not obtained by the conventional method. The aim of this study was to determine the proportion of urinary isomorphic erythrocytes in diabetic kidney disease. This was a descriptive cross-sectional study in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to July 2017. Subjects were 38 patients who have been diagnosed as diabetic kidney disease by clinicians and had hematuria. Random urine samples were collected for erythrocytes morphology assay by using flowcytometry method and u-ACR values by using spectrophotometry method. The result of this study was 57.9% male, with the most frequent age were 55-64 years old group (34.2%) and 63.2% from all subject were included in the macroalbuminuria category. In erythrocyte morphology assay, 84.2% was isomorphic erythrocyte which 83.3% was macroalbuminuria group. The proportion of hematuria in diabetic kidney disease with automated integrated urine flowcytometry method was dominated by isomorphic erythrocyte morphology. Isomorphic erythrocytes in DM did not mean absence of glomerular abnormalities.

scholarly journals Variation of Urine Parameters among Diabetic Patients: A Cross- Sectional Study

1970 ◽  
Vol 29 (1) ◽  
Author(s):  
Molla Abebe ◽  
Tiruneh Adane ◽  
Kassa Kefyalew ◽  
Tesfahun Munduno ◽  
Alebachew Fasil ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Blood Cells ◽  
Diabetic Kidney Disease ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Yeast Cells ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney

BACKGROUND: Diabetic kidney disease is a common and severe microvascular complication of diabetes mellitus (DM). There are limited data regarding alteration of urine parameters other than proteinuria among DM patients.METHODS: Institution based cross-sectional study was conducted from February to May 2017 to assess alteration of urine parameters among DM patients at the University of Gondar Hospital, Northwest Ethiopia. A Systematic random sampling technique was used to recruit adult (≥18 years) diabetic participants. Data were collected after ethical requirements had been fulfilled. The degree of association between variables was evaluated through bivariable and multivariable logistic regression models.RESULTS: The majority (69.4%) of the study participants were type 2 DM patients. The prevalence of altered urine chemical parameters was 11.3% proteinuria, 4.5% ketonuria, 13.6% hematuria, 53.8% glucosuria, 24.9% leukocyturia and 1.7% positive for nitrite. Diastolic blood pressure and poor glycemic control were significantly associated with proteinuria. Male participants were 2.4 times more likely to have leukocyturia than female participants. The prevalence of abnormally increased microscopic findings was red blood cells 3.1%, white blood cells 12.5%, epithelial cells 27.5%, yeast cells 1.7%, bacteria 17.8%, casts 3.7% and crystals 29.2%.CONCLUSIONS: The prevalence of altered urine parameters among DM patients is found to be considerable. These increased prevalences of altered urine parameters are potential indicators for diabetic kidney disease. 

Association between serum uric acid and chronic kidney disease in patients with hypertension: A multicenter nationwide cross‐sectional study

2019 ◽  
Vol 12 (4) ◽  
pp. 235-242 ◽  
Author(s):  
Wisit Kaewput ◽  
Charat Thongprayoon ◽  
Ram Rangsin ◽  
Prajej Ruangkanchanasetr ◽  
Tarun Bathini ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The effect of hepcidin on components of metabolic syndrome in chronic kidney disease: a cross-sectional study

2020 ◽  
Vol 66 (8) ◽  
pp. 1100-1107
Author(s):  
Sibel Gökçay Bek ◽  
Berna Üstüner ◽  
Necmi Eren ◽  
Zeynep Sentürk ◽  
Betül Kalender Gönüllü
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Renal Diseases ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

SUMMARY BACKGROUND Hepcidin is an important regulator of iron homeostasis. OBJECTIVES This cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD). DESIGN AND SETTING 103 CKD patients and 59 healthy volunteers were included in the study from the University Hospital. METHODS Serum hepcidin levels were measured by enyzme-linked immunosorbent assay (ELISA) test. As for the study parameters, age, sex, body mass index, renal diseases, serum biochemistry, complete blood count, iron and total iron-binding capacity, ferritin, high-sensitive C-reactive protein (hsCRP), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated. RESULTS The mean age of the patients was 58.63 ± 11.8 years. Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection. A negative correlation was found between hepcidin and estimated glomerular filtration rate (eGFR), hemoglobin, hematocrit, calcium, 25 OH vitamin D, pH, and bicarbonate levels. CONCLUSION Hepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.

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